Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
HBV-IN-39-d3 is a deuterated analog of the HBV inhibitor HBV-IN-39, designed to enhance oral bioavailability. This stable isotope-labeled compound is primarily used in pharmacokinetic studies and metabolic research related to hepatitis B virus (HBV) inhibition. Its unique isotopic composition allows for improved tracking and analysis in biological assays, facilitating further investigation into therapeutic strategies against HBV. -
Stable Isotope
Entecavir-13C2,15N-1 is a stable isotope-labeled form of Entecavir, which acts as a potent and selective inhibitor of hepatitis B virus (HBV) replication. This compound exhibits an EC50 of 3.75 nM in HepG2 cells, making it a valuable tool for studying HBV biology and antiviral mechanisms. Entecavir-13C2,15N-1 is ideally suited for applications in pharmacokinetic studies, drug metabolism research, and the development of HBV therapies. -
Stable Isotope
Nicotinamide-d3 is a deuterium-labeled form of Nicotinamide, a vital derivative of vitamin B3. It functions primarily by inhibiting SIRT1 and SIRT2 activity, with an IC50 of 2 μM for SIRT2. Biological studies show that Nicotinamide-d3 enhances cellular levels of NAD+, ATP, and reactive oxygen species (ROS), exhibiting potential anti-tumor effects and improved survival outcomes in various contexts. Additionally, this compound is recognized for its anti-hepatitis B virus (HBV) activity, making it valuable for research in metabolism and cancer biology. -
Stable Isotope
Famciclovir-d6 is a deuterated form of Famciclovir, serving as a stable isotope for research applications. This orally active nucleoside analogue exhibits potent antiviral activity against hepatitis B virus (HBV), herpes simplex virus (HSV), and varicella-zoster virus (VZV). Famciclovir-d6 is utilized in studies related to herpesvirus infections, enhancing the understanding of viral mechanisms and the development of therapeutic interventions. -
Stable Isotope
Lamivudine-13C,15N3 is a stable isotope-labeled derivative of Lamivudine, a nucleoside reverse transcriptase inhibitor (NRTI) with potent activity against HIV and hepatitis B virus reverse transcriptases. This isotopic labeling facilitates advanced metabolic studies and pharmacokinetic investigations. It is particularly useful in research focusing on antiviral drug mechanisms, therapeutic efficacy, and the pharmacodynamics of nucleoside analogs in various biological matrices. -
Stable Isotope
Sofosbuvir-d6 is a stable isotope-labeled form of Sofosbuvir, specifically deuterated for enhanced tracking in metabolic studies. Sofosbuvir is an effective inhibitor of hepatitis C virus (HCV) RNA replication, demonstrating significant antiviral activity against HCV in replicon assays. This reagent is primarily utilized in pharmacokinetic studies and isotopic labeling applications to investigate the metabolism and bioavailability of Sofosbuvir. -
Stable Isotope
2'-O-Methylcytidine-d3 is a deuterium-labeled form of 2'-O-Methylcytidine, a nucleoside that functions as an inhibitor of hepatitis C virus (HCV) replication. This compound exhibits competitive inhibition of RNA-dependent RNA polymerase (NS5B)-mediated RNA synthesis in vitro, targeting the enzyme's active site. Its isotopic labeling makes it an essential tool for studies involving metabolic pathways and nucleic acid synthesis in research settings. -
Stable Isotope
N-Acetyl sulfadiazine-d4 is a stable isotope-labeled version of N-Acetyl sulfadiazine, designed for use in metabolic studies and pharmacokinetic research. This compound serves as a valuable tracer in the investigation of drug metabolism and interactions within biological systems. Its deuterium labeling facilitates accurate tracking and quantification in isotopic analysis, making it essential for studies requiring precise measurement of drug disposition and kinetics. -
Stable Isotope
Boceprevir-d9 is a deuterated form of Boceprevir, a selective and potent inhibitor of the HCV NS3 protease with a Ki value of 14 nM in enzyme assays. It demonstrates an EC90 of 350 nM in cell-based replicon assays, showcasing its efficacy against hepatitis C virus replication. Additionally, Boceprevir has been shown to inhibit SARS-CoV-2 3CLpro activity, making it valuable for research in antiviral drug development and therapeutic applications targeting viral proteases. -
Stable Isotope
Daclatasvir-d6 is a deuterium-labeled derivative of Daclatasvir, a highly effective antagonist of the HCV NS5A protein, exhibiting EC50 values between 9-146 pM across various HCV replicon genotypes. Additionally, Daclatasvir serves as an inhibitor of organic anion transporting polypeptide 1B (OATP1B) and OATP1B3, with IC50 values of 1.5 μM and 3.27 μM, respectively. This labeled compound is valuable for studying the pharmacokinetics and metabolic pathways of Daclatasvir in research applications related to hepatitis C virus therapy. -
