Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Lauric acid-13C-1 is a stable isotope-labeled form of lauric acid, a medium-chain fatty acid known for its potent bactericidal activity. This compound exhibits strong antibacterial effects, with EC50 values of 2 μg/mL against P. acnes, 6 μg/mL against S. aureus, and 4 μg/mL against S. epidermidis. Lauric acid-13C-1 is useful in metabolic studies, tracing experiments, and other applications in lipid metabolism and antimicrobial research. -
Stable Isotope
4-Nitrobenzoic acid-d2 is a deuterium-labeled variant of 4-Nitrobenzoic acid, functioning primarily as a redox mediator and electron transfer promoter. This compound effectively accepts electrons from reduced glucose oxidase, subsequently transferring them to electrodes to enhance the glucose oxidation reaction. It is valuable in studies focusing on electron transfer mechanisms and redox cycling, particularly in biosensor applications and metabolic research. -
Stable Isotope
Flurofamide-d4 is a deuterated derivative of Flurofamide, designed for stable isotope labeling. This compound acts as a potent inhibitor of bacterial urease, which plays a critical role in the pathogenesis of infection-induced urinary stones. Flurofamide-d4 is primarily utilized in pharmacokinetic studies and metabolic research to trace and quantify the dynamics of Flurofamide in biological systems. -
Stable?Isotope
Lactate sodium-13C2 is a stable isotope-labeled form of lactic acid sodium, primarily targeting the hydroxycarboxylic acid receptor 1 (HCAR1). It serves as an epigenetic modulator by promoting lysine lactylation, linking glycolysis with oxidative phosphorylation. As an oncometabolite, it plays a significant role in anti-tumor immunity while also demonstrating antimicrobial activity, making it relevant for applications in food preservation and cancer research. -
Stable Isotope
Ethyl acetoacetate-13C4 is a stable isotope-labeled form of Ethyl acetoacetate, which serves as a crucial intermediate in the synthesis of various organic compounds. This compound demonstrates significant biological activity as an inhibitor of bacterial biofilm formation, making it a valuable tool in microbiological research and studies focused on combating biofilm-associated infections. Its labeled form facilitates tracking metabolic pathways and enhancing analytical techniques in chemical research. -
Stable Isotope
3-Methylanisole-d3 is a stable isotope-labeled derivative of 3-Methylanisole, utilized as an intermediate in pharmaceutical synthesis. This compound exhibits properties that contribute to antiseptic and antibacterial activities, as well as enhancing protein stability. It is valuable in research applications involving drug development and metabolic studies. -
Stable Isotope
Methyl paraben-d3 is a deuterated form of Methyl 4-hydroxybenzoate, serving as a stable isotope. This compound is widely recognized as a non-volatile preservative, commonly utilized in biochemical and cosmetic formulations. Methyl paraben-d3 is noted for its capacity to enhance histamine release, modulate immune responses, block sodium channels, and mitigate ischemia-reperfusion injury. Its applications extend to research involving allergenicity, preservation efficacy, and cellular signaling pathways. -
Stable Isotope
Antibacterial agent 265-13C,d3 is a deuterium and 13C-labeled derivative of Antibacterial agent 265, primarily targeting bacterial pathogens. This compound exhibits potent antibacterial activity against a range of organisms, including Staphylococcus aureus, Micrococcus luteus, Bacillus subtilis, Escherichia coli, Pseudomonas aeruginosa, and Flavobacterium devorans. Its stable isotope labeling makes it suitable for pharmacokinetic studies and metabolic research applications in microbiology and drug development. -
Stable Isotope
Levulinic acid-13C3 is a stable isotope-labeled form of Levulinic acid, primarily utilized as a precursor for the synthesis of biofuels, including ethyl levulinate. As a 5-keto-pentanoic acid, it serves as a valuable cosubstrate in biopolymer synthesis, facilitating metabolic studies. Additionally, Levulinic acid's antibacterial properties make it a relevant compound for research in antimicrobial applications. -
Stable Isotope
4-Nitrobenzoic acid-d4 is a deuterium-labeled derivative of 4-Nitrobenzoic acid, functioning as an oxidoreduction mediator and electron transfer promoter. This compound facilitates the transfer of electrons from reduced glucose oxidase to the electrode, enhancing the glucose oxidation reaction while reducing the generation of protonated amine groups. It serves as a valuable tool in studies involving electron transfer mechanisms and the design of biosensors. -
Stable Isotope
