Fig. 1 · Structure
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2-APQC
SIRT3 Activator
2-APQC is a selective activator of Sirtuin-3 (SIRT3), exhibiting an affinity of Kd=2.756 μM. This compound enhances mitochondrial proline metabolism through the SIRT3-PYCR1 axis and mitigates ROS-induced cytotoxicity by inhibiting the mTOR-p70S6K, JNK, and TGF-β/Smad3 signaling pathways. Additionally, 2-APQC activates the AMPK-Parkin axis, providing a protective effect against myocardial hypertrophy and fibrosis, making it a valuable tool for researching heart failure and related cardiac dysfunctions.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 500271-63-6 |
| Applications | SIRT3 Activator |
| Formula | C23H24FN5O |
| Molecular Weight | 405.47 |
| SMILES | CCCCCNC(C1=C(N(C2=NC3=C(N=C21)C=CC=C3)CC4=CC=C(C=C4)F)N)=O |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.