L 705589 is an inhibitor of 1,3-β-D-glucan synthase, targeting the synthesis of key structural components in the fungal cell wall. This semi-synthetic penicillin-type antifungal exhibits potent activity against various Candida species, including Candida albicans and Candida glabrata, with minimum fungicidal concentrations ranging from 0.06 to 8 µg/mL. It demonstrates limited efficacy against Cryptococcus neoformans (MFC: 32 - 64 µg/mL) yet maintains effectiveness against drug-resistant Candida strains and shows a reduced tendency to induce resistance. Additionally, L 705589 has been shown to enhance survival rates in models of minor invasive aspergillosis.
L 705589 is an inhibitor of 1,3-β-D-glucan synthase, targeting the synthesis of key structural components in the fungal cell wall. This semi-synthetic penicillin-type antifungal exhibits potent activity against various Candida species, including Candida albicans and Candida glabrata, with minimum fungicidal concentrations ranging from 0.06 to 8 µg/mL. It demonstrates limited efficacy against Cryptococcus neoformans (MFC: 32 - 64 µg/mL) yet maintains effectiveness against drug-resistant Candida strains and shows a reduced tendency to induce resistance. Additionally, L 705589 has been shown to enhance survival rates in models of minor invasive aspergillosis.
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