Catalog No.
Product Name
Application
Product Information
Citations
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Anti-inflammatory Agent
β-Bisabolol is a potent anti-inflammatory agent primarily acting through the inhibition of nitric oxide (NO) and pro-inflammatory cytokines such as TNF-α, IL-6, and IL-8 in LPS-stimulated macrophages and fibroblast cells. Its ability to decrease prostaglandin E2 (pGE2) production further underscores its anti-inflammatory properties. This compound is valuable for research on various inflammatory conditions, offering insights into therapeutic approaches for managing inflammation-related diseases. -
Anti-inflammatory Agent
MDL 201112 is a carbocyclic nucleoside functioning as an anti-inflammatory agent. It effectively reduces TNF-α production and inhibits the expression of MHC class II Ia+ antigens. This compound is valuable for research applications focused on inflammation and immunology, providing insights into the mechanisms underlying these biological processes. -
Anti-inflammatory Agent
Delmitide (RDP58) is an orally active d-isomer decapeptide that functions as a potent anti-inflammatory agent. It effectively inhibits the production of pro-inflammatory cytokines such as TNF-α, IFN-γ, and interleukin (IL)-12, while also up-regulating heme oxygenase 1 activity. Delmitide is valuable for research applications focused on ulcerative colitis and other inflammatory conditions. -
Anti-inflammatory Agent
Asperflavin is an anti-inflammatory agent derived from the marine fungus Eurotium amstelodami. It effectively inhibits the production of nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokines, along with downregulating the expression of inducible nitric oxide synthase (iNOS) in LPS-treated RAW 264.7 cells. Asperflavin serves as a valuable tool in the investigation of inflammatory diseases and their mechanisms. -
Anti-inflammatory Agent
TNF-α-IN-15 is a selective inhibitor of tumor necrosis factor-alpha (TNF-α), a key pro-inflammatory cytokine involved in various inflammatory processes. By decreasing TNF-α levels in the bloodstream, TNF-α-IN-15 exhibits significant anti-inflammatory activity. This compound is valuable for research applications investigating inflammatory diseases and may provide insights into therapeutic strategies targeting TNF-α-mediated pathways. -
Anti-Inflammatory Compound
Gnetifolin E is a derivative of resveratrol trimer, derived from Gnetum brunonianum. It exhibits significant anti-inflammatory activity by inhibiting tumor necrosis factor-alpha (TNF-α). Gnetifolin E is utilized in research focused on inflammatory diseases and could serve as a potential lead compound for therapeutic development. -
Anti-inflammatory Agent
Anti-inflammatory agent 105 targets the inhibition of TNF-α synthesis and release, demonstrating a potent biological activity with an IC50 of 0.124 nM in the human macrophage cell line U937. This compound is valuable for research applications focused on understanding inflammation-related pathways and the development of therapeutic strategies against inflammatory diseases. -
Anti-inflammatory Agent
Sinulatumolin C is an anti-inflammatory agent that exhibits significant inhibition of tumor necrosis factor-alpha (TNF-α), with an IC50 value of 2.6 μM. This compound is valuable for research applications focused on understanding inflammatory pathways and exploring potential therapeutic strategies for inflammatory diseases. Its efficacy in modulating TNF-α makes it a useful tool in the study of immune responses and related biological processes. -
Anti-inflammatory Agent
Kaempferol 3-O-(2G-glucosylrutinoside)-7-O-glucoside is a potent anti-inflammatory agent that targets key signaling pathways, including NF-κB, MAPK, and Akt. This compound significantly reduces the production of inflammatory mediators such as nitric oxide (NO) and prostaglandin E2 (PGE2) in LPS-induced RAW 264.7 macrophages. Additionally, it suppresses the secretion of pro-inflammatory cytokines, including TNF-α, IL-1β, and IL-6, making it valuable for research into inflammation and related disorders. -
Anti-inflammatory Agent
