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Catalog No.
Product Name
Application
Product Information
Citations
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Serine Palmitoyltransferase Inhibitor
Lipoxamycin hemisulfate is a potent inhibitor of serine palmitoyltransferase, exhibiting an IC50 of 21 nM. This compound displays antifungal properties, making it valuable for research in the development of antifungal therapies. Its ability to modulate sphingolipid metabolism further supports its use in studies investigating underlying mechanisms of fungal infections and potential treatment strategies. -
Fungal Inhibitor
Myclobutanil is a systemic fungicide belonging to the conazole class that targets fungal sterol biosynthesis. It exhibits potent antifungal activity against a range of pathogenic fungi, making it valuable in agricultural applications. Myclobutanil is utilized in research for studying fungal resistance mechanisms and evaluating the efficacy of fungicides in crop protection. -
Fungal Inhibitor
Terconazole is a broad-spectrum antifungal agent that targets fungal cell membrane synthesis. It exhibits significant activity against various Candida species, making it effective in treating vaginal yeast infections. This compound is used in research applications to study antifungal mechanisms and drug resistance in pathogenic fungi. -
ASADH Inhibitor
Naphthalene-2,3-Dicarboxaldehyde functions as a potent inhibitor of Aspergillus nidulans succinate semialdehyde dehydrogenase (ASADH), with a reported inhibition constant (Ki) of 45 μM. Its biological activity extends to inhibiting the growth of Candida albicans strain CAF2-1, exhibiting an IC50 of 58.2 μM and a minimum inhibitory concentration (MIC) of 12 μg/mL. This compound is valuable for research applications focused on antifungal mechanisms and metabolic pathway studies involving ASADH. -
β-1,3-glucan Inhibitor
Ibrexafungerp citrate is a potent β-1,3-glucan synthesis inhibitor with promising antifungal properties. This compound demonstrates efficacy against a range of fungal infections, specifically targeting Candida and Aspergillus species. Ibrexafungerp citrate is currently under investigation for its therapeutic potential in the treatment of these serious infections. -
Fungal Inhibitor
Paclobutrazol is a triazole-based compound that functions primarily as a fungal inhibitor by disrupting the biosynthesis of gibberellins. Its antifungal properties make it useful in investigating plant-pathogen interactions and enhancing plant resilience. Additionally, Paclobutrazol can suppress abscisic acid synthesis and promote chilling tolerance in various plant species, supporting research into plant stress responses and growth regulation. -
Histone Acetyltransferase Inhibitor
Rtt109 inhibitor 1 is a potent inhibitor of the histone acetyltransferase Rtt109, functioning through a tight-binding, uncompetitive mechanism. This compound demonstrates significant antifungal activity by specifically targeting acetylation at the H3K56 site. Rtt109 inhibitor 1 is suitable for research applications focused on histone modifications and their roles in fungal pathogenesis. -
HDM Inhibitor
HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance. -
Squalene Epoxidase Inhibitor
Liranaftate is a potent squalene epoxidase inhibitor exhibiting anti-fungal properties. It is primarily utilized in research focusing on dermatophyte infections. Additionally, Liranaftate has been shown to suppress the fungal element-mediated production of interleukin-8 (IL-8) and modulate inflammatory responses, making it valuable for studies involving inflammatory pathways in fungal infections. -
Fungal Inhibitor
Pseudolaric Acid C is a bioactive diterpenoid derived from the root bark of Pseudolarix amabilis, primarily acting as a fungal inhibitor. It exhibits significant antifungal activity, making it a valuable tool for research focused on fungal pathogenesis and the development of antifungal therapies. Its ability to disrupt fungal growth positions it as an important compound in the study of mycology and related fields. -
Fungal Inhibitor
5-Hydroxymethylfurfural is a furan derivative that serves as a potent fungal inhibitor. It exhibits anti-yeast activity by suppressing growth and fermentation under stress conditions, making it valuable for studies related to microbial resistance and fermentation processes. This compound is utilized in research focused on food preservation and biotechnological applications. -
Fungal Inhibitor
