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Catalog No.
Product Name
Application
Product Information
Citations
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Fungal Melanization Inhibitor
Coniferin is a glucoside derivative of coniferyl alcohol that functions as a fungal melanization inhibitor. It effectively disrupts the melanin biosynthesis pathway in fungi, making it useful for studies of fungal growth and pathogenicity. Additionally, Coniferin has been shown to inhibit the release of inflammatory mediators such as Prostaglandin E2 and Thromboxane B2, highlighting its potential in research focused on cellular signaling and inflammation. -
Cytochrome bc1 Inhibitor
Inz-5 is a selective inhibitor of the mitochondrial cytochrome bc1 complex, targeting fungal pathogens. This compound effectively impairs fungal virulence and may prevent the development of resistance to antifungal agents. Its unique mechanism of action makes it a valuable tool for research in mycology and antifungal drug development. -
Bacterial Inhibitor
Tricyclazole is a pentaketone compound that acts as a bacterial inhibitor primarily by disrupting melanin biosynthesis in fungi. This unique fungicide is effective in controlling rice blast disease by altering the structure and function of fungal cell walls, thereby reducing pathogenicity and penetration. Tricyclazole’s mechanism of action also highlights its potential for studying fungal biology and the effects of melanin on fungal virulence. -
Fungal Inhibitor
Enfumafungin is a triterpene glycoside that acts as a potent fungal inhibitor by targeting (1,3)-beta-D-glucan synthase in the fungal cell wall. This compound exhibits selective antifungal activity against yeasts and filamentous fungi, excluding Cryptococcus, and is not active against Bacillus subtilis. Enfumafungin is valuable for research applications focused on fungal pathogenesis and the development of antifungal therapeutics. -
Parasite Inhibitor
5,7,3',4'-Tetramethoxyflavone is a polymethoxyflavone that acts as a potent inhibitor of parasitic activity. Isolated from M. exotica, this compound demonstrates a range of bioactivities, including antifungal, antimalarial, antimycobacterial, and anti-inflammatory effects. Additionally, 5,7,3',4'-Tetramethoxyflavone exerts chondroprotective effects through modulation of β-catenin signaling, making it a valuable tool for research in both parasitology and inflammatory conditions. -
SDH Inhibitor
SDH-IN-1 is a selective inhibitor of succinate dehydrogenase (SDH), exhibiting an IC50 value of 4.53 μM. This compound demonstrates significant antifungal properties, particularly effective against S. sclerotiorum with an EC50 of 0.14 mg/L. SDH-IN-1 is a valuable tool for researchers studying fungal pathogenesis and metabolism, providing insights into SDH's role in cellular respiration and therapeutic strategies against fungal infections. -
Fungal Inhibitor
Thiophanate-Methyl is a systemic fungicide that targets fungal pathogens by inhibiting mycelial growth and spore germination. This compound exhibits broad-spectrum activity against a variety of fungi, making it useful in agricultural applications for disease management in crops. Its mechanism of action involves the disruption of cellular processes within the target fungi, providing an effective solution for controlling fungal infections in plants. -
Fungal Inhibitor
Deoxylapachol is a significant cytotoxic compound derived from the New Zealand brown alga Landsburgia quercifolia, primarily acting as a fungal inhibitor. It exhibits notable antifungal properties, making it a valuable agent in the study of fungal infections. Additionally, deoxylapachol demonstrates anti-cancer activity, positioning it as a candidate for research applications in oncology and pathogen interaction studies. -
Fungal CYP51 Inhibitor
VT-1598 is an orally active and selective inhibitor of fungal cytochrome P450 51 (CYP51). It exhibits potent antifungal activity against Candida auris, making it a valuable tool for research into fungal infections. Additionally, VT-1598 contains an alkyne group, allowing it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) for click chemistry applications, facilitating the study of various biological interactions. -
Bacterial/Fungal Inhibitor
2-Methoxybenzaldehyde, also known as o-Anisaldehyde, serves as a bacterial and fungal inhibitor, with a BA50 value of 0.19 against Salmonella. This compound is utilized in the investigation of bacterial and fungal infectious diseases, providing insights into their mechanisms and potential therapeutics. Its effectiveness in hindering microbial growth makes it a valuable reagent for microbiological research. -
