Catalog No.
Product Name
Application
Product Information
Citations
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SIRT2 Inhibitor
SIRT2-IN-18 is a selective SIRT2 inhibitor, exhibiting IC50 values of 5.3 μM for SmSIRT2 and 12.3 μM for hSIRT2. This compound demonstrates significant antischistosomal effects against both Liberian and Puerto Rican strains of Schistosoma mansoni, effectively reducing schistosomula viability, adult worm pairing, and egg production while maintaining low cytotoxicity in mammalian cells. SIRT2-IN-18 also promotes histone H3 hyperacetylation and triggers cytochrome c-mediated apoptosis, making it a valuable tool for research into both parasitic infections and the modulation of acetylation pathways. -
Sirtuin Inhibitor
Sirt1/2-IN-4 is a potent triple inhibitor of the sirtuin family, specifically targeting SIRT1 and SIRT2 with IC50 values of 1.2 μM and 1.9 μM, respectively, and showing moderate inhibition of SIRT3 at 18.6 μM. This compound effectively prevents the deacetylation of p53, highlighting its potential role in cancer research. Its ability to modulate sirtuin activity makes it a valuable tool for investigating the biological implications of sirtuin inhibition in various cancer models. -
SIRT6 Activator
MDL-811 is a selective allosteric activator of SIRT6, exhibiting an EC50 of 5.7 μM. This compound demonstrates significant anti-inflammatory, antitumor, and neuroprotective properties, making it a valuable tool for research. MDL-811 is particularly relevant for studies related to colorectal cancer and ischemic stroke, providing insights into potential therapeutic strategies targeting SIRT6 modulation. -
SIRT2/Hsp70 Inhibitor
YM-08 is a selective inhibitor of SIRT2 and Hsp70, exhibiting an IC50 of 19.9 μM for SIRT2. This compound effectively penetrates the blood-brain barrier, making it a valuable tool for studying neurodegenerative diseases and cellular stress responses. Its dual inhibitory activity allows for investigation into SIRT2 and Hsp70's roles in various biological processes and potential therapeutic applications. -
HSP70/SIRT2 Inhibitor
HSP70/SIRT2-IN-2 is a dual inhibitor targeting SIRT2 and HSP70, demonstrating an IC50 of 45.1±5.0 μM for SIRT2. This compound exhibits significant antitumor activity, making it a valuable tool for cancer research. Its ability to simultaneously inhibit these two proteins positions HSP70/SIRT2-IN-2 as a useful candidate for studies focused on tumor progression and potential therapeutic strategies. -
SIRT3 Agonist
SKLB-11A is a selective, orally active allosteric agonist of SIRT3 (sirtuin 3), exhibiting a Kd value of 4.7 μM and demonstrating high selectivity for SIRT family members. This compound activates autophagy-related signaling pathways and plays a critical role in preventing mitochondrial dysfunction. SKLB-11A has shown efficacy in improving cardiac function in models of Doxorubicin-induced cardiotoxicity and myocardial ischemia/reperfusion, making it a valuable tool for research in cardiovascular protection and mitochondrial biology. -
SIRT1/3 Inhibitor
SPC-180002 is a dual inhibitor of SIRT1 and SIRT3, exhibiting IC50 values of 1.13 μM and 5.41 μM, respectively. This compound disrupts redox homeostasis through reactive oxygen species (ROS) generation, resulting in enhanced stability of the p21 protein and consequential mitochondrial dysfunction. SPC-180002 effectively inhibits cell cycle progression and reduces cancer cell proliferation, while also activating the Nrf2 signaling pathway, making it a valuable tool for cancer research and studies on metabolic dysregulation. -
SIRT1 Activator
SRT 1720 dihydrochloride is a selective activator of SIRT1, exhibiting an EC50 of 0.10 μM. This compound demonstrates lower activity toward SIRT2 and SIRT3, making it an important tool for investigating SIRT1-related biological pathways. Its ability to modulate SIRT1 activity is particularly relevant in studies of metabolism, aging, and neuroprotection. -
SIRT2 Inhibitor
RK-9123016 is a selective inhibitor of SIRT2, effectively inhibiting its enzymatic activity with an IC50 of 0.18 µM, while showing no significant effect on SIRT1 or SIRT3 at concentrations up to 100 µM. This compound enhances the acetylation of eukaryotic translation initiation factor 5A (eIF5A), a known substrate of SIRT2, and is shown to decrease cell viability in human breast cancer cells, correlating with reduced expression of c-Myc. RK-9123016 is valuable for research into cancer biology and the role of sirtuins in cellular processes. -
