LacCer (d18:1/16:0)-d3 is a deuterium-labeled form of LacCer (d18:1/16:0), a bioactive sphingolipid involved in forming membrane microdomains with Lyn kinase and αi subunits of inhibitory G protein-coupled receptors (GPCRs). This compound is particularly relevant in studies of metabolic disorders, as elevated levels are found in the plasma of insulin-resistant cattle, and it is upregulated in models of Niemann-Pick type C1 disease, a neurodegenerative lysosomal storage disorder. LacCer (d18:1/16:0)-d3 serves as a valuable tool for elucidating the role of sphingolipids in various biological processes and disease pathways.
LacCer (d18:1/16:0)-d3 is a deuterium-labeled form of LacCer (d18:1/16:0), a bioactive sphingolipid involved in forming membrane microdomains with Lyn kinase and αi subunits of inhibitory G protein-coupled receptors (GPCRs). This compound is particularly relevant in studies of metabolic disorders, as elevated levels are found in the plasma of insulin-resistant cattle, and it is upregulated in models of Niemann-Pick type C1 disease, a neurodegenerative lysosomal storage disorder. LacCer (d18:1/16:0)-d3 serves as a valuable tool for elucidating the role of sphingolipids in various biological processes and disease pathways.
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