Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Pyridaben-d13 is a deuterium-labeled version of Pyridaben, a potent mitochondrial electron transport inhibitor (METI) and acaricide. This compound selectively targets complex I (NADH dehydrogenase), demonstrating an inhibitory efficacy with an IC50 value of 2.4 nM in rat liver and bovine heart mitochondria. Additionally, Pyridaben-d13 significantly affects mitochondrial nitric oxide synthase (mtNOS) function in rat models, making it a valuable reagent for studies on mitochondrial dysfunction and oxidative stress. -
Stable Isotope
Parbendazole-d3 is a deuterium-labeled derivative of Parbendazole, a potent inhibitor of microtubule assembly. This compound disrupts tubulin stability, demonstrating an effective EC50 of 530 nM, and is known for its broad-spectrum anthelmintic activity. Parbendazole-d3 is utilized in research applications aimed at studying microtubule dynamics and developing anthelmintic therapies. -
Stable Isotope
Hexythiazox-d11 is a deuterium-labeled derivative of Hexythiazox, a selective acaricide targeting mites. It exhibits ovicidal, larvicidal, and nymphicidal activities, making it effective for the chemical control of mite populations on cotton, fruits, and vegetables. Hexythiazox demonstrates a favorable safety profile, being non-toxic to mammals while preserving beneficial insect species and natural mite predators. This isotopically labeled compound is valuable for research applications in pesticide efficacy and environmental impact studies. -
Stable Isotope
Methyl Clonazepam-d3 is a deuterium-labeled derivative of Methylclonazepam, a benzodiazepine that exerts anxiolytic effects. This compound is known to inhibit the absorption of 5-hydroxytryptamine by Schistosoma mansoni, demonstrating potential anti-parasitic activity. Methyl Clonazepam derivatives are valuable tools for research focused on schistosomiasis and related disorders, aiding in the exploration of therapeutic interventions. -
Stable Isotope
DL-Methionine-d3 is a stable isotope-labeled form of the essential amino acid DL-Methionine, which contains sulfur and is known for its role in oxidative stress defense. This compound is primarily utilized in research focusing on metabolic studies and isotopic tracing in biological systems. Additionally, DL-Methionine exhibits efficacy against Heterodera rostochiensis in potato plants, making it pertinent for studies in agronomy and plant defense mechanisms. -
Stable Isotope
2,3-Diphosphoglyceric acid-13C3 is a stable isotope-labeled form of 2,3-Diphosphoglyceric acid, an intermediate in the glycolytic pathway. This compound primarily stabilizes the deoxygenated form of hemoglobin through allosteric binding, thereby facilitating oxygen release to tissues. Additionally, 2,3-Diphosphoglyceric acid exhibits antiparasitic activity and is valuable in research related to Alzheimer's disease, contributing to the understanding of metabolic processes and disease mechanisms. -
Stable Isotope
Temephos-d12 is a deuterated form of Temephos, an organophosphate larvicide. It targets the central nervous system of aquatic larvae, including those of mosquitoes, midges, and black flies, by inhibiting cholinesterase activity. This mechanism leads to larval mortality prior to reaching the adult stage, making Temephos-d12 valuable for research on pesticide efficacy and environmental impact studies. -
Stable Isotope
(-)-Fucose-13C-2 is a stable isotope-labeled derivative of (-)-Fucose, a hexose sugar. This compound is instrumental in studying blood group antigen structure, as well as selectin-mediated leukocyte-endothelial adhesion mechanisms. Additionally, (-)-Fucose-13C-2 has applications in examining host-microbe interactions, contributing to research in immunology, glycobiology, and cellular communication. -
Stable Isotope
HCV-IN-49 is a phosphoramidate ester derivative that functions as an inhibitor of Hepatitis C virus (HCV) protease. This compound exhibits notable antiviral activity and is instrumental in the study of HCV replication and pathogenesis. HCV-IN-49 serves as a valuable tool in research applications focused on HCV treatment development and drug resistance mechanisms. -
Stable Isotope
Faldaprevir-d7 is a deuterated analog of Faldaprevir, designed as a stable isotope for research applications. Its primary mechanism involves targeting the NS3 protease of the hepatitis C virus, facilitating studies in viral replication and protease inhibition. This compound is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of drug behavior in biological systems. -
