Fig. 1 · Structure

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ToP-DNJ

Cat. No. A50730 CAS 1508303-85-2

Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor

ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies.

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Specifications

Manufacturer Adooq Bioscience
Actions Inhibitor
CAS Number 1508303-85-2
Applications Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
Formula C40H71NO6
Molecular Weight 661.99
SMILES
O[C@@H]1[C@@H](CO)N(CCCCCOC2=C(C)C(C)=C3C(CC[C@](CCC[C@H](C)CCC[C@H](C)CCCC(C)C)(C)O3)=C2C)C[C@H](O)[C@H]1O

Storage & Solubility

In Vitro Solubility

Reported Solubility

No reported solubility data are available for this product.

Preparing Stock Solutions

Stock preparation is unavailable for this product molecular weight.

Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.

Storage

Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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