Catalog No.
Product Name
Application
Product Information
Citations
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Stable Isotope
4-Phenylbutyric acid-d5 is a deuterium-labeled derivative of 4-Phenylbutyric acid, a known inhibitor of histone deacetylases (HDACs) and a modulator of endoplasmic reticulum (ER) stress. This compound demonstrates significant biological activity in reducing ER stress and has potential applications in cancer research and studies related to infectious diseases. Its stable isotope labeling makes it suitable for advanced biochemical analyses and metabolic tracing in various experimental settings. -
Stable Isotope
Valproic acid-d4-1 is a deuterated form of Valproic acid, which functions as a histone deacetylase (HDAC) inhibitor. It exhibits biological activity by inhibiting HDAC1 and promoting the proteasomal degradation of HDAC2, contributing to its role in cancer research through the activation of Notch1 signaling and inhibition of proliferation in small cell lung cancer cells. This reagent is valuable for studies in neuropharmacology and cancer biology, particularly in assessing the effects of deuterated metabolites on therapeutic outcomes and drug metabolism. -
Stable Isotope
4-Phenylbutyric acid-d2 is the deuterated form of 4-Phenylbutyric acid, a known inhibitor of histone deacetylases (HDAC) and a mitigator of endoplasmic reticulum (ER) stress. This compound is widely utilized in cancer research and studies of infectious diseases due to its ability to modulate cellular stress responses and influence gene expression. The stable isotope labeling allows for advanced analytical techniques in metabolic studies and pathway elucidation. -
Stable Isotope
Valproic acid-d7 sodium is a deuterium-labeled form of valproic acid sodium salt, an established histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. This compound selectively inhibits HDAC1 (IC50 of 400 μM) and promotes the proteasomal degradation of HDAC2. In addition to its role in modulating HDAC activity, Valproic acid-d7 sodium activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly utilized in research related to epilepsy, bipolar disorder, and migraine prevention. -
Stable Isotope
Octanal-d16 is a deuterated form of octanal, functioning as a stable isotope. This fragrant aldehyde exhibits antioxidant and antibacterial properties, with notable antifungal activity against G. citri-aurantii, potentially due to its effect on cell membrane integrity. Furthermore, Octanal demonstrates cytotoxicity in HeLa cells with an IC50 value of 3.5 μg/mL, making it a valuable compound for research in cell biology and pharmacology applications. -
Stable Isotope
5-Hydroxymethylfurfural-13C6 is a stable isotope-labeled compound of 5-Hydroxymethylfurfural, which primarily targets metabolic pathways in yeast. This compound has demonstrated the ability to inhibit yeast growth and fermentation under stress conditions. It is useful for studies in metabolic flux analysis, tracing metabolic pathways, and investigating the effects of stress on fermentation processes in research applications related to food science and biotechnology. -
Stable Isotope
Anandamide-d8 is a deuterated form of the endocannabinoid Anandamide, primarily known for its interaction with cannabinoid receptors CB1 and CB2. This compound modulates various neuronal and immune functions and can also engage additional receptors, including PPARs, TRPV1, and GPR18/GPR55. Anandamide-d8 exhibits potential anti-fungal and anti-inflammatory properties, making it valuable for research applications in fields such as neurodegenerative diseases, including Alzheimer's disease, and inflammatory conditions like ulcerative colitis. -
Stable Isotope
Carbendazim-d4 is a deuterium-labeled derivative of the benzimidazole fungicide Carbendazim, which primarily targets fungal disease mechanisms. This compound exhibits broad-spectrum antifungal activity, making it valuable for research on pathogens such as Septoria, Fusarium, and Sclerotinia. Additionally, Carbendazim demonstrates antitumor properties, supporting cancer research focused on advanced solid tumors and lymphoma. Its stable isotope labeling enhances the study of metabolic pathways and environmental fate analysis in various biological contexts. -