Stable Isotope
Faldaprevir-d6 is a deuterium-labeled analogue of Faldaprevir, a potent inhibitor of the NS3/4A protease in the hepatitis C virus. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling, allowing for precise tracking of drug metabolism and clearance in biological systems. Its application in research contributes to a deeper understanding of antiviral drug behavior and efficacy. -
Stable Isotope
Darunavir-d9 is a stable isotope-labeled form of Darunavir, a next-generation HIV protease inhibitor. This compound exhibits significant antiviral activity against both wild-type and mutant HIV strains, displaying an IC50 of 0.003 μM and an IC90 of 0.009 μM while maintaining low cytotoxicity. Darunavir-d9 is primarily utilized in biochemical research applications, including drug metabolism studies and pharmacokinetics for advanced HIV research. -
Stable Isotope
Cabotegravir-d5 is a deuterium-labeled derivative of Cabotegravir, primarily used as a stable isotope. Its unique isotopic composition allows for advanced tracking and analysis in metabolic studies and pharmacokinetic research. This reagent serves as a valuable tool for elucidating the mechanisms of action of integrase inhibitors and for studying their pharmacodynamics in various biological systems. -
Stable Isotope
Rilpivirine-d6 is a deuterated form of Rilpivirine, a selective diarylpyrimidine non-nucleoside reverse transcriptase inhibitor (NNRTI) that targets HIV reverse transcriptase. This compound exhibits potent antiviral activity against both wild-type HIV (EC50=0.4 nM) and various mutant strains (EC50=0.1-2.0 nM). Rilpivirine demonstrates a notable genetic barrier to resistance, making it a valuable tool for research in HIV treatment and resistance profiling. Its isotopic labeling aids in pharmacokinetic and metabolic studies, enhancing understanding of drug behavior in biological systems. -
Stable Isotope
Atazanavir-d5 is a deuterium-labeled derivative of Atazanavir, a highly selective inhibitor of HIV-1 protease. This compound serves as a substrate and inhibitor of the cytochrome P450 enzyme CYP3A4, as well as an inhibitor and inducer of P-glycoprotein (P-gp). Additionally, Atazanavir exhibits activity against SARS-CoV 3CLpro with an IC50 of 3.49 μM, making it valuable for research into HIV and coronavirus-related mechanisms. -
Stable Isotope
Indinavir-d6 is a deuterium-labeled analog of the potent HIV protease inhibitor Indinavir. It specifically targets the HIV protease enzyme, inhibiting viral replication and demonstrating favorable oral bioavailability. This stable isotope is utilized in pharmacokinetic studies, metabolic tracing, and the investigation of drug interactions within HIV research. -
Stable Isotope
Raltegravir-d3 potassium is a deuterium-labeled form of Raltegravir, a potent integrase inhibitor utilized in the treatment of HIV infection. This stable isotope serves as a valuable tool for pharmacokinetic studies and drug metabolism research, providing insights into the biological mechanisms of integrase inhibition. Its labeling facilitates the quantification and tracking of Raltegravir in various biological matrices, aiding researchers in understanding its therapeutic effects and metabolic pathways. -
Stable Isotope
Plerixafor-d4 is a deuterated derivative of Plerixafor, a selective antagonist of the CXCR4 receptor with an IC50 of 44 nM. This compound serves as an immunostimulant and is known for its ability to mobilize hematopoietic stem cells (HSCs). Additionally, Plerixafor has demonstrated efficacy in inhibiting HIV-1 and HIV-2 replication, with an EC50 ranging from 1 to 10 nM. Plerixafor-d4 is useful in research applications requiring stable isotopes for tracking and quantification purposes. -
Stable Isotope
Amprenavir-d4 is a deuterated form of Amprenavir, a potent inhibitor of the HIV protease with a Ki value of 0.6 nM. In addition to its antiviral properties, Amprenavir has been identified as a SARS-CoV 3CLpro inhibitor, demonstrating an IC50 of 1.09 μM. This stable isotope is utilized in chemical research for quantitative analysis and metabolic studies of drug metabolism and pharmacokinetics. -
Stable Isotope
Raltegravir-d4 is a deuterated analog of Raltegravir, which functions as a potent inhibitor of HIV integrase (IN). This stable isotope-labeled compound is designed for use in pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Raltegravir in biological systems. Its application is essential for understanding drug metabolism and interaction mechanisms in HIV treatment protocols. -
Stable Isotope
