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Catalog No.
Product Name
Application
Product Information
Citations
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HIV-1 IN Chain Transfer Inhibitor
L-870810 is a potent inhibitor of HIV-1 integrase (IN) chain transfer, effectively interfering with the integration of viral DNA into the host genome. This compound exhibits significant antiviral activity, making it a valuable tool for researchers studying HIV-1 replication and potential therapeutic strategies. Its mechanism of action positions it as a key reagent for investigations into HIV-1 pathogenesis and drug development. -
HIV-1 Entry Inhibitor
RPR103611 is a derivative of betulinic acid that functions as a potent HIV-1 entry inhibitor. It displays IC50 values of 80 nM for CCR5-tropic virus YU2, 0.27 nM for CXCR4-tropic virus NL4-3, and 0.17 nM for dual tropic virus 89.6. This compound is valuable for research focused on the mechanisms of HIV-1 entry and the development of antiviral therapies. -
HIV-1 Inhibitor
HIV-1 Inhibitor-16 is a potent inhibitor targeting HIV-1 with an EC50 value of 1.3 nM against wild-type strains. This compound also demonstrates significant activity against various resistant strains, including HIV-1 K103N, E138K, Y181C, and L100I, with EC50 values of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. Its favorable solubility profile and stability in liver microsomes make it a valuable tool for research, while its minimal interaction with CYP enzymes reduces concerns regarding toxicity. This compound is ideally suited for studies focused on HIV-1 resistance and treatment strategies. -
HIV-1 Inhibitor
HIV-1 inhibitor-71 is a targeted inhibitor of HIV-1 that interferes with the transport of endocytosed HIV-1 particles into nuclear envelope invaginations (NEIs). This action effectively disrupts the viral entry process, thereby inhibiting productive infection. This compound is valuable for research applications focused on HIV-1 infection mechanisms and the development of novel antiviral strategies. -
HIV-1 RNase H Inhibitor
HIV-1 integrase inhibitor 9 is a potent inhibitor of HIV-1 RNase H, exhibiting an IC50 of 12.3 μM. This compound demonstrates significant antiviral activity, making it a valuable tool for research into HIV-1 replication and potential therapeutic strategies. Its role in inhibiting viral enzyme function supports the investigation of novel antiviral agents targeting HIV-1. -
HIV REV/RRE Binding Inhibitor
Fleephilone is a fungal metabolite derived from Trichoderma harzianum that acts as an HIV REV/RRE binding inhibitor. It effectively disrupts the interaction between the REV protein and RRE RNA, exhibiting an IC50 value of 7.6 μM. This compound is valuable for research focused on HIV replication mechanisms and the development of antiviral strategies targeting RNA-protein interactions. -
HIV Inhibitor
HIV-1 inhibitor-36 is a potent inhibitor targeting HIV-1, exhibiting significant antiviral activity against the virus. It has potential applications in the development of novel latency-reversing agents, making it a valuable tool for research in HIV treatment and eradication strategies. This compound may facilitate the understanding of viral latency and aid in the advancement of therapeutic approaches to HIV infection. -
HIV-1 Reverse Transcriptase Inhibitor
HI-236 is a potent non-nucleoside inhibitor of HIV-1 reverse transcriptase, effectively disrupting the replication of the HIV virus. It demonstrates exceptional antiviral activity, with an IC50 value of less than 0.001 μM against wild-type HTLVIIIB. This compound is primarily utilized in HIV research, particularly in the development of antiretroviral therapies. -
HIV Inhibitor
F1839-I is an HIV inhibitor derived from the fungus Stachybotrys. It exhibits anti-HIV activity with an IC50 value of 15.6 μM, demonstrating its potential in therapeutic applications against HIV infection. Additionally, F1839-I has shown weak cytotoxicity, supporting its feasibility for further research in antiviral drug development. -
HIV-1 Inhibitor
VIRIP, derived from human α1-AT(353-372), functions as an inhibitor of HIV-1 by targeting the gp41 fusion peptide. It prevents the entry of HIV-1 into host cells, thereby disrupting the viral lifecycle. This reagent is applicable in virology research and studies focused on HIV-1 entry mechanisms. -
HIV-1 Inhibitor