Stable Isotope
Skatole-d8 is a deuterium-labeled analog of Skatole, a compound derived from intestinal bacteria. It primarily targets aryl hydrocarbon receptors, playing a critical role in regulating intestinal epithelial cellular functions via p38 pathway activation. Skatole-d8 is valuable for research applications involving metabolic studies and the investigation of gut microbiota interactions with host intestinal health. -
Stable Isotope
Fluconazole-d4 is a stable isotope-labeled derivative of the triazole antifungal agent Fluconazole. It exhibits potent antifungal activity, particularly against Candida albicans and Candida kefyr, with IC99 values ranging from 0.20 μg/mL to 0.39 μg/mL. Fluconazole-d4 is specifically utilized in pharmacokinetic studies and metabolic pathway analyses, enabling in-depth investigations into the pharmacodynamics and efficacy of antifungal treatments. -
Stable Isotope
Isavuconazole-d4 is a deuterium-labeled derivative of Isavuconazole, a triazole antifungal agent. This stable isotope is utilized in pharmacokinetic studies and metabolic research to evaluate the behavior and kinetics of Isavuconazole in biological systems. Its effectiveness against a range of fungi, including yeasts, molds, and dimorphic fungi, makes it relevant for studies aimed at understanding antifungal action and resistance mechanisms. -
Stable Isotope
Triclosan-d3 is a deuterium-labeled derivative of Triclosan, an antimicrobial agent that exhibits antibacterial and antifungal properties. This stable isotope is utilized in research applications to trace and study the behavior of Triclosan in various environments and biological systems. Its incorporation allows for improved analytical measurements in studies assessing the efficacy and environmental impact of Triclosan in consumer products and medical applications. -
Stable Isotope
(E,E)-Farnesol-d6 is a deuterium-labeled variant of (E,E)-Farnesol, a known quorum-sensing molecule in various Candida species. This compound plays a critical role in inhibiting the growth, metabolism, and biofilm formation of Candida, while also influencing their morphology and invasiveness. (E,E)-Farnesol-d6 is valuable for research applications focused on fungal pathogenesis, quorum sensing mechanisms, and the development of antifungal strategies. -
Stable Isotope
Voriconazole-d3 is a deuterium-labeled derivative of the broad-spectrum triazole antifungal agent, Voriconazole. This compound primarily targets fungal cytochrome P450 enzymes, effectively inhibiting 14-α-lanosterol demethylation and subsequently disrupting ergosterol biosynthesis in fungi. Voriconazole-d3 is invaluable for pharmacokinetic studies and metabolic research relating to Voriconazole’s antifungal properties, providing insights into its biological pathways and enhancing understanding of its therapeutic effects. -
Stable Isotope
Skatole-d3 is a deuterium-labeled variant of Skatole, a compound produced by intestinal bacteria. It plays a critical role in regulating intestinal epithelial cellular functions by activating aryl hydrocarbon receptors and p38 mitogen-activated protein kinases. Skatole-d3 is useful in studies examining gut microbiota interactions and their influence on intestinal health and disease. -
Stable Isotope
Benzoic acid-d5 is a stable isotope-labeled form of benzoic acid, serving as a valuable internal standard in analytical chemistry. This compound is widely used in various applications, including metabolic studies and tracer experiments, enabling the investigation of benzoic acid's metabolic pathways and interactions in biological systems. Its deuterium labeling facilitates precise detection in mass spectrometry and other analytical techniques, enhancing the study of benzoic acid's role in different matrices such as food and beverages. -
Stable Isotope