Furaltadone-d5 is a deuterium-labeled derivative of Furaltadone, a nitrofuran compound. It exhibits antibacterial properties, demonstrating both inhibitory and bactericidal activity against Staphylococcus species in vitro. This reagent is suitable for research applications focused on studying infections, particularly those involving Salmonella enteritidis in poultry, facilitating enhanced tracking and analysis in biochemical assays. -
Stable Isotope
Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections. -
Stable Isotope
Captan-d6 is a deuterium-labeled analog of Captan, a widely used agricultural fungicide. Its primary mechanism involves inhibiting fungal growth through its action on various pathogens, including Botrytis, Fusarium, Fusicoccum, and Pythium. Captan-d6 is valuable in research applications focused on understanding the environmental fate of fungicides, studying microbial interactions, and assessing the effects of fungicides on soil microbial communities. -
Stable Isotope
p-Anisic acid-d7 is a deuterated form of p-Anisic acid, a well-known tyrosinase inhibitor. This stable isotope can be utilized in analytical studies to investigate biological pathways involving p-Anisic acid, which is recognized for its antioxidant, anti-inflammatory, and anti-diabetic activities. Additionally, it serves as a preservative in the cosmetic industry, making it relevant for research focused on dermatological applications and formulations. -
Stable Isotope
Ethyl acetoacetate-13C is a stable isotope-labeled variant of ethyl acetoacetate, an important ester utilized as an intermediate in various synthetic pathways. This compound exhibits biological activity as an inhibitor of bacterial biofilm formation, making it valuable in microbiological studies. Its isotopic labeling facilitates tracing and quantification in metabolic research and various analytical applications. -
Isotope-Labeled Compounds
Veratraldehyde-d3 is a deuterium-labeled derivative of veratraldehyde, which primarily targets the PilY1 protein. This aromatic compound exhibits notable antibacterial activity against Pseudomonas aeruginosa and demonstrates repellent effects against mosquitoes and ticks. Veratraldehyde-d3 is valuable in research applications involving microbial resistance and may also be utilized as a flavoring agent in various settings. -
Stable Isotope
3,4,5-Trimethoxybenzaldehyde-d3 is a deuterated analogue of 3,4,5-Trimethoxybenzaldehyde, serving as a stable isotope labeled compound. This reagent exhibits antimicrobial activity and acts as a crucial intermediate in the synthesis of various pharmaceuticals, including the antibiotic Trimethoprim. Its unique isotopic labeling makes it valuable for tracing studies in chemical research, metabolic profiling, and pathway elucidation. -
Stable Isotope
Calindol hydrochloride-13C,D2 is a deuterium and 13C-labeled variant of Calindol hydrochloride, a positive allosteric modulator of the calcium-sensing receptor (CaSR) with an EC50 value of 132 nM. This stable isotope-labeled compound is invaluable for mechanistic studies in calcium signaling and receptor pharmacology. It can be utilized in various research applications, including drug metabolism and kinetics, as well as in the development of novel calcimimetic agents. -
Stable Isotope
Cinacalcet-d4 hydrochloride is a deuterated form of Cinacalcet, an allosteric agonist of the calcium-sensing receptor (CaR). This stable isotope is employed in research to track and quantify metabolic processes involving the modulation of calcium homeostasis. It is particularly relevant in studies focused on cardiovascular diseases and related therapeutic interventions. -
Stable Isotope
Telcagepant-d8 is a deuterium-labeled variant of Telcagepant, a potent orally active antagonist of the calcitonin gene-related peptide (CGRP) receptor. This compound exhibits binding affinities (Kis) of 0.77 nM and 1.2 nM for human and rhesus CGRP receptors, respectively. Telcagepant-d8 is primarily utilized in pharmacokinetic studies and metabolic research, providing a valuable tool for investigating CGRP-related pathways and receptor interactions in various biological systems. -
Stable Isotope
Tildacerfont-d8 is a deuterium-labeled derivative of Tildacerfont, a potent and orally bioavailable antagonist of the corticotropin-releasing factor type 1 (CRF1) receptor. It effectively lowers levels of adrenocorticotropic hormone (ACTH) and adrenal androgens, demonstrating a favorable safety profile. Tildacerfont-d8 is valuable for research into congenital adrenal hyperplasia and related hormonal regulation studies, facilitating the investigation of CRF1 receptor dynamics. -
Stable Isotope