Hecogenin is a steroid saponin derived from Agave sisalana, known for its selective inhibition of human UDP-glucuronosyltransferases. It exhibits a diverse range of biological activities, particularly as a potent antifungal agent, while also demonstrating anti-inflammatory and gastroprotective properties. Hecogenin is of interest in pharmacological research for its potential therapeutic applications in treating fungal infections and inflammatory conditions. -
Antifungal/Exosome Inhibitor
Neticonazole hydrochloride is an imidazole derivative that acts as a potent antifungal agent through the inhibition of fungal sterol synthesis. In addition to its antifungal properties, it has shown promising anti-cancer effects, primarily through the modulation of exosome release and related pathways. This compound is suitable for research applications aimed at exploring antifungal therapies and investigating potential anti-cancer mechanisms. -
Fungal Inhibitor
Piroctone olamine is a pyridine derivative that acts as a potent fungal inhibitor by disrupting fungal cell membrane integrity. It exhibits fungicidal activity effective against a variety of dermatophytes and yeast, making it valuable for research in antifungal treatment and dermatological applications. Its mechanism of action supports investigations into fungal pathogenesis and the development of antifungal therapies. -
Fungal Inhibitor
Dehydroacetic acid sodium is a pyrone derivative known for its fungicidal properties. It exhibits antibacterial and antifungal activity, making it valuable for applications in microbial control in various settings. Additionally, dehydroacetic acid demonstrates phytotoxic effects, indicating its potential use in agricultural research. -
1,3-β-D-glucan Synthase Inhibitor
L 705589 is an inhibitor of 1,3-β-D-glucan synthase, targeting the synthesis of key structural components in the fungal cell wall. This semi-synthetic penicillin-type antifungal exhibits potent activity against various Candida species, including Candida albicans and Candida glabrata, with minimum fungicidal concentrations ranging from 0.06 to 8 µg/mL. It demonstrates limited efficacy against Cryptococcus neoformans (MFC: 32 - 64 µg/mL) yet maintains effectiveness against drug-resistant Candida strains and shows a reduced tendency to induce resistance. Additionally, L 705589 has been shown to enhance survival rates in models of minor invasive aspergillosis. -
Fungal Inhibitor
Aliconazole is an imidazole derivative that functions as an antifungal agent by inhibiting fungal ergosterol synthesis, which is critical for maintaining cell membrane integrity. This compound exhibits activity against a range of fungal pathogens, making it suitable for applications in mycology research and exploring antifungal mechanisms. Its efficacy in treating fungal infections makes it a valuable reagent for studies focused on antifungal drug development and resistance mechanisms. -
CYP51 Inhibitor
CYP51-IN-30 is a potent inhibitor of CYP51, targeting sterol 14α-demethylase, an essential enzyme in sterol biosynthesis. This compound exhibits significant fungicidal activity, demonstrated by an EC50 value of 2.97 mg/L against Sclerotinia sclerotiorum. Its efficacy makes it a valuable tool for research in antifungal studies and applications in plant pathology. -
Fungal Inhibitor
BHBM is an aromatic acylhydrazone compound that acts as a potent antifungal agent targeting Cryptococcus neoformans. Its high bactericidal activity makes it a valuable tool for research applications focused on fungal infections and the development of new antifungal therapies. BHBM can be used to explore mechanisms of action and resistance in fungi, contributing to advancements in infectious disease research. -
Group II introns Inhibitor
Group II intron-IN-1 acts as an inhibitor of fungal Group II introns, demonstrating an IC50 of 3 μM. This compound is valuable for research focusing on fungal infections, particularly those caused by Candida species. Its ability to selectively target intronic processes makes it a significant tool for studying fungal biology and the mechanisms of infection. -
Laccase Inhibitor
Laccase-IN-6 is a potent laccase inhibitor with an IC50 of 0.097 nM. This compound demonstrates a broad-spectrum anti-fungal activity, effectively disrupting normal fungal morphology. Laccase-IN-6 is suitable for research applications focused on fungal infections and the role of laccase in pathogenicity. -
Yck2 Inhibitor
GW461484A is a selective inhibitor of Candida albicans Yck2, demonstrating an IC50 of 0.11 µM. This compound exhibits significant antifungal activity, with a MIC80 of 12.5 µM against C. albicans. GW461484A is valuable for research into fungal infections, particularly those involving drug-resistant strains of Candida. -
