HIV-1 Inhibitor-16 is a potent inhibitor targeting HIV-1 with an EC50 value of 1.3 nM against wild-type strains. This compound also demonstrates significant activity against various resistant strains, including HIV-1 K103N, E138K, Y181C, and L100I, with EC50 values of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. Its favorable solubility profile and stability in liver microsomes make it a valuable tool for research, while its minimal interaction with CYP enzymes reduces concerns regarding toxicity. This compound is ideally suited for studies focused on HIV-1 resistance and treatment strategies.
HIV-1 Inhibitor-16 is a potent inhibitor targeting HIV-1 with an EC50 value of 1.3 nM against wild-type strains. This compound also demonstrates significant activity against various resistant strains, including HIV-1 K103N, E138K, Y181C, and L100I, with EC50 values of 5.4 nM, 9.2 nM, 22 nM, and 35 nM, respectively. Its favorable solubility profile and stability in liver microsomes make it a valuable tool for research, while its minimal interaction with CYP enzymes reduces concerns regarding toxicity. This compound is ideally suited for studies focused on HIV-1 resistance and treatment strategies.
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