Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
Alfuzosin-d6 is a deuterium-labeled derivative of Alfuzosin, a selective and competitive α1-adrenoceptor antagonist. This compound exhibits muscle-relaxing properties in the prostate and bladder neck, thereby facilitating urination. Alfuzosin-d6 is utilized in research related to benign prostatic hyperplasia (BPH) and offers valuable insights into the pharmacokinetics and dynamics of the original Alfuzosin compound. -
Stable Isotope
(rac)-Dobutamine-d4 hydrochloride is a stable isotope-labeled form of the synthetic catecholamine Dobutamine hydrochloride, which primarily targets β1-adrenergic receptors (β1-AR) with lower affinity for α1-adrenergic (α1-AR) and β2-adrenergic receptors (β2-AR). This compound is known for its ability to enhance cardiac output and ameliorate conditions of hypoperfusion. It serves as a valuable tool in pharmacological research, particularly in studies focused on cardiovascular function and receptor activity. -
Stable Isotope
Alfuzosin hydrochloride-d6 is a deuterium-labeled form of Alfuzosin hydrochloride, a selective and competitive antagonist of the α1-adrenoceptor. This compound effectively relaxes smooth muscles in the prostate and bladder neck, facilitating improved urinary flow. Alfuzosin hydrochloride-d6 is primarily used in research applications focused on benign prostatic hyperplasia (BPH) and serves as a valuable tool in pharmacokinetic and metabolic studies. -
Stable Isotope
Phentolamine-d4 hydrochloride is a deuterated form of Phentolamine hydrochloride, a reversible and non-selective inhibitor of α1 and α2 adrenergic receptors. This compound is utilized primarily for its vasodilatory effects, which reduce peripheral vascular resistance. Phentolamine-d4 hydrochloride is valuable in research applications related to pheochromocytoma-induced hypertension, heart failure, and erectile dysfunction, providing insights into adrenergic receptor modulation in these conditions. -
Stable Isotope
Mabuterol-d9 hydrochloride is a deuterium-labeled form of Mabuterol hydrochloride, targeting the beta-2 adrenergic receptor (ADRB2) as a selective agonist. This compound exhibits the ability to inhibit cellular proliferation and reduce PDGF-BB-induced increases in intracellular calcium levels. Additionally, Mabuterol hydrochloride downregulates the expression of key proteins such as Drp-1, cyclin D1, and PCNA, while promoting the expression of Mfn-2. This reagent is valuable for research involving cellular signaling, proliferation, and metabolic regulation. -
Stable Isotope
Mirabegron-d5 is a deuterated derivative of Mirabegron, a selective β3-adrenoceptor agonist with an EC50 of 22.4 nM. This stable isotope-labelled compound is instrumental for researchers investigating metabolic pathways and pharmacokinetics involving β3-adrenoceptor modulation. Mirabegron-d5 facilitates the study of drug metabolism and distribution in biological systems, enhancing the understanding of therapeutic strategies targeting bladder function and adipose tissue regulation. -
Stable Isotope
Silodosin-d4 is a deuterium-labeled form of Silodosin, a potent and selective α1A-adrenergic receptor (α1A-AR) blocker. This compound demonstrates a high affinity for the α1A-AR with a Ki value of 0.036 nM, while showing significantly lower binding to α1B-AR and α1D-AR, with Ki values of 21 nM and 2.0 nM, respectively. Silodosin-d4 can be utilized in research focused on lower urinary tract symptoms (LUTS) and benign prostatic hyperplasia (BPH), allowing for in-depth studies on receptor dynamics and pharmacokinetics. -
Stable Isotope
Ractopamine-d3 (hydrochloride) is a deuterated form of the potent β-adrenergic receptor (βAR) agonist, Ractopamine hydrochloride. With a Kd value of approximately 25 nM for pig β1AR and β2AR, this compound is known to promote muscle mass development, limit fat deposition, reduce feed consumption, and enhance protein synthesis in swine. It serves as a valuable tool in research focused on improving production efficiency and increasing lean tissue growth in agricultural settings. -
Stable Isotope
(rac)-Nebivolol-d4 is a stable isotope-labeled form of the racemic compound Nebivolol, which selectively targets the β1-adrenergic receptor with an IC50 of 0.8 nM. This reagent is valuable for pharmacokinetic studies and metabolic research, enabling precise tracking and quantification of Nebivolol in biological systems. Its stable isotope labeling facilitates investigations into drug interactions and receptor dynamics, offering insights into cardiovascular pharmacology. -
Stable Isotope
