Catalog No.
Product Name
Application
Product Information
Citations
-
Stable Isotope
Gramine-d2 is a deuterium-labeled derivative of Gramine, a natural alkaloid derived from giant reed. This compound functions as an adiponectin receptor agonist, exhibiting IC50 values of 3.2 μM for AdipoR2 and 4.2 μM for AdipoR1. Additionally, Gramine acts as an agonist for human and mouse β2-Adrenergic receptors, demonstrating anti-tumor, anti-viral, and anti-inflammatory activities. Gramine-d2 is valuable for research applications that require stable isotopic labeling in biological studies. -
Stable Isotope
Methotrexate metabolite-d3 is a deuterium-labeled form of the active Methotrexate metabolite known as DAMPA. This compound serves as a folic acid antagonist, playing a crucial role in inhibiting dihydrofolate reductase, which is critical for nucleotide synthesis. Methotrexate metabolite-d3 is utilized in various research applications, including pharmacokinetic studies and metabolic profiling, to better understand the dynamics of Methotrexate metabolism and its therapeutic effects. -
Stable Isotope
Gartisertib-d8 is a deuterated analog of Gartisertib, serving as a stable isotope labeled compound. As an ATP-competitive and selective inhibitor of ATR, Gartisertib exhibits a high binding affinity with a Ki of less than 150 pM. It effectively inhibits ATR-mediated phosphorylation of checkpoint kinase 1 (Chk1) with an IC50 of 8 nM, demonstrating significant antitumor activity. This reagent is suitable for research applications in cancer biology, particularly in studies focusing on DNA damage response and checkpoint regulation. -
Stable Isotope
Abemaciclib-d8 is a deuterium-labeled version of Abemaciclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It exhibits potent inhibition with IC50 values of 2 nM for CDK4 and 10 nM for CDK6. This stable isotope is useful in pharmacokinetic studies and metabolic research, allowing for detailed analysis of drug behavior in biological systems. -
Stable Isotope
Palbociclib-d8 is a deuterated form of Palbociclib, a selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4 and CDK6), showing IC50 values of 11 nM and 16 nM, respectively. This isotopically labeled compound allows for detailed pharmacokinetic studies and metabolic profiling. Palbociclib-d8 is particularly relevant in research on ER-positive and HER2-negative breast cancer, facilitating investigations into its mechanisms of action and therapeutic efficacy. -
Stable Isotope
Ribociclib-d8 is a deuterated form of Ribociclib, a selective inhibitor of CDK4 and CDK6. It demonstrates potent inhibitory activity with IC50 values of 10 nM for CDK4 and 39 nM for CDK6, while exhibiting over a 1,000-fold reduced potency against the cyclin B/CDK1 complex. This stable isotope-labeled compound is ideal for applications in pharmacokinetic studies, drug metabolism research, and metabolic profiling. -
Stable Isotope
Ribociclib-d6 is a deuterium-labeled derivative of Ribociclib, a highly selective inhibitor of cyclin-dependent kinases 4 and 6 (CDK4/6). It exhibits potent inhibitory activity with IC50 values of 10 nM and 39 nM for CDK4 and CDK6, respectively, while demonstrating over 1,000-fold reduced potency against the cyclin B/CDK1 complex. Ribociclib-d6 serves as a valuable tool for studying CDK4/6 dynamics and evaluating the pharmacokinetics of Ribociclib in chemical biology research and therapeutic applications in cancer treatment. -
Stable Isotope
CDK2-IN-14-d3 is a stable isotope-labeled inhibitor targeting Cyclin-Dependent Kinase 2 (CDK2). This compound exhibits potent and selective inhibition of CDK2, making it a valuable tool in cancer research. It is suitable for studies investigating cell cycle regulation and therapeutic strategies for CDK2-related malignancies. -
Stable Isotope
Palbociclib-d4 is a stable isotope-labeled form of Palbociclib, a selective inhibitor of CDK4 and CDK6, demonstrating IC50 values of 11 and 16 nM respectively. This compound exhibits strong anti-proliferative effects and effectively induces cell cycle arrest in cancer cells. Palbociclib-d4 is primarily utilized in research related to hormone receptor-positive and HER2-negative breast cancer, as well as hepatocellular carcinoma studies. -
Stable Isotope
EthD-d5 bromide is a deuterium-labeled variant of Ethidium bromide, serving as a stable isotope. It acts as an intercalating agent and is widely utilized as a fluorescent nucleic acid stain in molecular biology applications, including agarose gel electrophoresis. This reagent facilitates the visualization and analysis of nucleic acids, enhancing the accuracy of molecular assays. -
Stable Isotope