TNF-α-IN-12 is a potent inhibitor of tumor necrosis factor-alpha (TNF-α) with an IC50 value of 0.1 μM. This compound effectively reduces TNF-α levels in serum, demonstrating anti-inflammatory activity. It is suitable for research applications aimed at understanding inflammation-related diseases and evaluating potential therapeutic strategies targeting TNF-α signaling pathways. -
Anti-inflammatory Agent
rel-Cleroindicin F is an anti-inflammatory agent that targets the NF-κB signaling pathway. It effectively inhibits the production of nitric oxide (NO) and tumor necrosis factor-alpha (TNF-α) by downregulating NF-κB and its kinases in LPS-stimulated RAW 264.7 cells. This mechanism contributes to the suppression of inducible nitric oxide synthase expression, leading to decreased NO production. Rel-Cleroindicin F is valuable for research into inflammatory processes and potential therapeutic applications. -
Anti-inflammatory Agent
SKF 104351 is an orally active anti-inflammatory agent that functions by inhibiting the production of tumor necrosis factor-alpha (TNF-α). This compound plays a significant role in modulating inflammatory responses, making it valuable for research focused on chronic inflammatory diseases. Its ability to suppress cytokine production positions SKF 104351 as a crucial tool for studies aimed at understanding the mechanisms underlying inflammation and developing therapeutic interventions. -
Anti-inflammatory Agent
Arucadiol is a rosane-type diterpenoid known for its anti-inflammatory properties. It effectively inhibits the production of pro-inflammatory cytokines, specifically TNF-α, IL-1β, and IL-8, by 39.8%, 44.4%, and 34.5% respectively at a concentration of 5 μM. This compound functions by reducing the mRNA and protein expression of these inflammatory mediators, making it a valuable tool for research on inflammation-related cardiovascular conditions, such as atherosclerosis. Arucadiol can be naturally sourced from the roots of Salvia miltiorrhiza var. alba. -
Anti-Inflammatory Agent
Sinulatumolin E is a terpenoid that functions as an anti-inflammatory agent, primarily through its ability to inhibit TNF-α, with an IC50 value of 3.6 μM. This compound exhibits notable anti-inflammatory activity, making it potentially useful for research in inflammation-related pathways and conditions. -
Anti-inflammatory Agent
Trigraecum is a flavonoid compound derived from Dracaena steudneri and Dalbergia cochinchinensis, functioning as an anti-inflammatory agent. It effectively inhibits lipopolysaccharide (LPS)-induced production of pro-inflammatory cytokines such as IL-1β, IL-2, GM-CSF, and TNF-α in human peripheral blood mononuclear cells. Trigraecum is valuable for studies focused on inflammatory diseases and the underlying mechanisms of immune response modulation. -
Anti-inflammatory Agent
Anti-inflammatory agent 11 targets and inhibits key inflammatory processes by suppressing inducible nitric oxide synthase (iNOS) expression. This compound demonstrates significant antimycobacterial activity against Mycobacterium tuberculosis strains H37Rv and M299, with minimum inhibitory concentrations (MIC50) of 1.3 μM and 6.9 μM, respectively. Additionally, it effectively reduces the production of pro-inflammatory cytokines such as TNF-α and IL-1β. Anti-inflammatory agent 11 is suitable for research in tuberculosis and related inflammatory diseases. -
Anti-inflammatory Agent
Etiprednol dicloacetate is an anti-inflammatory agent that effectively inhibits eosinophil accumulation. This compound is valuable in the study of inflammatory airway diseases, including asthma, providing insights into potential therapeutic strategies. Its mechanism of action and biological activity render it a useful tool for researchers investigating respiratory inflammation. -
Anti-inflammatory Agent
Anti-inflammatory agent 41 is an effective inhibitor of lipopolysaccharide (LPS)-induced expression of pro-inflammatory cytokines IL-6 and TNF-α in J774A.1, THP-1, and LX-2 cells. This compound also inhibits the activation of the NF-κB signaling pathway. Its primary applications include investigating the mechanisms of inflammation and assessing potential therapeutic strategies in inflammation-related diseases. -
Anti-Cancer/Inflammatory Agent
