Ticlopidine hydrochloride-d6 is a deuterium-labeled derivative of Ticlopidine hydrochloride, functioning primarily as a stable isotope for research applications. Ticlopidine is recognized as an antithrombotic agent and acts as an allosteric, noncompetitive inhibitor of CD39, demonstrating an IC50 of 81.7 μM. Furthermore, it inhibits various NTPDase isoenzymes, with IC50 values of 170 μM for NTPDase2 and 149 μM for NTPDase3, in addition to its role as an inhibitor of CYP2C19, CYP2C9, and CYP3A4, with IC50s of 26.0 and 32.3 μM, respectively. This reagent is valuable for studies involving purinergic signaling and drug metabolism.
Ticlopidine hydrochloride-d6 is a deuterium-labeled derivative of Ticlopidine hydrochloride, functioning primarily as a stable isotope for research applications. Ticlopidine is recognized as an antithrombotic agent and acts as an allosteric, noncompetitive inhibitor of CD39, demonstrating an IC50 of 81.7 μM. Furthermore, it inhibits various NTPDase isoenzymes, with IC50 values of 170 μM for NTPDase2 and 149 μM for NTPDase3, in addition to its role as an inhibitor of CYP2C19, CYP2C9, and CYP3A4, with IC50s of 26.0 and 32.3 μM, respectively. This reagent is valuable for studies involving purinergic signaling and drug metabolism.
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