Nicotinamide N-oxide-d4 is a deuterium-labeled derivative of Nicotinamide N-oxide, which serves as a stable isotope for analytical studies. As a notable in vivo metabolite of nicotinamide, Nicotinamide N-oxide exhibits potent and selective antagonistic activity against the CXCR2 receptor. This compound is valuable for research applications involving receptor signaling, metabolic pathways, and the study of inflammatory responses. -
Stable Isotope
Dopamine-d3 hydrochloride is a deuterium-labeled analog of dopamine, serving as a stable isotope for research applications. It is utilized in studies involving neurotransmitter dynamics and metabolic pathways, providing insights into dopamine-related physiological processes. This reagent is valuable in mass spectrometry and tracer studies, aiding in the exploration of neurological disorders and drug interactions. -
Stable Isotope
L-DOPA-2,5,6-d3 is a deuterium-labeled form of L-DOPA, a metabolic precursor to the neurotransmitter dopamine. This stable isotope enables researchers to study dopamine synthesis and metabolism in vivo, particularly its ability to cross the blood-brain barrier and its subsequent conversion to dopamine in neural tissues. L-DOPA-2,5,6-d3 is instrumental in neurochemical studies, including investigations of neurological disorders and the evaluation of therapeutic strategies targeting dopaminergic signaling. -
Stable Isotope
L-DOPA-13C is a stable isotope-labeled form of L-DOPA, which serves as a metabolic precursor to the neurotransmitter dopamine. It effectively crosses the blood-brain barrier and is converted to dopamine in the central nervous system. L-DOPA-13C is utilized in research for understanding neurotransmitter dynamics and exploring its role in Parkinson's disease and related neurological conditions. Additionally, it exhibits anti-allodynic properties, making it relevant for studies on pain modulation. -
Stable Isotope
L-DOPA-d6 is a deuterium-labeled form of L-DOPA, a critical precursor in the biosynthesis of the neurotransmitter dopamine. This stable isotope enables precise tracing and quantification in metabolic studies involving neurotransmitter dynamics, particularly in the context of neurological disorders. L-DOPA-d6 is utilized in research applications focused on dopamine-related pathways, including the investigation of Parkinson's disease and its associated therapeutic strategies. -
Stable Isotope
L-DOPA-13C6 is a stable isotope-labeled form of L-DOPA, a critical metabolic precursor for the synthesis of the neurotransmitter dopamine. This compound effectively crosses the blood-brain barrier and is metabolized into dopamine within the central nervous system, making it a key agent in research related to neurotransmitter pathways. L-DOPA-13C6 is particularly valuable in studies investigating the pharmacokinetics of dopamine replacement therapies and has implications for understanding and treating Parkinson's disease. -
Stable Isotope
Amisulpride-d5 is a deuterium-labeled derivative of Amisulpride, a selective antagonist of the dopamine D2 and D3 receptors. It exhibits high affinity with Kis of 2.8 nM and 3.2 nM for human D2 and D3 receptors, respectively. This stable isotope is utilized in pharmacokinetic studies, metabolic research, and tracer studies to investigate the pharmacological properties and dynamics of dopamine receptor interactions. -
Stable Isotope
Pramipexole-d5 dihydrochloride is a deuterated form of Pramipexole dihydrochloride, a selective agonist of the dopamine D2-type receptor that effectively crosses the blood-brain barrier. With binding affinities (Kis) of 2.2 nM for D2-type receptors, alongside 3.9 nM, 0.5 nM, and 1.3 nM for D2, D3, and D4 receptors respectively, it serves as a valuable tool in research. This reagent is primarily utilized in studies related to Parkinson's disease and restless legs syndrome, facilitating analysis of dopaminergic pathways and receptor interactions. -
Stable Isotope
(R)-3-O-Methyldopa-d3 is a deuterated form of the R-enantiomer of 3-O-Methyldopa, which acts as a metabolite of L-DOPA. The compound exerts its biological activity by competitively inhibiting catechol-O-methyltransferase (COMT), thus influencing the pharmacological effects of both L-DOPA and dopamine. This stable isotope is essential for research applications involving metabolic pathways and neurological studies. -
Stable Isotope
Clomipramine-d3 hydrochloride is a deuterium-labeled analog of Clomipramine hydrochloride, primarily acting as an inhibitor of the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT) with Ki values of 0.14 nM, 54 nM, and 3 nM, respectively. This stable isotope-labeled compound is valuable for pharmacokinetic studies, metabolic profiling, and tracer experiments in neuroscience research. Its specificity and potency make it an essential reagent for investigating the pharmacological effects of antidepressants and their mechanisms of action within the central nervous system. -