Droxidopa-13C6 is a stable isotope-labeled form of Droxidopa, a potent orally active precursor to norepinephrine. This compound is primarily utilized in research focused on neurogenic orthostatic hypotension (nOH) and may also provide insights into alternative therapies for attention deficit hyperactivity disorder (ADHD). By enhancing blood pressure and improving standing ability, Droxidopa-13C6 serves as a valuable tool for investigating the physiological effects of norepinephrine-related pathways in neurovascular health. -
Stable Isotope
(Rac)-Nebivolol-d4 hydrochloride is a stable isotope-labeled analog of racemic Nebivolol, which serves as a selective β1-adrenergic receptor inhibitor with an IC50 of 0.8 nM. This reagent is primarily utilized in pharmacokinetic studies and metabolic profiling, offering insights into drug metabolism and receptor interactions in various biological systems. Its application in research facilitates a deeper understanding of adrenergic signaling pathways and cardiovascular pharmacotherapy. -
Stable Isotope
Acepromazine-d6 (maleate) is a deuterium-labeled derivative of Acepromazine, a phenothiazine tranquilizer that acts primarily as an alpha-adrenoceptor antagonist. This stable isotope is valuable for metabolic studies and pharmacokinetic research, allowing for tracking and quantification of Acepromazine metabolism in various biological systems. Its unique labeling enables enhanced sensitivity in analytic techniques, making it an essential tool for researchers studying psychopharmacology and related disciplines. -
Stable Isotope
Romifidine-d4 hydrochloride is a deuterated form of Romifidine hydrochloride, serving as a stable isotope used in various chemical research applications. This compound is primarily utilized to study pharmacokinetics, metabolic pathways, and mechanism of action in pharmacological research. Its isotopic labeling enhances the accuracy of tracer studies, making it a valuable tool for elucidating the behavior of drugs in biological systems. -
Stable Isotope
Tamsulosin-d4 is a deuterium-labeled analog of Tamsulosin, a selective antagonist of the α1-adrenergic receptor. This compound is primarily utilized in the study of benign prostatic hyperplasia and offers insights into its pharmacological effects. Additionally, Tamsulosin has been shown to mitigate abdominal aortic aneurysm growth in preclinical models, making it a valuable reagent for cardiovascular research. -
Stable Isotope
Valsartan-d8 is a deuterated form of Valsartan, an angiotensin II receptor antagonist. This stable isotope is utilized in pharmacokinetic studies and metabolic research to trace the pharmacodynamic and pharmacokinetic profiles of Valsartan in biological systems. Its applications extend to investigations involving hypertension and heart failure, providing valuable insights into the drug's effects and mechanisms of action. -
Stable Isotope
Candesartan-d4 is a deuterium-labeled version of Candesartan, a potent angiotensin II AT1 receptor blocker and PPAR-γ agonist. This stable isotope enables precise pharmacokinetic studies and metabolic profiling of Candesartan's antihypertensive effects. Research applications include investigations into hypertension, chronic heart failure, and traumatic brain injury, providing valuable insights into cardiovascular and neurological conditions. -
Stable Isotope
Olmesartan-d4 is a deuterium-labeled derivative of Olmesartan, functioning as an angiotensin II receptor (AT1R) antagonist. This stable isotope is primarily utilized in pharmacokinetic studies and metabolic profiling to trace its activity and distribution in biological systems. Olmesartan-d4 aids researchers in understanding the therapeutic effects and mechanisms of action associated with blood pressure regulation. -
Stable Isotope
Olmesartan-d6 is the deuterated form of Olmesartan, an angiotensin II receptor (AT1R) antagonist. This stable isotope serves as a valuable tool in pharmacokinetic studies and drug metabolism research. Its use allows for the precise tracking of Olmesartan in biological systems, facilitating a better understanding of its pharmacological properties and therapeutic effects in the management of hypertension. -
Stable Isotope
Irbesartan-d4 is a deuterated form of Irbesartan, a selective angiotensin II type 1 (AT1) receptor blocker. This stable isotope is utilized primarily in pharmacokinetic studies and metabolic research, enabling accurate tracing of Irbesartan metabolism and distribution within biological systems. The compound is particularly relevant in investigating conditions such as hypertension, heart failure, and diabetic nephropathy. -
Stable Isotope
Candesartan-d5 is a deuterated form of Candesartan, an angiotensin II receptor antagonist. With an IC50 of 0.26 nM, it effectively inhibits the angiotensin II type 1 receptor, playing a crucial role in the regulation of blood pressure and fluid balance. This stable isotope is valuable for pharmacokinetic studies and research involving drug metabolism and receptor binding kinetics. -