Antiseptic Agent; Fungal Inhibitor
Hexetidine, an orally active antiseptic agent, exhibits broad-spectrum antibacterial and antifungal activity. It is particularly effective in inhibiting fungal growth, especially when combined with IPBC. At concentrations exceeding 0.1%, hexetidine may lead to oral ulceration; however, it enhances plaque inhibition in conjunction with zinc. Additionally, its efficacy in treating purulent wounds has been demonstrated alongside ultrasound treatment. Hexetidine is a valuable candidate for research focusing on fungal infections and soft tissue purulent-inflammatory conditions. -
Serine Palmitoyltransferase Inhibitor
Lipoxamycin hemisulfate is a potent inhibitor of serine palmitoyltransferase, exhibiting an IC50 of 21 nM. This compound displays antifungal properties, making it valuable for research in the development of antifungal therapies. Its ability to modulate sphingolipid metabolism further supports its use in studies investigating underlying mechanisms of fungal infections and potential treatment strategies. -
Fungal Inhibitor
Myclobutanil is a systemic fungicide belonging to the conazole class that targets fungal sterol biosynthesis. It exhibits potent antifungal activity against a range of pathogenic fungi, making it valuable in agricultural applications. Myclobutanil is utilized in research for studying fungal resistance mechanisms and evaluating the efficacy of fungicides in crop protection. -
Fungal Inhibitor
Terconazole is a broad-spectrum antifungal agent that targets fungal cell membrane synthesis. It exhibits significant activity against various Candida species, making it effective in treating vaginal yeast infections. This compound is used in research applications to study antifungal mechanisms and drug resistance in pathogenic fungi. -
ASADH Inhibitor
Naphthalene-2,3-Dicarboxaldehyde functions as a potent inhibitor of Aspergillus nidulans succinate semialdehyde dehydrogenase (ASADH), with a reported inhibition constant (Ki) of 45 μM. Its biological activity extends to inhibiting the growth of Candida albicans strain CAF2-1, exhibiting an IC50 of 58.2 μM and a minimum inhibitory concentration (MIC) of 12 μg/mL. This compound is valuable for research applications focused on antifungal mechanisms and metabolic pathway studies involving ASADH. -
β-1,3-glucan Inhibitor
Ibrexafungerp citrate is a potent β-1,3-glucan synthesis inhibitor with promising antifungal properties. This compound demonstrates efficacy against a range of fungal infections, specifically targeting Candida and Aspergillus species. Ibrexafungerp citrate is currently under investigation for its therapeutic potential in the treatment of these serious infections. -
Fungal Inhibitor
Paclobutrazol is a triazole-based compound that functions primarily as a fungal inhibitor by disrupting the biosynthesis of gibberellins. Its antifungal properties make it useful in investigating plant-pathogen interactions and enhancing plant resilience. Additionally, Paclobutrazol can suppress abscisic acid synthesis and promote chilling tolerance in various plant species, supporting research into plant stress responses and growth regulation. -
Histone Acetyltransferase Inhibitor
Rtt109 inhibitor 1 is a potent inhibitor of the histone acetyltransferase Rtt109, functioning through a tight-binding, uncompetitive mechanism. This compound demonstrates significant antifungal activity by specifically targeting acetylation at the H3K56 site. Rtt109 inhibitor 1 is suitable for research applications focused on histone modifications and their roles in fungal pathogenesis. -
HDM Inhibitor
HDM-IN-1 is a potent inhibitor of histone demethylases (HDM), specifically targeting H3K27me3 methylation in fungal pathogens such as Cryptococcus neoformans and Candida auris, with IC50 values of 134 nM and 12 nM, respectively. This compound demonstrates significant antifungal activity, achieving MIC80 values between 0.5-2 μg/mL by disrupting biofilm and capsule formation. In vivo studies in an ICR mouse model further confirm its efficacy as an antifungal agent. HDM-IN-1 is a valuable tool for research on histone modifications and their implications in fungal virulence and drug resistance. -
Bacterial Inhibitor
Enoxacin is a fluoroquinolone antibacterial that primarily targets bacterial DNA gyrase and topoisomerase IV, with reported IC50 values of 126 µg/ml and 26.5 µg/ml, respectively. It exhibits strong inhibitory activity against both gram-positive and gram-negative bacteria. Additionally, Enoxacin acts as a miRNA processing activator, facilitating siRNA-mediated mRNA degradation and promoting the biogenesis of endogenous miRNAs. Notably, Enoxacin serves as a cancer-specific growth inhibitor through the enhancement of TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing, making it valuable for research in bacterial inhibition and cancer biology. -