Kadsuracoccinic acid A is a tetracyclic natural compound targeting HIV-1. It exhibits significant anti-HIV-1 activity in vitro, with an EC50 value of 68.7 μM. This compound is valuable for research in the development of antiviral therapies and understanding HIV-1 inhibition mechanisms. -
HIV Inhibitor
HIV-1 inhibitor-70 is a bifunctional inhibitor targeting both wild-type and K103N mutant reverse transcriptases of HIV-1. This compound effectively disrupts the replication of the virus, making it valuable in HIV research and therapeutic investigations. Its dual inhibitory action provides insights into resistance mechanisms and aids in the development of effective treatments for HIV infections. -
HIV protease inhibitor
SB 204144 is a potent inhibitor of HIV protease, disrupting the proteolytic processing of viral polyproteins and hindering the maturation of infectious HIV particles. This compound is valuable for research on HIV pathogenesis and immune system diseases, enabling studies on antiviral effects and the development of new therapeutic strategies against HIV. Its application in virology underlines its relevance in understanding and combating HIV infection. -
HIV Inhibitor
B07 is a potent HIV inhibitor that targets viral replication mechanisms. In addition to its antiviral properties, B07 also exhibits spermicidal activity with an EC50 of 1.5 mg/mL. This compound has valuable applications in HIV research and the development of contraceptive agents. -
HIV-1 Inhibitor
GS-9822 is a potent HIV-1 inhibitor that specifically targets the LEDGF/p75-integrase interaction, demonstrating robust antiviral activity with an IC50 of 0.07 μM against wild-type HIV-1 viruses. It exhibits high in vitro metabolic stability and favorable oral pharmacokinetic properties, characterized by low systemic clearance across various preclinical animal models, including rats, dogs, and monkeys. GS-9822 is a valuable tool for research applications focused on understanding HIV-1 integration and developing therapeutic strategies against viral infections. -
HIV-1 Inhibitor
Fosamprenavir-d4 is a deuterium-labeled inhibitor targeting HIV-1 protease. As a prodrug of Amprenavir, Fosamprenavir is hydrolyzed by cell phosphatases, converting it into Amprenavir, which subsequently binds to the active site of HIV-1 protease. This binding prevents the processing of essential viral precursors, inhibiting the production of mature and infectious virions. Fosamprenavir-d4 is useful for research focused on HIV-1 infection and therapeutic strategies against the virus. -
HIV Inhibitor
Tsugafolin is a dehydroflavone that acts as an inhibitor of HIV. It exhibits weak anti-HIV activity with an IC50 value of 118 μM while demonstrating low cytotoxicity at concentrations below 150 μM. Isolated from the plant Vitex leptobotrys, Tsugafolin serves as a valuable tool for research applications focused on HIV-1 replication and the development of therapeutic strategies. -
HIV-l Encoded Protease Inhibitor
L-738872 is a potent orally active inhibitor of the HIV-1 encoded protease. It effectively inhibits viral replication by interfering with the processing of viral polyproteins, which is critical for the maturation of infectious HIV particles. This compound is valuable in research focused on understanding HIV protease functionality and developing antiretroviral therapies. -
HIV-1 Reverse Transcriptase Inhibitor
Urushiol (15:3) is an inhibitor of HIV-1 reverse transcriptase, demonstrating moderate inhibitory activity with an IC50 value of 55.36 μM. This compound, derived from the leaves of Rhus verniciflua, exhibits significant cytotoxicity against prostate cancer PC-3 cells and normal MRC-5 cells. Urushiol (15:3) is relevant for research into anti-HIV-1 therapies and the study of prostate cancer biology. -
HIV NNRT Inhibitor
BI-2540 is a potent non-nucleoside reverse transcriptase (NNRT) inhibitor targeting HIV. This compound exhibits significant antiviral activity by inhibiting the reverse transcription process, thereby preventing viral replication. BI-2540 is utilized in research for the development of therapeutic strategies against HIV and contributes to the understanding of HIV resistance mechanisms. -
HIV-1 RT Inhibitor
L 738372 is a non-competitive reversible inhibitor of HIV-1 reverse transcriptase (RT) with a reported inhibition constant (Ki) of 140 nM against dTTP. This compound demonstrates synergistic inhibition of RT activity when used in combination with nucleoside analogs such as azidothymidine triphosphate, didexoyinosine triphosphate, or didexoycytidine triphosphate. Notably, L 738372 exhibits enhanced inhibitory potency against azidothymidine-resistant RT variants (D67N, K70R, T215Y, K219Q), making it a valuable tool for advancing research in HIV treatment strategies. -