Pelitinib-d6 is a stable isotope-labeled variant of Pelitinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR). Pelitinib demonstrates potent biological activity with an IC50 of 38.5 nM against EGFR and also exhibits moderate inhibition of Src, MEK/ERK, and ErbB2 with IC50 values of 282, 800, and 1255 nM, respectively. This deuterium-labeled compound is valuable for studies requiring precise tracking of drug metabolism and pharmacokinetics, as well as kinetic and mechanistic investigations in cancer research. -
Stable Isotope
Neratinib-d6 is a deuterium-labeled derivative of Neratinib, an irreversible tyrosine kinase inhibitor primarily targeting HER2 and EGFR. With IC50 values of 59 nM for HER2 and 92 nM for EGFR, it demonstrates significant inhibitory activity. This stable isotope form is valuable in research applications focusing on pharmacokinetics, metabolism studies, and the exploration of therapeutic strategies for cancers associated with HER2 and EGFR overexpression. -
Stable Isotope
Erlotinib-d4 is a deuterium-labeled analog of Erlotinib, a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 2 nM for human EGFR. This compound effectively reduces EGFR autophosphorylation in intact tumor cells with an IC50 of 20 nM and is utilized in the treatment of non-small cell lung cancer. Additionally, Erlotinib-d4 serves as a valuable click chemistry reagent, featuring an alkyne group for performing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules, facilitating various biochemical applications. -
Stable Isotope
N-Methyl-dosimertinib-d5 is a deuterium-labeled analog of N-Methyl-dosimertinib, designed for use as a stable isotope in biochemical research. This compound allows for accurate tracing and quantification in various biological studies, including pharmacokinetics and metabolic profiling. Its unique isotopic labeling facilitates advanced analytical techniques, making it invaluable for researchers exploring drug interactions and mechanisms of action. -
Stable Isotope
N-Desmethyl dosimertinib-d5 is a deuterated stable isotope of N-Desmethyl dosimertinib. This compound serves as a valuable tracer in pharmacokinetic studies, enabling researchers to track the metabolism and distribution of dosimertinib derivatives. Its unique isotopic labeling enhances the understanding of drug interactions and mechanisms of action in biological systems, making it a crucial tool for drug development and therapeutic research. -
Stable Isotope
Erlotinib-13C6 hydrochloride is a stable isotope-labeled derivative of Erlotinib hydrochloride, targeting the epidermal growth factor receptor (EGFR) kinase with an IC50 of 2 nM. This compound serves as a valuable tool in click chemistry applications due to its alkyne group, enabling efficient copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its isotopic labeling facilitates quantitative analysis in metabolic studies and drug metabolism research. -
Stable Isotope
Gefitinib-d6 is the deuterated form of Gefitinib, a highly selective and orally bioavailable inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase, with an IC50 of 33 nM. This compound effectively inhibits EGF-mediated tumor cell proliferation (IC50 of 54 nM) and prevents EGFR autophosphorylation in cancer cells. Additionally, Gefitinib can induce autophagy, further contributing to its antitumoral effects. Gefitinib-d6 is valuable for studies involving metabolic labeling and pharmacokinetics in cancer research. -
Stable Isotope
Osimertinib-13C,d3 is a stable isotope-labeled derivative of Osimertinib, a covalent, orally active, irreversible inhibitor of mutant-selective EGFR. This compound exhibits an apparent IC50 value of 12 nM against the L858R mutation and 1 nM against the L858R/T790M mutation. Osimertinib-13C,d3 is essential for analytical studies, including pharmacokinetics and metabolic profiling, enabling researchers to investigate the drug's biological activity and mechanism of action in various cancer research applications. -
Stable Isotope
AZ-5104-d2 is a deuterium-labeled derivative of AZ-5104, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR). It demonstrates potent inhibitory activity with IC50 values of 1 nM for EGFRL858R/T790M, 6 nM for EGFRL858R, 1 nM for EGFRL861Q, 25 nM for EGFR, and 7 nM for ErbB4. This stable isotope variant is valuable for applications in pharmacokinetics and metabolic studies, providing insights into EGFR-mediated signaling pathways and therapeutic interventions. -