SIRT1 Activator
Altissimacoumarin F is a terpenylated coumarin that acts as an activator of SIRT1, a protein implicated in cellular stress response and longevity. This compound, isolated from the stem bark of Ailanthus altissima, enhances SIRT1 activity while simultaneously decreasing p53 transcriptional activity. Altissimacoumarin F is valuable for research into age-related disorders and related pathways, providing insights into potential therapeutic strategies. -
SIRT1 Inhibitor
SIRT1-IN-6 is a selective SIRT1 inhibitor with an IC50 value of 9.7 μM. This compound effectively increases p53 acetylation, which is significant in regulating cell cycle and apoptosis. SIRT1-IN-6 is ideal for research applications related to neurodegenerative diseases and cancer, offering insights into potential therapeutic strategies for these conditions. -
SIRT1 Inhibitor
SIRT1-IN-1 is a selective inhibitor of SIRT1, exhibiting an IC50 of 0.205 μM. In addition to its primary target, it also inhibits SIRT2 with an IC50 of 11.5 μM. This indole compound demonstrates antiviral activity, particularly against cytomegalovirus (CMV), making it a valuable tool for research into SIRT1-related pathways and antiviral applications. -
SIRT Inhibitor
Nicotinamide hydrochloride is an inhibitor of SIRT1 and SIRT2, targeting the sirtuin family of proteins critical for cellular regulation. This reagent has been shown to enhance cellular levels of NAD+ and ATP while increasing reactive oxygen species (ROS) levels. Research applications include investigation into tumor growth inhibition and potential improvements in survival, as well as exploring its anti-hepatitis B virus (HBV) activity. -
SIRT6 Inhibitor
SIRT6-IN-6 is a selective inhibitor of SIRT6, demonstrating a potent IC50 of 4.93 μM and a Ki of approximately 10 μM. This compound shows significant selectivity against other histone deacetylases, including SIRT1-3 and HDAC1-11. Research findings indicate that SIRT6-IN-6 effectively elevates the expression of the glucose transporter GLUT-1, which contributes to the reduction of blood glucose levels in mouse models of type 2 diabetes. This reagent is valuable for studies focused on the mechanistic pathways associated with type 2 diabetes and metabolic regulation. -
Sirtuin Inhibitor
MC3482 is a selective inhibitor of sirtuin 5 (SIRT5), known for its role in mitochondrial metabolism and deacylation processes. This compound effectively modulates SIRT5 activity, making it valuable for studies examining the implications of SIRT5 in cellular energy regulation and metabolic disorders. Its use in research can contribute to understanding SIRT5's role in various physiological and pathological conditions, including cancer and neurodegeneration. -
SIRT5 Inhibitor
MC3138 is a selective SIRT5 inhibitor, demonstrating notable antitumor activity in human pancreatic ductal adenocarcinoma (PDAC) cells, with IC50 values ranging from 25.4 to 236.9 μM. In preclinical studies, MC3138 enhances the efficacy of Gemcitabine, significantly inhibiting tumor growth in murine models. This compound is valuable for research into targeted cancer therapies and the modulation of metabolic pathways related to SIRT5 activity. -
SIRT3 Activator
2-APQC is a selective activator of Sirtuin-3 (SIRT3), exhibiting an affinity of Kd=2.756 μM. This compound enhances mitochondrial proline metabolism through the SIRT3-PYCR1 axis and mitigates ROS-induced cytotoxicity by inhibiting the mTOR-p70S6K, JNK, and TGF-β/Smad3 signaling pathways. Additionally, 2-APQC activates the AMPK-Parkin axis, providing a protective effect against myocardial hypertrophy and fibrosis, making it a valuable tool for researching heart failure and related cardiac dysfunctions. -
Sirtuin Activator
ADTL-SA1215 is a novel small-molecule activator of SIRT3, targeting the regulation of autophagy pathways. This compound has demonstrated potential in inducing autophagy in triple-negative breast cancer cells, presenting opportunities for cancer research and therapeutic development. Its specificity for SIRT3 makes it an essential tool for studying the role of sirtuins in cellular metabolism and cancer progression. -
SIRT5 Inhibitor
Et-29 is a potent inhibitor of SIRT5, with a reported Ki value of 40 nM, demonstrating selectivity for this target. By modulating the activity of SIRT5, Et-29 plays a significant role in the study of metabolic processes and post-translational modifications. This reagent is ideal for research applications focused on the regulation of cellular metabolism and potential therapeutic strategies in metabolic diseases. -