Stable Isotope
Ledipasvir-d6 is a deuterated form of Ledipasvir, an effective inhibitor of the hepatitis C virus NS5A, exhibiting EC50 values of 34 pM against genotype 1a and 4 pM against genotype 1b replicons. Additionally, Ledipasvir serves as a SARS-CoV 3CLpro inhibitor, with an IC50 of 1.62 μM. This stable isotope is suitable for advanced research applications in virology and drug development, particularly in studies involving metabolic tracing and pharmacokinetics. -
Stable Isotope
1-Methylnaphthalene-13C is a stable isotope-labeled derivative of 1-Methylnaphthalene, an organic compound known for its antibacterial and antioxidant properties. This reagent serves as a useful tracer in environmental monitoring and research, allowing for the identification and quantification of pollutants. Additionally, 1-Methylnaphthalene-13C can function as an intermediate in petrochemical synthesis, enhancing reaction efficiency in various chemical processes. -
Stable Isotope
1-Tetradecanol-d29 is a deuterium-labeled derivative of 1-Tetradecanol, a straight-chain saturated fatty alcohol derived from Myristica fragrans. This compound exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. It serves as a stable isotope labeled reagent, enabling precise tracking and quantification in metabolic studies and lipid research applications. -
Stable Isotope
2-Chloroacetamide-d4 is a deuterium-labeled analogue of 2-Chloroacetamide, primarily known for its role as a biocide and herbicide in agricultural applications. It acts by inhibiting very-long-chain fatty acid elongase, impacting lipid biosynthesis pathways. This stable isotope label allows for precise tracking and analysis in research focused on plant metabolism, biocides, and fatty acid metabolism studies. -
Isotope-Labeled Compound
Diethyl phosphate-13C4 sodium is a stable isotope-labeled compound targeting metabolic and environmental studies. This compound serves as a key biomarker for the metabolic byproduct of Chlorpyrifos, a widely utilized insecticide. Its applications extend to tracing metabolic pathways and investigating environmental degradation processes, making it essential for research in toxicology and environmental science. -
Stable Isotope
Myristic acid-13C2 is a stable isotope-labeled variant of myristic acid, a saturated 14-carbon fatty acid commonly found in various animal and plant fats, including milk fat and coconut oil. This compound exhibits anti-inflammatory effects primarily through the NF-κB signaling pathway and demonstrates antibacterial, anti-inflammatory, and analgesic activities. Myristic acid-13C2 is valuable in metabolic studies, allowing researchers to investigate fatty acid metabolism and functionality in biochemical pathways. -
Stable Isotope
α-Terpineol-d6 is a deuterated variant of α-Terpineol, functioning as a stable isotope for chemical research. This compound exhibits notable antimicrobial activity against periodontopathic and cariogenic bacteria, as well as antifungal properties against T. mentagrophytes, potentially causing irreversible cellular disruption. Additionally, α-Terpineol-d6 demonstrates antineuropathic and anti-inflammatory effects, making it a valuable tool for studying conditions related to diarrhea, neuropathic pain, infections, and inflammation. -
Stable Isotope
Sulfanitran-d4 is a deuterium-labeled derivative of Sulfanitran, targeting the multidrug resistance protein 2 (MRP2). This reagent serves as an antibacterial and anticoccidial agent commonly utilized in poultry feeds. Sulfanitran-d4 enhances the interaction between MRP2 and estradiol-17-β-D-glucuronide (E217βG), making it a valuable tool for studying drug transport mechanisms and resistance in pharmacological research settings. -
Stable Isotope
Ramifenazone-d7 is a deuterium-labeled derivative of Ramifenazone, a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic, anti-inflammatory, and antimicrobial properties. Its stable isotope composition makes it particularly useful for metabolic studies and pharmacokinetic investigations. Researchers can leverage Ramifenazone-d7 for exploring the absorption, distribution, metabolism, and excretion (ADME) of NSAIDs in biological systems. -
Stable Isotope
