(+)-Mosnodenvir is a drug isomer that acts as an orally active pan-serotype inhibitor of the dengue virus (DENV). It demonstrates potent antiviral activity, with EC50 values ranging from 0.057 to 11 nM across four DENV serotypes. The compound functions by inhibiting the interaction between nonstructural proteins NS3 and NS4B, thereby disrupting viral replication and the synthesis of new viral RNA. (+)-Mosnodenvir has shown significant antiviral efficacy in vitro as well as in animal models, including mice and non-human primates, making it a valuable tool for dengue virus research.
(+)-Mosnodenvir is a drug isomer that acts as an orally active pan-serotype inhibitor of the dengue virus (DENV). It demonstrates potent antiviral activity, with EC50 values ranging from 0.057 to 11 nM across four DENV serotypes. The compound functions by inhibiting the interaction between nonstructural proteins NS3 and NS4B, thereby disrupting viral replication and the synthesis of new viral RNA. (+)-Mosnodenvir has shown significant antiviral efficacy in vitro as well as in animal models, including mice and non-human primates, making it a valuable tool for dengue virus research.
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