Catalog No.
Product Name
Application
Product Information
Citations
-
DENV Inhibitor
DENV-IN-10 is a potent tetravalent inhibitor targeting dengue virus (DENV). It demonstrates effective suppression of DENV replication with EC50 values of 1.36, 0.87, 0.94, and 0.95 μM against DENV serotypes 1-4, respectively. This compound functions as a post-entry replication inhibitor, exhibiting specificity for primate-derived cells, making it a valuable tool for research into dengue virus biology and therapeutic intervention. -
DENV Inhibitor
SDM25N is a Dengue virus (DENV) inhibitor that targets the NS4B protein, effectively disrupting genomic RNA replication. With an EC50 of 1.9 µM, SDM25N demonstrates cell type-specific inhibition of DENV. This compound is valuable for research into DENV infection and the mechanisms of viral replication. -
Polypeptide
2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a polypeptide substrate designed for the Dengue NS2B-NS3 protease. This substrate facilitates the understanding of protease activity by serving as a valuable tool in the development of selective inhibitors targeting the Dengue NS2B-NS3 protease. Its efficacy in research applications enhances the study of dengue virus pathogenesis and potential therapeutic strategies. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
NS4B Inhibitor
JMX0254 is a potent inhibitor of the dengue virus NS4B protein, exhibiting oral bioavailability. It displays effective antiviral activity with EC50 values of 0.78 µM, 0.16 µM, and 0.035 µM against DENV-1, DENV-2, and DENV-3, respectively. This compound is valuable for research applications focused on understanding and combating dengue virus infections. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
DENV MTase Inhibitor
CNP0296775 is a potent inhibitor of dengue virus methyltransferase (DENV MTase), targeting key enzymatic processes involved in viral replication. By disrupting the activity of this enzyme, CNP0296775 shows promise in studying dengue virus pathogenesis and could serve as a valuable tool in antiviral research. Its application in preclinical studies may aid in the development of novel therapeutic strategies for dengue virus infections. -
NS2B-NS3 Inhibitor
NS2B/NS3-IN-9 is a non-competitive inhibitor targeting the NS2B-NS3 protease of Orthoflavivirus, demonstrating broad-spectrum antiviral activity. It exhibits IC50 values of 2.4 μM, 7.2 μM, and 1.9 μM against the Dengue virus DENV2, West Nile virus WNV, and Zika virus ZIKV, respectively. Additionally, NS2B/NS3-IN-9 shows cellular EC50 values of 4.1 μM for DENV2, 4.9 μM for WNV, and 5.0 μM for ZIKV, while exhibiting minimal toxicity to host cells. This compound is suitable for research applications focused on inhibiting Orthoflavivirus infections. -
NS2B·NS3 Protease Inhibitor
CN-716 dihydrochloride is a reversible covalent inhibitor targeting the NS2B·NS3 protease of flaviviruses, demonstrating significant antiviral activity. This compound effectively impedes the replication of dengue virus (DENV2), West Nile virus (WNV), and Zika virus (ZIKV), with IC50 values of 0.066 μM, 0.11 μM, and 0.25 μM, respectively. Additionally, CN-716 dihydrochloride exhibits Ki values of 0.051 μM, 0.082 μM, and 0.04 μM against the same proteases. It serves as a valuable tool for investigating the infection mechanisms associated with dengue fever, West Nile fever, and Zika virus infection. -
NS2B-NS3 Inhibitor
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate designed to probe the NS2B-NS3 cleavage site. This reagent includes a readily hydrolyzable para-nitroanilide at the P1’ position, enhancing its reactivity. It is primarily used in studies of dengue virus type 2 and other flavivirus infections, facilitating the exploration of viral protease activity and potential therapeutic interventions. -
AAK1 Inhibitor
AAK1-IN-6 is a potent inhibitor of AP-2-associated protein kinase 1 (AAK1) with an IC50 value of 12 nM. This compound exhibits significant antiviral activity against dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 is a valuable tool for researchers investigating antiviral mechanisms and potential therapeutic strategies. -
NS2B-NS3/thrombin Inhibitor
