Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Umifenovir-d6 hydrochloride is a deuterated form of Umifenovir hydrochloride, a broad-spectrum antiviral agent. This compound demonstrates potent activity against both enveloped and non-enveloped viruses, primarily functioning by inhibiting the fusion of viral particles with host cells. Umifenovir hydrochloride is notably effective against influenza viruses and has shown significant in vitro inhibition of SARS-CoV-2. Additionally, it exhibits anti-inflammatory properties, making it a valuable tool for research in virology and therapeutic approaches targeting viral infections. -
Stable Isotope
Valganciclovir-d8 is a deuterium-labeled derivative of Valganciclovir, which serves as a prodrug for ganciclovir. This stable isotope-labeled compound is widely utilized in pharmacokinetic studies and metabolic research to trace drug metabolism and bioavailability, enabling a detailed understanding of its pharmacological effects. Its applications extend to studies on viral infections and potential therapeutic outcomes in disease contexts such as cytomegalovirus retinitis. -
Stable Isotope
Valganciclovir-d5 TFA is a deuterium-labeled derivative of valganciclovir, functioning as a stable isotope. As a prodrug of ganciclovir, it exhibits antiviral activity primarily against cytomegalovirus (CMV) infections. This reagent is valuable for metabolic studies, pharmacokinetic analyses, and tracing the pharmacodynamics of antiviral therapies in research applications. -
Stable Isotope
Brincidofovir-d6 is a deuterated form of Brincidofovir, functioning as a stable isotope for research applications. As a lipid-conjugated prodrug of Cidofovir, this compound exhibits potent antiviral activity against a wide range of DNA viruses, including cytomegalovirus, adenovirus, and orthopoxviruses. It is particularly valuable in studies focused on viral pathogenesis, therapeutic efficacy, and pharmacokinetics of antiviral agents. The isotopic labeling of Brincidofovir enhances the ability to track and quantify the compound's behavior in biological systems. -
Stable Isotope
Naringenin-d4 is a deuterated derivative of Naringenin, functioning as a stable isotope. Its primary biological activities include potent anti-inflammatory and antioxidant effects. Naringenin-d4 serves as a valuable tool for research applications, particularly in studies focused on inflammation, oxidative stress, and viral infections, including anti-dengue virus (DENV) investigations. -
Stable Isotope
Quinine-d3 is a deuterium-labeled derivative of quinine, primarily used as a stable isotope in chemical research. Quinine is an alkaloid isolated from the cinchona tree, known for its efficacy as an antimalarial agent and its role as a potassium channel inhibitor. It specifically inhibits wild-type mouse Slo3 (KCa5.1) channel currents induced by voltage pulses, exhibiting an IC50 of 169 μM. This reagent facilitates studies in pharmacology and biochemistry, enabling precise tracking and quantification in various applications. -
Stable Isotope
Fluticasone propionate-d5 is a deuterium-labeled derivative of fluticasone propionate, a potent topical anti-inflammatory corticosteroid. This compound selectively binds to the glucocorticoid receptor, exhibiting an absolute affinity (KD) of 0.5 nM, and demonstrates minimal interaction with other steroid receptors. It is primarily utilized in research involving anti-inflammatory and potential antiviral activities, making it a valuable reagent for studies focused on corticosteroid receptor mechanism and function. -
Stable Isotope
Vapendavir-d5 is a deuterium-labeled derivative of Vapendavir, a potent enteroviral capsid binder. This stable isotope is utilized in research to study the mechanisms of action against enterovirus 71 (EV71), exhibiting significant antiviral activity with EC50 values ranging from 0.5 to 1.4 μM across various EV71 strains. Vapendavir-d5 serves as a valuable tool in understanding enteroviral infections and developing therapeutic strategies. -
Stable Isotope
Pleconaril-d4 is a deuterated analog of Pleconaril, designed as a stable isotope for advanced chemical research. This labeled compound serves as a valuable tool for tracing and quantifying Pleconaril-related metabolic pathways and interactions. Its use in studies involving viral infections, particularly enteroviruses, enhances understanding of drug efficacy and pharmacokinetics in biological systems. -
Stable Isotope
Fmoc-leucine-15N is a stable isotope-labeled derivative of leucine, featuring a nitrogen-15 isotope, which facilitates studies in metabolic tracing and protein labeling. This compound is widely utilized in peptide synthesis and NMR spectroscopy, enabling researchers to gain insights into protein structure and dynamics. Its incorporation into peptides allows for enhanced monitoring of metabolic pathways and interactions in biological systems. -