2-Phenylethanol-13C2 is a stable isotope-labeled variant of 2-Phenylethanol, specifically designated for use in research applications that require precise isotopic tracking. Known for its aromatic characteristics and rose-like fragrance, 2-Phenylethanol serves as a flavoring and fragrance agent, and exhibits notable antimicrobial and antityrosinase properties. This compound is particularly useful in studies related to food preservation, cosmetic formulation, and metabolic research. -
Stable Isotope
Norethindrone-13C2 is a stable isotope-labeled form of Norethindrone, a synthetic progestin primarily targeting progesterone receptors. It exhibits key biological activities in regulating menstrual cycles and managing conditions such as endometriosis, uterine bleeding related to hormonal imbalances, and secondary amenorrhea. Norethindrone-13C2 is valuable for pharmacokinetic studies and isotopic tracing in biochemical research applications, facilitating in-depth investigations into hormone metabolism and therapeutic mechanisms. -
Stable Isotope
Cinnamyl acetate-13C2 is a stable isotope-labeled form of cinnamyl acetate. This compound exhibits broad-spectrum antibacterial activity and is widely utilized in the flavor and fragrance industry. Its stable isotope labeling makes it an essential tool for research applications in metabolic studies and tracing pathways in biochemical research. -
Stable Isotope
Rimonabant-d10 hydrochloride is a deuterium-labeled derivative of Rimonabant hydrochloride, a selective antagonist of the central cannabinoid receptor (CB1) with a Ki of 1.8 nM. This compound is utilized in studies investigating the role of CB1 receptors in various physiological processes and the development of obesity therapies. Additionally, Rimonabant hydrochloride is known to inhibit Mycobacterial membrane protein Large 3 (MMPL3), making it relevant for research in tuberculosis and related infectious diseases. -
Stable Isotope
Isopropyl 4-hydroxybenzoate-d7 is a deuterium-labeled derivative of Isopropyl 4-hydroxybenzoate, commonly known as Isopropylparaben. This stable isotope exhibits antimicrobial and antioxidant properties, making it a valuable tool in research involving the study of parabens and their biological effects. It is particularly useful in pharmacokinetic studies and metabolic research, allowing for enhanced tracking of compound behavior in biological systems. -
Stable Isotope
Hypoxanthine-13C,15N2 is a stable isotope-labeled form of hypoxanthine that incorporates both 13C and 15N isotopes. As a purine derivative, hypoxanthine serves as a potential free radical generator and may be utilized as a biomarker for hypoxic conditions. This reagent is valuable for research applications in metabolic studies, hypoxia-related investigations, and isotopic tracing in cellular and molecular biology. -
Stable Isotope
Isoeugenol-d3 is a deuterated form of Isoeugenol, a compound derived from various essential oils such as nutmeg, clove, and cinnamon. It serves as a stable isotope for use in research applications, particularly in studies involving the antimicrobial properties of isoeugenol. This compound demonstrates inhibitory effects on Escherichia coli and Listeria innocua, with minimum inhibitory concentrations (MICs) of 0.6 mg/mL and 1 mg/mL, respectively, making it valuable for microbiological studies. -
Stable Isotope
Itopride-d6 is a deuterated form of Itopride, a potent dopamine D2 receptor antagonist and acetylcholinesterase (AChE) inhibitor. Its unique stable isotope labeling allows for advanced metabolic and pharmacokinetic studies. Itopride enhances gastric motility through its combined antidopaminergic and anti-AChE actions, making it valuable in research applications focused on gastrointestinal prokinetics and conditions such as gastro-esophageal reflux disease (GERD). -
Stable Isotope
Probenecid-d7 is a stable isotope-labeled derivative of Probenecid, featuring seven deuterium atoms. This compound is primarily utilized in pharmacokinetic studies and drug metabolism research, enabling precise tracking of Probenecid in biological systems. Its unique isotopic labeling enhances analytical sensitivity and specificity in mass spectrometry applications, facilitating the investigation of metabolic pathways and drug interactions. -
Stable Isotope
Hexadecane-1,2-13C2 is a stable isotope-labeled form of hexadecane, a saturated hydrocarbon belonging to the alkane family. This compound serves as an effective organic solvent and is commonly utilized in research to study the microbial degradation of hydrophobic substrates. Its application in metabolic studies allows for the tracing of carbon flows in biochemical pathways, enhancing understanding of environmental processes and microbial dynamics. -
Stable Isotope
p-Anisic acid-13C6 is a stable isotope-labeled variant of p-Anisic acid (4-Methoxybenzoic acid), which is known for its antibacterial and antiseptic properties. This compound is utilized as a tracer in metabolic studies and is important for research involving the analysis of metabolic pathways and compound interactions. Its isotopic labeling allows for precise quantification in various biochemical investigations, enhancing the understanding of its biological activities. -
Stable Isotope
2,6-Dichlorodiphenylamine-13C6 serves as a stable isotope labeled analog of 2,6-Dichlorodiphenylamine. This compound demonstrates significant anti-Candida albicans activity, contributing to its potential utility in antifungal research. It is structurally related to Diclofenac Sodium, a well-known COX inhibitor with IC50 values of 4 and 1.3 nM for human COX-1 and COX-2, making 2,6-Dichlorodiphenylamine-13C6 valuable for studies in inflammation and enzyme inhibition mechanisms. -
Stable Isotope
Veratryl alcohol-13C (3,4-Dimethoxybenzyl alcohol-13C) is a stable isotope-labeled analog of Veratryl alcohol, a secondary metabolite produced by lignin-degrading fungi. This compound serves as a substrate for lignin peroxidase (LiP), enabling the assessment of lignin degradation activity. Additionally, Veratryl alcohol-13C protects LiP from inactivation by hydrogen peroxide and stabilizes manganese-dependent peroxidases (MnP). The compound also functions as a quorum-sensing inhibitor, demonstrating antibacterial properties, making it valuable for various biochemical and microbiological research applications. -
Stable Isotope
2-Undecanone-d5 is a deuterium-labeled analog of 2-Undecanone, serving as a stable isotope. This compound is a volatile organic compound that inhibits the DnaKJE-ClpB bichaperone dependent refolding of heat-inactivated bacterial luciferases. 2-Undecanone-d5 is of significant interest in studies related to cellular stress responses and has demonstrated activity in inhibiting lung tumorigenesis. -
Stable Isotope
Lauric acid-13C-1 is a stable isotope-labeled form of lauric acid, a medium-chain fatty acid known for its potent bactericidal activity. This compound exhibits strong antibacterial effects, with EC50 values of 2 μg/mL against P. acnes, 6 μg/mL against S. aureus, and 4 μg/mL against S. epidermidis. Lauric acid-13C-1 is useful in metabolic studies, tracing experiments, and other applications in lipid metabolism and antimicrobial research. -
Stable Isotope
4-Nitrobenzoic acid-d2 is a deuterium-labeled variant of 4-Nitrobenzoic acid, functioning primarily as a redox mediator and electron transfer promoter. This compound effectively accepts electrons from reduced glucose oxidase, subsequently transferring them to electrodes to enhance the glucose oxidation reaction. It is valuable in studies focusing on electron transfer mechanisms and redox cycling, particularly in biosensor applications and metabolic research. -
Stable Isotope
Flurofamide-d4 is a deuterated derivative of Flurofamide, designed for stable isotope labeling. This compound acts as a potent inhibitor of bacterial urease, which plays a critical role in the pathogenesis of infection-induced urinary stones. Flurofamide-d4 is primarily utilized in pharmacokinetic studies and metabolic research to trace and quantify the dynamics of Flurofamide in biological systems. -
Stable?Isotope
Lactate sodium-13C2 is a stable isotope-labeled form of lactic acid sodium, primarily targeting the hydroxycarboxylic acid receptor 1 (HCAR1). It serves as an epigenetic modulator by promoting lysine lactylation, linking glycolysis with oxidative phosphorylation. As an oncometabolite, it plays a significant role in anti-tumor immunity while also demonstrating antimicrobial activity, making it relevant for applications in food preservation and cancer research. -
Stable Isotope
Ethyl acetoacetate-13C4 is a stable isotope-labeled form of Ethyl acetoacetate, which serves as a crucial intermediate in the synthesis of various organic compounds. This compound demonstrates significant biological activity as an inhibitor of bacterial biofilm formation, making it a valuable tool in microbiological research and studies focused on combating biofilm-associated infections. Its labeled form facilitates tracking metabolic pathways and enhancing analytical techniques in chemical research. -
Stable Isotope
3-Methylanisole-d3 is a stable isotope-labeled derivative of 3-Methylanisole, utilized as an intermediate in pharmaceutical synthesis. This compound exhibits properties that contribute to antiseptic and antibacterial activities, as well as enhancing protein stability. It is valuable in research applications involving drug development and metabolic studies. -
Stable Isotope