5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione is a potent inhibitor of the dengue virus NS2B-NS3 protease and thrombin. This compound is valuable for studying the mechanisms of viral replication and coagulation processes, making it an essential tool in research focused on infectious diseases and related therapeutic interventions. Its dual activity highlights its potential for investigating the dynamics of viral pathology and thrombotic complications. -
Purine Analogue
ZX-2401 is a 1,3,5-Triazine-based analogue of purine that exhibits significant antiviral activity against viruses in the Flaviviridae family, including West Nile Virus (WNV), Hepatitis C (HCV), Yellow Fever Virus (YFV), Dengue Virus (DV), Bovine Viral Diarrhea Virus (BVDV), and Banzi Virus (BV), with effective concentrations (EC90s) ranging from 0.6 to 10 μg/mL. This compound effectively reduces viral production, demonstrating an EC90 of 3.3 mg/mL. ZX-2401 is suitable for research applications focused on influenza infections and related viral pathogenesis. -
HIV Protease Inhibitor
2α,19α-Dihydroxy-3-oxo-urs-12-en-28-oic acid is identified as a potent inhibitor of HIV protease, exhibiting significant antiviral activity. Additionally, this compound inhibits the activation of Epstein-Barr virus early antigen (EBV-EA), demonstrating its utility in virology research. Furthermore, it displays inhibitory effects on nitric oxide production in lipopolysaccharide-activated RAW 264.7 cells, highlighting its potential applications in immunology and inflammation studies. -
EV71 Inhibitor
Gylongiposide I is a selective inhibitor targeting enterovirus EV71, demonstrating an EC50 of 1.53 μM. It exerts antiviral activity by decreasing the expression of viral protein VP1 and reducing levels of viral genomic RNA. This compound is valuable for research and development of therapeutic agents aimed at combating hand, foot, and mouth disease associated with EV71. -
Antirhinovirus Compound
MDL-20610 is a potent antirhinovirus compound that exhibits a median plaque 50% inhibitory concentration (IC50) of 0.003 µg/mL. This compound also demonstrates antiviral activity against human, simian, and bovine rotaviruses, along with variable effectiveness against enteroviruses and paramyxoviruses. MDL-20610 is valuable for antiviral research applications, particularly in the study of viral infections and therapeutic interventions. -
Enteroviral Capsid Binder
Vapendavir diphosphate is a potent enteroviral capsid binder that exhibits significant antiviral activity against enterovirus 71 (EV71). With effective concentrations (EC50) ranging from 0.5 to 1.4 μM across various EV71 strains, it serves as a valuable tool for research focused on enteroviral pathogenesis and therapeutic development. Its ability to inhibit viral replication makes it a critical reagent for studying enteroviral infections and potential antiviral strategies. -
Enterovirus 71 Inhibitor
Norwogonin is an antiviral compound isolated from Scutellaria baicalensis Georgi that specifically targets Enterovirus 71 (EV71). It demonstrates a potent inhibitory effect, with an IC50 value of 31.83 μg/ml, making it a valuable tool for research in viral infection mechanisms and potential therapeutic strategies against EV71. This compound can contribute to studies focused on antiviral drug development and the exploration of natural product-derived therapeutics. -
EV71 Inhibitor
DMA-135 hydrochloride is a specific inhibitor of enterovirus 71 (EV71) that targets the IRES-dependent translation and replication pathways. It binds to the EV71 SLII domain with a moderately high affinity (KD = 520 nM), effectively suppressing viral activity. This compound exhibits minimal toxicity in cell-based studies, making it an important tool for research in virology and potential therapeutic applications against EV71 infections. -
Anti-virus Agent
2-Hydroxytetradecanoic acid is a hydroxy fatty acid that functions as an antiviral agent by inhibiting the cleavage between enterovirus capsid proteins VP4 and VP2. This compound exhibits significant antiviral activity, making it a valuable tool for research applications focused on viral infection mechanisms and the development of antiviral therapies. -
Antiviral Agent
Enviroxime (LY122772) is an antiviral agent that disrupts the replication of rhinoviruses and enteroviruses. By targeting the viral 3A coding region, Enviroxime effectively inhibits the synthesis of plus-strand viral RNA. This compound serves as a valuable tool for researchers studying the functional role of the 3A protein in viral pathogenesis and replication processes. -