2-Phenylbutyric acid-d5 is a deuterium-labeled derivative of 2-Phenylbutanoic acid, a monocarboxylic acid known for its interaction with various proteins. This stable isotope is utilized in biological research to study malignant lymphoma and HIV-related diseases. Its labeling enables precise tracking and quantification in biochemical assays, making it a valuable tool for understanding metabolic pathways and disease mechanisms. -
Stable Isotope
Emtricitabine-13C,15N2 is a stable isotope-labeled version of Emtricitabine, a nucleoside reverse transcriptase inhibitor (NRTI). With an EC50 of 0.01 μM in peripheral blood mononuclear cells (PBMCs), it exhibits potent antiviral activity against HIV. This labeled compound is primarily used in pharmacokinetic studies and metabolic research, aiding in understanding drug efficacy and dynamics within biological systems. -
Stable Isotope
Oltipraz-d3 is a deuterium-labeled derivative of Oltipraz, primarily targeting hypoxia-inducible factor 1-alpha (HIF-1α). It demonstrates inhibitory effects on HIF-1α activation in a time-dependent manner, fully suppressing its induction at concentrations of 10 μM or greater, with an IC50 value of 10 μM. Additionally, Oltipraz acts as a potent activator of Nrf2, making it a valuable reagent for studies investigating cellular responses to hypoxic conditions and oxidative stress. -
Stable Isotope
Lopinavir-d7 is a deuterated derivative of Lopinavir, a selective peptidomimetic inhibitor targeting the HIV-1 protease. It demonstrates potent activity, with Ki values ranging from 1.3 to 3.6 pM against both wild-type and mutant HIV proteases, effectively preventing HIV-1 maturation and subsequent infectivity. Additionally, Lopinavir has been identified as an inhibitor of SARS-CoV 3CLpro, showcasing an IC50 of 14.2 μM, making it valuable for research in virology and antiviral drug development. -
Stable Isotope
Atazanavir-d6 is a deuterium-labeled form of Atazanavir, a selective inhibitor of HIV-1 protease. Recognized for its capability as a CYP3A4 substrate and inhibitor, it also exerts dual effects as both an inhibitor and inducer of P-glycoprotein (P-gp). In addition, Atazanavir demonstrates antiviral activity by inhibiting the SARS-CoV 3CLpro with an IC50 of 3.49 μM, making it a valuable tool for research in HIV and coronavirus-related studies. -
Stable Isotope
Raltegravir-d6 is a deuterated derivative of Raltegravir, a well-established integrase (IN) inhibitor employed in the management of HIV infection. This stable isotope-labeled compound is instrumental for use in pharmacokinetic studies, enabling precise tracking of drug metabolism and distribution in biological systems. Its application in research contributes to a better understanding of drug dynamics and efficacy in antiretroviral therapy. -
Stable Isotope
Atazanavir-d15 is a stable isotope-labeled form of Atazanavir, an effective selective inhibitor of HIV-1 protease. This compound is utilized in biochemical research to help elucidate drug metabolism and pharmacokinetics. Its unique labeling allows for precise tracking in biological systems, enhancing studies focused on HIV infection and treatment strategies. -
Stable Isotope
(rel)-Lopinavir-d8 is a deuterium-labeled derivative of Lopinavir, a selective peptidomimetic inhibitor targeting HIV-1 protease. This compound demonstrates high potency, with inhibition constants ranging from 1.3 to 3.6 pM against both wild-type and mutant forms of the enzyme, effectively hindering HIV maturation and infectivity. Additionally, (rel)-Lopinavir-d8 exhibits activity as an inhibitor of the SARS-CoV 3CLpro with an IC50 of 14.2 μM, making it a valuable tool for HIV and coronavirus research applications. -
Stable Isotope
Elvitegravir-d5 is a deuterated form of Elvitegravir, a potent integrase inhibitor targeting HIV-1 and HIV-2 strains. It demonstrates impressive inhibitory activity with IC50 values of 0.7 nM, 2.8 nM, and 1.4 nM against HIV-1IIIB, HIV-2EHO, and HIV-2ROD, respectively. This stable isotope is valuable for biochemical and pharmacokinetic studies, offering insights into HIV integrase function and drug metabolism in research applications. -
Stable Isotope
Glurate-d5, a deuterium-labeled derivative of Glurate, primarily functions as an acylating agent. It is utilized in the development of antiviral compounds, particularly those effective against retroviruses, including herpes virus and HIV. Additionally, Glurate-d5 plays a crucial role in the synthesis of acyclic nucleoside derivatives and 5-hydroxyhexanoic acid, making it valuable for various biochemical research applications. -