Fluphenazine-d8 is a deuterium-labeled derivative of fluphenazine, functioning primarily as a dopamine receptor antagonist. It effectively inhibits postsynaptic dopamine-2 receptors in key neural pathways, including the mesolimbic, nigrostriatal, and tuberoinfundibular systems. This reagent is valuable in research areas such as psychosis and diabetic peripheral neuropathy, and it has shown potential in studies related to SARS-CoV-2 inhibition. Fluphenazine-d8 serves as a useful tool for elucidating the pharmacodynamics of dopaminergic activity and its downstream effects. -
Stable Isotope
FOY 251-d4 is a deuterium-labeled derivative of FOY 251, a potent proteinase inhibitor and active metabolite of Camostate. It effectively inhibits SARS-CoV-2 infection in cellular assays, making it a valuable tool for studying viral entry and proteolytic processes. FOY 251-d4 serves as a stable isotope research reagent for exploring protein interactions and mechanisms within virology and pharmacology. -
Stable Isotope
Nirmatrelvir-d6 is a deuterated form of Nirmatrelvir, a potent inhibitor of the SARS-CoV 3C-like protease (3CLPRO). This stable isotope is designed for use in research applications related to COVID-19, allowing researchers to study the pharmacokinetics and metabolic pathways of the original compound. By utilizing Nirmatrelvir-d6, scientists can gain insights into the effects of 3CLPRO inhibition on SARS-CoV-2, contributing to the development of therapeutic strategies against this virus. -
Stable Isotope
DL-Serine-2,3,3-d3 is a stable isotope-labeled form of DL-Serine, a crucial metabolite consisting of both D-Serine and L-Serine. This compound serves as a valuable tool for metabolic and pharmacological studies, particularly in understanding serine metabolism. Additionally, DL-Serine exhibits antiviral activity against the replication of tobacco mosaic virus (TMV), making it relevant for virology research. -
Stable Isotope
L-Lysine-13C6,15N2 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tool in metabolic research and tracer studies, allowing for the examination of amino acid metabolism and kinetics in biological systems. Its applications extend to understanding lysine's role in physiological processes, including calcium absorption and gut health. -
Stable Isotope
L-Lysine-d4 hydrochloride is a deuterium-labeled analog of the essential amino acid L-Lysine, which plays a crucial role in protein synthesis and metabolic functions. As a stable isotope, it serves as a valuable tracer in metabolic studies, particularly in amino acid metabolism and kinetics. Research applications include studying the pharmacokinetics of lysine-related compounds and its implications in health conditions such as herpes treatment and calcium absorption enhancement. -
Stable Isotope
Phenytoin-d10 is a deuterium-labeled derivative of Phenytoin, primarily targeting voltage-gated sodium channels (VGSCs). This compound exhibits significant antiepileptic activity and has been shown to inhibit breast tumor growth and metastasis in murine models. Phenytoin-d10 serves as a valuable tool for research involving drug metabolism, pharmacokinetics, and the investigation of sodium channel function in various biological contexts. -
Stable Isotope
L-Lysine-13C6 dihydrochloride is a stable isotope-labeled derivative of the essential amino acid L-Lysine. This compound plays a crucial role in various biological processes, including the synthesis of connective tissues and carnitine, as well as energy production and immune function. Its applications extend to metabolic studies, isotopic labeling experiments, and research focusing on amino acid metabolism and physiological functions in both human and animal systems. -
Stable Isotope
L-Lysine-13C6 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, targeting metabolic and biological research applications. This compound plays a critical role in protein synthesis, cellular function, and is involved in various physiological processes. Its isotopic labeling allows for precise tracing in metabolic studies, making it a valuable tool for researchers investigating amino acid utilization, metabolism, and related health effects. -
Stable Isotope
L-Lysine-15N2 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, which plays a crucial role in protein synthesis and metabolic processes. This reagent is valuable in biochemical research, particularly in the study of amino acid metabolism, nutritional biochemistry, and the tracking of metabolic pathways using stable isotope labeling techniques. Its applications extend to research on nutritional deficiencies, disease states, and the physiological impacts of lysine supplementation. -
Stable Isotope
