Catalog No.
Product Name
Application
Product Information
Citations
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DENV Inhibitor
(-)-JNJ-A07 is a potent and selective inhibitor of Dengue Virus (DENV) with an EC50 value of 31 nM. It demonstrates significant antiviral activity, making it a valuable tool for research in virology and the study of DENV pathogenesis. This compound is suitable for investigations into potential therapeutic strategies for dengue fever and other flavivirus-related diseases. -
Yellow Fever Virus Inhibitor
RCB16007 is a selective inhibitor of the Yellow Fever Virus (YFV). It demonstrates effective antiviral activity against the West Nile virus, with an EC50 value of 7.9 μM and a CC50 of 17 μM. This compound serves as a valuable tool for studies related to flavivirus infections and can aid in the development of therapeutics targeting RNA viruses. -
δ-Opioid Receptor Antagonist/DENV Inhibitor
SDM25N hydrochloride is a potent δ-opioid receptor antagonist that also serves as an effective inhibitor of the dengue virus (DENV). It specifically targets the viral NS4B protein, significantly limiting genomic RNA replication. This compound presents valuable opportunities for research on antiviral strategies and the role of δ-opioid receptors in viral pathogenesis. -
NS5 RdRp/NS2B-NS3pro Inhibitor
LabMol-301 is a potent inhibitor of both NS5 RNA-dependent RNA polymerase (RdRp) and NS2B-NS3 protease, with IC50 values of 0.8 μM and 7.4 μM, respectively. This reagent demonstrates cytoprotective properties by effectively preventing cell death induced by the Zika virus (ZIKV). LabMol-301 is valuable for research applications focusing on antiviral drug development and the mechanistic study of flavivirus pathogenesis. -
Anti-virus Agent
XA-E is a purified compound derived from a methanol-ethyl acetate extract of A. keiskei, targeting viral replication. This compound exhibits potent anti-Zika virus activity, with an IC50 value of 22.0 µM. XA-E is suitable for research applications focusing on antiviral drug development and the mechanistic study of flavivirus infections. -
STT3A-mediated Mega Protein Complex Assembly Inhibitor
NSC-323241 is an STT3A-mediated mega protein complex assembly inhibitor that effectively disrupts the endoplasmic reticulum (ER) mega complex essential for dengue virus (DENV) and Zika virus (ZIKV) infection. By targeting the interaction between the STT3A subcomplex, viral nonstructural proteins (e.g., NS2B, NS3), and host translocon proteins, NSC-323241 impedes the establishment of the viral replication microenvironment. This compound is valuable for investigating the mechanisms of flavivirus infections, including dengue fever and Zika virus. -
Flavivirus inhibitor
Flaviviruses-IN-1 is a potent inhibitor of various viruses within the Flaviviridae family, acting primarily by modulating the host cell immune response to viral infection. This compound has demonstrated significant efficacy in preventing viral replication and infection, making it a valuable tool in virology research. Flaviviruses-IN-1 was identified through high-throughput screening as a promising candidate for therapeutic development against flavivirus infections, offering new avenues for intervention in related diseases. -
Flaviviru Inhibitor
TYT-1 is a sulfonamide-thiourea compound that targets flavivirus replication. It demonstrates potent inhibitory activity against West Nile virus, with a 50% effective concentration of 0.7 µM, effectively blocking a post-entry, pre-assembly step in the viral life cycle. This compound is valuable for research applications focused on understanding flavivirus pathogenesis and developing antiviral strategies. -
Rna Virus Inhibitor
Galidesivir dihydrochloride is a broad-spectrum RNA virus inhibitor targeting various RNA viruses, including Ebola and yellow fever viruses. This compound exhibits potent antiviral activity against tick-borne encephalitis virus (TBEV) and inhibits the proliferation of several other medically significant flaviviruses. Its efficacy makes Galidesivir a valuable tool for research applications focused on viral pathogenesis and antiviral drug development. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-1 is a non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating an IC50 of 1.8 μM. This compound also effectively inhibits the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 is capable of inhibiting ZIKV replication and reducing virus-induced cytopathic effects, making it a valuable tool for research focused on ZIKV infection and associated viral pathogenesis. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-2 is an orally active, non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating IC50 values of 0.04 μM for the wild-type and 3.1 μM for the I156T mutant strains. This compound exhibits broad-spectrum activity against flaviviruses, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus serotype 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-2 effectively inhibits ZIKV replication and mitigates virus-induced cytopathic effects, making it a valuable tool for research on ZIKV infection and the study of flavivirus-related diseases. -
