Catalog No.
Product Name
Application
Product Information
Citations
-
Cardioprotective Agent
FX-06 (Fibrin-derived peptide Bβ15-42) is a cardioprotective agent that primarily targets VE-cadherin. It inhibits leukocyte transmigration and activates VE-cadherin-mediated signaling pathways, thus providing a protective effect in conditions involving ischemia/reperfusion injury. FX-06 is particularly relevant for research applications related to cardiovascular diseases and Dengue shock syndrome (DSS). -
AChE Inhibitor
Temephos is an organophosphate insecticide that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This inhibition leads to cholinergic overactivation, effectively disrupting the larval development of Aedes aegypti and Aedes albopictus, making it a valuable tool in research concerning Dengue Virus, Zika Virus, and other mosquito-borne pathogens. While exhibiting important biological activity, Temephos has been shown to cause genotoxicity, neurodevelopmental toxicity, and potential liver and reproductive system effects in mammals. Additionally, it can accumulate in adipose tissues and aquatic organisms, with its metabolism primarily occurring through oxidation and hydrolysis. Temephos serves as a critical reagent in studies of vector control and viral transmission dynamics. -
PAFR Antagonist
(Rac)-Modipafant is a selective, long-acting irreversible antagonist of the platelet activating factor receptor (PAFR). This compound demonstrates significant biological activity by effectively inhibiting PAFR-mediated pathways, which plays a critical role in regulating inflammatory responses. Research applications include the investigation of dengue virus infection mechanisms and the potential therapeutic effects of PAFR blockade in various inflammatory diseases. -
Golgicide A Derivative
Golgicide A-2 is a potent derivative of Golgicide A, exhibiting the highest activity among its enantiomers. This compound demonstrates significant selectivity and efficiency in eliminating Anopheles stephensi larvae, making it a valuable tool for research on dengue virus-related diseases. Its targeted action provides insight into vector control and disease transmission studies. -
Dengue Viru Inhibitor
BP13944 is a small molecule inhibitor that targets the dengue virus (DENV) by inhibiting its NS3 protease. It demonstrates significant antiviral activity, effectively suppressing the replication of all four DENV serotypes with an EC50 value of 1.03±0.09 μM, while showing no toxicity to host cells. Notably, the presence of the E66G mutation in the NS3 protease confers resistance to BP13944. As a promising candidate for dengue virus intervention, BP13944 represents a potential therapeutic agent in the absence of effective vaccines or treatments for dengue. -
Antiviral Agent
FGI-106 is a potent, broad-spectrum antiviral agent that targets multiple viral pathogens. It demonstrates significant inhibitory activity against Ebola, Rift Valley, and Dengue viruses with EC50 values of 100 nM, 800 nM, and 400-900 nM, respectively. Additionally, FGI-106 effectively inhibits non-hemorrhagic fever viruses such as HCV and HIV-1, exhibiting EC50 values of 200 nM and 150 nM, respectively. This compound is a valuable tool for research focusing on antiviral therapies and the study of viral infections. -
Dengue Viru Inhibitor
ST-148 is a novel small molecule compound that acts as a potent inhibitor of all four serotypes of the dengue virus. In studies using a nonlethal AG129 mouse model, ST-148 significantly decreased viremia and viral load in key organs, while also showing a tendency to reduce plasma cytokine levels. The mechanism of action involves direct interaction with the dengue virus capsid protein, indicating that ST-148 interferes with specific stages of the viral replication cycle, which may provide avenues for therapeutic development against dengue virus infections. -
DENV-1/DENV-2 Inhibitor
DENV-IN-12 is a potent inhibitor targeting Dengue Virus serotypes 1 and 2. This compound, a derivative of N-methylcytisine thio, demonstrates significant antiviral activity against DENV-2, with EC50 values ranging from 0.002 to 0.005 μM across various cell lines. DENV-IN-12 serves as a valuable tool for research applications focused on understanding dengue virus pathogenesis and developing antiviral therapeutics. -
DENV2 Inhibitor