Stable Isotope
Amprenavir-d4-1 is a deuterated form of Amprenavir, an effective HIV protease inhibitor with a Ki value of 0.6 nM. In addition to its antiviral activity, Amprenavir also demonstrates inhibition of the SARS-CoV 3CL pro enzyme with an IC50 of 1.09 μM. This stable isotope is valuable for research applications, including pharmacokinetics and metabolic studies of related compounds in virology and drug development contexts. -
Stable Isotope
Atazanavir-d18 is a stable isotope-labeled version of Atazanavir, a selective inhibitor of the HIV-1 protease. This compound is utilized in biochemical and pharmacokinetic studies, providing valuable insights into the metabolism and distribution of Atazanavir in biological systems. Its stable isotope labeling allows for precise quantification and tracking in research applications related to HIV treatment and drug development. -
Stable Isotope
Ditiocarb-d10 sodium is a deuterated form of sodium diethyldithiocarbamate, functioning as a stable isotope label. This compound acts primarily as a copper chelator and exhibits significant antioxidant properties, anti-tumor effects, immunomodulatory activity, and potential anti-HIV functions. Ditiocarb-d10 sodium is useful in research concerning tumor biology, inflammatory responses, and immune system modulation. -
Stable Isotope
Maraviroc-d6 is a deuterium-labeled analog of Maraviroc, a selective antagonist of the CCR5 receptor. This compound is primarily utilized in research to study HIV infection and the mechanisms of CCR5-mediated viral entry. Its stable isotope labeling allows for improved tracking and analysis in biological assays, facilitating investigations into antiviral drug development and efficacy. -
Stable Isotope
Etravirine-13C3 is a stable isotope-labeled derivative of Etravirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) utilized in HIV treatment. This compound serves as a valuable tool for metabolic studies and pharmacokinetic analyses involving Etravirine, aiding in the understanding of its biochemical properties and interactions. Its isotopic labeling facilitates precise measurements in various research applications related to HIV dynamics and drug metabolism. -
Stable Isotope
Rilpivirine-d6 hydrochloride is a deuterium-labeled analog of Rilpivirine, targeting the HIV-1 reverse transcriptase enzyme. This stable isotope variant enables precise quantification and tracking of Rilpivirine in pharmacokinetic studies and metabolic research. Its application is crucial for understanding drug metabolism and enhancing the development of antiretroviral therapies. -
Stable Isotope
Dolutegravir-d5 is a deuterium-labeled analog of Dolutegravir, a potent inhibitor of HIV-1 integrase strand transfer. It demonstrates exceptional antiviral activity with an IC50 value of 2.7 nM against HIV-1 integrase and an IC50 of 0.51 nM for suppressing viral replication in peripheral blood mononuclear cells. Additionally, Dolutegravir maintains strong efficacy against key HIV-1 variants, including Y143R, N155H, and G140S/Q148H mutants, with EC50 values ranging from 3.6 to 5.8 nM. This stable isotope is valuable for pharmacokinetic studies and metabolic research in HIV treatment. -
Stable Isotope
Emtricitabine-15N,d2 is a stable isotope-labeled form of Emtricitabine, a nucleoside reverse transcriptase inhibitor (NRTI). This compound exhibits antiviral activity against HIV with an EC50 of 0.01 μM in PBMC cells. Emtricitabine-15N,d2 is valuable for studies involving pharmacokinetics and drug metabolism, enabling precise tracking of the compound in biological systems. -
Stable Isotope
Lopinavir-d8 is a deuterated form of the potent HIV-1 protease inhibitor Lopinavir, functioning primarily by inhibiting the enzyme's activity, which is crucial for viral maturation. With an affinity (Kis) ranging from 1.3 to 3.6 pM against both wild-type and mutant strains of HIV protease, Lopinavir-d8 effectively blocks HIV-1 infectivity. Additionally, it serves as an inhibitor of SARS-CoV 3CLpro, exhibiting an IC50 value of 14.2 μM, making it valuable for research on viral proteases and potential therapeutic applications in retroviral and coronavirus research. -
Stable Isotope
Ditiocarb-d10 (Deuterium-labeled Diethyldithiocarbamic acid) serves as a stable isotope for research applications. Primarily, it acts as an accelerator in copper cementation processes. Additionally, Ditiocarb has been shown to reduce the incidence of HIV infections and may enhance adjuvant immunotherapy strategies in high-risk breast cancer research. This stable isotope variant enables more precise tracking and analysis in related biochemical and clinical studies. -