L-Lysine-d8 hydrochloride is a stable isotope of the essential amino acid L-lysine. This compound serves as a valuable tool in biochemical and metabolic research applications, particularly in studies involving protein metabolism and amino acid tracking. The deuterium labeling facilitates precise quantification and tracing in various experimental settings, enhancing understanding of metabolic pathways and physiological effects associated with L-lysine supplementation. -
Stable Isotope
L-Lysine-d9 hydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tool in metabolic studies and isotopic tracing applications. Its role in various biological processes makes it relevant for research related to amino acid metabolism, dietary interventions, and the physiological effects of lysine supplementation in health and disease contexts. -
Stable Isotope
L-Lysine-d3 hydrochloride is a deuterated form of the essential amino acid L-Lysine, which primarily functions as a stable isotope. This compound plays a crucial role in various biological processes, including the synthesis of connective tissues and carnitine, energy metabolism, and supporting immune functions. It is widely utilized in metabolic studies and tracer experiments, facilitating research in nutrition, developmental biology, and related fields. -
Stable Isotope
L-Lysine-13C dihydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine. This compound serves as a valuable tracer in metabolic studies and is significant for research involving amino acid metabolism, cellular transport, and protein synthesis. Its applications include investigating lysine's role in various biological processes and exploring therapeutic potentials for conditions such as herpes, calcium absorption, and diabetes-related disorders. -
Stable Isotope
N-Desmethylclozapine-d8 is a deuterium-labeled analogue of N-Desmethylclozapine, a significant active metabolite of the atypical antipsychotic clozapine. This compound serves as a potent partial agonist at M1 receptors (EC50 = 115 nM), effectively enhancing hippocampal NMDA receptor currents through M1 receptor activation. Additionally, it functions as a δ-opioid agonist, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychiatric disorders. -
Stable Isotope
N-Desmethylclozapine-d8 hydrochloride is a deuterated form of N-Desmethylclozapine hydrochloride, an important active metabolite of the atypical antipsychotic Clozapine. This compound acts as a potent allosteric and partial agonist of M1 receptors (EC50 = 115 nM) and enhances hippocampal N-methyl-D-aspartate (NMDA) receptor currents via M1 receptor activation. Additionally, N-Desmethylclozapine-d8 exhibits δ-opioid agonist activity, making it valuable for research in neuropharmacology and receptor signaling pathways. -
Stable Isotope
Probucol-13C3 is a stable isotope-labeled form of Probucol, a recognized anti-hyperlipidemic agent. It functions by reducing cholesterol levels in the bloodstream through enhanced low-density lipoprotein (LDL) catabolism. This compound is valuable for metabolic studies and can be used in research investigating lipid metabolism and cardiovascular health. -
Stable Isotope
Anthraquinone-d8 is a deuterated form of anthraquinone, serving as a stable isotope for scientific research. This compound is primarily utilized in studies involving organic synthesis and dye formation, providing enhanced accuracy in analytical applications. Its stable isotopic nature aids in tracing pathways and reaction mechanisms in complex biochemical processes. -
Stable Isotope
4-Methylanisole-d3 is a deuterium-labeled derivative of 4-Methylanisole, also known as 4-Methoxytoluene. This stable isotope is primarily utilized in various analytical applications, particularly in the field of mass spectrometry, to enhance the accuracy and sensitivity of detection methods. 4-Methylanisole-d3 is valuable for studying flavor compounds, fragrance profiles, and their metabolic pathways in food and cosmetic research. -
Stable Isotope
L-Lysine-13C6,15N2,d9 dihydrochloride is a stable isotope-labeled form of the essential amino acid L-lysine, featuring both deuterium and 13C and 15N isotopes. This compound is utilized in metabolic studies and tracer experiments to elucidate amino acid metabolism and protein synthesis pathways. Its incorporation in research can enhance the understanding of calcium absorption processes, gastrointestinal health, and the management of conditions related to diabetes and herpes. -
Stable Isotope
Phenytoin-15N2,13C is a stable isotope-labeled variant of Phenytoin, which acts primarily as a blocker of voltage-gated sodium channels (VGSCs). This compound demonstrates significant antiepileptic properties and has been shown to inhibit breast tumor growth and metastasis in murine models. It is valuable for research applications involving metabolic tracking and pharmacokinetic studies related to Phenytoin's therapeutic effects and mechanisms of action. -