Stable Isotope
Valsartan-d3 is a deuterated derivative of Valsartan, an angiotensin II receptor antagonist. This stable isotope is primarily used in pharmacokinetic studies and metabolic research to trace the pharmacodynamics of Valsartan in biological systems. Its application is significant in understanding the mechanisms of action related to hypertension and heart failure therapies. -
Stable Isotope
Eprosartan-d3 is a deuterium-labeled variant of Eprosartan, a selective and competitive angiotensin II receptor antagonist. Eprosartan exhibits potent antihypertensive activity by binding to angiotensin II receptors with IC50 values of 9.2 nM and 3.9 nM in rat and human adrenal cortical membranes, respectively. This stable isotope is primarily utilized in biochemical research to study receptor interactions and pharmacokinetic properties of Eprosartan in various biological systems. -
Stable Isotope
Losartan-d3 Carboxylic Acid is a deuterium-labeled derivative of Losartan, which serves as an angiotensin II receptor antagonist. It inhibits the binding of angiotensin II to AT1 receptors with an IC50 of 20 nM, making it valuable in cardiovascular research. This stable isotope is particularly useful for pharmacokinetic studies, enabling accurate tracking and quantification of Losartan in biological systems. -
Stable Isotope
Losartan-d2 is a deuterated form of Losartan, an angiotensin II receptor antagonist. It competitively inhibits the binding of angiotensin II to the AT1 receptor with an IC50 value of 20 nM. This stable isotope is useful for research applications in pharmacokinetics, drug metabolism studies, and receptor binding assays, facilitating the investigation of Losartan's biological activity in various experimental contexts. -
Stable Isotope
Losartan-d9 is a deuterated form of Losartan, which serves as an angiotensin II receptor antagonist. It effectively competes with angiotensin II for binding to AT1 receptors, demonstrating an IC50 value of 20 nM. This stable isotope is valuable in pharmacokinetic studies and metabolic research, providing insights into drug metabolism and pharmacodynamics. -
Stable Isotope
Olmesartan medoxomil-d6 is a deuterium-labeled derivative of olmesartan medoxomil, a selective angiotensin AT1 receptor inhibitor. This compound demonstrates an IC50 of 66.2 μM, indicating its efficacy in modulating blood pressure and cardiovascular responses. Olmesartan medoxomil-d6 is primarily used in pharmacokinetic studies and metabolic research to trace the pharmacological properties and disposition of olmesartan in biological systems. -
Stable Isotope
Sparsentan-d5 is a deuterated form of Sparsentan, a potent dual antagonist of angiotensin II and endothelin A receptors with inhibition constants (Kis) of 0.8 nM and 9.3 nM, respectively. This stable isotope-labeled reagent is suitable for pharmacokinetic studies, enabling precise tracking and quantification in biological systems. Its unique properties make it an invaluable tool in the exploration of receptor biology and the development of therapeutics targeting cardiovascular and renal diseases. -
Stable Isotope
2-Phenylphenol-d5 is a stable isotope-labeled variant of 2-Phenylphenol, featuring five deuterium atoms. This compound is utilized primarily in analytical chemistry and mass spectrometry for tracing and quantifying organic compounds. Its incorporation of deuterium enhances the sensitivity and accuracy of assays in research applications, including environmental monitoring and pharmaceutical studies. -
Stable Isotope
2-Arachidonoylglycerol-d8 is a deuterated analog of 2-Arachidonoylglycerol, a natural endocannabinoid that acts as a ligand for cannabinoid receptors in the central nervous system. This stable isotope is utilized in biochemical and pharmacological research to study cannabinoid signaling and interactions. Its application includes mass spectrometry-based analysis, enabling precise quantification of endocannabinoid levels in biological samples for further investigation of their physiological roles. -
Stable Isotope
2-Arachidonoylglycerol-d5 is a deuterium-labeled analogue of 2-Arachidonoylglycerol, a naturally occurring endogenous cannabinoid in the central nervous system. This stable isotope is instrumental in studying the pharmacokinetics and metabolic pathways of cannabinoid compounds. It is widely used in biochemical research to elucidate the role of cannabinoids in physiological and pathological processes. -
Stable Isotope
Linoleoyl ethanolamide-d4 is a deuterated analog of Linoleoyl ethanolamide, targeting cannabinoid receptors type-1 (CB1) and type-2 (CB2). This compound exhibits weak binding affinity, with inhibition constants (Kis) of 10 μM and 25 μM for CB1 and CB2, respectively. It is utilized in biochemical research to investigate cannabinoid receptor dynamics and efficacy in functional assays. Additionally, Linoleoyl ethanolamide-d4 serves as a useful tool in studies exploring fatty acid ethanolamides and their biological effects. -