DENV-IN-9 (Compound 5f) is a potent inhibitor of the dengue virus serotype 2 (DENV2), exhibiting an EC50 of 0.88 μM. This compound effectively curtails viral replication, making it a valuable tool for research focused on dengue virus pathology and potential antiviral therapeutic strategies. Its potency and specificity position DENV-IN-9 as a significant candidate for studies aimed at understanding DENV2 inhibition mechanisms. -
Antimicrobial Peptides
Hs-1 is an antimicrobial peptide that exhibits significant antiviral activity, offering approximately 80% protection against the dengue-2 virus. This peptide is valuable for research into therapeutic agents targeting viral infections. Its mechanism involves perturbation of viral membrane integrity, making it a useful tool for studies on peptide-based antiviral strategies. -
Antiviral Agent
OSL-95II is a potent antiviral agent that targets various viral infections. It effectively inhibits Bovine Viral Diarrhea Virus (BVDV) and West Nile Virus (WNV), displaying superior activity against Hepatitis B Virus (HBV) compared to other compounds. Additionally, OSL-95II demonstrates significant inhibitory effects on dengue virus production, making it a valuable tool for research in virology and antiviral therapeutics. -
Antiviral Agent
ZK-806450 is an antiviral agent that exhibits high binding affinity to the allosteric site of the SARS-CoV-2 3CL protease. Additionally, ZK-806450 demonstrates specific and stable binding to the GAG site of the dengue virus envelope protein. This compound is valuable for research focused on the inhibition of viral replication and the development of antiviral therapies. -
DENV2 Inhibitor
DENV-IN-8 is a selective DENV2 inhibitor that exhibits an EC50 value of 0.068 μM. This compound effectively disrupts viral replication, making it a valuable tool for research aimed at understanding dengue virus pathogenesis and developing antiviral strategies. Its high potency and specificity for DENV2 facilitate studies in virology and drug discovery. -
Anti-Dengue Agent
Sinococuline is a potent anti-dengue agent that specifically targets all four serotypes of Dengue virus (DENV). In addition to its antiviral properties, Sinococuline demonstrates significant efficacy as a tumor cell growth inhibitor, making it a valuable reagent for both infectious disease research and cancer studies. Its dual functionality allows for exploration in diverse biological applications and therapeutic strategies. -
RdRp Domain Inhibitor
NITD-203 is an inhibitor targeting the RNA-dependent RNA polymerase (RdRp) domain. It exhibits potent inhibitory activity against all four serotypes of dengue virus (DENV), as well as yellow fever virus (YFV) and West Nile virus (WNV). This compound is valuable for research applications focusing on the development of antiviral therapies and understanding the molecular mechanisms of viral replication. -
WNV Protease Substrate
DEPN-8 is a substrate specifically designed for West Nile Virus (WNV) protease. Its primary application lies in the development of inhibitors targeting the protease of the dengue virus. This compound is crucial for advancing research in antiviral drug discovery and understanding proteolytic processes associated with flavivirus infections. -
Antiviral Agent
DN59 is a 33 amino acid peptide that targets dengue virus type 2 by mimicking the E stem region. It exhibits potent antiviral activity against all four serotypes of the dengue virus, with an IC50 ranging from 2 to 5 μM, and also acts against other flaviviruses. By interacting directly with viral particles, DN59 facilitates the release of genomic RNA, making it a valuable tool in virology research and the development of antiviral strategies. -
DENV Inhibitor
DENV-IN-10 is a potent tetravalent inhibitor targeting dengue virus (DENV). It demonstrates effective suppression of DENV replication with EC50 values of 1.36, 0.87, 0.94, and 0.95 μM against DENV serotypes 1-4, respectively. This compound functions as a post-entry replication inhibitor, exhibiting specificity for primate-derived cells, making it a valuable tool for research into dengue virus biology and therapeutic intervention. -
DENV Inhibitor
SDM25N is a Dengue virus (DENV) inhibitor that targets the NS4B protein, effectively disrupting genomic RNA replication. With an EC50 of 1.9 µM, SDM25N demonstrates cell type-specific inhibition of DENV. This compound is valuable for research into DENV infection and the mechanisms of viral replication. -