Stable Isotope
Pirlindole-d4 is a deuterium-labeled analogue of Pirlindole, serving as a stable isotope for research applications. This compound is primarily utilized in metabolic studies and tracer experiments due to its isotopic labeling, facilitating the investigation of pharmacokinetics and drug metabolism. Pirlindole itself is known for its role as a serotonin and norepinephrine reuptake inhibitor, contributing to its therapeutic potential in the treatment of depression and other mood disorders. -
Stable Isotope
EIDD-1931-d2 is a deuterium-labeled derivative of 3,6-Dichloro-2-methoxybenzoic acid. This stable isotope is utilized in metabolic and pharmacokinetic studies to trace compounds in biological systems. EIDD-1931-d2 facilitates research into drug metabolism, providing insights into the biological fate of its parent compound in various applications. -
Stable Isotope
Vapendavir-d6 is a deuterium-labeled derivative of Vapendavir, functioning as a stable isotope. It is utilized in research applications requiring isotopic labeling to study viral replication and to trace metabolic pathways. This reagent aids in the investigation of antiviral mechanisms and supports the development of therapeutic strategies against viral infections. -
Stable Isotope
(Rac)-Tenofovir-d6 is a labeled isotopologue of Tenofovir, which functions as a nucleotide reverse transcriptase inhibitor. It is primarily used in the treatment of HIV and chronic Hepatitis B (HBV). This stable isotope is valuable for pharmacokinetic studies, drug metabolism research, and analytical applications involving mass spectrometry. -
Stable Isotope
Lamivudine-13C,d2 is a stable isotope-labeled form of Lamivudine, a potent nucleoside reverse transcriptase inhibitor (NRTI). This compound effectively inhibits the reverse transcriptase enzyme of both HIV and hepatitis B virus, making it valuable in antiviral research. Additionally, Lamivudine's ability to penetrate the central nervous system (CNS) enhances its significance in studies related to neurological implications of viral infections. -
Stable Isotope
Telbivudine-d4 is a deuterated form of Telbivudine, a thymidine nucleoside analog that serves as a potent antiviral agent targeting hepatitis B virus (HBV) replication. This stable isotope variant is essential for research applications requiring isotopic labeling, including pharmacokinetic studies and metabolic pathway investigations. Telbivudine-d4 provides a valuable tool for understanding the dynamics of HBV replication and the pharmacological properties of nucleoside analogs in antiviral therapy. -
Stable Isotope
Adefovir-d4 is a deuterium-labeled form of Adefovir, an adenosine monophosphate analog that serves as an antiviral agent. Upon intracellular conversion to Adefovir diphosphate, it effectively inhibits HBV DNA polymerase, exhibiting an IC50 of 0.7 μM against HBV in the HepG2.2.15 cell line. Adefovir demonstrates significant antiviral activity against a range of viruses, including hepatitis B virus (HBV) and various herpesviruses. Its isotopic label makes Adefovir-d4 ideal for tracer studies in viral research and pharmacokinetic evaluations. -
Stable Isotope
HBV-IN-39-d3 is a deuterated analog of the HBV inhibitor HBV-IN-39, designed to enhance oral bioavailability. This stable isotope-labeled compound is primarily used in pharmacokinetic studies and metabolic research related to hepatitis B virus (HBV) inhibition. Its unique isotopic composition allows for improved tracking and analysis in biological assays, facilitating further investigation into therapeutic strategies against HBV. -
Stable Isotope
Entecavir-13C2,15N-1 is a stable isotope-labeled form of Entecavir, which acts as a potent and selective inhibitor of hepatitis B virus (HBV) replication. This compound exhibits an EC50 of 3.75 nM in HepG2 cells, making it a valuable tool for studying HBV biology and antiviral mechanisms. Entecavir-13C2,15N-1 is ideally suited for applications in pharmacokinetic studies, drug metabolism research, and the development of HBV therapies. -
Stable Isotope
Nicotinamide-d3 is a deuterium-labeled form of Nicotinamide, a vital derivative of vitamin B3. It functions primarily by inhibiting SIRT1 and SIRT2 activity, with an IC50 of 2 μM for SIRT2. Biological studies show that Nicotinamide-d3 enhances cellular levels of NAD+, ATP, and reactive oxygen species (ROS), exhibiting potential anti-tumor effects and improved survival outcomes in various contexts. Additionally, this compound is recognized for its anti-hepatitis B virus (HBV) activity, making it valuable for research in metabolism and cancer biology. -
Stable Isotope