Stable Isotope
Gefitinib-d3 is a deuterium-labeled derivative of Gefitinib, acting as a selective inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. It exhibits robust antitumor activity by inhibiting EGF-stimulated growth in tumor cells with an IC50 of 54 nM and effectively blocking EGF-induced EGFR autophosphorylation. This stable isotope variant is particularly valuable for research applications involving drug metabolism and pharmacokinetics, as well as studying the mechanisms of autophagy associated with EGFR signaling. -
Stable Isotope
Gefitinib-d8 is a deuterium-labeled analogue of Gefitinib, a potent inhibitor of the epidermal growth factor receptor (EGFR) tyrosine kinase. With an IC50 ranging from 2 to 37 nM in NR6wtEGFR cells, this stable isotope serves as a valuable tool in quantitative analysis and metabolic studies. It is particularly useful for research applications involving drug metabolism and pharmacokinetics, enabling detailed investigations of EGFR-targeted therapies. -
Stable Isotope
Afatinib-d6 is a deuterium-labeled derivative of Afatinib, an irreversible inhibitor of the epidermal growth factor receptor (EGFR) family. This stable isotope variant is utilized primarily in pharmacokinetic studies to trace the metabolic pathways of Afatinib and assess drug distribution and elimination in various biological systems. It offers valuable insights for researchers in oncology and drug development, enhancing the understanding of EGFR-targeted therapies. -
Stable Isotope
Benzamide-d5 is a deuterium-labeled derivative of Benzamide, serving as a stable isotope for use in chemical research. This compound acts as a potent inhibitor of poly(ADP-ribose) polymerase (PARP), demonstrating protective effects against neurotoxicity induced by glutamate and methamphetamine in vitro. Benzamide-d5 is valuable for studies assessing neuroprotective mechanisms and the modulation of dopamine metabolism in models of neurodegeneration and substance abuse. Its unique isotopic labeling allows for precise tracking and quantification in metabolic studies. -
Stable Isotope
Benzamide-15N is a stable isotope-labeled variant of Benzamide, featuring a nitrogen-15 (15N) isotope. This compound functions as a poly(ADP-ribose) polymerase (PARP) inhibitor, which is crucial in the study of DNA repair mechanisms. Benzamide-15N is applicable in research involving cellular processes impacted by PARP activity, aiding in the understanding of therapeutic approaches for cancer and other diseases related to DNA damage response. -
Stable Isotope
Olaparib-d4-1 is a deuterium-labeled derivative of Olaparib, a potent and orally active inhibitor of poly(ADP-ribose) polymerase (PARP). It exhibits IC50 values of 5 nM and 1 nM for PARP1 and PARP2, respectively, effectively inducing cellular responses associated with DNA repair inhibition. This stable isotope compound is valuable for research applications in cancer therapeutics, particularly in studies involving PARP-mediated pathways and autophagy activation. -
Stable Isotope
Nudifloramide-d6 is a deuterium-labeled analog of Nudifloramide, functioning as a stable isotope. This reagent is primarily utilized in quantitative mass spectrometry applications to study drug metabolism and pharmacokinetics. Its incorporation into research enables detailed investigations of biological pathways and the effects of Nudifloramide in various therapeutic contexts. -
Stable Isotope
Olaparib-d5 is a deuterated version of Olaparib, a potent and orally active inhibitor of the poly (ADP-ribose) polymerases PARP1 and PARP2, exhibiting IC50 values of 5 nM and 1 nM, respectively. This stable isotope is valuable for pharmacokinetic and metabolic studies, enabling precise tracking of Olaparib metabolism in biological systems. Additionally, Olaparib has been shown to activate autophagy and mitophagy, thereby contributing to its therapeutic efficacy in cancer research. -
Stable Isotope