Polypeptide
2A/2B Dengue protease substrate (Ac-RTSKKR-pNA) is a polypeptide substrate designed for the Dengue NS2B-NS3 protease. This substrate facilitates the understanding of protease activity by serving as a valuable tool in the development of selective inhibitors targeting the Dengue NS2B-NS3 protease. Its efficacy in research applications enhances the study of dengue virus pathogenesis and potential therapeutic strategies. -
Endoplasmic Reticulum α-glucosidase II (GluII) Inhibitor
ToP-DNJ is a specific inhibitor of endoplasmic reticulum α-glucosidase II (GluII), demonstrating an IC50 value of 9.0 μM. It selectively interferes with both catalytic reactions of GluII, showing enhanced activity in the initial conversion of di-glycosylated to mono-glycosylated glycans. Additionally, ToP-DNJ exhibits anti-DENV activity, making it a valuable tool for research into dengue virus infection and related glycobiology studies. -
NS4B Inhibitor
JMX0254 is a potent inhibitor of the dengue virus NS4B protein, exhibiting oral bioavailability. It displays effective antiviral activity with EC50 values of 0.78 µM, 0.16 µM, and 0.035 µM against DENV-1, DENV-2, and DENV-3, respectively. This compound is valuable for research applications focused on understanding and combating dengue virus infections. -
Influenza Viru Inhibitor
SP187 hydrochloride is a host-targeting iminosaccharide that primarily inhibits endoplasmic reticulum glucosidase, rendering it effective against filovirus infections. This compound demonstrates antiviral activity, notably against the Dengue virus, in vivo. SP187 hydrochloride is a valuable tool for researchers investigating antiviral mechanisms and developing therapeutic strategies against viral infections. -
DENV MTase Inhibitor
CNP0296775 is a potent inhibitor of dengue virus methyltransferase (DENV MTase), targeting key enzymatic processes involved in viral replication. By disrupting the activity of this enzyme, CNP0296775 shows promise in studying dengue virus pathogenesis and could serve as a valuable tool in antiviral research. Its application in preclinical studies may aid in the development of novel therapeutic strategies for dengue virus infections. -
NS2B-NS3 Inhibitor
NS2B/NS3-IN-9 is a non-competitive inhibitor targeting the NS2B-NS3 protease of Orthoflavivirus, demonstrating broad-spectrum antiviral activity. It exhibits IC50 values of 2.4 μM, 7.2 μM, and 1.9 μM against the Dengue virus DENV2, West Nile virus WNV, and Zika virus ZIKV, respectively. Additionally, NS2B/NS3-IN-9 shows cellular EC50 values of 4.1 μM for DENV2, 4.9 μM for WNV, and 5.0 μM for ZIKV, while exhibiting minimal toxicity to host cells. This compound is suitable for research applications focused on inhibiting Orthoflavivirus infections. -
NS2B·NS3 Protease Inhibitor
CN-716 dihydrochloride is a reversible covalent inhibitor targeting the NS2B·NS3 protease of flaviviruses, demonstrating significant antiviral activity. This compound effectively impedes the replication of dengue virus (DENV2), West Nile virus (WNV), and Zika virus (ZIKV), with IC50 values of 0.066 μM, 0.11 μM, and 0.25 μM, respectively. Additionally, CN-716 dihydrochloride exhibits Ki values of 0.051 μM, 0.082 μM, and 0.04 μM against the same proteases. It serves as a valuable tool for investigating the infection mechanisms associated with dengue fever, West Nile fever, and Zika virus infection. -
NS2B-NS3 Inhibitor
Ac-EVKKQR-pNA is a competitive chromogenic para-nitroanilide substrate designed to probe the NS2B-NS3 cleavage site. This reagent includes a readily hydrolyzable para-nitroanilide at the P1’ position, enhancing its reactivity. It is primarily used in studies of dengue virus type 2 and other flavivirus infections, facilitating the exploration of viral protease activity and potential therapeutic interventions. -
AAK1 Inhibitor
AAK1-IN-6 is a potent inhibitor of AP-2-associated protein kinase 1 (AAK1) with an IC50 value of 12 nM. This compound exhibits significant antiviral activity against dengue virus (DNEV2, EC50 = 0.24 μM) and Venezuelan equine encephalitis virus (VEEV, EC50 = 0.30 μM). AAK1-IN-6 is a valuable tool for researchers investigating antiviral mechanisms and potential therapeutic strategies. -
NS2B-NS3/thrombin Inhibitor
