Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections.
Prothionamide-d5 is a deuterium-labeled analog of Prothionamide, a thioamide antibacterial agent that plays a critical role in combating tuberculosis and leprosy. The compound acts as a substrate for the uptake transporter OCT1 and forms a covalent adduct with NAD, which is a potent inhibitor of Mycobacterium tuberculosis and Mycobacterium leprae's InhA enzyme. Prothionamide demonstrates significant antibacterial activity, effectively inhibiting Mycobacterium tuberculosis with a minimum inhibitory concentration (MIC) of approximately 0.5 µg/mL. This reagent is essential for research applications focused on understanding the mechanisms of action and treatment strategies for mycobacterial infections.
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