Nudifloramide-d3 is a deuterium-labeled derivative of Nudifloramide, which is a significant end product of nicotinamide-adenine dinucleotide (NAD) degradation. This compound demonstrates potent inhibitory activity against poly(ADP-ribose) polymerase (PARP-1) in vitro, making it a valuable tool for studying PARP-1 mediated pathways. Its use in research applications includes investigating cellular responses to DNA damage and elucidating mechanisms of cellular stress response. -
Stable Isotope
Acetaminophen-13C6 is a stable isotope-labeled derivative of acetaminophen, primarily utilized for metabolic studies and tracing experiments. This compound functions as a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 25.8 μM, demonstrating significant antipyretic and analgesic properties. Additionally, it acts as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2), making it valuable for pharmacokinetic research and understanding drug metabolism. -
Stable Isotope
Acetaminophen-d4 is a stable isotope-labeled variant of Acetaminophen, functioning primarily as a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 value of 25.8 μM. This compound is commonly utilized in research for its antipyretic and analgesic properties, as well as its role as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). Its deuterium labeling enhances its utility in metabolic studies and pharmacokinetic investigations. -
Stable Isotope
Acetaminophen-d7 is a deuterium-labeled form of acetaminophen, functioning primarily as a selective inhibitor of cyclooxygenase-2 (COX-2), with an IC50 of 25.8 μM. This stable isotope variant is utilized in pharmacokinetic studies to trace the metabolic pathways of acetaminophen while minimizing interference from natural acetaminophen. Its applications include investigations into analgesic and antipyretic effects, as well as studies on hepatic N-acetyltransferase 2 (NAT2) inhibition. -
Stable Isotope
Acetaminophen-d3 is the deuterium-labeled form of Acetaminophen, a selective inhibitor of cyclooxygenase-2 (COX-2) with an IC50 of 25.8 μM. It exhibits significant antipyretic and analgesic properties, making it a widely utilized therapeutic agent. Additionally, Acetaminophen has been shown to act as a potent inhibitor of hepatic N-acetyltransferase 2 (NAT2). This stable isotope is valuable for research applications involving drug metabolism, pharmacokinetics, and the study of COX-2-related pathways. -
Stable Isotope
Acetaminophen-13C2,15N is a stable isotope-labeled version of Acetaminophen, featuring both 13C and 15N isotopes. As a selective cyclooxygenase-2 (COX-2) inhibitor with an IC50 of 25.8 μM, it serves as an effective antipyretic and analgesic. In addition, Acetaminophen exhibits strong inhibitory action on hepatic N-acetyltransferase 2 (NAT2), making it valuable for biochemical and pharmacological research applications. -
Stable Isotope
α-Hydroxyglutaric acid-13C5 disodium is a stable isotope-labeled form of α-Hydroxyglutaric acid, an α-hydroxy acid derived from glutaric acid. This compound acts as a competitive inhibitor of various α-ketoglutarate-dependent dioxygenases, including histone demethylases and the TET family of 5-methylcytosine hydroxylases. It is useful in research applications involving epigenetics, metabolism studies, and cellular response to metabolic changes. -
Stable Isotope
Phenelzine-d5 sulfate is a deuterium-labeled derivative of the antidepressant phenelzine sulfate, functioning primarily as an irreversible inhibitor of monoamine oxidase (MAO-A and MAO-B). It exhibits significant biological activities, including the inhibition of GABA transaminase and primary amine oxidase, and plays a role in sequestering reactive aldehydes. This compound is utilized in research related to neurological and metabolic disorders, as well as in cancer studies, particularly for conditions such as depression, anxiety, stroke, and neurodegenerative diseases. -
Stable Isotope
Belinostat-d5 is a deuterium-labeled derivative of Belinostat, a potent histone deacetylase (HDAC) inhibitor. With an IC50 of 27 nM in HeLa cell extracts, it effectively modulates gene expression through the inhibition of HDAC activity. This stable isotope-labeled compound is valuable for quantitative studies in chemical biology and drug development, allowing for precise tracking and analysis of Belinostat metabolism and pharmacokinetics in various biological systems. -
