Asundexian-d3 is a deuterium-labeled derivative of Asundexian, an orally active inhibitor of coagulation factor XIa (FXIa). It binds directly and reversibly to the active site of FXIa, effectively inhibiting its activity with an IC50 of 1 nM in human assays. This reagent is valuable for studies aimed at understanding blood coagulation mechanisms and evaluating FXIa's role in thrombosis and related disorders.
Asundexian-d3 is a deuterium-labeled derivative of Asundexian, an orally active inhibitor of coagulation factor XIa (FXIa). It binds directly and reversibly to the active site of FXIa, effectively inhibiting its activity with an IC50 of 1 nM in human assays. This reagent is valuable for studies aimed at understanding blood coagulation mechanisms and evaluating FXIa's role in thrombosis and related disorders.
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