SIRT6 Inhibitor
SIRT6-IN-2 is a selective and competitive inhibitor of SIRT6, exhibiting an IC50 of 34 μM. This compound enhances the acetylation of H3K9 and promotes glucose uptake in cultured cells. Additionally, SIRT6-IN-2 demonstrates the ability to reduce T cell proliferation, showcasing its immunosuppressive properties and potential chemosensitizing effects. Research applications include the study of metabolic regulation and immune response modulation. -
SIRT Inhibitor
SIRT-IN-3 is a selective inhibitor of SIRT1 with an IC50 of 17 μM. It demonstrates approximately 4-fold selectivity over SIRT2 and 14-fold selectivity over SIRT3, exhibiting IC50 values of 74 μM and 235 μM, respectively, for these isoforms. This compound is valuable for research applications investigating the role of SIRT1 in cellular processes, including aging, metabolism, and gene regulation. -
SIRT5 Inhibitor
SIRT5 Inhibitor 3 is a potent and competitive inhibitor of SIRT5, exhibiting an IC50 value of 5.9 μM. This compound effectively inhibits the desuccinylation activity of SIRT5, making it a valuable tool for studying the enzyme's role in various biological processes. SIRT5 Inhibitor 3 is applicable in research focused on cancer and neurodegenerative diseases, providing insights into potential therapeutic strategies. -
SIRT3 Activator
SIRT3 Activator 2 is a selective activator of the SIRT3 enzyme. This compound enhances the thermal stability of SIRT3 in SH-SY5Y cells through direct binding, facilitating the clearance of α-synuclein in a SIRT3-dependent manner. In vivo studies demonstrate that SIRT3 Activator 2 improves motor function in Parkinson’s disease models and prevents the loss of dopamine neurons in the substantia nigra in a dose-dependent fashion, making it a valuable tool for research into neurodegenerative disorders. -
Sirt1 Activator
Lumbokinase is a Sirt1 activator that plays a crucial role in mitigating myocardial ischemia-reperfusion (I-R) injury. By enhancing Sirt1 signaling, it promotes autophagic flux while simultaneously reducing oxidative damage, inflammation, and apoptosis associated with I-R events. This compound is valuable for research applications focused on cardiac protection, autophagy modulation, and the underlying mechanisms of ischemic injury. -
Sirtuin Modulator
Sirtuin Modulator 1 is a selective modulator of SIRT1, a member of the sirtuin family of NAD+-dependent deacetylases. With an effective concentration of less than 1 μM, it demonstrates significant biological activity in the regulation of cellular aging and metabolism. This reagent holds potential for research applications in studying age-related diseases, metabolic disorders, and the mechanisms of epigenetic regulation mediated by sirtuins. -
SIRT1 Inhibitor
SIRT1-IN-4 is a selective SIRT1 inhibitor that demonstrates an IC50 of 10.04 μM. This compound is utilized in research focused on cancer biology, providing valuable insights into the role of SIRT1 in tumorigenesis and potential therapeutic approaches. Further studies may explore its utility in modulating cellular processes regulated by SIRT1. -
SIRT1 Activator
E1231 is a potent activator of Sirtuin 1 (SIRT1), exhibiting an EC50 of 0.83 μM. This compound enhances cholesterol and lipid metabolism by interacting with SIRT1 (KD = 9.61 μM) and promoting the deacetylation of liver X receptor-alpha (LXRα), which subsequently increases the expression of ATP-binding cassette transporter A1 (ABCA1). Additionally, E1231 has demonstrated efficacy in reducing atherosclerotic plaque development in ApoE-/- mouse models, making it a valuable tool for research into lipid disorders and related diseases. -
SIRT1 Inhibitor
(S)-Selisistat is a selective inhibitor of SIRT1, demonstrating an IC50 value of 98 nM. This compound effectively modulates the activity of the sirtuin family of proteins, which are implicated in various cellular processes, including metabolism and aging. (S)-Selisistat is valuable for research exploring the role of SIRT1 in age-related diseases and metabolic disorders, making it a crucial tool for investigating therapeutic strategies in these areas. -
SIRT3 Inhibitor