HIV Inhibitor
H-Gly-Pro-Gly-NH2 is a tripeptide that serves as an inhibitor of HIV-1 and HIV-2 replication. Demonstrating EC50 values of 35 µM for HIV-1 IIIB and 30 µM for HIV-2 ROD, H-Gly-Pro-Gly-NH2 reduces viral replication by disrupting capsid formation in vitro. This compound possesses significant antiviral activity, making it a valuable tool for research into HIV and related viral mechanisms. -
HIV-1 Inhibitor
GSK3532795 oxalate is a potent second-generation inhibitor of HIV-1 maturation, acting primarily through the disruption of viral particle assembly. It exhibits notable efficacy with EC50 values of 1.9 nM for HIV-1 wild type, 10.2 nM in human serum, as well as 2.7 nM and 13 nM for the HIV-1 V370A and ΔV370 variants, respectively. This compound is essential for research focused on HIV-1 infection mechanisms and therapeutic strategies. -
HIV-1 Inhibitor
HIV-1 inhibitor-34 is a potent and selective inhibitor of HIV-1, exhibiting an EC50 value of 6.4 nM in HIV-1 assays and a CC50 of 16 μM in MT-4 cells. This compound is valuable for research applications focused on understanding HIV-1 replication and pathogenesis, making it a useful tool for studies related to AIDS therapeutics. -
HIV Inhibitor
SJ-3366 is a potent inhibitor of HIV non-nucleoside reverse transcriptase. This compound demonstrates significant inhibitory activity at sub-nanomolar concentrations, functioning through a typical non-nucleoside mechanism. SJ-3366 is utilized in research applications focused on HIV replication and the development of antiretroviral therapies. -
HIV-I Integrase Inhibitor
Bis-T-23 is a potent inhibitor of HIV-1 integrase, acting through a tyrphostin derivative mechanism. This compound has been shown to promote actin-dependent dynamin oligomerization, highlighting its role in cellular processes related to viral replication. Bis-T-23 is valuable for research focused on HIV and chronic kidney diseases (CKD), providing insights into the intersection of viral infection and renal pathophysiology. -
Myosin I Inhibitor
ZJS178 is a selective inhibitor of myosin I, exhibiting significant antifungal activity against Fusarium graminearum. This compound effectively reduces the synthesis of the mycotoxin deoxynivalenol (DON) and is valuable for research on plant diseases, particularly wheat scab. ZJS178 serves as a potent tool for studies aimed at understanding myosin I functions in fungal pathogenesis and developing strategies for disease management in crops. -
Bacterial Inhibitor
Allergen Gal d 4 (46-61), chicken is a peptide derived from hen egg white lysozyme, exhibiting bacterial inhibitory activity. This compound is utilized in research related to allergenic responses and microbial interactions, making it significant in studies of food allergies and immunological reactions. Its targeted application in bacterial inhibition aids in understanding the role of allergens in various biological systems. -
Bacterial Inhibitor
Levonadifloxacin arginine is a potent bacterial inhibitor targeting both methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MSSA and MRSA). This broad-spectrum antistaphylococcal agent exhibits significant antimicrobial activity and has been shown to reduce the phagocytosis of MRSA and MSSA strains by monocytic THP-1 cells. Its applications in research include studies focused on bacterial resistance mechanisms and potential therapeutic interventions for staphylococcal infections. -
Bacterial Inhibitor
Antibacterial Agent 53 is a potent bacterial inhibitor that targets specific bacterial pathways to disrupt cell function. Demonstrating significant antibacterial activity, this compound is primarily utilized in research focusing on the development of novel antimicrobial agents and therapeutic strategies against bacterial infections. Its effectiveness makes it a valuable reagent for studies aimed at understanding bacterial resistance mechanisms. -
Bacterial Inhibitor
Anti Gram-Positive/Negative Bacteria Agent 1 is a bacterial inhibitor that functions through the mechanism of an antibiotic conjugate linked to an artificial MECAM-based siderophore. This compound exhibits significant antibacterial activity against both Gram-positive and Gram-negative bacteria. It is suitable for research applications aimed at studying bacterial infections and developing new antimicrobial strategies. -
Bacterial Inhibitor