Yck2 Inhibitor
Yck2-IN-1 is a potent inhibitor of the Yck2 kinase in Candida albicans, exhibiting an IC50 of approximately 80 nM. This compound demonstrates effective antifungal activity, with a MIC80 of 12.5 µM against C. albicans and a favorable metabolic profile, retaining 66% stability in mouse liver microsomes. In preclinical studies, Yck2-IN-1 significantly reduced fungal load in the kidneys of mice with drug-resistant candidiasis, highlighting its potential for research applications in antifungal treatment development. -
CDA Inhibitor
CDA-IN-4 is a chitin deacetylase (CDA) inhibitor. It demonstrates a protective effect of 61.2% against rice blast disease at a concentration of 100 μg/mL. This compound is pertinent for research applications targeting fungal infections in plants and exploring mechanisms of disease resistance. -
Fungal Inhibitor
Methoxyanigorufone is a fungal inhibitor derived from Musa acuminata var. "Yangambi km 5." This compound exhibits significant antifungal activity, demonstrating effectiveness against a range of pathogenic fungi. It is particularly useful in studies exploring fungal resistance mechanisms and the development of antifungal agents in research applications. -
BcSDH Inhibitor
SDH-IN-45 is an inhibitor of succinate dehydrogenase (BcSDH) that targets Botrytis cinerea, exhibiting an IC50 of 5.97 μg/mL. This compound impedes fungal energy metabolism through a distinct binding mode, leading to morphological disruptions, including structural collapse and shrinkage of mycelial forms. SDH-IN-45 demonstrates potent in vitro fungicidal activity against Botrytis cinerea, making it a valuable reagent for research focused on cucumber gray mold and related phytopathological studies. -
TMV Inhibitor
TMV-IN-15 is a potent inhibitor of Tobacco Mosaic Virus (TMV) by targeting the TMV coat protein (TMV-CP). This compound effectively suppresses viral particle assembly, leading to significant aggregation and structural fusion of viral components. TMV-IN-15 also demonstrates inhibitory activity against important fungal pathogens such as Physalospora piricola and Rhizoctonia cerealis. This reagent is valuable for research applications in antiviral and antifungal pesticide development. -
Succinate Dehydrogenase Inhibitor
SDH-IN-38 is a potent inhibitor of succinate dehydrogenase, primarily targeting mycelial respiration. Demonstrating significant antifungal activity, SDH-IN-38 exhibits an EC50 value of 0.009 μg/mL against R. solani mycelia, effectively inhibiting mycelial growth. Additionally, this compound induces cellular senescence and reduces mitochondrial membrane potential in fungal cells, making it a valuable tool for research in fungal biology and disease management. -
Calcineurin Inhibitor
JH-FK-08 is a potent inhibitor of the serine/threonine-specific phosphatase calcineurin. It demonstrates significant antifungal activity against Cryptococcus neoformans, with a MIC80 of 0.8 µg/mL, and displays immunosuppressive properties by inhibiting IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 also shows efficacy in mouse models for anti-infectious applications, making it valuable for research in immunology and infectious disease. -
Fungal Inhibitor
Bromomonilicin is a selective inhibitor of fungal cell membranes. It exerts its antifungal activity by disrupting the integrity of fungal cell membranes, making it a valuable tool for studying plant pathogenic fungal infections, such as those caused by Monilinia fructicola leading to brown rot, as well as superficial mycoses, including dermatophyte infections. This compound is essential for research aimed at understanding and combating fungal diseases in both agricultural and clinical settings. -
Squalene Synthase Inhibitor
E5700 is a potent squalene synthase inhibitor, exhibiting an IC50 of 0.49 nM against squalene synthase from Trypanosoma cruzi epimastigotes. This compound demonstrates notable antiparasitic activity, effectively inhibiting the growth of Trypanosoma cruzi and Leishmania amazonensis. Additionally, E5700 impacts the lipid profile and ultrastructure of multi-drug resistant Candida tropicalis strains, making it a valuable tool for research on parasitic infections and antifungal resistance mechanisms. -
Fungal Inhibitor