Biochemical Assay Reagent
N-Phenylbenzamide is a biochemical assay reagent that functions primarily as a compound skeleton for various research applications. It demonstrates significant biological activity in studies related to cancer and infectious diseases, including enterovirus and cervical cancer. This compound is essential for exploring the underlying mechanisms of these conditions and developing potential therapeutic strategies. -
Antipicornavirus Agent
WIN 54954 functions as an orally active, broad-spectrum antipicornavirus agent, targeting various strains of picornaviruses. It demonstrates significant efficacy against human rhinovirus, echovirus 9, and enterovirus infections. This compound is valuable for research on viral pathogenesis and the development of therapeutic strategies against picornavirus-related diseases. -
Monoamine Oxidase Inhibitor
Pirlindole is a selective and reversible inhibitor of monoamine oxidase A (MAO-A). This compound exhibits significant antiviral activity against enterovirus-D68 and coxsackievirus B3 (CV-B3). Pirlindole is primarily utilized in research focusing on the modulation of monoamine levels and the investigation of viral pathologies. -
Glucosidase Inhibitor
Ganoderic acid Y is an α-glucosidase inhibitor, exhibiting an IC50 of 170 μM against yeast α-glucosidase. This compound demonstrates antiviral properties by inhibiting the replication of enterovirus 71 (EV71) through the disruption of the virus uncoating process. Ganoderic acid Y is relevant for research applications investigating glycosidase activity and antiviral strategies. -
EV71 3C Protease Inhibitor
DC07090 dihydrochloride is a potent, reversible, and competitive inhibitor of the human enterovirus 71 (EV71) 3C protease. It exhibits low toxicity with an IC50 of 21.72 μM and a Ki value of 23.29 μM. Additionally, DC07090 dihydrochloride effectively inhibits coxsackievirus A16 (CVA16) replication, with an EC50 of 27.76 μM. This compound is valuable for research into enteroviral infections and potential therapeutic interventions against these viruses. -
Stable Isotope
Vapendavir-d5 is a deuterium-labeled derivative of Vapendavir, a potent enteroviral capsid binder. This stable isotope is utilized in research to study the mechanisms of action against enterovirus 71 (EV71), exhibiting significant antiviral activity with EC50 values ranging from 0.5 to 1.4 μM across various EV71 strains. Vapendavir-d5 serves as a valuable tool in understanding enteroviral infections and developing therapeutic strategies. -
EV71 Inhibitor
Methyl 3,4-dihydroxyphenylacetate is a potent inhibitor of enterovirus 71 (EV71) replication. This compound effectively reduces viral replication in rhabdomyosarcoma (RD) cells, highlighting its potential as an antiviral agent. Its biological activity makes it valuable for research into therapeutic strategies against EV71 and other enteroviral infections. -
Antiviral Agent
Antiviral Agent 24 is a potent antiviral compound that primarily targets viral replication pathways. Exhibiting EC50 values of 0.101 µM for Enterovirus 71 (EV71), 19.9 µM for Coxsackievirus A21 (CVA21), and 91.2 µM for Enterovirus 68 (EV68), this reagent demonstrates significant antiviral activity. Additionally, Antiviral Agent 24 inhibits the enzymatic activity of METTL3/METTL14 in a dose-dependent manner, showcasing its potential utility in antiviral research applications. -
Polioviruses Inhibitor
Disoxaril is a potent inhibitor of polioviruses, effectively impeding the replication of types 1 and 2 within host cells. It operates by binding to virion capsid proteins, facilitating viral uncoating stabilization, while still permitting virus entry through receptor-mediated endocytosis. Additionally, Disoxaril demonstrates inhibitory activity against enterovirus replication, making it a valuable reagent for virology research and studies on enterovirus-related diseases. -
Antienterovirus Agent
AN-12-H5 is an antienterovirus agent that specifically targets the replication processes of poliovirus (PV) and enterovirus 71 (EV71). This compound exhibits significant antiviral activity, making it a valuable tool for research into enteroviral infections and their mechanisms. Its ability to inhibit viral replication positions AN-12-H5 as a promising candidate for studies aimed at developing therapeutic strategies against enterovirus-related diseases. -
Antiviral Drug