Stable Isotope
Zuclopenthixol-d4 succinate is a deuterium-labeled derivative of Zuclopenthixol, a thioxanthene compound that functions primarily as a mixed antagonist of dopamine D1 and D2 receptors. This stable isotope is utilized in pharmacokinetic studies and drug metabolism research, enabling precise tracking of the compound's behavior in biological systems. Its unique isotopic labeling enhances the accuracy of analytical methods in various studies related to neurological disorders and the pharmacodynamics of antipsychotic agents. -
Stable Isotope
Azaperone-d4 is a deuterium-labeled variant of Azaperone, which primarily functions as a dopamine antagonist. It exhibits additional antihistaminic and anticholinergic properties, making it a versatile tool in pharmacological studies. This pyridinylpiperazine and butyrophenone neuroleptic agent also demonstrates antiemetic effects, finding utility chiefly as a tranquilizer in veterinary medicine. Its stable isotope labeling provides valuable support for research applications involving drug metabolism and pharmacokinetics. -
Stable Isotope
Propionylpromazine-d6 hydrochloride is a deuterium-labeled derivative of Propionylpromazine hydrochloride, a potent dopamine receptor D2 (DRD2) antagonist. This reagent is primarily utilized in pharmacological research focusing on Parkinson's disease, enabling the study of dopamine signaling pathways and receptor interactions. The stable isotope labeling provides enhanced analytical precision, making it suitable for advanced bioanalytical applications. -
Stable Isotope
Amisulpride-d5 N-Oxide is a deuterium-labeled analog of Amisulpride, functioning as a dopamine D2/D3 receptor antagonist with inhibition constants (Kis) of 2.8 nM and 3.2 nM for human dopamine D2 and D3 receptors, respectively. This stable isotope-labeled compound is essential for research involving pharmacokinetics, biomarker discovery, and labeling in metabolic studies. Its precision and reliability make it suitable for various applications in neuroscientific research and drug development. -
Stable Isotope
Pramipexole-d5 is a deuterium-labeled derivative of Pramipexole, a selective dopamine D2-type receptor agonist that effectively crosses the blood-brain barrier. With binding affinities (Kis) of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for the D2-type, D2, D3, and D4 receptors respectively, Pramipexole-d5 serves as a valuable tool for exploring dopamine receptor interactions. This compound is particularly relevant for research into neurodegenerative disorders such as Parkinson's disease and conditions like restless legs syndrome. -
Stable Isotope
Clomipramine-d3 is a deuterium-labeled derivative of Clomipramine that primarily targets the serotonin transporter (SERT), norepinephrine transporter (NET), and dopamine transporter (DAT), exhibiting inhibition with Ki values of 0.14 nM, 54 nM, and 3 nM, respectively. This stable isotope is valuable for pharmacokinetic studies and metabolic research, enabling the tracking and quantification of Clomipramine in biological samples. Clomipramine-d3 facilitates investigations into its biochemical interactions and the influence of neurotransmitter systems on various physiological processes. -
Stable Isotope
Ropinirole-d14 is a deuterium-labeled derivative of Ropinirole, designed for use in various analytical applications. This stable isotope allows for precise tracking and quantification of Ropinirole in biological systems through advanced techniques such as mass spectrometry. It is particularly useful in pharmacokinetic studies, metabolic profiling, and drug interaction investigations, facilitating deeper insights into Ropinirole's biological activity and efficacy. -
Stable Isotope
Acetophenazine dimaleate-d4 is a deuterium-labeled derivative of Acetophenazine, a phenothiazine-based antipsychotic agent. This compound primarily exerts its effects by selectively blocking dopamine D2 receptors in the central nervous system. Acetophenazine dimaleate-d4 is valuable for studying psychotic disorders, including schizophrenia and anxiety-related depression, providing insights into the pharmacodynamics of antipsychotic treatments. -
Stable Isotope
Pramipexole-d7-1 dihydrochloride is a deuterium-labeled analog of Pramipexole dihydrochloride, a selective agonist of dopamine D2-type receptors. This compound effectively penetrates the blood-brain barrier and exhibits Ki values of 2.2 nM, 3.9 nM, 0.5 nM, and 1.3 nM for the D2-type receptor, D2, D3, and D4 receptors, respectively. Pramipexole-d7-1 dihydrochloride is valuable for research on Parkinson's disease and restless legs syndrome, facilitating advanced studies in neuropharmacology and the pharmacokinetics of dopamine receptor interactions. -