Butenafine-d4 is a deuterium-labeled analogue of Butenafine, a potent benzylamine antifungal agent. It exerts its antifungal activity by specifically inhibiting ergosterol biosynthesis at the squalene epoxidation step, which disrupts fungal cell membrane integrity. Butenafine displays effectiveness against a range of dermatophyte infections, including tinea pedis, tinea cruris, and tinea versicolor. This reagent is suitable for research applications focused on antifungal mechanisms and the study of fungal pathogens. -
Aminoacyl tRNA Synthetase Inhibitor
Aminoacyl tRNA synthetase-IN-4 is a potent inhibitor of aminoacyl tRNA synthetase, exhibiting an IC50 value of 0.026 μM against Candida albicans prolyl-tRNA synthetase. This compound is valuable for antifungal research, providing insights into the role of aminoacyl tRNA synthetase in fungal biology and potential therapeutic strategies against infections. Its selective inhibition profile makes it an important tool for exploring the mechanisms of antifungal resistance and treatment efficacy. -
SDH Inhibitor
SDH-IN-37 is a potent inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 0.0263 μM. Additionally, this compound demonstrates significant antifungal activity against pathogens such as Rhizoctonia solani, Sclerotinia sclerotiorum, and Fusarium graminearum, with EC50 values of 0.0144, 0.882, and 1.99 μg/mL, respectively. SDH-IN-37 is therefore a valuable tool for research applications focused on fungal pathogenesis and metabolic regulation in various organisms. -
Histidine kinase Inhibitor
RWJ-49815 is a potent inhibitor of histidine kinases, exhibiting an IC50 value of 1.6 µM. It effectively inhibits the autophosphorylation activity of kinase A within the KinA-Spo0F two-component signaling system in vitro. This compound demonstrates significant antimicrobial activity against resistant bacterial strains, including methicillin-resistant Staphylococcus aureus, vancomycin-resistant Enterococcus faecium, and penicillin-resistant Streptococcus pneumoniae. Additionally, RWJ-49815 shows inhibitory effects on fungal species such as Saccharomyces cerevisiae and Candida albicans, making it a valuable tool for studying kinase-mediated processes and developing antimicrobial strategies. -
Fungal Inhibitor
Fenpyrazamine is an antifungal agent that primarily targets 3-keto reductase within the ergosterol biosynthesis pathway. It exhibits significant antifungal, preventative, systemic, and lesion-inhibiting properties, providing a prolonged therapeutic effect. Fenpyrazamine is efficacious against pathogens such as gray mold, stem rot, and brown rot, making it a valuable reagent for research focused on fungal infections and plant pathology. -
Fungal Inhibitor
Inz-4 is a selective inhibitor of mitochondrial cytochrome bc1 in fungi, demonstrating an IC50 of 0.026 μM. This compound effectively disrupts mitochondrial respiration in fungal species, making it a valuable tool for studying fungal metabolism and potential therapeutic applications in antifungal research. Its potent activity underscores its utility in investigating the biochemical pathways of fungi and the development of antifungal agents. -
Fungal Inhibitor
Candicidin A3 is a potent antifungal antibiotic that demonstrates significant inhibitory activity against fungal growth. Its unique three-dimensional structure and seven-membered ring configuration enhance its biological efficacy and interaction with fungal targets. This compound presents potential for development as a therapeutic agent in the treatment of fungal infections, making it a valuable tool for researchers studying antifungal mechanisms and developing new treatments for mycotic diseases. -
14α-lanosterol demethylase Inhibitor
Arasertaconazole is a potent inhibitor of 14α-lanosterol demethylase, an enzyme critical in the biosynthesis of sterols in fungi. This compound exhibits significant antifungal and antibacterial activities, making it valuable in studies focused on the treatment of fungal infections and bacterial pathogens. Its inhibition of key enzymatic pathways underscores its research applications in drug development and microbiology. -
Fungal Inhibitor
Stichloroside B1 is a triterpenoid oligosaccharide that acts as a fungal inhibitor. Isolated from the sea cucumber Stichopus chloronotus, it exhibits significant antifungal activity, making it valuable for research in mycology and the development of antifungal agents. Its unique structure and mechanism of action are of particular interest in studying fungal biology and potential therapeutic applications. -
Cytochrome Bc1 Inhibitor
