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Catalog No.
Product Name
Application
Product Information
Citations
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Influenza A Virus Inhibitor
Influenza virus-IN-1 is a potent inhibitor of Influenza A virus, exhibiting an EC50 of 2.46 µM and a CC50 exceeding 200 µM. This compound demonstrates concentration-dependent inhibition of the PAN endonuclease, with an EC50 of 312.36 nM. Influenza virus-IN-1 is valuable for research focused on evaluating anti-influenza A virus therapies and elucidating viral mechanisms. -
Neuraminidase Inhibitor
Neuraminidase-IN-5 is a potent neuraminidase inhibitor, demonstrating an IC50 of 0.02 μM. Targeting the neuraminidase enzyme makes this compound a promising candidate for the development of novel anti-influenza therapies. As a dihydrofurocoumarin derivative, Neuraminidase-IN-5 offers significant potential for research applications in virology and antiviral drug discovery. -
Influenza Virus Inhibitor
Influenza virus-IN-4 is a potent inhibitor of the influenza virus neuraminidase, exhibiting IC50 values of 3.4 µM, 0.094 µM, 0.79 µM, and 0.077 µM against H5N1, H5N2, H5N6, and H5N8, respectively. This compound demonstrates effective NA-inhibitory activity, contributing to its role in antiviral research. Additionally, Influenza virus-IN-4 exhibits low cytotoxicity, with a CC50 greater than 200 µM, and displays no significant toxicity at doses of 1500 mg/kg in murine models. Its safety profile and efficacy in inhibiting neuraminidase make it a valuable tool for studying influenza virus pathogenesis and developing therapeutic strategies. -
CEN Inhibitor
Cap-dependent endonuclease-IN-8 is a potent inhibitor of cap-dependent endonuclease (CEN), a crucial enzyme in the replication of orthomyxoviruses. This compound effectively demonstrates antiviral activity against diverse strains, including influenza A, B, and C. It serves as a valuable tool for research investigating the molecular mechanisms of viral replication and the development of novel antiviral therapies. -
Neuraminidase Inhibitor
Neuraminidase-IN-6 is a potent inhibitor of neuraminidase, exhibiting an IC50 of 0.11 μM. As a 1,3,4-triazole-3-acetamide derivative, it demonstrates effective inhibition of viral neuraminidase, an essential target for anti-influenza drug development. This compound is valuable for research focused on influenza virus mechanisms and potential therapeutic strategies. -
Influenza A Viruses Inhibitor
Antiviral agent 43 is a potent entry inhibitor targeting influenza A viruses. This compound effectively inhibits the replication of various influenza A strains, including VH04-H5N1 and PR8-H1N1, with EC50 values of 240 nM and 72 nM, respectively. Its oral bioavailability makes it a valuable tool for research into antiviral therapies against influenza A virus infections. -
CEN Inhibitor
Sebaloxavir marboxil is a potent inhibitor of cap-dependent endonuclease (CEN). This compound effectively suppresses the replication of influenza viruses, making it a valuable tool in the investigation of viral infections associated with these pathogens. Its mechanism of action highlights its potential applications in antiviral research and the development of therapeutic strategies against influenza. -
Neuraminidase Inhibitor
Massarilactone H is a polyketide that acts as a neuraminidase inhibitor, exhibiting an IC50 value of 8.18 µM. This compound demonstrates significant biological activity in modulating viral replication and has potential research applications in virology and therapeutic development against influenza and other neuraminidase-dependent pathogens. -
NS1 inhibitor
NS1-IN-1 is a potent inhibitor of the NS1 protein, a critical virulence factor for the influenza A virus that disrupts host gene expression. By targeting the NS1 protein, NS1-IN-1 effectively reduces viral protein levels and inhibits virus replication. Its antiviral activity is mediated through the repression of mTORC1 signaling in a TSC1-TSC2-dependent manner, making it a valuable tool for research into influenza virus pathogenesis and potential therapeutic strategies. -
Neuraminidase Inhibitor
Neuraminidase-IN-18 is a potent neuraminidase inhibitor designed to target the neuraminidase enzyme in influenza viruses. It exhibits significant inhibitory activity against H5N1 neuraminidase, with IC50 values of 0.14 μM for the wild-type strain and 0.27 μM for the H5N1-H274Y mutant. This compound effectively inhibits influenza virus replication at the cellular level, making it a valuable tool for research in antiviral drug development and the study of influenza pathogenicity. -
