Catalog No.
Product Name
Application
Product Information
Citations
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HIV-1 Reverse Transcriptase Inhibitor
HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase, effectively disrupting the replication of the HIV virus. It demonstrates exceptional antiviral activity, with an IC50 value of less than 0.001 μM against wild-type HTLVIIIB. This compound is primarily utilized in HIV research, particularly in the development of antiretroviral therapies. -
HIV Inhibitor
F1839-I is an HIV inhibitor derived from the fungus Stachybotrys. It exhibits anti-HIV activity with an IC50 value of 15.6 μM, demonstrating its potential in therapeutic applications against HIV infection. Additionally, F1839-I has shown weak cytotoxicity, supporting its feasibility for further research in antiviral drug development. -
HIV-1 Nef Binder, Calnexin Binder
NSC 13987 is a selective inhibitor of the HIV-1 Nef protein, specifically targeting site I. By binding to Nef, NSC 13987 disrupts its interaction with calnexin, leading to the restoration of cholesterol efflux that is typically inhibited by Nef. This compound is valuable for research into HIV-associated atherosclerosis, providing insights into the mechanisms behind HIV infection and its impact on lipid metabolism. -
HIV-1 Inhibitor
VIRIP, derived from human α1-AT(353-372), functions as an inhibitor of HIV-1 by targeting the gp41 fusion peptide. It prevents the entry of HIV-1 into host cells, thereby disrupting the viral lifecycle. This reagent is applicable in virology research and studies focused on HIV-1 entry mechanisms. -
HIV-1 Inhibitor
Kadsuracoccinic acid A is a tetracyclic natural compound targeting HIV-1. It exhibits significant anti-HIV-1 activity in vitro, with an EC50 value of 68.7 μM. This compound is valuable for research in the development of antiviral therapies and understanding HIV-1 inhibition mechanisms. -
CCR5 Antagonist
Ancriviroc is a small molecule CCR5 antagonist that demonstrates potent antiviral activity against various HIV-1 isolates that utilize CCR5 as an entry coreceptor, with IC50 values ranging from 0.4 to 9 nM. This compound effectively inhibits the replication of R5-utilizing HIV-1 strains in the SCID-hu Thy/Liv mice model of HIV-1 infection. Ancriviroc is a valuable tool for research focused on HIV infection and the exploration of therapeutic strategies targeting CCR5. -
HIV Inhibitor
HIV-1 inhibitor-70 is a bifunctional inhibitor targeting both wild-type and K103N mutant reverse transcriptases of HIV-1. This compound effectively disrupts the replication of the virus, making it valuable in HIV research and therapeutic investigations. Its dual inhibitory action provides insights into resistance mechanisms and aids in the development of effective treatments for HIV infections. -
HIV protease inhibitor
SB 204144 is a potent inhibitor of HIV protease, disrupting the proteolytic processing of viral polyproteins and hindering the maturation of infectious HIV particles. This compound is valuable for research on HIV pathogenesis and immune system diseases, enabling studies on antiviral effects and the development of new therapeutic strategies against HIV. Its application in virology underlines its relevance in understanding and combating HIV infection. -
HIV Inhibitor
B07 is a potent HIV inhibitor that targets viral replication mechanisms. In addition to its antiviral properties, B07 also exhibits spermicidal activity with an EC50 of 1.5 mg/mL. This compound has valuable applications in HIV research and the development of contraceptive agents. -
CCR5 Antagonist
INCB9471 is a potent and selective CCR5 antagonist that serves as a critical resource for HIV-1 research. This orally active compound effectively inhibits CCR5-mediated entry of HIV-1 into host cells, demonstrating significant anti-HIV-1 activity. Its targeted mechanism of action makes INCB9471 a valuable tool for studying HIV pathogenesis and developing therapeutic strategies against HIV infection. -
HIV-1 Inhibitor
GS-9822 is a potent HIV-1 inhibitor that specifically targets the LEDGF/p75-integrase interaction, demonstrating robust antiviral activity with an IC50 of 0.07 μM against wild-type HIV-1 viruses. It exhibits high in vitro metabolic stability and favorable oral pharmacokinetic properties, characterized by low systemic clearance across various preclinical animal models, including rats, dogs, and monkeys. GS-9822 is a valuable tool for research applications focused on understanding HIV-1 integration and developing therapeutic strategies against viral infections. -