Antitubercular agent-9 is a bacterial inhibitor that demonstrates effective antitubercular activity, with a minimum inhibitory concentration (MIC) ranging from 1.03 to 2.32 μM. This compound is suitable for research focused on tuberculosis treatment mechanisms and the development of new antitubercular therapies. It serves as a valuable tool for understanding bacterial resistance and evaluating potential drug candidates in infectious disease research. -
Bacterial Inhibitor
Antibacterial Agent 62 is a novel redox cycling compound that targets bacterial cells, demonstrating potent bactericidal activity against both growing and nutrient-starved phenotypically drug-resistant nongrowing bacteria. This reagent is particularly useful in research applications focused on tuberculosis and the development of new antibacterial therapies. Its unique mechanism of action may also aid in understanding resistance mechanisms in various bacterial strains. -
Bacterial Inhibitor
Antibacterial Agent 30 is a potent bacterial inhibitor, exhibiting significant in vitro activity against Xanthomonas oryzae pv. oryzae with an EC50 value of 1.9 μg/mL. This compound is suitable for research applications aimed at understanding bacterial pathogenesis and developing new antibacterial strategies. -
Bacterial Inhibitor
NDM-1 inhibitor-2 is a selective inhibitor of New Delhi metallo-β-lactamase-1 (NDM-1) that effectively inhibits NDM-1 enzymatic activity. This compound demonstrates significant antibacterial activity against drug-resistant bacterial strains that overexpress NDM-1, providing insights into overcoming resistance mechanisms. Additionally, NDM-1 inhibitor-2 can enhance the efficacy of the carbapenem antibiotic meropenem, resulting in a synergistic effect that supports research in antimicrobial therapy and resistance management. -
Bacterial Inhibitor
1-Amino-2,5-anhydro-1-deoxy-D-mannitol is a potent antibacterial agent targeting a range of Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococci (VRE). Its significant antibacterial activity makes it a valuable candidate for addressing drug-resistant bacterial infections. Research applications may include investigations into its efficacy as a therapeutic tool against prevalent multidrug-resistant pathogens in clinical settings. -
Bacterial Inhibitor
Altertoxin III is a bacterial inhibitor known for its mutagenic effects on Salmonella typhimurium strains TA98, TA100, and TA1537. Derived from an extract of the A. alternata isolate, this compound exhibits significant mutagenicity as demonstrated in the Ames assay. It is valuable for studies focused on mutagenesis and the mechanisms of bacterial resistance. -
Bacterial Inhibitor
Heraclenol is a coumarin compound that targets bacterial pathogens. Isolated from the fruits of Angelica lucida, Heraclenol demonstrates notable antibacterial activity, making it valuable for research applications focused on combatting bacterial infections. Its mechanism of action contributes to the understanding of antimicrobial resistance and the development of new therapeutic strategies. -
Bacterial Inhibitor
L-689065 is a potent bacterial inhibitor that acts by targeting essential bacterial processes. It exhibits significant antimicrobial activity against a range of bacterial strains, making it a valuable reagent for studies on bacterial resistance and infection mechanisms. This compound is applicable in microbiological research focused on identifying new antibacterial agents and understanding the pathways of bacterial growth inhibition. -
Bacterial Inhibitor
FK-518 is a potent inhibitor of AmpC β-lactamase, targeting resistance mechanisms in bacteria. This compound exhibits strong antimicrobial activity against Pseudomonas aeruginosa strains that overexpress AmpC β-lactamase, making it a valuable tool in the study of bacterial infections. FK-518 is particularly useful for research investigating therapeutic strategies against resistant bacterial strains. -
Bacterial Inhibitor
RO7075573 is a bacterial inhibitor that targets the lipopolysaccharide (LPS) transport machinery in Acinetobacter species. This compound has demonstrated protective effects in preclinical models against Acinetobacter baumannii infections, highlighting its potential for therapeutic applications in combating antibiotic-resistant bacterial pathogens. Research applications may include studying bacterial pathogenesis and developing new antibiotic strategies. -
Bacterial Inhibitor
