HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance.
HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance.
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