Crocatin B is a natural compound derived from P. crocatum Ruiz & Pav that functions as an anti-cancer and anti-inflammatory agent. It exerts its anti-inflammatory effects by inhibiting the expression of TNF-α and ICAM-1. Additionally, Crocatin B demonstrates notable anti-tumor activity, making it a valuable reagent for research in cancer therapies and inflammation studies. -
Anti-inflammatory Agent
Anti-inflammatory agent 20 is a potent inhibitor of nitric oxide (NO) activity, demonstrating significant anti-inflammatory properties. This compound effectively suppresses lipopolysaccharide (LPS)-induced inflammation by inhibiting the activation of NF-κB and MAPK signaling pathways, leading to a reduction in pro-inflammatory cytokines such as IL-6, TNF-α, as well as the enzymes iNOS and COX-2. It serves as a valuable tool for research applications focused on inflammation and related signaling mechanisms. -
Anti-inflammatory Agent
Antcin K is a selective inhibitor targeting multiple signaling pathways, including PI3K/Akt, NF-κB, MEK1/2-ERK, p38, and AP-1. It upregulates IL-10 expression, effectively inhibiting pro-inflammatory factor production, reducing monocyte adhesion, and minimizing tissue damage, while promoting myogenesis. Antcin K exhibits robust anti-inflammatory and tissue protective properties, making it valuable for research applications related to inflammation-associated diseases such as periodontitis, rheumatoid arthritis, and skeletal muscle injury. -
Anti-inflammatory Agent
Secologanic acid is a secoiridoid glycoside that acts as an anti-inflammatory agent. It inhibits nitric oxide (NO) production and modulates the expression of AKT and phosphorylated AKT (p-AKT). This compound demonstrates significant anti-inflammatory activity, making it valuable for research in chronic inflammatory conditions and related therapeutic applications. -
Anti-inflammatory Agent
Oleanolic acid 28-O-β-D-glucopyranoside, a pentacyclic triterpenoid, primarily acts as an anti-inflammatory agent. It has demonstrated the ability to inhibit inflammatory responses in ulcerative colitis models, enhance intestinal epithelial barrier function, and modulate gut microbiota. The compound's mechanism involves the modulation of the PI3K-AKT and MAPK signaling pathways. Oleanolic acid 28-O-β-D-glucopyranoside is valuable for research into inflammatory diseases, particularly colitis. -
Antiinflammatory Agent
Ethyl linoleate, an unsaturated fatty acid derivative, acts as an anti-inflammatory agent by inhibiting the Akt/GSK3β/β-catenin signaling pathway and blocking NF-κB activation. Additionally, it induces heme oxygenase-1 and inhibits tyrosinase, contributing to its whitening and anti-inflammatory properties. Ethyl linoleate promotes absorption of compounds and has notable implications for atherosclerosis research. Its applications extend to the study of various inflammatory diseases and cosmetic formulations. -
Anti-inflammatory Reagent
Syringaresinol is a lignan-type phytochemical that primarily targets anti-inflammatory pathways. It effectively inhibits the NF-κB and AKT signaling pathways in IL-1β-activated mouse chondrocytes, demonstrating significant anti-inflammatory activity. Additionally, Syringaresinol enhances the phosphorylation of AMPK and eNOS while increasing intracellular Ca2+ levels in HUVECs. Its ability to attenuate the progression of osteoarthritis in mouse models of DMM-induced osteoarthritis makes it a valuable reagent for research focused on OA. -
Anti-inflammatory/Oxidant
Astringin is a natural flavonoid compound that primarily targets inflammatory pathways and oxidative stress. It exhibits significant anti-inflammatory, antioxidant, and anti-apoptotic activities, while also functioning as a ferroptosis inhibitor. Research applications include its potential use in studying diseases characterized by oxidative damage and inflammation, such as acute lung injury. -
Anti-inflammatory Agent
Strictosamide is a natural compound isolated from Nauclea officinalis, primarily functioning as an anti-inflammatory agent. It exhibits multiple biological activities, including analgesic properties, anti-Plasmodium effects, antifungal activity, and the promotion of wound healing. This compound is valuable for research in inflammation, pain management, and infectious disease studies. -
