Fig. 1 · Structure
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E1231
SIRT1 Activator
E1231 is a potent activator of Sirtuin 1 (SIRT1), exhibiting an EC50 of 0.83 μM. This compound enhances cholesterol and lipid metabolism by interacting with SIRT1 (KD = 9.61 μM) and promoting the deacetylation of liver X receptor-alpha (LXRα), which subsequently increases the expression of ATP-binding cassette transporter A1 (ABCA1). Additionally, E1231 has demonstrated efficacy in reducing atherosclerotic plaque development in ApoE-/- mouse models, making it a valuable tool for research into lipid disorders and related diseases.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 1031195-19-3 |
| Applications | SIRT1 Activator |
| Formula | C21H21N3O3 |
| Molecular Weight | 363.41 |
| Synonyms | 1-{4-[2-(5-Methylfuran-2-yl)quinoline-4-carbonyl]piperazin-1-yl}ethan-1-one |
| SMILES | CC(N1CCN(C(C2=CC(C3=CC=C(C)O3)=NC4=CC=CC=C24)=O)CC1)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.