Stable Isotope
Nicotinamide-d3 is a deuterium-labeled form of Nicotinamide, a vital derivative of vitamin B3. It functions primarily by inhibiting SIRT1 and SIRT2 activity, with an IC50 of 2 μM for SIRT2. Biological studies show that Nicotinamide-d3 enhances cellular levels of NAD+, ATP, and reactive oxygen species (ROS), exhibiting potential anti-tumor effects and improved survival outcomes in various contexts. Additionally, this compound is recognized for its anti-hepatitis B virus (HBV) activity, making it valuable for research in metabolism and cancer biology. -
Stable Isotope
Famciclovir-d6 is a deuterated form of Famciclovir, serving as a stable isotope for research applications. This orally active nucleoside analogue exhibits potent antiviral activity against hepatitis B virus (HBV), herpes simplex virus (HSV), and varicella-zoster virus (VZV). Famciclovir-d6 is utilized in studies related to herpesvirus infections, enhancing the understanding of viral mechanisms and the development of therapeutic interventions. -
Stable Isotope
Lamivudine-13C,15N3 is a stable isotope-labeled derivative of Lamivudine, a nucleoside reverse transcriptase inhibitor (NRTI) with potent activity against HIV and hepatitis B virus reverse transcriptases. This isotopic labeling facilitates advanced metabolic studies and pharmacokinetic investigations. It is particularly useful in research focusing on antiviral drug mechanisms, therapeutic efficacy, and the pharmacodynamics of nucleoside analogs in various biological matrices. -
Stable Isotope
Sofosbuvir-d6 is a stable isotope-labeled form of Sofosbuvir, specifically deuterated for enhanced tracking in metabolic studies. Sofosbuvir is an effective inhibitor of hepatitis C virus (HCV) RNA replication, demonstrating significant antiviral activity against HCV in replicon assays. This reagent is primarily utilized in pharmacokinetic studies and isotopic labeling applications to investigate the metabolism and bioavailability of Sofosbuvir. -
Stable Isotope
2'-O-Methylcytidine-d3 is a deuterium-labeled form of 2'-O-Methylcytidine, a nucleoside that functions as an inhibitor of hepatitis C virus (HCV) replication. This compound exhibits competitive inhibition of RNA-dependent RNA polymerase (NS5B)-mediated RNA synthesis in vitro, targeting the enzyme's active site. Its isotopic labeling makes it an essential tool for studies involving metabolic pathways and nucleic acid synthesis in research settings. -
Stable Isotope
N-Acetyl sulfadiazine-d4 is a stable isotope-labeled version of N-Acetyl sulfadiazine, designed for use in metabolic studies and pharmacokinetic research. This compound serves as a valuable tracer in the investigation of drug metabolism and interactions within biological systems. Its deuterium labeling facilitates accurate tracking and quantification in isotopic analysis, making it essential for studies requiring precise measurement of drug disposition and kinetics. -
Stable Isotope
Boceprevir-d9 is a deuterated form of Boceprevir, a selective and potent inhibitor of the HCV NS3 protease with a Ki value of 14 nM in enzyme assays. It demonstrates an EC90 of 350 nM in cell-based replicon assays, showcasing its efficacy against hepatitis C virus replication. Additionally, Boceprevir has been shown to inhibit SARS-CoV-2 3CLpro activity, making it valuable for research in antiviral drug development and therapeutic applications targeting viral proteases. -
Stable Isotope
Daclatasvir-d6 is a deuterium-labeled derivative of Daclatasvir, a highly effective antagonist of the HCV NS5A protein, exhibiting EC50 values between 9-146 pM across various HCV replicon genotypes. Additionally, Daclatasvir serves as an inhibitor of organic anion transporting polypeptide 1B (OATP1B) and OATP1B3, with IC50 values of 1.5 μM and 3.27 μM, respectively. This labeled compound is valuable for studying the pharmacokinetics and metabolic pathways of Daclatasvir in research applications related to hepatitis C virus therapy. -
Stable Isotope
Ledipasvir-d6 is a deuterated form of Ledipasvir, an effective inhibitor of the hepatitis C virus NS5A, exhibiting EC50 values of 34 pM against genotype 1a and 4 pM against genotype 1b replicons. Additionally, Ledipasvir serves as a SARS-CoV 3CLpro inhibitor, with an IC50 of 1.62 μM. This stable isotope is suitable for advanced research applications in virology and drug development, particularly in studies involving metabolic tracing and pharmacokinetics. -
Stable Isotope
