Itraconazole-d5 is a deuterium-labeled form of Itraconazole, a triazole antifungal agent that functions primarily as a Hedgehog (Hh) signaling pathway antagonist with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, blocking the conversion of lanosterol to ergosterol. Itraconazole-d5 is utilized in research applications investigating antifungal mechanisms, anticancer effects, and antiangiogenic properties.
Itraconazole-d5 is a deuterium-labeled form of Itraconazole, a triazole antifungal agent that functions primarily as a Hedgehog (Hh) signaling pathway antagonist with an IC50 of approximately 800 nM. This compound effectively inhibits lanosterol 14α-demethylase, a cytochrome P450 enzyme, blocking the conversion of lanosterol to ergosterol. Itraconazole-d5 is utilized in research applications investigating antifungal mechanisms, anticancer effects, and antiangiogenic properties.
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