HIV-1 Inhibitor
Fosamprenavir-d4 is a deuterium-labeled inhibitor targeting HIV-1 protease. As a prodrug of Amprenavir, Fosamprenavir is hydrolyzed by cell phosphatases, converting it into Amprenavir, which subsequently binds to the active site of HIV-1 protease. This binding prevents the processing of essential viral precursors, inhibiting the production of mature and infectious virions. Fosamprenavir-d4 is useful for research focused on HIV-1 infection and therapeutic strategies against the virus. -
HIV Inhibitor
Tsugafolin is a dehydroflavone that acts as an inhibitor of HIV. It exhibits weak anti-HIV activity with an IC50 value of 118 μM while demonstrating low cytotoxicity at concentrations below 150 μM. Isolated from the plant Vitex leptobotrys, Tsugafolin serves as a valuable tool for research applications focused on HIV-1 replication and the development of therapeutic strategies. -
HIV
(S)-BMS-378806 is a potent HIV-1 inhibitor that primarily targets the gp120-CD4 interaction, disrupting the crucial binding necessary for viral entry into host cells. This compound demonstrates micromolar inhibition of HIV-1 gp120-CD4 binding, making it a valuable tool for understanding HIV pathogenesis and developing therapeutic strategies. The design of (S)-BMS-378806 was informed by detailed studies of protein-ligand interactions, leading to the synthesis of innovative symmetrical N,N'-disubstituted aminoureas and thioureas. Its inhibitory activity has been confirmed through HIV-1 gp120-CD4 capture ELISA. -
HIV-l Encoded Protease Inhibitor
L-738872 is a potent orally active inhibitor of the HIV-1 encoded protease. It effectively inhibits viral replication by interfering with the processing of viral polyproteins, which is critical for the maturation of infectious HIV particles. This compound is valuable in research focused on understanding HIV protease functionality and developing antiretroviral therapies. -
HIV-1 Reverse Transcriptase Inhibitor
Urushiol (15:3) is an inhibitor of HIV-1 reverse transcriptase, demonstrating moderate inhibitory activity with an IC50 value of 55.36 μM. This compound, derived from the leaves of Rhus verniciflua, exhibits significant cytotoxicity against prostate cancer PC-3 cells and normal MRC-5 cells. Urushiol (15:3) is relevant for research into anti-HIV-1 therapies and the study of prostate cancer biology. -
CCR5 Antagonist
Vicriviroc is a potent CCR5 antagonist with an IC50 of 10 nM. It effectively inhibits the release of MIP-1α and intracellular calcium levels induced by the ligand RANTES, with IC50 values of 0.91 nM and 16 nM, respectively. Vicriviroc is primarily utilized in research related to human immunodeficiency virus type 1 (HIV-1) infection and holds potential for cancer studies. -
HIV NNRT Inhibitor
BI-2540 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor targeting HIV. This compound exhibits significant antiviral activity by inhibiting the reverse transcription process, thereby preventing viral replication. BI-2540 is utilized in research for the development of therapeutic strategies against HIV and contributes to the understanding of HIV resistance mechanisms. -
HIV-1 RT Inhibitor
L 738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with a reported inhibition constant (Ki) of 140 nM against dTTP. This compound demonstrates synergistic inhibition of RT activity when used in combination with nucleoside analogs such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate. Notably, L 738372 exhibits enhanced inhibitory potency against azidothymidine-resistant RT variants (D67N, K70R, T215Y, K219Q), making it a valuable tool for advancing research in HIV treatment strategies. -
Reverse Transcriptase
Etravirine-d4 is a deuterium-labeled analog of Etravirine, a non-nucleoside reverse transcriptase inhibitor (NNRTI) targeting HIV reverse transcriptase. This compound is utilized in research to study the mechanisms of HIV inhibition and resistance. Etravirine-d4 is particularly valuable for pharmacokinetic studies and metabolic profiling in antiviral research. -
HIV Inhibitor
H-Gly-Pro-Gly-NH2 is a tripeptide that serves as an inhibitor of HIV-1 and HIV-2 replication. Demonstrating EC50 values of 35 µM for HIV-1 IIIB and 30 µM for HIV-2 ROD, H-Gly-Pro-Gly-NH2 reduces viral replication by disrupting capsid formation in vitro. This compound possesses significant antiviral activity, making it a valuable tool for research into HIV and related viral mechanisms. -