Famciclovir-d6 is a deuterated form of Famciclovir, serving as a stable isotope for research applications. This orally active nucleoside analogue exhibits potent antiviral activity against hepatitis B virus (HBV), herpes simplex virus (HSV), and varicella-zoster virus (VZV). Famciclovir-d6 is utilized in studies related to herpesvirus infections, enhancing the understanding of viral mechanisms and the development of therapeutic interventions. -
Stable Isotope
Lamivudine-13C,15N3 is a stable isotope-labeled derivative of Lamivudine, a nucleoside reverse transcriptase inhibitor (NRTI) with potent activity against HIV and hepatitis B virus reverse transcriptases. This isotopic labeling facilitates advanced metabolic studies and pharmacokinetic investigations. It is particularly useful in research focusing on antiviral drug mechanisms, therapeutic efficacy, and the pharmacodynamics of nucleoside analogs in various biological matrices. -
Stable Isotope
Sofosbuvir-d6 is a stable isotope-labeled form of Sofosbuvir, specifically deuterated for enhanced tracking in metabolic studies. Sofosbuvir is an effective inhibitor of hepatitis C virus (HCV) RNA replication, demonstrating significant antiviral activity against HCV in replicon assays. This reagent is primarily utilized in pharmacokinetic studies and isotopic labeling applications to investigate the metabolism and bioavailability of Sofosbuvir. -
Stable Isotope
2'-O-Methylcytidine-d3 is a deuterium-labeled form of 2'-O-Methylcytidine, a nucleoside that functions as an inhibitor of hepatitis C virus (HCV) replication. This compound exhibits competitive inhibition of RNA-dependent RNA polymerase (NS5B)-mediated RNA synthesis in vitro, targeting the enzyme's active site. Its isotopic labeling makes it an essential tool for studies involving metabolic pathways and nucleic acid synthesis in research settings. -
Stable Isotope
N-Acetyl sulfadiazine-d4 is a stable isotope-labeled version of N-Acetyl sulfadiazine, designed for use in metabolic studies and pharmacokinetic research. This compound serves as a valuable tracer in the investigation of drug metabolism and interactions within biological systems. Its deuterium labeling facilitates accurate tracking and quantification in isotopic analysis, making it essential for studies requiring precise measurement of drug disposition and kinetics. -
Stable Isotope
Boceprevir-d9 is a deuterated form of Boceprevir, a selective and potent inhibitor of the HCV NS3 protease with a Ki value of 14 nM in enzyme assays. It demonstrates an EC90 of 350 nM in cell-based replicon assays, showcasing its efficacy against hepatitis C virus replication. Additionally, Boceprevir has been shown to inhibit SARS-CoV-2 3CLpro activity, making it valuable for research in antiviral drug development and therapeutic applications targeting viral proteases. -
Stable Isotope
Daclatasvir-d6 is a deuterium-labeled derivative of Daclatasvir, a highly effective antagonist of the HCV NS5A protein, exhibiting EC50 values between 9-146 pM across various HCV replicon genotypes. Additionally, Daclatasvir serves as an inhibitor of organic anion transporting polypeptide 1B (OATP1B) and OATP1B3, with IC50 values of 1.5 μM and 3.27 μM, respectively. This labeled compound is valuable for studying the pharmacokinetics and metabolic pathways of Daclatasvir in research applications related to hepatitis C virus therapy. -
Stable Isotope
Ledipasvir-d6 is a deuterated form of Ledipasvir, an effective inhibitor of the hepatitis C virus NS5A, exhibiting EC50 values of 34 pM against genotype 1a and 4 pM against genotype 1b replicons. Additionally, Ledipasvir serves as a SARS-CoV 3CLpro inhibitor, with an IC50 of 1.62 μM. This stable isotope is suitable for advanced research applications in virology and drug development, particularly in studies involving metabolic tracing and pharmacokinetics. -
Stable Isotope
1-Methylnaphthalene-13C is a stable isotope-labeled derivative of 1-Methylnaphthalene, an organic compound known for its antibacterial and antioxidant properties. This reagent serves as a useful tracer in environmental monitoring and research, allowing for the identification and quantification of pollutants. Additionally, 1-Methylnaphthalene-13C can function as an intermediate in petrochemical synthesis, enhancing reaction efficiency in various chemical processes. -
Stable Isotope
1-Tetradecanol-d29 is a deuterium-labeled derivative of 1-Tetradecanol, a straight-chain saturated fatty alcohol derived from Myristica fragrans. This compound exhibits notable antibacterial and anti-inflammatory properties, particularly in the context of periodontitis. It serves as a stable isotope labeled reagent, enabling precise tracking and quantification in metabolic studies and lipid research applications. -
Stable Isotope
