Catalog No.
Product Name
Application
Product Information
Citations
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HDM Inhibitor
HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance. -
Antifungal Agent
Fluconazole is a triazole antifungal agent that primarily targets fungal infections by inhibiting the synthesis of ergosterol, an essential component of fungal cell membranes. It exhibits potent activity against a wide spectrum of fungi, particularly Candida albicans and Candida kefyr, with IC99 values ranging from 0.20 μg/mL to 0.39 μg/mL. Fluconazole is widely utilized in research to study fungal pathogenesis and develop therapeutic strategies against fungal infections. -
Antifungal Agent
Miconazole is an imidazole antifungal agent that acts through the inhibition of ergosterol synthesis, disrupting fungal cell membrane integrity. In addition to its antifungal properties, Miconazole exhibits antibacterial effects, making it a versatile compound in microbiological studies. This reagent is commonly utilized in research focusing on antifungal therapies and mechanisms of microbial resistance. -
Antifungal Agent
Miconazole nitrate is an imidazole antifungal agent that exhibits its primary mechanism through the inhibition of ergosterol synthesis, leading to compromised fungal membrane integrity. This compound demonstrates significant antifungal activity against a broad spectrum of fungi, making it valuable for research in antifungal drug development and therapeutic applications. Additionally, Miconazole nitrate possesses antibacterial properties, contributing to its utility in studies related to infections and microbial resistance. -
Antimicrobial Agent
Terbinafine is a potent antimicrobial agent that primarily acts as a non-competitive inhibitor of squalene epoxidase, exhibiting a Ki of 30 nM against Candida species. This compound demonstrates significant antifungal activity and also shows antibacterial effects against select Gram-positive and Gram-negative bacteria. Additionally, Terbinafine features an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for versatile chemical applications in research. -
Antifungal Agent
Oxiconazole nitrate is a broad-spectrum antifungal agent targeting various fungal pathogens, including Candida, Aspergillus, and Trichophyton. In addition to its antifungal properties, it acts as a potent activator of CYP3A4 transactivation, with the potential for competitive antagonism by Rifampicin. Furthermore, Oxiconazole nitrate exhibits inhibitory effects against colorectal cancer through mechanisms involving peroxiredoxin-2 (PRDX2)-mediated autophagy arrest, making it valuable for research in both antifungal therapy and cancer biology. -
Squalene Epoxidase Inhibitor
Liranaftate is a potent squalene epoxidase inhibitor exhibiting anti-fungal properties. It is primarily utilized in research focusing on dermatophyte infections. Additionally, Liranaftate has been shown to suppress the fungal element-mediated production of interleukin-8 (IL-8) and modulate inflammatory responses, making it valuable for studies involving inflammatory pathways in fungal infections. -
Antifungal Agent
Gartanin is a natural xanthone derived from mangosteen, primarily functioning as an antifungal agent. It exhibits significant antioxidant and anti-inflammatory properties, alongside neuroprotective and antineoplastic effects. Gartanin has been shown to induce cell cycle arrest and autophagy, while also inhibiting migration in human glioma cells, making it a valuable compound for research in cancer and fungal pathologies. -
Fungal Inhibitor
Pseudolaric Acid C is a bioactive diterpenoid derived from the root bark of Pseudolarix amabilis, primarily acting as a fungal inhibitor. It exhibits significant antifungal activity, making it a valuable tool for research focused on fungal pathogenesis and the development of antifungal therapies. Its ability to disrupt fungal growth positions it as an important compound in the study of mycology and related fields. -
Fungal Inhibitor
5-Hydroxymethylfurfural is a furan derivative that serves as a potent fungal inhibitor. It exhibits anti-yeast activity by suppressing growth and fermentation under stress conditions, making it valuable for studies related to microbial resistance and fermentation processes. This compound is utilized in research focused on food preservation and biotechnological applications. -
Bactericidal Agent
Terpinen-4-ol, a naturally occurring monoterpene, acts primarily as a bactericidal agent. This compound exhibits significant antifungal, anti-inflammatory, and antitumor activities, making it a valuable tool for diverse research applications, especially in the study of microbial resistance and inflammation. Its multiple biological effects also support investigations into potential therapeutic uses in various diseases. -
Bicyclic Sesquiterpene
Caryophyllene oxide is a bicyclic sesquiterpene known for its anticancer properties, particularly its ability to induce apoptosis in PC-3 prostate cancer cells. This compound also exhibits significant analgesic and anti-inflammatory activities, making it valuable for pain management research. Additionally, caryophyllene oxide demonstrates a range of biological activities, including insecticidal, antioxidant, antimicrobial, antifungal, and antiparasitic effects, supporting its utility in various pharmacological studies and natural product research. -
Anti-Fungal Agent
Hypocrellin B is a photosensitizer with significant apoptotic properties, primarily used in photodynamic therapy for cancer treatment. Isolated from the fungi Hypocrella bambusae and Shiraia bambusicola, it exhibits both antimicrobial and antileishmanial activities. This compound is valuable in research exploring its efficacy against various fungal infections and its potential therapeutic applications in oncology. -
Antifungal Agent
4-Methylcinnamic acid is a cinnamic acid derivative primarily known for its antifungal properties. This compound demonstrates the capability to enhance the efficacy of traditional antifungal agents by lowering their minimum inhibitory concentrations, particularly in the presence of glutathione reductase mutants. Its mechanism includes disrupting fungal cell walls, making it a promising candidate for research into combating drug-resistant fungi. 4-Methylcinnamic acid shows potential applications in the development of more effective antifungal therapies. -
Antifungal Agent
Vincetoxicoside B is an antifungal agent that exhibits potent activity against various fungal pathogens. This compound can be utilized in research focused on fungal infections and the development of new therapeutic strategies. Its mechanism of action and efficacy make it a valuable tool in the study of antifungal mechanisms and resistance. -
Fungal Inhibitor
Hecogenin is a steroid saponin derived from Agave sisalana, known for its selective inhibition of human UDP-glucuronosyltransferases. It exhibits a diverse range of biological activities, particularly as a potent antifungal agent, while also demonstrating anti-inflammatory and gastroprotective properties. Hecogenin is of interest in pharmacological research for its potential therapeutic applications in treating fungal infections and inflammatory conditions. -
Cytochrome P450 1A1 Inactivator
Rhapontigenin is a potent and selective inactivator of cytochrome P450 1A1, demonstrating an IC50 of 400 nM. This natural analog of resveratrol exhibits significant anticancer, antioxidant, antifungal, and antibacterial properties. Due to its 400-fold and 23-fold selectivity for P450 1A1 over P450 1A2 and P450 1B1, respectively, Rhapontigenin is a valuable tool for research focused on cancer biology and drug metabolism. -
Antifungal Agent
Xanthoxylin, an antifungal agent derived from Zanthoxylum simulans, exhibits notable antifungal and antioxidant properties. It demonstrates minimum inhibitory concentrations (MIC) of 50 µg/mL against Toxoplasma neonatorum and 75 µg/mL against Aspergillus fumigatus. This compound is valuable for investigating antifungal therapies and exploring potential applications in the context of anti-epileptic diseases. -
Antibacterial/Antifungal agent
Dehydroacetic acid is a pyrone derivative known for its antibacterial and antifungal properties. This compound exhibits significant phytotoxic activity, making it a valuable agent in various applications such as preservation in cosmetics, food, and beverages. Additionally, dehydroacetic acid serves as a precursor in the synthesis of various heterocycles and cycloaddition products, providing utility in chemical research and development. -
Antifungal Agent
Sertaconazole nitrate is a broad-spectrum topical antifungal agent that primarily targets fungal infections. In addition to its antifungal properties, it exhibits anti-inflammatory activity through the activation of the p38-COX-2-PGE2 pathway. Sertaconazole nitrate also acts as a microtubule inhibitor, demonstrating antiproliferative effects, as well as the ability to induce apoptosis and autophagy. Furthermore, it can inhibit cell migration, making it valuable for various research applications in mycology and cellular biology. -
Antifungal Agent
Sulconazole mononitrate is an imidazole derivative that acts as a broad-spectrum antifungal agent. It exhibits significant efficacy against various fungal infections, making it useful for research related to dermatomycoses, pityriasis versicolor, and cutaneous candidiasis. This compound can facilitate studies aimed at understanding the mechanisms of fungal resistance and the development of effective treatment options. -
Antimicrobial Agent
Mafenide Acetate is a potent sulfonamide antimicrobial agent primarily targeting bacterial infections. It exhibits significant antibacterial activity against Staphylococcus aureus and Pseudomonas aeruginosa, as well as antifungal activity against filamentous fungi, including Lichtheimia and Aspergillus flavus. This compound is valuable in research applications related to skin grafts on burn wounds, post-traumatic invasive fungal infections, and the treatment of bacterially contaminated wounds. -
Antifungal Agent
10-Undecenoic acid zinc salt is an antifungal agent that targets various fungal pathogens. It demonstrates biological activity by inhibiting Aβ oligomerization, scavenging reactive oxygen species (ROS), and inhibiting μ-calpain activity, contributing to its neuroprotective properties. Additionally, this compound has anticancer effects against multiple tumor types and effectively inhibits biofilm formation by C. albicans as well as infections from MRSA. Furthermore, 10-Undecenoic acid zinc salt disrupts quorum sensing signals in Bacillus subtilis and Pseudomonas aeruginosa, highlighting its broad-spectrum antimicrobial potential. -
Antifungal/Exosome Inhibitor
Neticonazole hydrochloride is an imidazole derivative that acts as a potent antifungal agent through the inhibition of fungal sterol synthesis. In addition to its antifungal properties, it has shown promising anti-cancer effects, primarily through the modulation of exosome release and related pathways. This compound is suitable for research applications aimed at exploring antifungal therapies and investigating potential anti-cancer mechanisms. -
Fungal Inhibitor
Piroctone olamine is a pyridine derivative that acts as a potent fungal inhibitor by disrupting fungal cell membrane integrity. It exhibits fungicidal activity effective against a variety of dermatophytes and yeast, making it valuable for research in antifungal treatment and dermatological applications. Its mechanism of action supports investigations into fungal pathogenesis and the development of antifungal therapies. -
Antifungal Agent
Econazole is an orally active imidazole antifungal agent that primarily targets the cytochrome P-450 enzyme system. It demonstrates significant antifungal activity against various fungi and some Gram-positive bacteria, while lacking efficacy against Gram-negative bacteria. Additionally, econazole is known to inhibit prostaglandin synthesis and may induce hepatotoxicity, making it valuable in the study of antifungal resistance and the mechanisms of liver injury. -
Fungal Inhibitor
Dehydroacetic acid sodium is a pyrone derivative known for its fungicidal properties. It exhibits antibacterial and antifungal activity, making it valuable for applications in microbial control in various settings. Additionally, dehydroacetic acid demonstrates phytotoxic effects, indicating its potential use in agricultural research. -
Anti-Fungal Agent
Enactin Va is an anti-fungal agent derived from the strain of Streptomyces roseoviridis. It exhibits mild antifungal activity, making it suitable for research applications aimed at exploring antifungal properties and mechanisms of action. This compound can be utilized in studies focused on the development of novel antifungal therapies and the assessment of fungal resistance. -
Antifungal Agent
Cryptosporiopsin A is a polyketide that acts as an antifungal agent, demonstrating significant motility inhibitory and lytic activities against the zoospores of Plasmopara viticola, the pathogen responsible for grapevine downy mildew. This compound is valuable for research applications focused on understanding fungal biology and developing innovative antifungal strategies. -
Antimicrobial Agent
Octacosamicin B is an antimicrobial agent that exhibits activity against yeast and filamentous fungi. While its efficacy against bacteria is limited, it serves as a valuable tool in the study of antifungal mechanisms and the development of new antifungal therapies. This compound is useful in various research applications focused on microbial resistance and antifungal activity. -
Antifungal Antibiotic
Mucidin is an antifungal antibiotic that primarily targets the cytochrome bc1 complex within the mitochondrial respiratory chain, inhibiting electron-transfer reactions. This mechanism disrupts ATP production in fungi, leading to their growth inhibition. Mucidin is useful in research applications focused on fungal pathogenesis and mitochondrial function, providing insights into antifungal resistance and treatment strategies. -
Anti-Fungal Agent
Clavamycin A functions as a potent anti-fungal agent, exhibiting significant activity against Candida species. Its antifungal mechanism is characterized by substantial effectiveness that can be antagonized by the presence of dipeptides or tripeptides, while amino acids do not interfere with its action. Notably, Clavamycin A demonstrates no antibacterial properties and does not inhibit β-lactamase activity. This compound is valuable in studying fungal infections and antifungal resistance mechanisms. -
Antifungal Agent
Amphocil is an equimolar mixture of Amphotericin B and cholesteryl sulfate, serving as a potent antifungal agent. It demonstrates significant antifungal activity, making it particularly relevant for research focused on disseminated cryptococcosis. This formulation enhances the efficacy of Amphotericin B, thereby supporting investigations into treatment strategies for this invasive fungal infection. -
Antifungal Agent
Tetrahydroechinocandin B is a potent antifungal agent that primarily inhibits 1,3-beta-D-glucan synthesis, exhibiting an IC50 value of 0.85 μg/mL. This mechanism of action disrupts fungal cell wall integrity, making it effective against various fungal pathogens. Tetrahydroechinocandin B is commonly utilized in research applications aimed at understanding antifungal mechanisms and developing therapeutic strategies against fungal infections. -
Anti-Fungal Agent
Crocacin B is an anti-fungal agent that exhibits significant activity against both yeast and filamentous fungi. It has been shown to inhibit mouse fibroblast cells (L929), demonstrating its potential cytotoxic effects. Additionally, Crocacin B disrupts the bc1 segment of electron transport in calf heart microsomes, resulting in a redshift of the 569 nm peak in the cytochrome b reduction spectrum. This compound may serve as a valuable tool in fungal research and related applications. -
Antimicrobial Agent
Scorodonin is an antimicrobial agent that exhibits potent antibacterial and antifungal activities, particularly against Streptomyces species. It functions by inhibiting DNA-dependent RNA polymerases, demonstrating an IC50 of 25 μg/mL. This compound may be utilized in research applications focused on microbial resistance, the characterization of RNA polymerase activity, and the development of new antimicrobial agents. -
Anti-Fungal Agent
Neoenactin M2 is an anti-fungal agent that exhibits potent activity against both yeast-like and filamentous fungi. Its mechanism involves disrupting fungal cell membrane integrity, leading to cell death. This compound is valuable for research applications focused on fungal pathogenesis, drug resistance studies, and the development of antifungal therapies. -
Anti-Fungal Agent
Cyclopaldic acid is a potent anti-fungal agent that effectively inhibits spore germination in Garlic botrytis, demonstrating an inhibition rate of 95%-100% at a concentration of 2.5 μg/mL. This compound is valuable for research in fungal biology and plant pathology, providing insights into fungal inhibition mechanisms and potential agricultural applications. -
Phytotoxin
Zinniol is a penta-substituted benzene phytotoxin primarily associated with various phytopathogenic fungi. It has been identified in sunflower tissues during the early stages of infection, suggesting a role in the pathogenesis of sunflower diseases. This compound serves as a valuable tool for research into plant-fungal interactions and the biochemical mechanisms underlying plant diseases. -
Antimicrobial Agent
Darlucin B is an antimicrobial agent exhibiting potent antibacterial and antifungal activity while demonstrating weak cytotoxicity. It is primarily utilized in research applications focused on developing new antimicrobial therapies and understanding microbial resistance mechanisms. Its diverse biological activity makes it a valuable tool in the field of infectious disease research. -
Macrocyclic dilactone
De-N-methylpamamycin-593B is a macrocyclic dilactone characterized by its 16-membered ring structure. This compound exhibits Aerial Mycelium-inducing activity, making it a valuable tool for the study of fungal development and morphology. Its unique properties facilitate research into microbial fermentation processes and the regulation of secondary metabolism in various organisms. -