HIV
GPI2A is a 20-mer antisense oligonucleotide targeting the HIV-1 gag gene. This compound demonstrates significant inhibition of the viral proteins p55 and its cleavage products p39/41, making it a valuable tool for HIV research. GPI2A may be used to study the mechanisms of HIV replication and the potential for therapeutic intervention in HIV-1 infections. -
HIV-1 Inhibitor
GSK3532795 oxalate is a potent second-generation inhibitor of HIV-1 maturation, acting primarily through the disruption of viral particle assembly. It exhibits notable efficacy with EC50 values of 1.9 nM for HIV-1 wild type, 10.2 nM in human serum, as well as 2.7 nM and 13 nM for the HIV-1 V370A and ΔV370 variants, respectively. This compound is essential for research focused on HIV-1 infection mechanisms and therapeutic strategies. -
Non-nucleoside Reverse Transcriptase Inhibitor
Capravirine is an orally active non-nucleoside reverse transcriptase inhibitor (NNRTI) primarily targeting the HIV-1 reverse transcriptase enzyme. It demonstrates potent antiviral activity against various strains of HIV-1, including those resistant to both nucleoside/nucleotide reverse transcriptase inhibitors and other NNRTIs. Capravirine is metabolized by the cytochrome P450 enzyme CYP3A4, making it relevant for studies on drug interactions and resistance mechanisms in HIV research. -
HIV-1 Inhibitor
HIV-1 inhibitor-34 is a potent and selective inhibitor of HIV-1, exhibiting an EC50 value of 6.4 nM in HIV-1 assays and a CC50 of 16 μM in MT-4 cells. This compound is valuable for research applications focused on understanding HIV-1 replication and pathogenesis, making it a useful tool for studies related to AIDS therapeutics. -
HIV Inhibitor
SJ-3366 is a potent inhibitor of HIV non-nucleoside reverse transcriptase. This compound demonstrates significant inhibitory activity at sub-nanomolar concentrations, functioning through a typical non-nucleoside mechanism. SJ-3366 is utilized in research applications focused on HIV replication and the development of antiretroviral therapies. -
Beta-Lactamase Inhibitor
β-Lactamase-IN-2 is a beta-lactamase inhibitor that targets and inhibits the activity of beta-lactamase enzymes. This compound exhibits significant anti-microbial and anti-bacterial properties, making it useful in overcoming antibiotic resistance. Its application extends to research focused on enhancing the efficacy of beta-lactam antibiotics in clinical settings. -
Antibiotic
Gatifloxacin sesquihydrate is a potent fluoroquinolone antibiotic that primarily targets bacterial type II topoisomerases. It exhibits broad-spectrum antibacterial activity, demonstrating significant inhibition of S. aureus topoisomerase IV and E. coli DNA gyrase with IC50 values of 13.8 μg/ml and 0.109 μg/ml, respectively. This compound is particularly useful in research related to bacterial infections and may serve as a therapeutic agent for conditions such as bacterial conjunctivitis. -
Antibacterial Agent
Ticarcillin is a semisynthetic carboxypenicillin with extended-spectrum antibacterial activity, primarily targeting bacterial cell wall synthesis. It is effective against a range of gram-positive cocci, such as streptococci and staphylococci, as well as most gram-negative organisms, including Pseudomonas aeruginosa. Ticarcillin is relevant for research applications involving lower respiratory tract infections, skin and skin structure infections, urinary tract infections, and intra-abdominal infections. -
Antibiotic
Secnidazole hemihydrate is an orally active azole antibiotic that targets bacterial virulence through its amelioration of Serratia marcescens. This compound acts as an analog of acylhomoserine lactones, effectively inhibiting quorum sensing and reducing the pathogenesis of Pseudomonas aeruginosa. Secnidazole hemihydrate demonstrates antimicrobial activity against a range of anaerobic Gram-negative and Gram-positive bacteria in vitro. Its versatile applications in research include the study of diseases such as amoebiasis, giardiasis, and bacterial vaginitis. -
Antibiotic
Teixobactin is a potent antibiotic that primarily targets cell wall synthesis in bacteria. It demonstrates significant antibacterial activity against gram-negative bacteria by binding to the conserved motifs of lipid II and lipid III. This mechanism of action makes Teixobactin a valuable reagent for research focused on bacterial resistance and the development of new antibiotic therapies. -