2-Chloroacetamide-d4 is a deuterium-labeled analogue of 2-Chloroacetamide, primarily known for its role as a biocide and herbicide in agricultural applications. It acts by inhibiting very-long-chain fatty acid elongase, impacting lipid biosynthesis pathways. This stable isotope label allows for precise tracking and analysis in research focused on plant metabolism, biocides, and fatty acid metabolism studies. -
Isotope-Labeled Compound
Diethyl phosphate-13C4 sodium is a stable isotope-labeled compound targeting metabolic and environmental studies. This compound serves as a key biomarker for the metabolic byproduct of Chlorpyrifos, a widely utilized insecticide. Its applications extend to tracing metabolic pathways and investigating environmental degradation processes, making it essential for research in toxicology and environmental science. -
Stable Isotope
Myristic acid-13C2 is a stable isotope-labeled variant of myristic acid, a saturated 14-carbon fatty acid commonly found in various animal and plant fats, including milk fat and coconut oil. This compound exhibits anti-inflammatory effects primarily through the NF-κB signaling pathway and demonstrates antibacterial, anti-inflammatory, and analgesic activities. Myristic acid-13C2 is valuable in metabolic studies, allowing researchers to investigate fatty acid metabolism and functionality in biochemical pathways. -
Stable Isotope
α-Terpineol-d6 is a deuterated variant of α-Terpineol, functioning as a stable isotope for chemical research. This compound exhibits notable antimicrobial activity against periodontopathic and cariogenic bacteria, as well as antifungal properties against T. mentagrophytes, potentially causing irreversible cellular disruption. Additionally, α-Terpineol-d6 demonstrates antineuropathic and anti-inflammatory effects, making it a valuable tool for studying conditions related to diarrhea, neuropathic pain, infections, and inflammation. -
Stable Isotope
Sulfanitran-d4 is a deuterium-labeled derivative of Sulfanitran, targeting the multidrug resistance protein 2 (MRP2). This reagent serves as an antibacterial and anticoccidial agent commonly utilized in poultry feeds. Sulfanitran-d4 enhances the interaction between MRP2 and estradiol-17-β-D-glucuronide (E217βG), making it a valuable tool for studying drug transport mechanisms and resistance in pharmacological research settings. -
Stable Isotope
Ramifenazone-d7 is a deuterium-labeled derivative of Ramifenazone, a non-steroidal anti-inflammatory drug (NSAID) that exhibits analgesic, antipyretic, anti-inflammatory, and antimicrobial properties. Its stable isotope composition makes it particularly useful for metabolic studies and pharmacokinetic investigations. Researchers can leverage Ramifenazone-d7 for exploring the absorption, distribution, metabolism, and excretion (ADME) of NSAIDs in biological systems. -
Stable Isotope
2-Phenylethanol-13C2 is a stable isotope-labeled variant of 2-Phenylethanol, specifically designated for use in research applications that require precise isotopic tracking. Known for its aromatic characteristics and rose-like fragrance, 2-Phenylethanol serves as a flavoring and fragrance agent, and exhibits notable antimicrobial and antityrosinase properties. This compound is particularly useful in studies related to food preservation, cosmetic formulation, and metabolic research. -
Stable Isotope
Norethindrone-13C2 is a stable isotope-labeled form of Norethindrone, a synthetic progestin primarily targeting progesterone receptors. It exhibits key biological activities in regulating menstrual cycles and managing conditions such as endometriosis, uterine bleeding related to hormonal imbalances, and secondary amenorrhea. Norethindrone-13C2 is valuable for pharmacokinetic studies and isotopic tracing in biochemical research applications, facilitating in-depth investigations into hormone metabolism and therapeutic mechanisms. -
Stable Isotope
Cinnamyl acetate-13C2 is a stable isotope-labeled form of cinnamyl acetate. This compound exhibits broad-spectrum antibacterial activity and is widely utilized in the flavor and fragrance industry. Its stable isotope labeling makes it an essential tool for research applications in metabolic studies and tracing pathways in biochemical research. -
Stable Isotope
Rimonabant-d10 hydrochloride is a deuterium-labeled derivative of Rimonabant hydrochloride, a selective antagonist of the central cannabinoid receptor (CB1) with a Ki of 1.8 nM. This compound is utilized in studies investigating the role of CB1 receptors in various physiological processes and the development of obesity therapies. Additionally, Rimonabant hydrochloride is known to inhibit Mycobacterial membrane protein Large 3 (MMPL3), making it relevant for research in tuberculosis and related infectious diseases. -
Stable Isotope