Parasite Inhibitor
Dihydroartemisinic acid, a biosynthetic precursor to the antimalarial compound Artemisinin, functions primarily as a parasite inhibitor. This compound demonstrates potent activity against malaria-causing Plasmodium species, making it valuable for research in malaria treatment and drug development. Its role in synthesizing Artemisinin positions it as an important reagent for studies focusing on antimalarial therapies. -
Bacterial Inhibitor
Roxithromycin is a semi-synthetic macrolide antibiotic that exerts its antibacterial effects by inhibiting protein biosynthesis at the elongation step through binding to the 50S subunit of the bacterial ribosome. This compound demonstrates broad biological activity, including antimicrobial, antiproliferative, and anti-inflammatory properties. Additionally, Roxithromycin has been shown to inhibit tumor vasculature and alleviate lung injury, making it a valuable reagent for research applications in infectious disease, cancer therapy, and respiratory health. -
Nucleoside Reverse Transcriptase Inhibitor
Stavudine is an orally active nucleoside reverse transcriptase inhibitor (NRTI) that selectively targets HIV-1 and HIV-2. In addition to its antiviral properties, Stavudine inhibits mitochondrial DNA replication and has been shown to reduce NLRP3 inflammasome activation while modulating Amyloid-β autophagy. Furthermore, Stavudine is associated with the induction of apoptosis, making it a valuable tool for research in HIV treatment and cellular apoptosis mechanisms. -
Squalene Epoxidase Inhibitor
Liranaftate is a potent squalene epoxidase inhibitor exhibiting anti-fungal properties. It is primarily utilized in research focusing on dermatophyte infections. Additionally, Liranaftate has been shown to suppress the fungal element-mediated production of interleukin-8 (IL-8) and modulate inflammatory responses, making it valuable for studies involving inflammatory pathways in fungal infections. -
Fungal Inhibitor
Pseudolaric Acid C is a bioactive diterpenoid derived from the root bark of Pseudolarix amabilis, primarily acting as a fungal inhibitor. It exhibits significant antifungal activity, making it a valuable tool for research focused on fungal pathogenesis and the development of antifungal therapies. Its ability to disrupt fungal growth positions it as an important compound in the study of mycology and related fields. -
Fungal Inhibitor
5-Hydroxymethylfurfural is a furan derivative that serves as a potent fungal inhibitor. It exhibits anti-yeast activity by suppressing growth and fermentation under stress conditions, making it valuable for studies related to microbial resistance and fermentation processes. This compound is utilized in research focused on food preservation and biotechnological applications. -
Fungal Inhibitor
Hecogenin is a steroid saponin derived from Agave sisalana, known for its selective inhibition of human UDP-glucuronosyltransferases. It exhibits a diverse range of biological activities, particularly as a potent antifungal agent, while also demonstrating anti-inflammatory and gastroprotective properties. Hecogenin is of interest in pharmacological research for its potential therapeutic applications in treating fungal infections and inflammatory conditions. -
Bacterial Inhibitor
Benzoic acid is an aromatic carboxylic acid that functions as a bacterial inhibitor. It demonstrates significant antimicrobial activity by inhibiting the growth of bacteria and fungi, making it an effective preservative. Benzoic acid is widely utilized in food, beverages, cosmetics, and various research applications to study microbial growth inhibition and preservation techniques. -
Bacterial Inhibitor
Tilmicosin is a macrolide antibiotic and calcium channel antagonist that targets the bacterial ribosome's 50S subunit, effectively inhibiting protein synthesis. It possesses significant antimicrobial activity and is primarily utilized in treating respiratory diseases in livestock, including cattle, sheep, and pigs. Additionally, Tilmicosin exhibits immunomodulatory and anti-inflammatory properties, making it a valuable reagent in veterinary medicine research. -
Antifungal/Exosome Inhibitor