HIV/HBV Inhibitor
Emtricitabine triphosphate tetrasodium salt is the tetrasodium salt form of Emtricitabine triphosphate, a phosphorylated metabolite of Emtricitabine. This compound functions as a nucleoside reverse transcriptase inhibitor, effectively targeting both HIV and HBV. Emtricitabine triphosphate tetrasodium salt is utilized in research applications focused on antiviral drug development and the mechanisms of viral replication. -
HIV Inhibitor
(S)-Tenofovir is an S-enantiomer of Tenofovir, functioning primarily as a nucleotide reverse transcriptase inhibitor. This compound demonstrates significant biological activity against HIV and is also relevant in the treatment of chronic Hepatitis B (HBV). It is commonly utilized in research applications focused on antiviral therapies and the mechanistic study of retroviral infections. -
Antiviral Agent
Helioxanthin is an antiviral agent with demonstrated in vitro activity, exhibiting an effective concentration (EC50) of 1 μM against hepatitis B virus (HBV). Additionally, Helioxanthin shows efficacy against flaviviruses, making it a valuable compound in antiviral research. It is suitable for studies focusing on the development of treatments for viral infections. -
HIV/HBV Inhibitor
L-Fd4A is an adenine derivative that inhibits both human immunodeficiency virus (HIV) and hepatitis B virus (HBV) with effective concentrations (EC50) of 1.5 μM and 1.7 μM, respectively. This compound demonstrates promising antiviral activity while exhibiting low cytotoxicity, making it suitable for research applications in studying HIV and HBV inhibition mechanisms. -
anti-HBV/HIV-1 Agent
Periglaucine A is a hasubanane-type alkaloid that targets anti-HBV and anti-HIV-1 activity. It effectively inhibits the secretion of HBV surface antigen (HBsAg) in Hep G2.2.15 cells, demonstrating its potential as a therapeutic agent against hepatitis B virus. Additionally, Periglaucine A exhibits anti-HIV-1 efficacy in C8166 cells, with an EC50 value of 204 μM, making it a valuable compound for research in viral infections. -
IRF3 Activator
KIN1400 is a potent IRF3 activator that stimulates the expression of IRF3-dependent antiviral genes, including RIG-I, MDA5, IFIT1, and Mx1, as well as IFN-β production. This compound effectively inhibits the replication of West Nile Virus (WNV) and Dengue Virus (DV), both of which are mosquito-borne flaviviruses, as well as Hepatitis C Virus (HCV). KIN1400 activates innate antiviral immunity via the MAVS-IRF3 signaling pathway, making it a valuable tool for research focused on antiviral responses and immune modulation. -
HCV/HIV Inhibitor
C5A is a microbicidal peptide that targets and inhibits both hepatitis C virus (HCV) and human immunodeficiency virus (HIV). By disrupting the membrane integrity of the HIV virion and affecting the conical capsid core that encases the viral genome, C5A significantly reduces the infectivity of a wide range of HIV isolates in various primary target cells in vitro. Additionally, studies have demonstrated that C5A offers protective effects in mice against vaginal and rectal challenges with HIV, highlighting its potential utility in antiviral research applications. -
COVID-19 Inhibitor
RBT-9 is a COVID-19 inhibitor that targets viral replication and inflammation pathways. It has demonstrated efficacy in preventing the progression to severe COVID-19 and associated organ failure. Furthermore, RBT-9 exhibits antiviral activity against various enveloped viruses, including influenza, hepatitis C virus (HCV), dengue, and yellow fever, making it a valuable tool for research in viral pathogenesis and therapeutic intervention. -
Antibacterial Agent