Antibiotic
Sitafloxacin hydrochloride is a potent fluoroquinolone antibiotic that functions by inhibiting bacterial DNA gyrase and topoisomerase IV, ultimately disrupting bacterial replication. It exhibits significant antibacterial activity against a wide spectrum of both gram-positive and gram-negative bacteria, including anaerobic organisms and atypical pathogens. This compound is primarily applied in research related to respiratory and urinary tract infections. -
Antibiotic
Amoxicillin arginine is an antibiotic that effectively inhibits cell wall biosynthesis by targeting polypeptide synthesis, leading to the disruption of bacterial growth. With good oral absorption and a broad spectrum of antimicrobial activity, it is utilized in various research applications related to bacterial infections and resistance mechanisms. This compound serves as an important tool for studying the pharmacological effects of β-lactam antibiotics in both clinical and laboratory settings. -
Antibiotic
Zanamivir (hydrate)(5:1) is a potent inhibitor of influenza viral neuraminidase, exhibiting IC50 values of 0.95 nM for influenza A and 2.7 nM for influenza B. This compound is widely employed in antiviral research to elucidate the mechanisms of viral infection and to develop therapeutic strategies against influenza viruses. Its high inhibitory efficacy makes it a valuable tool for studying the effects of neuraminidase inhibition in both laboratory and clinical settings. -
Antibacterial Agent
Cloxacillin is an orally active antibacterial agent and β-lactamase inhibitor, exhibiting an IC50 of 0.04 µM. It effectively suppresses the inflammatory response induced by Staphylococcus aureus by inhibiting the activation of mitogen-activated protein kinases (MAPKs), nuclear factor kappa B (NF-κB), and proteins associated with the NLRP3 inflammasome. This compound is useful for research applications focused on bacterial infections and inflammatory processes. -
Cephalosporin Antibiotic
Cefotiam is a parenteral cephalosporin antibiotic that targets bacterial cell wall synthesis. It exhibits broad-spectrum antimicrobial activity against both Gram-positive and Gram-negative bacteria, making it a valuable reagent for research in microbiology and infectious disease studies. This compound is commonly used in evaluating bacterial susceptibility and understanding the mechanisms of antibiotic resistance. -
Antibiotic
Netilmicin is a broad-spectrum semisynthetic aminoglycoside antibiotic targeting bacterial protein synthesis. It demonstrates significant antibacterial activity against aminoglycoside-susceptible gram-negative strains as well as aminoglycoside-resistant strains, including Escherichia coli, Pseudomonas aeruginosa, Proteus, Staphylococcus aureus, Streptococcus, Serratia, and Enterobacter, with a minimum inhibitory concentration (MIC) ranging from 0.125 to 8 μg/mL. This compound is widely used in research applications focusing on antimicrobial susceptibility and resistance mechanisms. -
Antibiotic
Cefepime chloride is a broad-spectrum cephalosporin antibiotic that effectively targets both Gram-positive and Gram-negative aerobic bacteria. Its ability to penetrate the blood-brain barrier makes it a valuable agent in the treatment of central nervous system infections. Additionally, it is noted for its neurotoxic effects, making it relevant for studies investigating antimicrobial toxicity and resistance mechanisms. -
Antibacterial Antibiotic
Tebipenem pivoxil hydrochloride is an orally active antibacterial agent that targets penicillin-binding proteins (PBPs) to inhibit cell wall synthesis in pathogenic bacteria. This mechanism of action makes it effective against a broad spectrum of Gram-positive and Gram-negative organisms. It is utilized in research applications focused on antibiotic resistance and the development of novel antibacterial therapies. -
Cephalosporin Antibiotic
Cephalexin hydrochloride monohydrate is a semisynthetic cephalosporin antibiotic that primarily targets penicillin-binding proteins (PBPs) to disrupt bacterial cell wall synthesis. It exhibits a wide antibacterial spectrum, effective against various gram-positive and gram-negative bacteria. This compound is utilized in research related to bacterial infections, including pneumonia, strep throat, and bacterial endocarditis. -