Stable Isotope
Valproic acid-d15 is a deuterium-labeled variant of Valproic acid, a known histone deacetylase (HDAC) inhibitor with an IC50 ranging from 0.5 to 2 mM. It specifically inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d15 activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. This stable isotope is valuable for pharmacokinetic studies, allowing researchers to trace the metabolic pathways and biological effects of Valproic acid in various therapeutic contexts. -
Stable Isotope
4-Phenylbutyric acid-d11 is the deuterated form of 4-Phenylbutyric acid, a known inhibitor of histone deacetylases (HDAC) and a modulator of endoplasmic reticulum (ER) stress. This compound exhibits significant biological activity in cancer therapy and infection studies, facilitating research on cellular stress responses and epigenetic regulation. Its stable isotope labeling enables advanced metabolic studies and applications in the fields of biochemistry and pharmacology. -
Stable Isotope
Valproic acid-d6 is a deuterium-labeled derivative of Valproic acid, primarily recognized for its role as a histone deacetylase (HDAC) inhibitor, exhibiting an IC50 range of 0.5 to 2 mM. It selectively inhibits HDAC1 (IC50, 400 μM) and promotes the proteasomal degradation of HDAC2. Valproic acid-d6 has demonstrated the ability to activate Notch1 signaling while inhibiting cell proliferation in small cell lung cancer (SCLC) models. This stable isotope is beneficial for studies requiring precise quantification in metabolic and pharmacokinetic research related to neurological disorders and cancer therapeutics. -
Stable Isotope
Valproic acid-d4 is a deuterium-labeled form of Valproic acid, a potent histone deacetylase (HDAC) inhibitor with an IC50 range of 0.5 to 2 mM. This compound specifically inhibits HDAC1 (IC50, 400 μM) and prompts proteasomal degradation of HDAC2. Valproic acid also activates Notch1 signaling and demonstrates antiproliferative effects in small cell lung cancer (SCLC) cells. It is commonly employed in research pertaining to neurological disorders, including epilepsy and bipolar disorder, as well as in studies investigating its potential for migraine prevention. -
Stable Isotopes
Tasquinimod-d3 is a deuterated form of Tasquinimod, an oral antiangiogenic agent targeting castration-resistant prostate cancer. This compound selectively binds to the regulatory Zn2+ binding domain of HDAC4 with a Kd of 10-30 nM, thereby influencing histone deacetylation processes. Additionally, Tasquinimod-d3 acts as an inhibitor of S100A9, highlighting its potential for diverse applications in cancer research and therapeutic development. -
Stable Isotope
Deferasirox-d4 is a deuterium-labeled form of Deferasirox, an oral iron chelator that targets excess iron accumulation in patients with transfusion-related iron overload. This stable isotope compound allows for precise tracing and quantification in biological studies, facilitating research on metabolic pathways and iron homeostasis. Deferasirox-d4 is essential for studies related to iron dysregulation and its associated pathologies. -
Stable Isotope
PRMT5-MTA-IN-3-d3 is a deuterated form of the PRMT5-MTA inhibitor, designed for stable isotope applications. This compound exhibits notable antiproliferative activity against colorectal cancer cell lines, specifically showing IC50 values of 6 nM in MTAP-deficient HTC116-MTAP del cells and 961 nM in wild-type HCT-116 cells. PRMT5-MTA-IN-3-d3 is particularly relevant for research on cancers involving MTAP deficiency, including non-small cell lung cancer (NSCLC) and pancreatic cancer. -
Stable Isotope
Acedapsone-d8 is a deuterium-labeled derivative of Acedapsone, designed for use as a stable isotope in research applications. Acedapsone exhibits significant antimalarial and antimicrobial properties and is primarily employed as a long-acting inhibitor for leprosy treatment. This labeled compound is suitable for pharmacokinetic studies and metabolic investigations, offering a valuable tool for researchers studying the pharmacology and therapeutic potential of Acedapsone.