Neorauflavene is a phenolic isoflavonoid derived from Neorautanenia edulis, functioning as a bacterial inhibitor. This compound exhibits significant antibacterial activity against various strains, including Enterococcus faecalis, Streptococcus suis, Streptococcus agalactiae, Pseudomonas aeruginosa, Bacillus subtilis, and Riemerella anatipestifer. Neorauflavene's antibacterial properties make it a valuable tool for research in microbiology and the development of therapeutic agents targeting bacterial infections. -
Bacterial Virulence Factor Inhibitor
Anti-virulence factor-IN-1 is a bacterial virulence factor inhibitor that disrupts the bacterial infection process. It demonstrates potent antibacterial activity against Xanthomonas oryzae pv. oryzae (Xoo) with an EC50 value of 0.28 µg/mL. This compound is applicable for the management of rice bacterial leaf blight in vivo and offers significant potential for research related to plant bacterial diseases. -
Bacterial Peptide Deformylase Inhibitor
Lanopepden camsylate is a high-affinity inhibitor of bacterial peptide deformylase, an enzyme critical for protein maturation in bacteria. This compound exhibits potent activity against bacterial infections by disrupting essential protein processing. Lanopepden camsylate is primarily utilized in research applications focused on the development of new antibacterial agents and the study of bacterial pathogenicity. -
Bacterial Inhibitor
TP-271 is a bacterial inhibitor specifically designed to target pathogens associated with community-acquired pneumonia. This compound exhibits significant antimicrobial activity, making it suitable for research applications focused on bacterial infections and respiratory diseases. Its potential to disrupt bacterial growth presents promising avenues for further exploration in the development of effective therapeutics. -
Bacterial Inhibitor
Cefonicid is a broad-spectrum beta-lactam antibiotic targeting bacterial cell wall synthesis. It exhibits potent antibacterial activity against a variety of Gram-positive and Gram-negative bacteria, making it valuable in treating various infectious diseases. Pharmacokinetic studies indicate that high plasma concentrations are swiftly attained following intravenous or intramuscular administration, and its half-life may be extended with concomitant use of albendazole, leading to reduced renal clearance. Cefonicid serves as an essential tool in bacterial infection research and the development of therapeutic strategies. -
Bacterial Inhibitor
Penicillin N is a penicillin-type antibiotic that primarily targets bacterial cell wall synthesis. It exhibits potent antibacterial activity against enteric bacilli, making it effective for the treatment of infections caused by these pathogens. This compound is widely utilized in microbiological research to study antibacterial mechanisms and evaluate susceptibility of bacterial strains. -
Bacterial Inhibitor
Methyl sterculate is a potent bacterial inhibitor that targets Δ9 desaturase. This compound effectively inhibits the growth of Rhodococcus opacus at a concentration of 0.75 mM, demonstrating toxicity towards the bacteria. Furthermore, it alters the fatty acid profile by decreasing overall fatty acid content while increasing the palmitate ratio and reducing stearate and oleate levels at concentrations of 0.25 or 0.5 mM. Methyl sterculate also exhibits a synergistic effect on tumor growth induced by aflatoxin Q1 in rainbow trout at a concentration of 50 ppm. -
Bacterial Inhibitor
Quorum sensing-IN-2 is a potent quorum sensing inhibitor that targets bacterial communication mechanisms to diminish pathogenicity while preserving overall bacterial growth. This compound effectively reduces bacterial infections with minimal hemolytic activity. Additionally, Quorum sensing-IN-2 exhibits a synergistic effect when combined with Ciprofloxacin in models of Pseudomonas aeruginosa PAO1 bacteremia, making it a valuable tool for investigating bacterial virulence and developing novel therapeutic strategies. -
Bacterial Inhibitor
ORM-3819 is a bacterial inhibitor targeting Staphylococcus aureus. This compound exhibits broad-spectrum antimicrobial activity against both methicillin-susceptible (MSSA) and methicillin-resistant Staphylococcus aureus (MRSA). Additionally, ORM-3819 reduces the phagocytosis of MRSA and MSSA strains by monocytic THP-1 cells, making it valuable for research related to bacterial infections and resistance mechanisms. Its efficacy in combatting staphylococcal infections positions it as a critical tool in antimicrobial studies.