5-((1H-Indol-3-yl)methylene)imidazolidine-2,4-dione is a potent inhibitor of the dengue virus NS2B-NS3 protease and thrombin. This compound is valuable for studying the mechanisms of viral replication and coagulation processes, making it an essential tool in research focused on infectious diseases and related therapeutic interventions. Its dual activity highlights its potential for investigating the dynamics of viral pathology and thrombotic complications. -
Purine Analogue
ZX-2401 is a 1,3,5-Triazine-based analogue of purine that exhibits significant antiviral activity against viruses in the Flaviviridae family, including West Nile Virus (WNV), Hepatitis C (HCV), Yellow Fever Virus (YFV), Dengue Virus (DV), Bovine Viral Diarrhea Virus (BVDV), and Banzi Virus (BV), with effective concentrations (EC90s) ranging from 0.6 to 10 μg/mL. This compound effectively reduces viral production, demonstrating an EC90 of 3.3 mg/mL. ZX-2401 is suitable for research applications focused on influenza infections and related viral pathogenesis. -
Psoralen Derivative, Viral Inactivator
Aminomethyltrioxsalen hydrochloride is a psoralen derivative that acts as a viral inactivator through nucleic acid intercalation. It effectively penetrates intact cells, allowing it to react with nucleic acid secondary structures in vivo while preserving the integrity of natural nucleoprotein tissues. Upon exposure to UV-A radiation, it crosslinks pyrimidine residues in viral nucleic acids, leading to inactivation of viruses. This reagent is valuable for research applications related to viral infections, including studies on dengue virus. -
DENV Inhibitor
(-)-JNJ-A07 is a potent and selective inhibitor of Dengue Virus (DENV) with an EC50 value of 31 nM. It demonstrates significant antiviral activity, making it a valuable tool for research in virology and the study of DENV pathogenesis. This compound is suitable for investigations into potential therapeutic strategies for dengue fever and other flavivirus-related diseases. -
δ-Opioid Receptor Antagonist/DENV Inhibitor
SDM25N hydrochloride is a potent δ-opioid receptor antagonist that also serves as an effective inhibitor of the dengue virus (DENV). It specifically targets the viral NS4B protein, significantly limiting genomic RNA replication. This compound presents valuable opportunities for research on antiviral strategies and the role of δ-opioid receptors in viral pathogenesis. -
STT3A-mediated Mega Protein Complex Assembly Inhibitor
NSC-323241 is an STT3A-mediated mega protein complex assembly inhibitor that effectively disrupts the endoplasmic reticulum (ER) mega complex essential for dengue virus (DENV) and Zika virus (ZIKV) infection. By targeting the interaction between the STT3A subcomplex, viral nonstructural proteins (e.g., NS2B, NS3), and host translocon proteins, NSC-323241 impedes the establishment of the viral replication microenvironment. This compound is valuable for investigating the mechanisms of flavivirus infections, including dengue fever and Zika virus. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-1 is a non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating an IC50 of 1.8 μM. This compound also effectively inhibits the NS2B-NS3 proteases of T156I-mutated dengue virus 2 (DENV2) and West Nile virus (WNV), with IC50 values of 3.9 μM and 4.7 μM, respectively. IRBM-Z-1 is capable of inhibiting ZIKV replication and reducing virus-induced cytopathic effects, making it a valuable tool for research focused on ZIKV infection and associated viral pathogenesis. -
ZIKV NS2B-NS3 Protease Inhibitor
IRBM-Z-2 is an orally active, non-competitive inhibitor targeting the Zika virus (ZIKV) NS2B-NS3 protease, demonstrating IC50 values of 0.04 μM for the wild-type and 3.1 μM for the I156T mutant strains. This compound exhibits broad-spectrum activity against flaviviruses, with IC50 values of 2.1 μM and 0.09 μM against the NS2B-NS3 proteases of dengue virus serotype 2 (DENV2) and West Nile virus (WNV), respectively. IRBM-Z-2 effectively inhibits ZIKV replication and mitigates virus-induced cytopathic effects, making it a valuable tool for research on ZIKV infection and the study of flavivirus-related diseases. -
IRF3 Activator