Stable Isotope
β-Caryophyllene-d2 is a deuterium-labeled form of β-Caryophyllene, a compound known for its role as a CB2 receptor agonist. This stable isotope serves as a valuable tool in chemical research, enabling the tracing and quantification of β-Caryophyllene in biological systems. Its applications include studying cannabinoid signaling pathways and investigating the therapeutic potential of CB2 receptor modulation. -
Stable Isotope
Eicosapentaenoyl ethanolamide-d4 is a deuterium-labeled analogue of Eicosapentaenoyl ethanolamide, targeting cannabinoid receptors CB1 and CB2. This compound exhibits significant biological activity as a metabolic signal and is involved in modulating lifespan extension related to dietary restriction. Research applications include studies on the effects of Eicosapentaenoyl ethanolamide on lifespan dynamics in wild-type models and TOR pathway mutants, contributing to the understanding of metabolic and signaling pathways in physiology. -
Stable Isotope
Anandamide-d11 is a deuterium-labeled analog of Anandamide, a known immune modulator in the central nervous system. It primarily targets cannabinoid receptors CB1 and CB2, while also engaging other pathways such as GPR18 and GPR55. This stable isotope is valuable for research applications in pharmacology and biochemistry, particularly in studies investigating endocannabinoid signaling and its role in various physiological processes. -
Stable Isotope
Palmitoyl serinol-d5 is a deuterated analog of N-Palmitoyl serinol, a compound that targets and modulates the endocannabinoid system, specifically resembling N-palmitoyl ethanolamine (PEA). This reagent is known for its significant role in enhancing the epidermal permeability barrier in both healthy and inflamed skin models. It is utilized in research applications focused on skin barrier function and the therapeutic potential of endocannabinoid-related compounds in dermatological studies. -
Stable Isotope
AM404-d4 is a deuterium-labeled analog of AM404, which functions as an endocannabinoid reuptake inhibitor. By blocking the transport of anandamide, AM404 exhibits biological activity with an IC50 in the low micromolar range. Additionally, it demonstrates vasodilatory effects in rat isolated hepatic arteries contracted with phenylephrine, with a pEC50 of 7.4, indicating an EC50 of 0.04 μM. This compound is of particular interest in neuroprotection and cannabinoid research applications. -
Stable Isotope
Olivetol-d9 is a deuterium-labeled derivative of Olivetol, a naturally occurring phenol primarily found in lichens and produced by specific insects. It functions as a competitive inhibitor of cannabinoid receptors CB1 and CB2, thus influencing endocannabinoid signaling pathways. Additionally, Olivetol-d9 has inhibitory effects on the cytochrome P450 enzymes CYP2C19 and CYP2D6, making it a valuable tool in pharmacological research and studies related to cannabinoid biology. -
Stable Isotope
2-Arachidonoylglycerol-d11 is a deuterated form of 2-arachidonoylglycerol, a naturally occurring cannabinoid that acts as an endogenous ligand for cannabinoid receptors in the central nervous system. This stable isotope is useful for tracing and quantifying the metabolism of endocannabinoids in various biological studies. Its applications include pharmacokinetic research and studies of cannabinoid signaling pathways. -
Stable Isotope
O-Arachidonoyl glycidol-d5 is a deuterium-labeled analog of O-Arachidonoyl glycidol, serving as a stable isotope for research applications. This compound functions primarily by inhibiting the hydrolysis of 2-oleoylglycerol (2-OG) with an IC50 of 4.5 μM, impacting lipid signaling pathways. Additionally, O-Arachidonoyl glycidol-d5 inhibits anandamide hydrolysis, demonstrating IC50 values of 19 μM and 12 μM, respectively. This reagent is valuable for studies in lipid metabolism and endocannabinoid signaling. -
Stable Isotope
N-Arachidonyldopamine-d8 is a deuterium-labeled derivative of N-Arachidonyldopamine. This stable isotope is utilized in metabolic studies, allowing for precise tracking of molecular interactions and pathways in biological systems. Its key applications include research in neurobiology and pharmacology, particularly in understanding endocannabinoid signaling and dopamine receptor interactions. -
Stable Isotope