Neticonazole hydrochloride is an imidazole derivative that acts as a potent antifungal agent through the inhibition of fungal sterol synthesis. In addition to its antifungal properties, it has shown promising anti-cancer effects, primarily through the modulation of exosome release and related pathways. This compound is suitable for research applications aimed at exploring antifungal therapies and investigating potential anti-cancer mechanisms. -
Fungal Inhibitor
Piroctone olamine is a pyridine derivative that acts as a potent fungal inhibitor by disrupting fungal cell membrane integrity. It exhibits fungicidal activity effective against a variety of dermatophytes and yeast, making it valuable for research in antifungal treatment and dermatological applications. Its mechanism of action supports investigations into fungal pathogenesis and the development of antifungal therapies. -
Fungal Inhibitor
Dehydroacetic acid sodium is a pyrone derivative known for its fungicidal properties. It exhibits antibacterial and antifungal activity, making it valuable for applications in microbial control in various settings. Additionally, dehydroacetic acid demonstrates phytotoxic effects, indicating its potential use in agricultural research. -
Bacterial Inhibitor
Sodium citrate dihydrate is a bacterial inhibitor that acts by disrupting cellular processes in bacteria. This compound exhibits antibacterial, anti-tumor, and antioxidant activities, demonstrating potential in both microbial and cancer research applications. It can be utilized as a cosolvent or buffer in various biochemical assays, facilitating enhanced stability and solubility of target compounds. -
1,3-β-D-glucan Synthase Inhibitor
L 705589 is an inhibitor of 1,3-β-D-glucan synthase, targeting the synthesis of key structural components in the fungal cell wall. This semi-synthetic penicillin-type antifungal exhibits potent activity against various Candida species, including Candida albicans and Candida glabrata, with minimum fungicidal concentrations ranging from 0.06 to 8 µg/mL. It demonstrates limited efficacy against Cryptococcus neoformans (MFC: 32 - 64 µg/mL) yet maintains effectiveness against drug-resistant Candida strains and shows a reduced tendency to induce resistance. Additionally, L 705589 has been shown to enhance survival rates in models of minor invasive aspergillosis. -
Fungal Inhibitor
Aliconazole is an imidazole derivative that functions as an antifungal agent by inhibiting fungal ergosterol synthesis, which is critical for maintaining cell membrane integrity. This compound exhibits activity against a range of fungal pathogens, making it suitable for applications in mycology research and exploring antifungal mechanisms. Its efficacy in treating fungal infections makes it a valuable reagent for studies focused on antifungal drug development and resistance mechanisms. -
CYP51 Inhibitor
CYP51-IN-30 is a potent inhibitor of CYP51, targeting sterol 14α-demethylase, an essential enzyme in sterol biosynthesis. This compound exhibits significant fungicidal activity, demonstrated by an EC50 value of 2.97 mg/L against Sclerotinia sclerotiorum. Its efficacy makes it a valuable tool for research in antifungal studies and applications in plant pathology. -
Fungal Inhibitor
BHBM is an aromatic acylhydrazone compound that acts as a potent antifungal agent targeting Cryptococcus neoformans. Its high bactericidal activity makes it a valuable tool for research applications focused on fungal infections and the development of new antifungal therapies. BHBM can be used to explore mechanisms of action and resistance in fungi, contributing to advancements in infectious disease research. -
Group II introns Inhibitor
Group II intron-IN-1 acts as an inhibitor of fungal Group II introns, demonstrating an IC50 of 3 μM. This compound is valuable for research focusing on fungal infections, particularly those caused by Candida species. Its ability to selectively target intronic processes makes it a significant tool for studying fungal biology and the mechanisms of infection. -
Laccase Inhibitor
Laccase-IN-6 is a potent laccase inhibitor with an IC50 of 0.097 nM. This compound demonstrates a broad-spectrum anti-fungal activity, effectively disrupting normal fungal morphology. Laccase-IN-6 is suitable for research applications focused on fungal infections and the role of laccase in pathogenicity. -
Yck2 Inhibitor
GW461484A is a selective inhibitor of Candida albicans Yck2, demonstrating an IC50 of 0.11 µM. This compound exhibits significant antifungal activity, with a MIC80 of 12.5 µM against C. albicans. GW461484A is valuable for research into fungal infections, particularly those involving drug-resistant strains of Candida. -
Yck2 Inhibitor
