Fig. 1 · Structure
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SIRT3 activator 2
SIRT3 Activator
SIRT3 Activator 2 is a selective activator of the SIRT3 enzyme. This compound enhances the thermal stability of SIRT3 in SH-SY5Y cells through direct binding, facilitating the clearance of α-synuclein in a SIRT3-dependent manner. In vivo studies demonstrate that SIRT3 Activator 2 improves motor function in Parkinson’s disease models and prevents the loss of dopamine neurons in the substantia nigra in a dose-dependent fashion, making it a valuable tool for research into neurodegenerative disorders.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| Actions | Activator |
| CAS Number | 3061491-60-6 |
| Applications | SIRT3 Activator |
| Formula | C22H24N2O9S |
| Molecular Weight | 492.50 |
| SMILES | CC(CC1(C(N2CCC3=O)=O)CC2=O)(C(N1S(C4=CC(C(OCCCO3)=O)=CC=C4)(=O)=O)=O)C |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.