Dianionic Cephem Antibiotic
Ceftibuten monohydrate is a dianionic cephem antibiotic that exhibits potent antibacterial activity. It is effective against a broad spectrum of gram-negative bacteria and select gram-positive strains. Ceftibuten is primarily utilized in research applications focusing on antibiotic resistance and the pharmacological evaluation of cephalosporins. Its oral bioavailability makes it a valuable compound for studying systemic infection models. -
Antibiotic
Sitafloxacin monohydrate is a potent fluoroquinolone antibiotic that exhibits strong antibacterial activity against a wide spectrum of both gram-positive and gram-negative bacteria, including anaerobic organisms and atypical pathogens. Its antichlamydial properties make it a valuable reagent in the study of various infections. Sitafloxacin monohydrate is particularly relevant in research focused on respiratory and urinary tract infections. -
Cephalosporin Antibiotic
Cephalexin (lysine) is a semisynthetic cephalosporin antibiotic that primarily targets penicillin-binding proteins (PBPs) to disrupt bacterial cell wall synthesis. This compound exhibits broad-spectrum antibacterial activity against a range of gram-positive and gram-negative bacteria. Cephalexin (lysine) is used in research applications related to various infections, including pneumonia, streptococcal throat infections, and bacterial endocarditis. -
β-lactam Antibiotic
Dicloxacillin is a β-lactam antibiotic belonging to the penicillin family, primarily targeting Gram-positive bacteria. It demonstrates effectiveness against β-lactamase-producing organisms, including Staphylococcus aureus. This compound is widely utilized in research and clinical applications to investigate bacterial resistance mechanisms and evaluate the efficacy of antibacterial treatments. -
Antibiotic
A83016A is a kinamycin-type antibiotic that inhibits bacterial growth by targeting essential cellular processes. It exhibits a minimum inhibitory concentration (MIC) of 4 µg/ml against Enterococcus faecium, demonstrating its potent antibacterial activity. This compound is suitable for research applications focused on antibiotic resistance and efficacy studies in microbiology. -
Antibiotic
Antibiotic SF-2132 is a peptide antibiotic derived from Nocardiopsis sp., demonstrating potent inhibitory activity against β-lactam antibiotic-resistant strains, including Pseudomonas and Escherichia. This compound is particularly valuable in research aimed at addressing antibiotic resistance and investigating novel antimicrobial mechanisms. Its efficacy against resistant pathogens makes it a crucial tool for studies in microbiology and infectious disease. -
Antibiotic
Aurodox is an antibiotic derived from a variant of Streptomyces, primarily targeting gram-positive bacteria. It exhibits potent antibacterial activity while demonstrating low toxicity in murine models. Aurodox is utilized in research applications related to antibiotic efficacy and potential growth promotion in agricultural settings. -
Cephalosporin Antibiotic
Cefetecol is a broad-spectrum cephalosporin antibiotic that targets penicillin-binding proteins (PBPs) to inhibit bacterial cell wall synthesis, leading to cell lysis. In addition to its antibacterial properties, Cefetecol also acts as an α-glucosidase inhibitor, demonstrating in vivo anti-diabetic activity in diabetic mouse models. This compound is suitable for research applications in both antibacterial and anti-diabetic studies. -
Antibiotic
Anti-MRSA agent 19 is an antibiotic that targets methicillin-resistant Staphylococcus aureus (MRSA), demonstrating significant antimicrobial activity with a median MIC of 4 μg/mL. This compound effectively inhibits a diverse range of bacterial species, including those resistant to vancomycin, aminoglycosides, tetracyclines, and oxazolidinones. It serves as a valuable research tool for studying antibiotic resistance mechanisms and developing novel therapeutic strategies against resistant infections. -
Antibiotic
Antibiotic TAN-592B is a potent antibiotic targeting bacterial infections. It exhibits strong antimicrobial activity against a wide range of Gram-positive and Gram-negative bacteria, making it suitable for research in bacterial pathogenesis and antibiotic resistance studies. This compound can be utilized in assays to evaluate the effectiveness of antibiotic treatments and to explore novel therapeutic approaches to combat bacterial infections.