Yck2-IN-1 is a potent inhibitor of the Yck2 kinase in Candida albicans, exhibiting an IC50 of approximately 80 nM. This compound demonstrates effective antifungal activity, with a MIC80 of 12.5 µM against C. albicans and a favorable metabolic profile, retaining 66% stability in mouse liver microsomes. In preclinical studies, Yck2-IN-1 significantly reduced fungal load in the kidneys of mice with drug-resistant candidiasis, highlighting its potential for research applications in antifungal treatment development. -
CDA Inhibitor
CDA-IN-4 is a chitin deacetylase (CDA) inhibitor. It demonstrates a protective effect of 61.2% against rice blast disease at a concentration of 100 μg/mL. This compound is pertinent for research applications targeting fungal infections in plants and exploring mechanisms of disease resistance. -
Fungal Inhibitor
Methoxyanigorufone is a fungal inhibitor derived from Musa acuminata var. "Yangambi km 5." This compound exhibits significant antifungal activity, demonstrating effectiveness against a range of pathogenic fungi. It is particularly useful in studies exploring fungal resistance mechanisms and the development of antifungal agents in research applications. -
BcSDH Inhibitor
SDH-IN-45 is an inhibitor of succinate dehydrogenase (BcSDH) that targets Botrytis cinerea, exhibiting an IC50 of 5.97 μg/mL. This compound impedes fungal energy metabolism through a distinct binding mode, leading to morphological disruptions, including structural collapse and shrinkage of mycelial forms. SDH-IN-45 demonstrates potent in vitro fungicidal activity against Botrytis cinerea, making it a valuable reagent for research focused on cucumber gray mold and related phytopathological studies. -
TMV Inhibitor
TMV-IN-15 is a potent inhibitor of Tobacco Mosaic Virus (TMV) by targeting the TMV coat protein (TMV-CP). This compound effectively suppresses viral particle assembly, leading to significant aggregation and structural fusion of viral components. TMV-IN-15 also demonstrates inhibitory activity against important fungal pathogens such as Physalospora piricola and Rhizoctonia cerealis. This reagent is valuable for research applications in antiviral and antifungal pesticide development. -
Succinate Dehydrogenase Inhibitor
SDH-IN-38 is a potent inhibitor of succinate dehydrogenase, primarily targeting mycelial respiration. Demonstrating significant antifungal activity, SDH-IN-38 exhibits an EC50 value of 0.009 μg/mL against R. solani mycelia, effectively inhibiting mycelial growth. Additionally, this compound induces cellular senescence and reduces mitochondrial membrane potential in fungal cells, making it a valuable tool for research in fungal biology and disease management. -
Calcineurin Inhibitor
JH-FK-08 is a potent inhibitor of the serine/threonine-specific phosphatase calcineurin. It demonstrates significant antifungal activity against Cryptococcus neoformans, with a MIC80 of 0.8 µg/mL, and displays immunosuppressive properties by inhibiting IL-2 expression with an IC50 of 42.6 nM. JH-FK-08 also shows efficacy in mouse models for anti-infectious applications, making it valuable for research in immunology and infectious disease. -
Fungal Inhibitor
Bromomonilicin is a selective inhibitor of fungal cell membranes. It exerts its antifungal activity by disrupting the integrity of fungal cell membranes, making it a valuable tool for studying plant pathogenic fungal infections, such as those caused by Monilinia fructicola leading to brown rot, as well as superficial mycoses, including dermatophyte infections. This compound is essential for research aimed at understanding and combating fungal diseases in both agricultural and clinical settings. -
Squalene Synthase Inhibitor
E5700 is a potent squalene synthase inhibitor, exhibiting an IC50 of 0.49 nM against squalene synthase from Trypanosoma cruzi epimastigotes. This compound demonstrates notable antiparasitic activity, effectively inhibiting the growth of Trypanosoma cruzi and Leishmania amazonensis. Additionally, E5700 impacts the lipid profile and ultrastructure of multi-drug resistant Candida tropicalis strains, making it a valuable tool for research on parasitic infections and antifungal resistance mechanisms. -
Fungal Inhibitor
Butenafine-d4 is a deuterium-labeled analogue of Butenafine, a potent benzylamine antifungal agent. It exerts its antifungal activity by specifically inhibiting ergosterol biosynthesis at the squalene epoxidation step, which disrupts fungal cell membrane integrity. Butenafine displays effectiveness against a range of dermatophyte infections, including tinea pedis, tinea cruris, and tinea versicolor. This reagent is suitable for research applications focused on antifungal mechanisms and the study of fungal pathogens.