HSGN-218 is an antibacterial agent that demonstrates potent efficacy against various strains of Clostridium difficile, exhibiting minimum inhibitory concentration (MIC) values between 0.007 μM and 0.07 μM. Despite its low permeability across Caco-2 cells, HSGN-218 is a valuable tool for investigating bacterial growth inhibition and exploring therapeutic options for C. difficile infections in research applications. -
Bacterial Inhibitor
Pyrroxamycin is a novel antibiotic with a primary mechanism targeting Gram-positive bacteria and dermatophytes. Derived from the fermentation of Streptomyces, it exhibits potent antibacterial activity. This compound has potential applications in pharmaceutical research for the development of new antimicrobials, particularly against resistant bacterial strains. Detailed analysis of its chemical structure was performed using X-ray crystallography and 13C NMR spectroscopy, elucidating its physicochemical properties and enhancing its utility in microbiological studies. -
Antibacterial Agent
Antibacterial Agent 39 is a potent antibacterial compound that demonstrates synergistic effects by significantly lowering the minimum inhibitory concentration (MIC) of Ceftazidime. This compound exhibits strong antibacterial activity against various Gram-negative bacteria, making it a valuable tool for research focused on combating antibiotic resistance and enhancing the efficacy of existing antibiotics. Its application in microbiological studies can provide insights into the mechanisms of action and interactions between different antibacterial agents. -
Quorum Sensing Inhibitor
Aculene D is a quorum sensing inhibitor derived from fungal metabolites that targets the signaling mechanisms in bacteria. It effectively reduces violacein production in Chromobacterium violaceum CV026 cultures induced by N-hexanoyl-L-homoserine lactone (C6-HSL) at sub-inhibitory concentrations. This compound is valuable for research exploring bacterial communication and the modulation of biofilm formation, with potential applications in combating antibiotic resistance and developing new antimicrobial strategies. -
Anti-Bacterial Agent
Juncuenin D is an anti-bacterial agent known for its ability to induce caspase-3-mediated cytotoxicity in HT22 cells. This compound exhibits significant anti-bacterial activity against methicillin-resistant Staphylococcus aureus (MRSA) strains. Juncuenin D is derived from Juncus effusus and serves as a valuable tool for research in infectious disease and cell death mechanisms. -
Antibacterial Peptide
Latarcin 2a is a linear cationic antibacterial peptide derived from the venom of the spider Lachesana tarabaevi, exhibiting broad-spectrum antibacterial activity. It demonstrates a minimum inhibitory concentration (MIC) of 0.5 μM against both Bacillus subtilis and Escherichia coli. This peptide is primarily utilized in research related to infectious diseases and the development of novel antimicrobial agents. -
Antibacterial Agent
Antibacterial Agent 60 is a potent antibacterial compound that enhances the efficacy of Ceftazidime by significantly reducing its minimum inhibitory concentration (MIC). This agent exhibits strong antibacterial activity, making it particularly useful in overcoming bacterial resistance. It can be employed in various research applications focused on developing improved antimicrobial therapies and optimizing existing antibiotics against resistant strains. -
Bacterial Inhibitor
β-Lactamase-IN-6 is a potent inhibitor of β-Lactamase enzymes, which play a crucial role in bacterial resistance to β-lactam antibiotics. This compound demonstrates significant antibacterial activity by preventing the enzymatic breakdown of β-lactam antibiotics, thereby enhancing their effectiveness against resistant bacterial strains. β-Lactamase-IN-6 serves as a valuable tool in microbiological research and antibiotic development, providing insights into combating bacterial infections and resistance mechanisms. -
Antibacterial Agent
Antibacterial Agent 51 primarily targets bacterial cell growth and division. It exhibits minimum inhibitory concentration (MIC) values of 4 mcg/mL against E. coli NCTC 13351 and 8 mcg/mL against both E. coli strains M 50 and 7 MP. This compound is valuable for research applications focused on bacterial resistance and the development of new antibacterial therapies. -
Bacterial Inhibitor
(R)-Gyramide A hydrochloride is a bacterial DNA gyrase inhibitor that effectively disrupts DNA supercoiling, exhibiting an IC50 of 3.3 µM. This compound demonstrates significant antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, and Salmonella enterica, with minimum inhibitory concentrations ranging from 10 to 80 µM. Notably, (R)-Gyramide A hydrochloride does not inhibit topoisomerase IV, making it a valuable tool for studying bacterial mechanisms and antibiotic resistance. -