SIRT3-IN-1 is a potent Sirtuin 3 (SIRT3) inhibitor with an IC50 value of 0.043 μM. This compound selectively inhibits SIRT3, making it a valuable tool for studying the role of SIRT3 in acute myeloid leukemia (AML) and other related conditions. Its specific action on SIRT3 allows for targeted investigations into cellular metabolism, oxidative stress response, and potential therapeutic strategies in AML research. -
SIRT7 Inhibitor
YZL-51N is a selective inhibitor of SIRT7, with an IC50 value of 12.71 μM. By occupying the NAD+ binding pocket, YZL-51N inhibits SIRT7 enzyme activity, thereby compromising DNA damage repair mechanisms and reducing cancer cell viability. Its demonstrated anti-tumor activity makes YZL-51N a valuable tool for cancer research applications. -
SIRT1 Inhibitor
SIRT1-IN-3 is a selective inhibitor of SIRT1, exhibiting an IC50 value of 4.2 μM. This compound effectively modulates SIRT1 activity, making it a valuable tool for studies investigating the role of SIRT1 in various biological processes. Research applications include the exploration of SIRT1's involvement in metabolism, aging, and stress response pathways. -
Sirtuin
(R)-Selisistat (R)-EX-527 is a selective inhibitor of SIRT1, exhibiting an IC50 of 98 nM. This compound primarily targets the Sirtuin family of proteins, known to play critical roles in cellular regulation, metabolism, and aging. Research applications include the investigation of SIRT1's involvement in neurodegenerative diseases, metabolic disorders, and cancer biology. (R)-Selisistat serves as a valuable tool for studying the modulation of SIRT1 activity in various biological contexts. -
SIRT1 Inhibitor
SIRT1-IN-2 is a potent and selective inhibitor of SIRT1 (silent information regulator 1), demonstrating an IC50 value of 1.6 μM. This compound plays a critical role in research focused on understanding the regulation of cellular metabolism, aging, and stress response pathways. Its specific inhibition of SIRT1 makes it a valuable tool for studying related biological processes and therapeutic interventions. -
Sirt2 Inhibitor
Sirt2-IN-2 is a selective inhibitor of the Sirtuin 2 (Sirt2) enzyme, exhibiting an IC50 of 0.118 μM. This compound is instrumental in research aimed at studying the role of Sirt2 in cellular processes and its implications in neurodegenerative diseases. Its use facilitates investigations into the potential therapeutic effects of Sirt2 modulation. -
Sirtuin Modulator
Sirtuin modulator 6 is a selective modulator of sirtuin proteins, known for its role in enhancing cellular longevity. This compound exhibits potential therapeutic effects in the context of metabolic disorders such as diabetes and obesity, as well as neurodegenerative and cardiovascular diseases. Its mechanism of action supports research into the modulation of sirtuin pathways, providing insights into various age-related health conditions. -
Sirtuin Modulator
Sirtuin modulator 8 is an effective activator of sirtuin proteins, demonstrating the capacity to enhance sirtuin activity. This compound significantly reduces the expression of monocyte chemoattractant protein-1 (MCP-1) while increasing fibroblast growth factor 21 (FGF21) levels. By regulating genes associated with inflammation and metabolism, Sirtuin modulator 8 is a valuable tool for researching metabolic disorders such as diabetes and obesity, as well as inflammatory diseases. -
Sirt2 inhibitor
SirReal-1 is a selective inhibitor of SIRT2, with an IC50 of 3.7 μM. This compound is utilized in research to investigate the biological role of SIRT2 in various cellular processes and its potential implications in cancer and neurodegenerative diseases. SirReal-1 serves as a valuable tool for elucidating the mechanisms of SIRT2-related signaling pathways. -
Sirtuin Inhibitor
Sirtuin-1 Inhibitor 1 is a selective inhibitor of Sirtuin-1, a key regulator in metabolic processes and cellular aging. This compound demonstrates potential in the study of obesity-related diabetes and age-associated diseases by modulating the activity of Sirtuin-1. Its application in research can enhance understanding of metabolic disorders and the molecular underpinnings of aging. -
SIRT1 Activator
YK-3-237 is a selective activator of SIRT1, targeting mutant p53 proteins. This compound has demonstrated the ability to inhibit the proliferation of triple-negative breast cancer cells, making it a valuable tool for research into cancer biology and potential therapeutic strategies. It may provide insights into the role of SIRT1 in tumor progression and cellular metabolism. -
SirT1 Enhancer