Isopropyl 4-hydroxybenzoate-d7 is a deuterium-labeled derivative of Isopropyl 4-hydroxybenzoate, commonly known as Isopropylparaben. This stable isotope exhibits antimicrobial and antioxidant properties, making it a valuable tool in research involving the study of parabens and their biological effects. It is particularly useful in pharmacokinetic studies and metabolic research, allowing for enhanced tracking of compound behavior in biological systems. -
Stable Isotope
Hypoxanthine-13C,15N2 is a stable isotope-labeled form of hypoxanthine that incorporates both 13C and 15N isotopes. As a purine derivative, hypoxanthine serves as a potential free radical generator and may be utilized as a biomarker for hypoxic conditions. This reagent is valuable for research applications in metabolic studies, hypoxia-related investigations, and isotopic tracing in cellular and molecular biology. -
Stable Isotope
Isoeugenol-d3 is a deuterated form of Isoeugenol, a compound derived from various essential oils such as nutmeg, clove, and cinnamon. It serves as a stable isotope for use in research applications, particularly in studies involving the antimicrobial properties of isoeugenol. This compound demonstrates inhibitory effects on Escherichia coli and Listeria innocua, with minimum inhibitory concentrations (MICs) of 0.6 mg/mL and 1 mg/mL, respectively, making it valuable for microbiological studies. -
Stable Isotope
Itopride-d6 is a deuterated form of Itopride, a potent dopamine D2 receptor antagonist and acetylcholinesterase (AChE) inhibitor. Its unique stable isotope labeling allows for advanced metabolic and pharmacokinetic studies. Itopride enhances gastric motility through its combined antidopaminergic and anti-AChE actions, making it valuable in research applications focused on gastrointestinal prokinetics and conditions such as gastro-esophageal reflux disease (GERD). -
Stable Isotope
Probenecid-d7 is a stable isotope-labeled derivative of Probenecid, featuring seven deuterium atoms. This compound is primarily utilized in pharmacokinetic studies and drug metabolism research, enabling precise tracking of Probenecid in biological systems. Its unique isotopic labeling enhances analytical sensitivity and specificity in mass spectrometry applications, facilitating the investigation of metabolic pathways and drug interactions. -
Stable Isotope
Hexadecane-1,2-13C2 is a stable isotope-labeled form of hexadecane, a saturated hydrocarbon belonging to the alkane family. This compound serves as an effective organic solvent and is commonly utilized in research to study the microbial degradation of hydrophobic substrates. Its application in metabolic studies allows for the tracing of carbon flows in biochemical pathways, enhancing understanding of environmental processes and microbial dynamics. -
Stable Isotope
p-Anisic acid-13C6 is a stable isotope-labeled variant of p-Anisic acid (4-Methoxybenzoic acid), which is known for its antibacterial and antiseptic properties. This compound is utilized as a tracer in metabolic studies and is important for research involving the analysis of metabolic pathways and compound interactions. Its isotopic labeling allows for precise quantification in various biochemical investigations, enhancing the understanding of its biological activities. -
Stable Isotope
2,6-Dichlorodiphenylamine-13C6 serves as a stable isotope labeled analog of 2,6-Dichlorodiphenylamine. This compound demonstrates significant anti-Candida albicans activity, contributing to its potential utility in antifungal research. It is structurally related to Diclofenac Sodium, a well-known COX inhibitor with IC50 values of 4 and 1.3 nM for human COX-1 and COX-2, making 2,6-Dichlorodiphenylamine-13C6 valuable for studies in inflammation and enzyme inhibition mechanisms. -
Stable Isotope
Veratryl alcohol-13C (3,4-Dimethoxybenzyl alcohol-13C) is a stable isotope-labeled analog of Veratryl alcohol, a secondary metabolite produced by lignin-degrading fungi. This compound serves as a substrate for lignin peroxidase (LiP), enabling the assessment of lignin degradation activity. Additionally, Veratryl alcohol-13C protects LiP from inactivation by hydrogen peroxide and stabilizes manganese-dependent peroxidases (MnP). The compound also functions as a quorum-sensing inhibitor, demonstrating antibacterial properties, making it valuable for various biochemical and microbiological research applications. -
Stable Isotope
2-Undecanone-d5 is a deuterium-labeled analog of 2-Undecanone, serving as a stable isotope. This compound is a volatile organic compound that inhibits the DnaKJE-ClpB bichaperone dependent refolding of heat-inactivated bacterial luciferases. 2-Undecanone-d5 is of significant interest in studies related to cellular stress responses and has demonstrated activity in inhibiting lung tumorigenesis.
