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DN59

Catalog No.: A50726
Antiviral Agent
DN59 is a 33 amino acid peptide that targets dengue virus type 2 by mimicking the E stem region. It exhibits potent antiviral activity against all four serotypes of the dengue virus, with an IC50 ranging from 2 to 5 μM, and also acts against other flaviviruses. By interacting directly with viral particles, DN59 facilitates the release of genomic RNA, making it a valuable tool in virology research and the development of antiviral strategies.
DN59 869011-94-9 Antiviral Agent
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Research use only. We do not sell to patients.
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Adooq Products cited in reputable paper
Science VOLUME 380, ISSUE 6663 (2023)
Science VOLUME 369, ISSUE 6510 (2020)
Science VOLUME 356, ISSUE 6336 (2017)
Cell Vol. 185 Issue 23 p4428-4447.e28
Cell Vol 177, Issue 7, p1933-1947.e25
Cell Vol 156, Issue 5, p857-1114
Nature Volume 622 Issue 7982 (2023)
Nature volume 620, pages890-897 (2023)
Nature volume 610, pages540-546 (2022)
Nature volume 588, pages83-88 (2020)
Nature volume 574, pages268-272 (2019)
Nature volume 573, pages539-545 (2019)
Nature volume 567, pages118-122 (2019)
Nature volume 551, pages639-643 (2017)
Nature volume 551, pages247-250 (2017)
Nature volume 548, pages356-360 (2017)
Nature volume 545, pages187-192 (2017)
Biological Activity
DescriptionDN59 is a 33 amino acid peptide that targets dengue virus type 2 by mimicking the E stem region. It exhibits potent antiviral activity against all four serotypes of the dengue virus, with an IC50 ranging from 2 to 5 μM, and also acts against other flaviviruses. By interacting directly with viral particles, DN59 facilitates the release of genomic RNA, making it a valuable tool in virology research and the development of antiviral strategies.
Product Information
Catalog NumA50726
FormulaC161H240N38O44S
Molecular Weight3443.92
CAS Number869011-94-9
SequenceMet-Ala-Ile-Leu-Gly-Asp-Thr-Ala-Trp-Asp-Phe-Gly-Ser-Leu-Gly-Gly-Val-Phe-Thr-Ser-Ile-Gly-Lys-Ala-Leu-His-Gln-Val-Phe-Gly-Ala-Ile-Tyr
Sequence shorteningMAILGDTAWDFGSLGGVFTSIGKALHQVFGAIY
SMILESC([C@@H](C(N[C@H](C(N[C@@H](CC1=CC=CC=C1)C(NCC(N[C@H](C(N[C@H](C(NCC(NCC(N[C@H](C(N[C@@H](CC2=CC=CC=C2)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=CC=C4)C(NCC(N[C@H](C(N[C@H](C(N[C@@H](CC5=CC=C(O)C=C5)C(O)=O)=O)[C@H](CC)C)=O)C)=O)=O)=O)[C@H](C)C)=O)CCC(N)=O)=O)=O)CC(C)C)=O)C)=O)CCCCN)=O)=O)[C@H](CC)C)=O)CO)=O)[C@@H](C)O)=O)=O)[C@H](C)C)=O)=O)=O)CC(C)C)=O)CO)=O)=O)=O)CC(O)=O)=O)NC([C@@H](NC([C@@H](NC([C@@H](NC(CNC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](CCSC)N)=O)C)=O)[C@H](CC)C)=O)CC(C)C)=O)=O)CC(O)=O)=O)[C@@H](C)O)=O)C)=O)C=6C=7C(NC6)=CC=CC7
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Microbiology > Antifection > Dengue Virus
Microbiology > Antifection > Flavivirus