DL-Norepinephrine-d6 hydrochloride is a deuterium-labeled form of DL-Norepinephrine hydrochloride, a racemic catecholamine neurotransmitter. This compound comprises equal parts of the biologically active L-isomer and the inactive D-isomer. DL-Norepinephrine-d6 hydrochloride serves as a stable isotope tracer, facilitating research applications related to neurological disorders, including Parkinson’s disease, by enabling the tracking of neurotransmitter dynamics and metabolism in biological systems. -
Stable Isotope
Atenolol-d7 is a deuterium-labeled variant of Atenolol, a cardioselective β1-adrenergic receptor blocker that exhibits a Ki value of 697 nM at the β1-adrenoceptor in guinea pig left ventricle membranes. This stable isotope is instrumental in pharmacokinetic studies and metabolic research related to hypertension and angina pectoris. Its unique properties facilitate the investigation of drug metabolism and disposition in biological systems. -
Stable Isotope
Calcium phosphorylcholine-d9 chloride is a deuterium-labeled derivative of calcium phosphorylcholine chloride, a key phospholipid component found in eukaryotic biofilms. This compound is prevalent in both commensal and pathogenic bacteria that associate with eukaryotic hosts in prokaryotic environments. Additionally, calcium phosphorylcholine chloride displays a diverse array of immunomodulatory properties, making it useful for research in immunology and microbiology. -
Stable Isotope
Metoprolol-d7 hydrochloride is a deuterated form of Metoprolol, a selective β1-adrenoceptor antagonist. This compound exhibits notable anti-inflammatory, antitumor, and anti-angiogenic properties, making it valuable for various biochemical studies. Metoprolol-d7 hydrochloride is instrumental in pharmacokinetic studies and tracer applications due to its stable isotope nature, enabling precise tracking and analysis in metabolic research. -
Stable Isotope
Propranolol-d7 is a stable isotope-labeled form of Propranolol, a nonselective β-adrenergic receptor (βAR) antagonist. It exhibits high affinity for β1AR and β2AR, with inhibition constants (Ki) of 1.8 nM and 0.8 nM, respectively. Propranolol's capability to inhibit [3H]-DHA binding to rat brain membranes, with an IC50 of 12 nM, makes it a valuable tool for researching conditions such as hypertension, myocardial infarction, cardiac arrhythmias, and other cardiovascular disorders. -
Stable Isotope
DL-Norepinephrine-d6 is a deuterium-labeled form of DL-Norepinephrine, a racemic catecholamine neurotransmitter. This compound comprises equal parts of the active L-stereoisomer and the inactive D-stereoisomer. DL-Norepinephrine-d6 serves as a valuable tracer in biochemical studies, including investigations into neurodegenerative diseases such as Parkinson's disease, enabling researchers to study neurotransmitter dynamics and metabolic pathways with enhanced precision. -
Stable Isotope
Propranolol-d7 (ring-d7) is a deuterated analogue of Propranolol hydrochloride, a nonselective β-adrenergic receptor antagonist. It exhibits high affinity for both β1 and β2 adrenergic receptors, with Ki values of 1.8 nM and 0.8 nM, respectively. This compound inhibits [3H]-DHA binding in rat brain membranes with an IC50 of 12 nM, making it a valuable tool for studying cardiovascular conditions such as hypertension, myocardial infarction, and cardiac arrhythmias. Propranolol-d7 (ring-d7) is particularly useful in pharmacokinetic and metabolic studies using mass spectrometry due to its stable isotope labeling. -
Stable Isotope
Medetomidine-13C,d3 hydrochloride is a deuterated derivative of Medetomidine, functioning primarily as a stable isotope. As a potent α2-adrenoceptor agonist with a Ki of 1.08 nM, it exhibits significant sedative and analgesic properties. Its activation of α2-adrenoceptors leads to peripheral vasoconstriction, making it valuable for pharmacological studies aimed at understanding its effects on sedation and pain management in various biological contexts. -
Stable Isotope
Clenbuterol-d9 is a deuterium-labeled derivative of Clenbuterol, a selective β2-adrenergic receptor agonist known for its potent biological activity, with an EC50 of 31.9 nM. This stable isotope serves as a valuable tool for pharmacokinetic studies and metabolic research, enabling precise tracking of drug interactions and bioavailability in various biological systems. Clenbuterol-d9 is instrumental in advancing research on β-adrenergic signaling and its implications in respiratory and metabolic disorders. -
Stable Isotope
Isoxsuprine-d6 hydrochloride is a deuterium-labeled form of Isoxsuprine hydrochloride, a selective beta-adrenergic receptor agonist. It exhibits inhibitory constants (Kis) of 13.65 μM and 3.48 μM for myometrial and placental beta-adrenergic receptors, respectively, and also functions as an NMDA receptor antagonist. This stable isotope variant is valuable for pharmacokinetic studies and metabolic tracing in biological research, facilitating an understanding of drug interactions and mechanisms of action.