Stable Isotope
ZK-316 is a stable isotope and a potent broad-spectrum non-nucleoside reverse transcriptase inhibitor (NNRTI) that demonstrates EC50 values ranging from 0.99 to 75.1 nM. This compound is essential for HIV research, facilitating the understanding of viral replication and the development of antiretroviral therapies. Its efficacy makes it a valuable tool for studying the mechanisms of HIV infection and resistance to treatment. -
Stable Isotope
Nevirapine-d3 is a deuterated form of Nevirapine, a non-nucleoside inhibitor targeting HIV-1 reverse transcriptase, with a Ki of 270 μM. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic research involving HIV/AIDS treatments. Its incorporation into studies can enhance the understanding of drug pharmacodynamics and metabolic pathways in the context of antiviral therapies. -
Stable Isotope
Bictegravir-d7 is a deuterium-labeled form of Bictegravir, a potent inhibitor of HIV-1 integrase. It exhibits an IC50 of 7.5 nM, demonstrating strong inhibitory activity against the virus. This stable isotope is primarily utilized in research applications that require precise tracking of compound metabolism and pharmacokinetics in biological systems. -
Stable Isotope
Nevirapine-d8 is a deuterated derivative of Nevirapine, serving as a stable isotope. Nevirapine functions as a non-nucleoside inhibitor of HIV-1 reverse transcriptase, demonstrating a Ki value of 270 μM. This reagent is valuable for pharmacokinetic studies and the development of analytical methods in HIV research. Its stable isotope labeling enables precise quantification and tracing in various biological assays. -
Stable Isotope
Etravirine-d8 is a deuterium-labeled variant of Etravirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting the HIV reverse transcriptase enzyme. This stable isotope is utilized in research to track pharmacokinetics and metabolic pathways of Etravirine, enhancing the understanding of its biological activity in HIV treatment. Etravirine-d8 serves as a valuable tool in drug development and pharmacological studies. -
Stable Isotope
Finafloxacin-d4 hydrochloride is a deuterium-labeled derivative of Finafloxacin, serving as a stable isotope. This compound can be utilized in pharmacokinetic studies and metabolic research to track drug metabolism and distribution in biological systems. Its labeled form allows for enhanced detection and quantification in analytical techniques, supporting research applications in drug development and therapeutic monitoring. -
Stable Isotope
Trofosfamide-d4 is a stable isotope-labeled form of Trofosfamide, an orally bioavailable oxazaphosphorine derivative known for its antineoplastic properties. The deuterium labeling allows for enhanced tracking and quantification in metabolic studies. This reagent is suitable for research applications such as pharmacokinetics, drug metabolism, and isotope labeling studies in oncology research. -
Stable Isotope
Cletoquine-d4 is a deuterium-labeled derivative of Cletoquine, the primary active metabolite of Hydroxychloroquine. This stable isotope is utilized in pharmacokinetic studies and metabolic pathway investigations due to its unique labeling. Cletoquine exhibits notable antimalarial activity and has demonstrated efficacy against the chikungunya virus (CHIKV), alongside potential therapeutic implications for autoimmune diseases. Its use in research can enhance the understanding of drug metabolism and therapeutic mechanisms. -
Stable Isotope
Cletoquine-d4-1 is a deuterium-labeled derivative of Cletoquine, a significant active metabolite of Hydroxychloroquine. This compound is produced by the liver through the action of CYP2D6, CYP3A4, CYP3A5, and CYP2C8 isoenzymes. Cletoquine-d4-1 exhibits antiviral activity against the chikungunya virus (CHIKV) and possesses antimalarial properties, making it valuable in research applications focused on malaria and autoimmune disease therapies. -
Stable Isotope
Cletoquine-d4 Oxalate is a stable isotope of Cletoquine, a significant active metabolite of Hydroxychloroquine. This compound, produced in the liver by various cytochrome P450 isoenzymes, exhibits antimalarial properties and shows promise in the treatment of autoimmune diseases. Additionally, as a Chloroquine derivative, Cletoquine-d4 Oxalate has demonstrated antiviral activity against the chikungunya virus (CHIKV), making it a valuable reagent for research applications in virology and pharmacology.