Inflammatory Modulator
Cholesta-3,5-diene is an inflammatory modulator that primarily targets immune cells, including neutrophils, to enhance wound healing processes. It facilitates neutrophil chemotaxis and fibroblast migration by activating chemokine receptor-mediated signaling pathways, such as the PI3K/Akt pathway. This compound can be utilized in topical applications for wound repair and exhibits potential therapeutic benefits in managing chronic ulcers and skin lesions. -
Anti-Inflammatory/Immunosuppressive Signal
Phosphatidylserine is a phospholipid that serves as an important anti-inflammatory and immunosuppressive signal. It is known to facilitate membrane translocation and activate protein kinase C, which is integral to Akt signaling through its interaction with PIP3. Additionally, localized exposure to phosphatidylserine promotes microglial phagocytosis, aiding in synaptic refinement, and acts as a pro-coagulant factor in the extracellular space by signaling for the clearance of apoptotic cells. This reagent has significant implications in research focused on inflammation regulation and immune response modulation. -
Anti-inflammatory And Antioxidant
Tamarixetin, a 4'-O-Methyl Quercetin derivative, serves as a potent inhibitor of the caseinolytic protease P (ClpP) and exhibits significant anti-inflammatory and antioxidant properties. This natural flavonoid effectively inhibits ClpP's hydrolytic activity towards the substrate Suc-LY-AMC with an IC50 of 49.73 μM, making it relevant for research involving Staphylococcus aureus infections. Additionally, Tamarixetin demonstrates the ability to inhibit tumor cell growth, induce apoptosis, and induce cell cycle arrest, while also preventing cardiac hypertrophy through the modulation of NFAT and AKT signaling pathways. -
Anticancer/Anti-inflammatory/Anti-diabetic Agent
Phellopterin is a furocoumarin compound recognized for its anticancer, anti-inflammatory, and anti-diabetic activities. It functions as a partial agonist of central benzodiazepine receptors and demonstrates significant anti-inflammatory properties by modulating key pathways such as SIRT1 and TLR4/NF-κB, which may aid in conditions like chronic inflammation and atopic dermatitis. Additionally, Phellopterin has been shown to inhibit ovarian cancer progression through the PU.1/CLEC5A/PI3K-AKT signaling loop and promotes adipocyte differentiation, contributing to its anti-diabetic effects. This compound is valuable for research in cancer, inflammation, diabetes management, and antiviral studies. -
Anti-neuroinflammatory Agent
2-O-Methylatromentin is an anti-neuroinflammatory agent that effectively inhibits the production of pro-inflammatory cytokines, including TNF-α, IL-6, and IL-1β, in lipopolysaccharide (LPS)-induced BV-2 microglial cells. This compound is valuable for research into neuroinflammatory diseases, providing insights into the mechanisms underlying inflammation in the central nervous system. Its efficacy in modulating inflammatory responses makes it a useful tool for investigating potential therapeutic strategies in neuroinflammatory conditions. -
Anti-inflammatory Agent
Anti-inflammatory Agent 22 is an orally active compound targeting the inhibition of lipopolysaccharide (LPS)-induced tumor necrosis factor-alpha (TNF-α) production, demonstrated by an IC50 of 14.6 μM. This agent exhibits preventive effects on lymphedematous tissue by suppressing adipogenesis. Additionally, Anti-inflammatory Agent 22 has been shown to reduce limb lymphedema volume in murine models, making it a valuable tool for research into inflammatory conditions and lymphedema management. -
Anti-inflammatory Agent
Anti-inflammatory Agent 15 is a potent compound targeting inflammation through inhibition of nitric oxide synthase (iNOS). It demonstrates significant antimycobacterial activity against Mycobacterium tuberculosis strains H37Rv and M299, with MIC50 values of 2.3 μM and 7.8 μM, respectively. This agent effectively reduces pro-inflammatory cytokines TNF-α and IL-1β, making it a valuable tool for researching tuberculosis and related inflammatory pathways. -
Anti-inflammatory Agent