BTA-188 is a pyridazinyl oxime ether that functions as a potent antiviral agent, specifically targeting rhinoviruses and enterovirus 71. It demonstrates remarkable efficacy with an IC50 of 0.8 nM and IC90 of 11 nM against HRV-2, while effectively inhibiting enterovirus replication with an IC50 of 82 nM and an IC90 of 109 nM. BTA-188 holds potential as a chemotherapeutic candidate for treating infections associated with the Picornaviridae family of viruses. -
Enterovirus Inhibitor
Antiviral agent 23 is a potent inhibitor of enterovirus 71 (EV71) with an EC50 value of 94 nM. It effectively suppresses the activity of the methyltransferase complex METTL3/METTL14, demonstrating significant antiviral activity. This compound is suitable for research focused on enteroviral infections and the mechanisms of RNA modification in viral pathogenesis. -
HIV/EV-A71 Inhibitor
AL-470 is a potent antiviral compound targeting HIV-1, HIV-2, and EV-A71, exhibiting EC50 values of 0.27 µM, 0.63 µM, and 0.35 µM, respectively. This compound demonstrates significant inhibition of viral replication and is suitable for studies focused on HIV and enterovirus A71 infections. AL-470 serves as a valuable tool for researchers investigating antiviral mechanisms and therapeutic strategies against these viral pathogens. -
Stable Isotope
Pleconaril-d4 is a deuterated analog of Pleconaril, designed as a stable isotope for advanced chemical research. This labeled compound serves as a valuable tool for tracing and quantifying Pleconaril-related metabolic pathways and interactions. Its use in studies involving viral infections, particularly enteroviruses, enhances understanding of drug efficacy and pharmacokinetics in biological systems. -
Antiviral Agent
JX040 is an antiviral agent that demonstrates significant activity against non-polio enteroviruses, while exhibiting weaker efficacy against polioviruses. This compound is valuable for research applications focusing on enteroviral infections, potentially aiding in the development of therapeutic interventions for these viral diseases. -
Enterovirus Antiviral Agent
Viral 2C Protein Inhibitor 1 is a potent enterovirus antiviral agent that targets the viral 2C protein, effectively inhibiting various strains, including EV-D68, EV-A71, and CVB3. With EC50 values ranging from 0.1 to 3.6 µM, this compound demonstrates a high selectivity index and low cytotoxicity, making it a valuable tool for research into enterovirus-related diseases and potential therapeutic applications. -
Enteroviru Inhibitor
R78206 is an antiviral pyridazinamine compound that targets enteroviruses by providing protection against thermal inactivation. This compound exhibits varied effects on different strains of poliovirus depending on concentration and demonstrates a potent stabilizing effect on Mahoney procapsids. R78206 is valuable for research applications focused on enteroviral pathogenesis and potential therapeutic interventions. -
EV71 3C Protease Inhibitor
DC07090 is a potent, reversible, and competitive inhibitor of the human enterovirus 71 (EV71) 3C protease, with an IC50 of 21.72 μM and a Ki value of 23.29 μM. This compound also demonstrates inhibitory activity against coxsackievirus A16 (CVA16) replication, exhibiting an EC50 value of 27.76 μM. DC07090 is valuable for research applications focused on the development of antiviral strategies targeting enteroviruses. -
Golgicide A Racemate
(Rac)-Golgicide A is a racemic mixture of the potent and selective inhibitor Golgicide A, targeting the cis-Golgi ADP-ribosylation factor guanine nucleotide exchange factor GBF1. This compound exhibits significant inhibitory activity against coxsackievirus B3 and other enteroviruses, making it a valuable tool for studying viral replication mechanisms. Its reversible nature allows for detailed exploration of cellular processes associated with Golgi function and virus-host interactions in research applications. -
EV-A71 Inhibitor
EV-A71-IN-1 is an inhibitor targeting the human enterovirus A71 (EV-A71) capsid protein, exhibiting an EC50 of 0.27 μM. This compound functions as a capsid binder, effectively interfering with the interaction between the viral VP1 protein and the host receptor hSCARB2. Additionally, EV-A71-IN-1 demonstrates broad inhibitory activity against various human enteroviruses while maintaining low cytotoxicity (CC50 > 56.2 μM), making it a valuable tool for research on enteroviral infections and potential therapeutic interventions. -