Antibacterial Agent
Heronapyrrole B is a Gram-positive-selective antibacterial agent with an IC50 range of 0.6-1.1 μM against Staphylococcus aureus ATCC9144. This compound demonstrates potent antibacterial activity, making it a valuable tool in the study of bacterial infections. Its specific mechanism of action and efficacy position it for potential applications in antibiotic research and development. -
Antibacterial Agent
Antibacterial Agent 192 is an antibacterial compound that targets and disrupts iron homeostasis in Escherichia coli. This mechanism leads to impaired bacterial growth and viability, making it a valuable tool for studying bacterial metabolism and resistance mechanisms. Its applications include research in antibiotic development and the investigation of bacterial iron regulation processes. -
Antimycobacterial Agent
3β,7β,15β-Trihydroxy-11-oxo-lanosta-8-en-24→20 lactone is a natural compound with noted antimycobacterial activity. Isolated from Ganoderma lucidum, this compound demonstrates effectiveness against mycobacterial infections, making it a valuable resource in antibacterial research. Its unique structure and biological properties render it a promising candidate for further investigation in the development of antimycobacterial therapies. -
Antibacterial Agent
Ro 24-4383 is a carbamate-linked compound that exhibits antibacterial activity through a dual mechanism of action. It effectively targets bacterial cell processes, making it a valuable tool in antibacterial research. This compound is useful for studies related to bacterial resistance and the development of new antibacterial therapies. -
Bacterial
B1912 is an antibacterial compound that demonstrates significant efficacy against various bacterial strains. Its primary mechanism involves disrupting bacterial cell wall synthesis, leading to cell lysis and death. This reagent is valuable for research applications focused on developing new antibacterial therapies and studying bacterial resistance mechanisms. -
Antibacterial Agent
DPI-2016 is an antibacterial agent that demonstrates potent bactericidal activity, with minimum inhibitory concentrations (MIC) ranging from 0.25 to 8 μg/mL across various bacterial strains. This compound exhibits enhanced effectiveness compared to standard treatments such as aztreonam, which has MIC values between 16 and greater than 64 μg/mL. DPI-2016 is suitable for research applications aimed at investigating bacterial resistance and efficacy in therapeutic interventions. -
Antibacterial Agent
Bauer-7-ene-3β,16α-diol is a triterpenoid with demonstrated antibacterial properties, primarily targeting bacterial strains such as E. coli. Isolated from the dried flower buds of Tussilago farfara L. or Petasites tricholobus, it exhibits medium antibacterial activity, making it a valuable reagent for research in natural product pharmacology and the development of antimicrobial agents. Its structural features and potency may facilitate investigations into the mechanisms of bacterial resistance and alternative therapeutic strategies. -
Antibacterial Agent
Antibacterial agent 99 (compound 7b) is a potent antibacterial compound that targets bacterial cell wall synthesis. It exhibits significant antibacterial and antifungal activity, making it suitable for various microbiological research applications. Additionally, antibacterial agent 99 demonstrates no hemolytic activity, indicating a favorable safety profile for potential therapeutic use. -
Bacterial Inhibitor
Acrisorcin is a topical anti-infective compound that functions primarily as a bacterial inhibitor. It exhibits potent fungicidal properties, making it valuable for research into antifungal therapies and the understanding of bacterial resistance mechanisms. Its efficacy in mitigating fungal infections supports its application in various microbiological studies and therapeutic evaluations. -
Antibacterial Agent
Antibacterial Agent 45 is an effective antibacterial compound that enhances the efficacy of Ceftazidime by significantly lowering its minimum inhibitory concentration (MIC) value. This agent demonstrates potent antibacterial activity, making it a valuable tool for researchers studying bacterial resistance and developing novel antimicrobial therapies. Its application in combinatorial therapies holds promise for advancing understanding of bacterial pathogenesis and treatment strategies. -