3-O-Caffeoyl-5-O-feruloylquinic acid is a phenolic compound with potent anti-inflammatory properties, primarily targeting free radical scavenging mechanisms. It effectively regulates inflammatory pathways by inhibiting TNF-α-induced production of reactive oxygen species (ROS) and monocyte chemoattractant protein-1 (MCP-1) in human umbilical vein endothelial cells (HUVECs). This compound is valuable in research applications focused on oxidative stress and inflammation pathways, offering insights into potential therapeutic strategies for inflammatory disorders. -
Anti-inflammatory Agent
Anti-inflammatory agent 104 is a potent anti-inflammatory compound that specifically inhibits TNF-α synthesis and release in the human macrophage cell line U937, with an IC50 value of 0.024 nM. This agent demonstrates significant biological activity by reducing eosinophil levels in rat lungs by 63%, making it a valuable tool for studying inflammatory responses and evaluating therapeutic strategies in related research applications. -
Anti-inflammatory Agent
Anti-inflammatory Agent 55 is a derivative of Coixol that primarily inhibits the NF-κB signaling pathway. It effectively reduces the expression of pro-inflammatory markers such as iNOS, TNF-α, IL-6, and IL-1β. This compound significantly decreases LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 value of 0.8 μM and demonstrates noteworthy in vivo anti-inflammatory effects in a mouse auricular edema model, making it a valuable tool for research in inflammation and immune responses. -
Anti-inflammatory Agent
Siaresinolic acid is an anti-inflammatory compound derived from the leaves of Sabicea grisea. It exhibits significant antinociceptive properties by modulating ATP-dependent potassium channels and inhibiting the influx of leukocytes, plasma leakage, and the production of pro-inflammatory mediators such as TNF-α and IL-1β. Importantly, Siaresinolic acid demonstrates a lack of cytotoxicity in murine macrophages and does not affect locomotor activity even at elevated doses. This compound is suitable for research applications involving pleurisy and pain management. -
Anti-inflammatory agent
Taxamairin B is a potent anti-inflammatory agent that targets proinflammatory cytokine production. It effectively reduces the expression of TNF-α, IL-1β, and IL-6, as well as the oxidative stress markers nitric oxide (NO) and reactive oxygen species (ROS) in LPS-induced RAW264.7 macrophage cells. Additionally, Taxamairin B demonstrates significant protective effects in models of LPS-induced acute lung injury in mice, making it a valuable compound for research on inflammatory pathways and potential therapeutic applications. -
Anti-inflammatory Agent
Oleracone is an alkaloid derived from Portulaca oleracea L. that functions as an anti-inflammatory agent. It demonstrates potent anti-inflammatory effects in the RAW 264.7 macrophage model, effectively inhibiting nitric oxide production and reducing the secretion of pro-inflammatory cytokines such as TNF-α, IL-6, and prostaglandin E₂ (PGE₂). Oleracone is suitable for researching inflammatory diseases and exploring potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 54, a derivative of Coixol, targets the NF-κB signaling pathway to exert its anti-inflammatory effects. This compound effectively downregulates pro-inflammatory mediators including iNOS, TNF-α, IL-6, and IL-1β. Notably, anti-inflammatory agent 54 inhibits lipopolysaccharide (LPS)-induced nitric oxide production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates significant in vivo anti-inflammatory activity in a mouse model of auricular edema. -
Proinflammatory Cytokine Inhibitor
Semapimod is a potent inhibitor of proinflammatory cytokine production, targeting Toll-like receptor 4 (TLR4) signaling with an IC50 of approximately 0.3 μM. It effectively inhibits the production of key cytokines such as TNF-α, IL-1β, and IL-6, as well as p38 MAPK activity and nitric oxide production in macrophages. This compound holds promise for research in various inflammatory and autoimmune disorders. -
Antioxidant/Anti-inflammatory/Anti-fibrotic Agent