KIN1400 is a potent IRF3 activator that stimulates the expression of IRF3-dependent antiviral genes, including RIG-I, MDA5, IFIT1, and Mx1, as well as IFN-β production. This compound effectively inhibits the replication of West Nile Virus (WNV) and Dengue Virus (DV), both of which are mosquito-borne flaviviruses, as well as Hepatitis C Virus (HCV). KIN1400 activates innate antiviral immunity via the MAVS-IRF3 signaling pathway, making it a valuable tool for research focused on antiviral responses and immune modulation. -
COVID-19 Inhibitor
RBT-9 is a COVID-19 inhibitor that targets viral replication and inflammation pathways. It has demonstrated efficacy in preventing the progression to severe COVID-19 and associated organ failure. Furthermore, RBT-9 exhibits antiviral activity against various enveloped viruses, including influenza, hepatitis C virus (HCV), dengue, and yellow fever, making it a valuable tool for research in viral pathogenesis and therapeutic intervention. -
α-glucosidase Inhibitor
CM-10-18 is a potent inhibitor of α-glucosidases I and II, demonstrating significant activity in vitro and in animal models. This compound also exhibits antiviral properties by inhibiting dengue virus (DENV) infection in cultured human cells, while effectively reducing peak viremia in mice. CM-10-18 is valuable for research applications related to glycosidase inhibition and viral pathogenesis. -
Anti-Viral Agent
IHVR-17028 is a broad-spectrum antiviral agent that primarily targets endoplasmic reticulum α-glucosidase I. It demonstrates significant antiviral activity against various viruses, including Bovine viral diarrhea virus (BVDV), Tick-borne choriomeningitis virus (TCRV), and Dengue virus (DENV), with EC50 values of 0.4 μM, 0.26 μM, and 0.3 μM, respectively. With an IC50 of 0.24 μM, it effectively inhibits ER α-glucosidase I, making it a valuable tool for research into infectious diseases. -
Stable Isotope
Loratadine-d5-1 is a deuterated analog of Loratadine, which serves as a selective inverse agonist of peripheral histamine H1 receptors. It exhibits an IC50 of greater than 32 μM and has been shown to possess anti-dengue virus (DENV) activity. Additionally, Loratadine is capable of inhibiting the immunologic release of inflammatory mediators, making it a valuable tool for research in allergy and inflammation studies. -
Fluorescent Dye
Primulin is a fluorescent dye that exhibits strong binding affinity for albumin, making it a valuable tool in various analytical and biological studies. This compound effectively labels plant cell walls and distinguishes between live and dead spermatozoa through distinct fluorescence patterns. In neurobiology, Primulin serves as a retrograde axonal tracer, while its derivatives demonstrate inhibitory activity against HCV NS3 and interference with dengue virus NS3-mediated ATP hydrolysis. Additionally, Primulin disrupts HCV replicase assembly, highlighting its potential in virology research applications. -
D2R Antagonist
Prochlorperazine dimaleate is an orally active dopamine D2 receptor (D2R) antagonist. It demonstrates notable anti-cancer activity in vitro against a range of cancer cell lines, with IC50 values of 6.4 μM for NOX1, 4.5 μM for NOX2, and 2.3 μM for NOX5. Additionally, prochlorperazine dimaleate exhibits antedesmosidic activity against the dengue virus (DENV). This compound is valuable for research aimed at understanding and treating conditions such as nausea, vomiting, migraine, and schizophrenia. -
Drug Isomer
(+)-Mosnodenvir is a drug isomer that acts as an orally active pan-serotype inhibitor of the dengue virus (DENV). It demonstrates potent antiviral activity, with EC50 values ranging from 0.057 to 11 nM across four DENV serotypes. The compound functions by inhibiting the interaction between nonstructural proteins NS3 and NS4B, thereby disrupting viral replication and the synthesis of new viral RNA. (+)-Mosnodenvir has shown significant antiviral efficacy in vitro as well as in animal models, including mice and non-human primates, making it a valuable tool for dengue virus research. -
Insecticide
Tetramethylfluthrin is an insecticide that effectively targets Aedes albopictus, demonstrating rapid population reduction when delivered through unmanned aerial vehicle cold mist spray. This compound exhibits a strong knock-down effect and high toxicity to the target insect species. Tetramethylfluthrin is valuable for research related to dengue fever and dengue hemorrhagic fever, facilitating studies on vector control and disease transmission.