Inz-1 is a selective inhibitor of mitochondrial cytochrome bc1, exhibiting an IC50 of 8.092 μM in yeast and 45.320 μM in human cells. This compound effectively reverses resistance to Fluconazole and other triazole antifungals in Candida albicans, making it a valuable tool for studying antifungal resistance mechanisms and developing new therapeutic strategies. Researchers can utilize Inz-1 to investigate the role of cytochrome bc1 in fungal pathogenesis and drug resistance. -
Chitin Deacetylase Inhibitor
CDA-IN-5 is a chitin deacetylase inhibitor with a Ki value of 27.5 μM against PstCDA. This compound exhibits antifungal activity, effectively inhibiting the growth of pathogens such as Rhizoctonia solani, Pyricularia oryzae, and Botrytis cinerea. CDA-IN-5 demonstrates moderate efficacy in controlling rice sheath blight, making it a valuable tool for research in agricultural plant pathology and fungal disease management. -
Inhibitor of Uredospore Germination
Methyl 3,4-dimethoxycinnamate is a potent inhibitor of uredospore germination, targeting fungal spores to impede their growth and development. In addition to its antifungal properties, it also suppresses global DNA methylation in Hep3B cells, making it a valuable reagent for research on epigenetic modifications. This compound is suitable for studies in plant pathology and epigenetics, facilitating further investigation into its biological roles and potential applications. -
SDH Inhibitor
SDH-IN-29 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 of 0.0709 μM. This compound demonstrates broad-spectrum antifungal activity, with EC50 values of 0.356 μg/mL for Fusarium graminearum, 0.798 μg/mL for Sclerotinia sclerotiorum, and 0.146 μg/mL for Rhizoctonia solani. SDH-IN-29 also shows moderate to significant protective effects against rice blast, wheat scab, and cucumber powdery mildew, making it a valuable tool for agricultural research and fungal disease management. -
CYP51 Inhibitor
CYP51-IN-32 is a selective inhibitor of CYP51, demonstrating a potent antifungal activity with an IC50 of 0.331 μM against Candida albicans. This compound not only inhibits the growth of Candida albicans by disrupting hyphal formation and biofilm development, but it also releases hydrogen sulfide (H2S), contributing to its antifungal effects. CYP51-IN-32 is suitable for investigating Candida albicans infections and can be formulated into PEG-based nanovesicles for enhanced delivery in research applications. -
Fungal Inhibitor
Prumycin dihydrochloride is an antifungal compound that targets fungal pathogens, specifically demonstrating efficacy against cucumber powdery mildew. This reagent significantly inhibits disease progression while not inducing plant defense gene expression, suggesting its mechanism does not rely on host defensive responses. Additionally, it has shown effectiveness in preventing spore germination of P. fusca, making it valuable for research into fungal pathogenesis and disease management in agriculture. -
CYP51 Inhibitor
(Rac)-Ketoconazole is an imidazole antifungal agent that acts as a potent inhibitor of cytochrome P450-dependent 14α-sterol demethylase (CYP51). By disrupting ergosterol synthesis, it induces membrane dysfunction, thereby inhibiting the growth and reproduction of various fungi. This compound is primarily utilized in research relating to fungal infections and the mechanisms of antifungal resistance. -
OSBP Inhibitor
Antifungal agent 107 is an oxysterol-binding protein (OSBP) inhibitor that exhibits antifungal activity. This compound is effective in managing cucumber downy mildew and potato late blight in greenhouse settings, making it a valuable tool for researchers investigating plant pathology and disease control strategies. Its targeted mechanism of action provides a means to explore the role of OSBP in fungal biology. -
Cer1 Inhibitor
Cs-2d is a selective inhibitor of ceramide synthase 1 (Cer1) with notable potency against C. neoformans. This compound demonstrates significant antifungal activity, effectively inhibiting growth while exhibiting minimal off-target effects on human ceramide synthase 1 (hCerS1). Cs-2d is a valuable tool for research focused on invasive fungal infections, facilitating the study of therapeutic strategies targeting ceramide metabolism. -
Fungal Inhibitor
Griseofulvic acid is a metabolite of the antifungal agent Griseofulvin, acting as a potent fungal inhibitor. It is known to induce protein aggregation and facilitate tubulin polymerization in cell-free assays, making it a valuable tool in the study of fungal biology and cell dynamics. This compound can be utilized in research applications focusing on the mechanisms of antifungal activity and cytoskeletal interactions.
