Fig. 1 · Structure
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(R)-Selisistat
Sirtuin
(R)-Selisistat (R)-EX-527 is a selective inhibitor of SIRT1, exhibiting an IC50 of 98 nM. This compound primarily targets the Sirtuin family of proteins, known to play critical roles in cellular regulation, metabolism, and aging. Research applications include the investigation of SIRT1's involvement in neurodegenerative diseases, metabolic disorders, and cancer biology. (R)-Selisistat serves as a valuable tool for studying the modulation of SIRT1 activity in various biological contexts.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Inhibitor |
| CAS Number | 848193-69-1 |
| Applications | Sirtuin |
| Formula | C13H13ClN2O |
| Molecular Weight | 248.71 |
| Synonyms | (R)-EX-527 |
| SMILES | O=C([C@H]1C(NC2=C3C=C(Cl)C=C2)=C3CCC1)N |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.