Itraconazole-d9 is a deuterium-labeled derivative of itraconazole, a triazole antifungal agent known for its function as a potent inhibitor of the Hedgehog (Hh) signaling pathway, with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, disrupting the conversion of lanosterol to ergosterol. Itraconazole-d9 exhibits notable anticancer and antiangiogenic properties, making it suitable for research in cancer biology and related therapeutic applications. Additionally, it serves as an oxysterol-binding protein (OSBP) inhibitor, highlighting its versatility in biochemical research.
Itraconazole-d9 is a deuterium-labeled derivative of itraconazole, a triazole antifungal agent known for its function as a potent inhibitor of the Hedgehog (Hh) signaling pathway, with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, disrupting the conversion of lanosterol to ergosterol. Itraconazole-d9 exhibits notable anticancer and antiangiogenic properties, making it suitable for research in cancer biology and related therapeutic applications. Additionally, it serves as an oxysterol-binding protein (OSBP) inhibitor, highlighting its versatility in biochemical research.
This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:
