Isavuconazonium sulfate (BAL8557-002) is an orally active, broad-spectrum antifungal prodrug that is rapidly hydrolyzed in vivo to yield the active triazole compound **Isavuconazole**. It exhibits potent antifungal activity by inhibiting lanosterol 14α-demethylase, a key enzyme in the ergosterol biosynthesis pathway, thereby disrupting fungal cell membrane integrity.
Isavuconazonium sulfate is effective against a wide range of pathogenic fungi, including *Aspergillus* and *Mucorales* species, and is used in the study and treatment of invasive aspergillosis, mucormycosis, blastomycosis, and *Acanthamoeba* keratitis. Its excellent oral bioavailability and favorable safety profile make it a valuable therapeutic and research tool in antifungal pharmacology.
Isavuconazonium sulfate (BAL8557-002) is an orally active, broad-spectrum antifungal prodrug that is rapidly hydrolyzed in vivo to yield the active triazole compound **Isavuconazole**. It exhibits potent antifungal activity by inhibiting lanosterol 14α-demethylase, a key enzyme in the ergosterol biosynthesis pathway, thereby disrupting fungal cell membrane integrity.
Isavuconazonium sulfate is effective against a wide range of pathogenic fungi, including *Aspergillus* and *Mucorales* species, and is used in the study and treatment of invasive aspergillosis, mucormycosis, blastomycosis, and *Acanthamoeba* keratitis. Its excellent oral bioavailability and favorable safety profile make it a valuable therapeutic and research tool in antifungal pharmacology.
Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 1 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
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