1-Methylnaphthalene-13C is a stable isotope-labeled derivative of 1-Methylnaphthalene, an organic compound known for its antibacterial and antioxidant properties. This reagent serves as a useful tracer in environmental monitoring and research, allowing for the identification and quantification of pollutants. Additionally, 1-Methylnaphthalene-13C can function as an intermediate in petrochemical synthesis, enhancing reaction efficiency in various chemical processes. -
Stable Isotope
1-Tetradecanol-d29 is a deuterium-labeled derivative of 1-Tetradecanol, a straight-chain saturated fatty alcohol derived from Myristica fragrans. This compound exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. It serves as a stable isotope labeled reagent, enabling precise tracking and quantification in metabolic studies and lipid research applications. -
Stable Isotope
2-Chloroacetamide-d4 is a deuterium-labeled analogue of 2-Chloroacetamide, primarily known for its role as a biocide and herbicide in agricultural applications. It acts by inhibiting very-long-chain fatty acid elongase, impacting lipid biosynthesis pathways. This stable isotope label allows for precise tracking and analysis in research focused on plant metabolism, biocides, and fatty acid metabolism studies. -
Isotope-Labeled Compound
Diethyl phosphate-13C4 sodium is a stable isotope-labeled compound targeting metabolic and environmental studies. This compound serves as a key biomarker for the metabolic byproduct of Chlorpyrifos, a widely utilized insecticide. Its applications extend to tracing metabolic pathways and investigating environmental degradation processes, making it essential for research in toxicology and environmental science. -
Stable Isotope
Myristic acid-13C2 is a stable isotope-labeled variant of myristic acid, a saturated 14-carbon fatty acid commonly found in various animal and plant fats, including milk fat and coconut oil. This compound exhibits anti-inflammatory effects primarily through the NF-κB signaling pathway and demonstrates antibacterial, anti-inflammatory, and analgesic activities. Myristic acid-13C2 is valuable in metabolic studies, allowing researchers to investigate fatty acid metabolism and functionality in biochemical pathways. -
Stable Isotope
α-Terpineol-d6 is a deuterated variant of α-Terpineol, functioning as a stable isotope for chemical research. This compound exhibits notable antimicrobial activity against periodontopathic and cariogenic bacteria, as well as antifungal properties against T. mentagrophytes, potentially causing irreversible cellular disruption. Additionally, α-Terpineol-d6 demonstrates antineuropathic and anti-inflammatory effects, making it a valuable tool for studying conditions related to diarrhea, neuropathic pain, infections, and inflammation. -
Stable Isotope
Sulfanitran-d4 is a deuterium-labeled derivative of Sulfanitran, targeting the multidrug resistance protein 2 (MRP2). This reagent serves as an antibacterial and anticoccidial agent commonly utilized in poultry feeds. Sulfanitran-d4 enhances the interaction between MRP2 and estradiol-17-β-D-glucuronide (E217βG), making it a valuable tool for studying drug transport mechanisms and resistance in pharmacological research settings. -
Stable Isotope
Ramifenazone-d7 is a deuterium-labeled derivative of Ramifenazone, a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic, anti-inflammatory, and antimicrobial properties. Its stable isotope composition makes it particularly useful for metabolic studies and pharmacokinetic investigations. Researchers can leverage Ramifenazone-d7 for exploring the absorption, distribution, metabolism, and excretion (ADME) of NSAIDs in biological systems. -
Stable Isotope
2-Phenylethanol-13C2 is a stable isotope-labeled variant of 2-Phenylethanol, specifically designated for use in research applications that require precise isotopic tracking. Known for its aromatic characteristics and rose-like fragrance, 2-Phenylethanol serves as a flavoring and fragrance agent, and exhibits notable antimicrobial and antityrosinase properties. This compound is particularly useful in studies related to food preservation, cosmetic formulation, and metabolic research. -
Stable Isotope
Norethindrone-13C2 is a stable isotope-labeled form of Norethindrone, a synthetic progestin primarily targeting progesterone receptors. It exhibits key biological activities in regulating menstrual cycles and managing conditions such as endometriosis, uterine bleeding related to hormonal imbalances, and secondary amenorrhea. Norethindrone-13C2 is valuable for pharmacokinetic studies and isotopic tracing in biochemical research applications, facilitating in-depth investigations into hormone metabolism and therapeutic mechanisms.