DDL-218 is a potent enhancer of the SirT1 protein, specifically targeting its activity. It has demonstrated efficacy in augmenting SirT1 function in ApoE4-expressing neurons and in murine models of Alzheimer's disease. DDL-218 serves as a valuable tool for investigating SirT1-related pathways and their implications in neurodegenerative disorders, particularly Alzheimer's disease. -
SIRT2 Inhibitor
SIRT2-IN-11 is a selective inhibitor of the SIRT2 enzyme, exhibiting an IC50 value of 18.5 μM. This compound induces apoptosis in a p53-dependent manner, leading to the upregulation of CDKN1A, PUMA, and NOXA, along with increased p53 acetylation. SIRT2-IN-11 is a valuable tool for investigating p53-related cancer mechanisms and therapeutic strategies. -
SIRT2 Inhibitor
AC-93253 is a potent and selective inhibitor of SIRT2, achieving an IC50 value of 6 μM. This compound is instrumental in investigating the role of SIRT2 in tumor biology and may aid in the development of therapeutic strategies targeting SIRT2-related pathways in cancer research. Its specificity enhances the potential for targeted studies in cellular and molecular biology. -
SIRT2 Inhibitor
MIND4-19 is a selective inhibitor of SIRT2, demonstrating an IC50 value of 7.0 μM. This compound is primarily utilized in research related to Huntington's disease, offering insights into the therapeutic potential of SIRT2 modulation in neurodegenerative disorders. Its potency and target specificity make MIND4-19 a valuable tool for studying the role of SIRT2 in disease mechanisms and potential treatments. -
SIRT1 Activator
SIRT1 Activator 2 is a potent SIRT1 activator with an ED50 of less than 5 μM. This compound enhances the activity of SIRT1, a key regulator of cellular lifespan and metabolism. It is utilized in research applications focused on aging, metabolic disorders, and the modulation of cellular stress responses. -
Sirtuin Activator
SIRT1 Activator 3 is a potent activator of Sirtuin 1 (SIRT1), which plays a critical role in cellular metabolism and aging. This compound demonstrates the ability to suppress tumor necrosis factor-alpha (TNF-α) in a dose-dependent manner, highlighting its potential in inflammation modulation. SIRT1 Activator 3 is applicable in research focused on anti-obesity and anti-diabetic therapies, offering insights into metabolic regulation and therapeutic interventions for related disorders. -
SIRT6 Fluorogenic Substrate
CrBKA is a fluorogenic small-molecule substrate specifically designed for SIRT6, a member of the sirtuin family of NAD+-dependent deacetylases. This compound exhibits weak activity, making it suitable for probing SIRT6 enzymatic function in various biological contexts. Its application in research includes the study of cellular metabolism, aging, and the modulation of gene expression through deacetylation processes. -
SIRT1/3 Activator
Nicotinamide riboside is an orally active NAD+ precursor that functions as an activator of SIRT1 and SIRT3. This compound elevates NAD+ levels, enhances oxidative metabolism, and provides protective effects against metabolic abnormalities induced by high-fat diets. Additionally, nicotinamide riboside has been shown to mitigate cognitive decline in transgenic mouse models of Alzheimer’s disease, making it a valuable reagent for research in metabolism and neurodegenerative disorders. -
SIRT1 Modulator
Cannabisin F is a modulator of SIRT1, derived from hempseed lignanamide. It exhibits significant anti-inflammatory and antioxidant properties, making it a valuable candidate for research focused on neurodegenerative diseases. Cannabisin F may influence critical pathways involving SIRT1, NF-κB, and Nrf2, contributing to its potential therapeutic applications. -
Sirtuin Inhibitor
Z26395438 is a potent inhibitor of Sirtuin-1, exhibiting an IC50 value of 1.6 μM. This compound is instrumental in research involving metabolic regulation, aging, and cellular stress responses. Its ability to modulate Sirtuin activity highlights its potential applications in studying various physiological and pathological processes. -
Sirtuin Modulator
Sirtuin modulator 3 is a N-phenyl benzamide derivative that functions as a sirtuin modulator. This compound has been shown to influence sirtuin activity, which is implicated in various biological processes, including aging and cellular regulation. Its biological activity makes it a valuable tool for research in the fields of metabolism, epigenetics, and age-related diseases.