7-O-Galloyl-D-sedoheptulose is a polyphenolic compound recognized for its antioxidant, anti-inflammatory, and anti-fibrotic properties. It lowers serum levels of glucose, leptin, insulin, and pro-inflammatory cytokines such as TNF-α and IL-6, while increasing adiponectin levels. This compound effectively reduces reactive oxygen species (ROS) and lipid peroxidation by inhibiting the expression of NADPH oxidase components. Additionally, it down-regulates NF-κB signaling and relevant fibrotic markers, highlighting its potential applications in studying type 2 diabetes and associated complications in hepatic and pancreatic tissues. -
Anti-inflammatory Agents
CZEN-002 is a derivative of alpha-melanocyte-stimulating hormone that acts as an anti-inflammatory agent by inhibiting the production of TNF-α. It exhibits both anti-inflammatory and antibacterial properties, making it a valuable tool for researching inflammatory diseases and potential therapeutic interventions. Its mechanism of action opens avenues for studies related to immune response modulation and pathogen resistance. -
Anti-inflammatory Agent
HSP90-IN-31 is an anti-inflammatory agent that targets heat shock protein 90 (HSP90). It effectively reduces the expression of costimulatory molecules CD80 and CD86 on dendritic cells, leading to decreased production of pro-inflammatory cytokines, including IL-6, TNF-α, and IL-1β, in bone marrow-derived dendritic cells and peritoneal macrophages upon LPS stimulation. In a delayed-type hypersensitivity mouse model, HSP90-IN-31 significantly diminishes ear swelling and lowers pro-inflammatory cytokine levels in the spleen, making it a valuable tool for studying inflammatory processes and potential therapeutic applications. -
Anti-inflammatory Agent
Anti-inflammatory agent 17 is a potent orally active compound that targets inflammatory pathways by inhibiting the release of pro-inflammatory cytokines IL-6 and TNF-α. In vitro studies demonstrate its ability to reduce inflammation without inducing cytotoxicity. Additionally, anti-inflammatory agent 17 exhibits significant anti-inflammatory activity in vivo, making it a valuable tool for research into acute lung injury (ALI) and other inflammatory conditions. -
Anti-inflammatory Agent
CX-659S is an orally active 5-carboxamide uracil derivative with anti-inflammatory properties. It effectively inhibits lipid peroxidation with an IC50 of 5.9 μM and reduces the infiltration of neutrophils and eosinophils. CX-659S also inhibits the mRNA expression of pro-inflammatory cytokines IL-1β and TNF-α, making it a valuable tool for research on inflammatory conditions. -
Anti-inflammatory/Anti-tumor/Anti-mite Agent
2′-Hydroxy-5′-methoxyacetophenone is an acetophenone derivative that modulates inflammatory responses primarily through inhibition of the NF-κB signaling pathway. This compound demonstrates significant anti-tumor properties, particularly against ovarian cancer, and exhibits acaricidal activity. Additionally, it effectively inhibits enzymes such as α-amylase, collagenase, and aldose reductase with IC50 values of 0.928 μM, 3.264 μM, and 20.046 μM, respectively, indicating its potential in diabetes research. -
Anti-inflammatory Agent
Desoxo-narchinol A is a potent anti-inflammatory agent that is derived from the roots and rhizomes of Nardostachys jatamansi. This compound exhibits significant biological activity, making it a valuable tool for research into septic shock and various inflammatory diseases. Its oral activity further enhances its applicability in preclinical studies, providing insight into therapeutic strategies for managing inflammation-related conditions. -
Anti-inflammatory Analgesic/Anti-tumor/Diuretic Agent
Hecogenin acetate is an orally active steroid saponin aglycone that functions primarily as an anti-inflammatory and analgesic agent. It exerts its biological effects by inhibiting the phosphorylation of NF-κB and p38 MAPK signaling pathways, antagonizing TRPA1/TRPM8 channels, and reducing the production of pro-inflammatory cytokines. Additionally, Hecogenin acetate demonstrates neuroprotective and anti-tumor properties, inhibits reactive oxygen species (ROS) production, and downregulates MMP-2 expression. This compound also enhances gastric mucosal defense and promotes ulcer healing while potentially restoring antibiotic sensitivity when used in combination with specific antibiotics.