1,3-β-D-glucan Synthase Inhibitor
L 705589 is an inhibitor of 1,3-β-D-glucan synthase, targeting the synthesis of key structural components in the fungal cell wall. This semi-synthetic penicillin-type antifungal exhibits potent activity against various Candida species, including Candida albicans and Candida glabrata, with minimum fungicidal concentrations ranging from 0.06 to 8 µg/mL. It demonstrates limited efficacy against Cryptococcus neoformans (MFC: 32 - 64 µg/mL) yet maintains effectiveness against drug-resistant Candida strains and shows a reduced tendency to induce resistance. Additionally, L 705589 has been shown to enhance survival rates in models of minor invasive aspergillosis. -
Antifungal Agent
10-Undecenoic acid (copper) serves as an antifungal agent through its diverse mechanisms of action. It inhibits Aβ oligomerization, scavenges reactive oxygen species (ROS), and suppresses μ-calpain activity, contributing to its neuroprotective effects. Additionally, it demonstrates anticancer properties across various tumor types and effectively inhibits biofilm formation by Candida albicans and infections caused by Methicillin-resistant Staphylococcus aureus (MRSA). Furthermore, 10-Undecenoic acid (copper) disrupts quorum sensing signals in Bacillus subtilis and Pseudomonas aeruginosa, making it a valuable reagent for research in fungal infections and cancer biology. -
Secondary Metabolite
Aranorosinol A is a secondary metabolite known for its moderate antibacterial and antifungal activity. This compound is primarily utilized in research applications focused on natural product chemistry and pharmacological screening. Its efficacy against microbial pathogens makes it a valuable candidate for investigating new therapeutic approaches in infectious disease treatments. -
Fungal Inhibitor
Aliconazole is an imidazole derivative that functions as an antifungal agent by inhibiting fungal ergosterol synthesis, which is critical for maintaining cell membrane integrity. This compound exhibits activity against a range of fungal pathogens, making it suitable for applications in mycology research and exploring antifungal mechanisms. Its efficacy in treating fungal infections makes it a valuable reagent for studies focused on antifungal drug development and resistance mechanisms. -
CYP51 Inhibitor
CYP51-IN-30 is a potent inhibitor of CYP51, targeting sterol 14α-demethylase, an essential enzyme in sterol biosynthesis. This compound exhibits significant fungicidal activity, demonstrated by an EC50 value of 2.97 mg/L against Sclerotinia sclerotiorum. Its efficacy makes it a valuable tool for research in antifungal studies and applications in plant pathology. -
Antifungal Agent
Appenolide A is an antifungal furanone compound that derives from the coprophilous fungus Podospora appendiculata. It exhibits significant antifungal activity, making it a valuable tool for studying fungal biology and developing antifungal therapies. Its unique mechanism of action provides insights into fungal resistance and can aid in the discovery of new antifungal agents. -
Antifungal Agent
Rhizocticin A is an antifungal phosphono-oligopeptide that effectively targets fungi such as Ascodesmis, Plicaria, and Rhizoctonia. With a minimum inhibitory concentration (MIC) of 3.5 μg/mL, Rhizocticin A is capable of inhibiting fungal growth by producing the toxic metabolite L-2-Amino-5-phospho-3-cis-pentenoic acid (L-APPA), which disrupts vital cellular metabolism. This compound is valuable for research focused on fungal pathogenesis and the development of antifungal agents. -
Lead Compound
3-Amino-1,2,4-triazin-5(2H)-one is a lead compound targeting various biological pathways. This organic triazine derivative exhibits a wide array of biological activities, including antibacterial, antifungal, antiviral, and potential antitumor effects, which are influenced by its chemical structure and functional groups. It serves as a valuable reagent for research applications in pharmacology and medicinal chemistry, facilitating the discovery of new therapeutic agents. -
Fungicide
Iprovalicarb is a fungicide that functions by inhibiting fungal growth, targeting specific pathways involved in fungal cell metabolism. This compound is primarily utilized in research focused on fungal diseases, particularly within the winemaking industry. Its effectiveness against various fungal pathogens makes it a valuable tool for studying disease management strategies and developing protective measures in viticulture.