MAO-A Inhibitor
Pirlindole mesylate is a selective and reversible inhibitor of monoamine oxidase A (MAO-A), playing a crucial role in the modulation of neurotransmitter metabolism. Additionally, Pirlindole exhibits antiviral activity against enterovirus D68 and coxsackievirus B3 (CV-B3), positioning it as a potential agent in virology research. This compound is valuable for studies focusing on depression, anxiety disorders, and the therapeutic mechanisms of neuronal regulation and viral infections. -
Anti-EV71 Agent
Antiviral Agent 21 exhibits potent activity against Enterovirus 71 (EV71), targeting viral replication mechanisms. This compound effectively inhibits the proliferation of EV71, making it a valuable tool for research into antiviral therapies and the mechanism of viral infection. Its application is particularly relevant for studies focusing on neurotropic viruses and associated diseases, facilitating the development of therapeutic interventions. -
Antiviral Agent
Antiviral Agent 64 is a diarylheptanoid derived from Alpinia officinarum, primarily targeting viral pathogens. This compound demonstrates notable cytotoxicity in human neuroblastoma cells (IMR-32) with an IC50 value of 0.23 μM. Additionally, Antiviral Agent 64 exhibits significant antiviral activity against respiratory syncytial virus (RSV), poliovirus, measles virus, herpes simplex virus type 1 (HSV-1), and influenza virus H1N1, with EC50 values of 13.3, 3.7, 6.3, 5.7, and <10 μg/mL, respectively. This makes it a valuable tool for research in virology and therapeutic development. -
ROC/EV-A71 Inhibitor
Fukinolic acid serves as a receptor-operated Ca2+ channel (ROC) inhibitor, effectively suppressing extracellular Ca2+ influx activated by norepinephrine while preserving the function of voltage-dependent Ca2+ channels. This compound demonstrates notable antiviral activity against enterovirus A71 (EV-A71) replication, making it a valuable tool in research related to enteroviral infections. Additionally, its vasodilatory properties further enhance its potential applications in cardiovascular studies. -
Enteroviruses Replication Inhibitor
MRL-1237 is an enterovirus replication inhibitor that targets the non-structural protein 2C. It demonstrates effective inhibition of poliovirus and other enteroviruses, making it a valuable tool for studying viral infections. Notably, MRL-1237 does not interfere with the NTPase (ATPase) activity of the 2C protein, allowing for specific mechanistic investigations in enteroviral research applications. -
EVs 2C Inhibitor
Jun15716 is an inhibitor of the Enterovirus (EVs) 2C protein, exhibiting dissociation constants (Kis) of 15.9, 44.2, and 17.8 μM for EV-D68, EV-A71, and CVB3, respectively. This compound demonstrates significant antiviral activity, with effective concentrations (EC50) of 1.0 μM against EV-D68 and 0.7 μM against CVB3 in relevant cellular models. Jun15716 is applicable in virology research, particularly in studies related to viral infections such as meningitis, hand, foot and mouth disease (HFMD), and viral myocarditis. -
2C Inhibitor
R523062 is a viral 2C inhibitor that targets the 2C protein of enteroviruses. This compound effectively reduces the levels of the viral VP1 protein, thereby impairing viral replication. R523062 exhibits broad-spectrum antiviral activity against enterovirus D68 (EV-D68) strains, making it a valuable tool for research in antiviral therapeutics and virology. -
CV-B3 2C ATPase Inhibitor
ATPase-IN-8 is a selective inhibitor of CV-B3 2C ATPase, exhibiting an IC50 of 1.4 μM. This compound demonstrates significant anti-enteroviral activity, particularly against coxsackievirus B3 (CV-B3) and enterovirus D68 (EV-D68). ATPase-IN-8 is suitable for research applications focusing on enteroviral infections and their molecular mechanisms. -
EV71 Inhibitor
ZHSI-1 is a potent inhibitor of Enterovirus 71 (EV71), targeting viral replication and mitigating virus-induced pyroptosis linked to pathogenesis. This compound effectively prevents EV71 infection in neonatal and young murine models, making it a valuable tool for research in viral infections, specifically related to hand, foot, and mouth disease (HFMD). Its application may contribute to the understanding of EV71 behavior and aid in developing therapeutic strategies against this virus.