Stable Isotope
Ropinirole-d7 hydrochloride is a deuterium-labeled analog of Ropinirole hydrochloride, functioning as a potent agonist for D2 and D3 dopamine receptors. With a Ki value of 29 nM for the D2 receptor, it demonstrates strong biological activity, exhibiting pEC50 values of 7.4, 8.4, and 6.8 for human D2, D3, and D4 receptors, respectively, while showing no affinity for D1 receptors. This compound is particularly relevant in research focused on Parkinson's disease and neuropharmacology. -
Stable Isotope
(R)-3-O-Methyldopa-d3 hydrochloride is a deuterium-labeled analog of (R)-3-O-Methyldopa, which is the R-enantiomer of 3-O-Methyldopa. This compound acts as a stable isotope and serves as a valuable tool for studying metabolic pathways involving L-DOPA, a precursor to dopamine. 3-O-Methyldopa is known to competitively inhibit the actions of L-DOPA and dopamine, making it useful in research focused on neurotransmitter regulation and related pharmacodynamics. -
Stable Isotope
(rac)-Dobutamine-d6 hydrochloride is a stable isotope-labeled form of racemic Dobutamine hydrochloride, which targets α1-AR, β1-AR, and β2-AR adrenoceptors. This compound primarily functions as a selective β1-AR agonist, exhibiting a relatively weaker effect on α1-AR and β2-AR. Notably, (rac)-Dobutamine-d6 hydrochloride is utilized in research applications focused on cardiovascular studies, particularly for analyzing cardiac output and addressing conditions of hypoperfusion. -
Stable Isotope
Tetrahydrozoline-d4 hydrochloride is a deuterium-labeled form of Tetrahydrozoline hydrochloride, an α-adrenergic agonist that targets α-adrenergic receptors to induce vasoconstriction. This stable isotope is utilized in research applications focusing on nasal and conjunctival congestion. Its unique isotopic labeling allows for enhanced tracking and quantification in various biochemical studies. -
Stable Isotope
5,6-Epoxyeicosatrienoic acid-d11 is a deuterium-labeled analogue of 5,6-Epoxyeicosatrienoic acid (5,6-EET), a compound synthesized from arachidonic acid by cytochrome P450 enzymes. This stable isotope is valuable for studying the biological activities of 5,6-EET, which include modulation of calcium mobilization and hormone secretion in neuroendocrine cells, as well as inhibition of T-type voltage-gated calcium channels (Cav3.1, Cav3.2). Additionally, it functions as a substrate for COX-1 and COX-2, facilitating detailed metabolic studies. 5,6-Epoxyeicosatrienoic acid-d11 aids in quantification and mechanistic investigations through methods such as GC-MS. -
Stable Isotope
Moxonidine-d4 is a deuterium-labeled analogue of Moxonidine, which functions primarily as an imidazoline type 1 receptor (I1-R) agonist. This compound activates I1 receptors and α2 adrenoceptors, modulating the uptake of oxidized low-density lipoprotein. Moxonidine has been shown to effectively reduce atherosclerotic lesions and lower blood pressure, making it a valuable tool for researching hypertension, heart failure, and atherosclerosis. -
Stable Isotope
Mapenterol-d6 hydrochloride is a deuterium-labeled analogue of Mapenterol hydrochloride, functioning as a selective β2-adrenoceptor agonist. This stable isotope is instrumental in pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution. It is valuable in research focusing on respiratory diseases and other therapeutic applications involving β2-adrenergic pathways. -
Stable Isotope
Harmane-d4 is a deuterium-labeled derivative of Harmane, serving as a stable isotope for biochemical research. This compound is useful in studies involving metabolic pathways and can aid in the characterization of Harmane's biological activity. Its application extends to isotopic labeling in pharmacokinetic studies, enabling accurate analyses of drug kinetics and dynamics. -
Stable Isotope
Solabegron-d8 is a deuterium-labeled derivative of Solabegron, a selective β3-adrenergic receptor agonist. It effectively stimulates cAMP accumulation in Chinese hamster ovary cells expressing human β3-adrenergic receptors, exhibiting an EC50 value of 22 nM. This compound is primarily utilized in research focused on the treatment of overactive bladder and irritable bowel syndrome, allowing for the investigation of β3-adrenergic signaling pathways in various biological contexts. -
Stable Isotope
Lofexidine-d4 is a deuterium-labeled derivative of Lofexidine (hydrochloride), a selective α2-adrenergic receptor agonist. This compound is primarily employed in research related to opioid withdrawal by mimicking the activity of Lofexidine in biological assays. The stable isotope labeling enables precise tracking in pharmacokinetic studies and helps in elucidating the pharmacological properties of opioid withdrawal treatments.
