(R)-STU104-d6 is a deuterium-labeled derivative of (R)-STU104, a potent inhibitor of the TAK1-MKK3 interaction, exhibiting IC50 values of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation, respectively. This compound effectively disrupts the TAK1/MKK3/p38/MnK1/MK2/eIF4E signaling pathways by binding to MKK3, thereby inhibiting its phosphorylation by TAK1. (R)-STU104-d6 is suitable for applications in research focused on ulcerative colitis and related inflammatory conditions.
(R)-STU104-d6 is a deuterium-labeled derivative of (R)-STU104, a potent inhibitor of the TAK1-MKK3 interaction, exhibiting IC50 values of 0.58 μM and 4.0 μM for TNF-α and MKK3 phosphorylation, respectively. This compound effectively disrupts the TAK1/MKK3/p38/MnK1/MK2/eIF4E signaling pathways by binding to MKK3, thereby inhibiting its phosphorylation by TAK1. (R)-STU104-d6 is suitable for applications in research focused on ulcerative colitis and related inflammatory conditions.
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