Methyl paraben-d3 is a deuterated form of Methyl 4-hydroxybenzoate, serving as a stable isotope. This compound is widely recognized as a non-volatile preservative, commonly utilized in biochemical and cosmetic formulations. Methyl paraben-d3 is noted for its capacity to enhance histamine release, modulate immune responses, block sodium channels, and mitigate ischemia-reperfusion injury. Its applications extend to research involving allergenicity, preservation efficacy, and cellular signaling pathways. -
Stable Isotope
Antibacterial agent 265-13C,d3 is a deuterium and 13C-labeled derivative of Antibacterial agent 265, primarily targeting bacterial pathogens. This compound exhibits potent antibacterial activity against a range of organisms, including Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Flavobacterium devorans. Its stable isotope labeling makes it suitable for pharmacokinetic studies and metabolic research applications in microbiology and drug development. -
Stable Isotope
Levulinic acid-13C3 is a stable isotope-labeled form of Levulinic acid, primarily utilized as a precursor for the synthesis of biofuels, including ethyl levulinate. As a 5-keto-pentanoic acid, it serves as a valuable cosubstrate in biopolymer synthesis, facilitating metabolic studies. Additionally, Levulinic acid's antibacterial properties make it a relevant compound for research in antimicrobial applications. -
Stable Isotope
4-Nitrobenzoic acid-d4 is a deuterium-labeled derivative of 4-Nitrobenzoic acid, functioning as an oxidoreduction mediator and electron transfer promoter. This compound facilitates the transfer of electrons from reduced glucose oxidase to the electrode, enhancing the glucose oxidation reaction while reducing the generation of protonated amine groups. It serves as a valuable tool in studies involving electron transfer mechanisms and the design of biosensors. -
Stable Isotope
Furaltadone-d5 is a deuterium-labeled derivative of Furaltadone, a nitrofuran compound. It exhibits antibacterial properties, demonstrating both inhibitory and bactericidal activity against Staphylococcus species in vitro. This reagent is suitable for research applications focused on studying infections, particularly those involving Salmonella enteritidis in poultry, facilitating enhanced tracking and analysis in biochemical assays. -
Stable Isotope
Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections. -
Stable Isotope
Captan-d6 is a deuterium-labeled analog of Captan, a widely used agricultural fungicide. Its primary mechanism involves inhibiting fungal growth through its action on various pathogens, including Botrytis, Fusarium, Fusicoccum, and Pythium. Captan-d6 is valuable in research applications focused on understanding the environmental fate of fungicides, studying microbial interactions, and assessing the effects of fungicides on soil microbial communities. -
Stable Isotope
p-Anisic acid-d7 is a deuterated form of p-Anisic acid, a well-known tyrosinase inhibitor. This stable isotope can be utilized in analytical studies to investigate biological pathways involving p-Anisic acid, which is recognized for its antioxidant, anti-inflammatory, and anti-diabetic activities. Additionally, it serves as a preservative in the cosmetic industry, making it relevant for research focused on dermatological applications and formulations. -
Stable Isotope
Ethyl acetoacetate-13C is a stable isotope-labeled variant of ethyl acetoacetate, an important ester utilized as an intermediate in various synthetic pathways. This compound exhibits biological activity as an inhibitor of bacterial biofilm formation, making it valuable in microbiological studies. Its isotopic labeling facilitates tracing and quantification in metabolic research and various analytical applications. -
Isotope-Labeled Compounds
Veratraldehyde-d3 is a deuterium-labeled derivative of veratraldehyde, which primarily targets the PilY1 protein. This aromatic compound exhibits notable antibacterial activity against Pseudomonas aeruginosa and demonstrates repellent effects against mosquitoes and ticks. Veratraldehyde-d3 is valuable in research applications involving microbial resistance and may also be utilized as a flavoring agent in various settings. -
Stable Isotope
3,4,5-Trimethoxybenzaldehyde-d3 is a deuterated analogue of 3,4,5-Trimethoxybenzaldehyde, serving as a stable isotope labeled compound. This reagent exhibits antimicrobial activity and acts as a crucial intermediate in the synthesis of various pharmaceuticals, including the antibiotic Trimethoprim. Its unique isotopic labeling makes it valuable for tracing studies in chemical research, metabolic profiling, and pathway elucidation.