Antibacterial Agent
Prenylterphenyllin is an antibacterial agent derived from the marine fungus Aspergillus candidus IF10. It exhibits significant cytotoxic activity against KB3-1 cells, with an IC50 value of 8.5 mg/mL. Additionally, Prenylterphenyllin demonstrates antibacterial properties against Xanthomonas oryzae and Erwinia amylovora, both exhibiting minimum inhibitory concentrations (MICs) of 20 μg/mL. This compound is useful for research in antimicrobial drug development and the study of marine-derived natural products. -
Antibacterial agent
Antibacterial Agent 245 (Dc-2) is an effective antibacterial compound targeting plant pathogenic fungi and bacteria. It demonstrates a potent activity with an EC50 value of 1.29 μg/mL against Botrytis cinerea. This reagent is suitable for research applications in plant pathology and the development of biocontrol agents. -
Anti-Bacterial Agent
Galacardin A is an anti-bacterial agent that primarily exhibits activity against Gram-positive bacteria. Its mechanism of action involves disrupting bacterial cell wall synthesis, resulting in inhibition of bacterial growth. Galacardin A is suitable for research applications focused on developing new antibacterial therapies and studying microbial resistance. -
Anti-Bacterial Agent
Polymyxin S1 is an anti-bacterial agent derived from Bacillus polymyxa RS-6, known for its potent activity against Gram-negative bacteria. This compound disrupts bacterial cell membrane integrity, leading to cell lysis and death. Polymyxin S1 is primarily utilized in research focusing on antibiotic action mechanisms and the development of new antimicrobial strategies. It offers valuable insights for studies targeting drug resistance and the efficacy of antibacterial compounds. -
Anti-Bacterial Agent
Pacidamycin 5 is an anti-bacterial agent that exhibits inhibitory activity against Pseudomonas aeruginosa. Additionally, it demonstrates effectiveness against various strains of bacteria, including Staphylococcus aureus and Escherichia coli. This compound is valuable for research applications focused on the development of novel antibacterial therapies. -
Anti-Bacterial Agent
Cephamycin A is an antibiotic that primarily targets bacterial cell wall synthesis. It exhibits moderate antibacterial activity against a range of Gram-positive and Gram-negative bacteria. This compound is useful in research applications focused on developing novel antibacterial agents and studying bacterial resistance mechanisms. -
Anti-Bacterial Agent
Fluoropolyoxin M is an anti-bacterial agent that exhibits inhibitory activity against Escherichia coli and Streptococcus faecalis. This compound is primarily utilized in research focused on bacterial infections and antibiotic resistance mechanisms. Its effectiveness against these pathogens makes it a valuable tool for studies in microbiology and pharmacology. -
Bacterial Inhibitor
CID21480113 is an inhibitor targeting bacterial pathways, specifically effective against dapsone-resistant strains of leprosy. This compound demonstrates significant antibacterial activity, making it a valuable tool for research in microbial resistance and infectious disease studies. Its ability to combat resistant bacteria positions CID21480113 as a relevant reagent for investigations into alternative therapies for leprosy. -
Anti-Bacterial Agent
Cyclacidin is an anti-bacterial agent targeting Gram-positive bacteria, including Bacillus subtilis and Gambusia occidentalis. It exhibits significant antimicrobial activity and demonstrates an inhibitory effect on sarcoma 180 cells. This compound is valuable for research applications focused on bacterial infections and cancer therapeutic strategies. -
Streptomycin Biosynthesis Inducer
A-Factor is a potent inducer of streptomycin biosynthesis in the inactive mutant strain of Streptomyces griseus. Additionally, A-Factor promotes spore formation during the conidial development of Magnaporthe oryzae. This reagent is valuable for researchers studying antibiotic production and fungal development processes. -
Anti-Bacterial Agent
1-Hydroxycrisamicin A is an effective anti-bacterial agent primarily targeting Gram-positive bacteria. It exhibits potent activity with a minimum inhibitory concentration (MIC) ranging from 0.78 to 3.12 μg/mL. This compound holds significant potential for research applications in the study of bacterial infections and the development of new antimicrobial therapies.
