SIRT3 Activator 2 is a selective activator of the SIRT3 enzyme. This compound enhances the thermal stability of SIRT3 in SH-SY5Y cells through direct binding, facilitating the clearance of α-synuclein in a SIRT3-dependent manner. In vivo studies demonstrate that SIRT3 Activator 2 improves motor function in Parkinson’s disease models and prevents the loss of dopamine neurons in the substantia nigra in a dose-dependent fashion, making it a valuable tool for research into neurodegenerative disorders.
SIRT3 Activator 2 is a selective activator of the SIRT3 enzyme. This compound enhances the thermal stability of SIRT3 in SH-SY5Y cells through direct binding, facilitating the clearance of α-synuclein in a SIRT3-dependent manner. In vivo studies demonstrate that SIRT3 Activator 2 improves motor function in Parkinson’s disease models and prevents the loss of dopamine neurons in the substantia nigra in a dose-dependent fashion, making it a valuable tool for research into neurodegenerative disorders.
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