CEN Inhibitor
Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN), a critical enzyme involved in viral RNA synthesis. As a macrocyclic pyridotriazine derivative, it exhibits significant potential for research focused on viral infections, particularly those caused by the Orthomyxoviridae family, including influenza viruses. This compound serves as a valuable tool in studying the mechanisms of viral replication and may aid in the development of antiviral therapeutics. -
Endonuclease Inhibitor
Suraxavir marboxil is an endonuclease inhibitor specifically targeting the PA subunit of cap-dependent endonucleases, demonstrating significant antiviral activity against influenza A and B viruses. By inhibiting the PA subunit, Suraxavir marboxil effectively disrupts viral replication. This reagent can be utilized in research to explore therapeutic strategies for preventing influenza A and B infections, both as a standalone treatment and in combination with other antiviral agents. -
Influenza Virus Inhibitor
Influenza virus-IN-8 is a potent inhibitor targeting the influenza virus by inducing the aggregation of viral nucleoprotein (NP) and blocking its nuclear accumulation. This compound demonstrates broad-spectrum anti-influenza activity, effectively inhibiting both the replication and transcription of influenza A viruses. Additionally, Influenza virus-IN-8 is effective against Oseltamivir-resistant H1N1/pdm09 strains, making it a valuable tool for research in combating influenza virus variants. -
CEN Inhibitor
Cap-dependent endonuclease-IN-17 is a highly selective inhibitor of cap-dependent endonuclease (CEN). This compound exhibits significant antiviral activity against influenza virus A/Hanfang/359/95 (H3N2), with an IC50 value of 1.29 μM. It serves as a valuable tool for research focused on antiviral therapies and the inhibition of viral replication mechanisms. -
Influenza Neuraminidase Inhibitor
Neuraminidase-IN-9 is a highly effective inhibitor of influenza neuraminidase, exhibiting IC50 values of 0.12 µM for H5N1, 0.049 µM for H5N2, and 0.16 µM for H5N6. This compound demonstrates significant antiviral activity, making it a valuable tool in influenza research. Neuraminidase-IN-9 can be utilized in studies aimed at understanding and combating influenza virus infections. -
CEN Inhibitor
Cap-dependent endonuclease-IN-7 is a potent inhibitor of cap-dependent endonuclease (CEN), disrupting the synthesis of viral mRNA. This inhibition subsequently hampers viral proliferation. Cap-dependent endonuclease-IN-7 is valuable for research into viral infections, including strains of influenza A, B, and C. -
Neuraminidase Inhibitor
DS-22-inf-021 is a neuraminidase inhibitor that exhibits antiviral activity against influenza viruses. By inhibiting neuraminidase, this compound disrupts viral replication and spread, making it a valuable tool for research in virology and antiviral drug development. Its effectiveness against influenza strains positions DS-22-inf-021 as a potential candidate for further exploration in therapeutic applications. -
Influenza Virus Inhibitor
Zanamivir-Cholesterol Conjugate is a long-acting neuraminidase inhibitor targeting the influenza virus. This compound exhibits potent efficacy against both drug-sensitive and drug-resistant strains of the virus, making it valuable for studying influenza pathogenesis and developing therapeutic strategies. Its unique conjugation to cholesterol enhances membrane association, potentially improving bioavailability and antiviral activity in cellular systems. -
Neuraminidase Inhibitor
4-O-Methylepisappanol is a potent neuraminidase inhibitor derived from the heartwood of Caesalpinia sappan. It effectively inhibits neuraminidase activity in various strains of influenza viruses, demonstrating IC50 values of 42.8 µM for A/Chicken/Korea/MS96/96 [H9N2] and 63.2 µM for both A/PR/8/34 [H1N1] and A/Hong Kong/8/68 [H3N2]. This compound is valuable for studying viral pathogenesis and developing antiviral therapies targeting influenza neuraminidase. -
Influenza Virus Inhibitor
Influenza virus-IN-3 is a selective inhibitor targeting the influenza virus, demonstrating potent antiviral activity with IC50 values of 0.88, 0.10, 5.5, and 0.51 µM against H5N1, H5N2, H5N6, and H5N8 strains, respectively. This compound effectively inhibits neuraminidase (NA) enzyme activity, making it a valuable tool in influenza research. With a CC50 greater than 200 µM, Influenza virus-IN-3 displays low cytotoxicity, supporting its potential use in therapeutic applications. -
CEN Inhibitor
Cap-dependent endonuclease-IN-23 is a selective inhibitor of cap-dependent endonuclease (CEN), effectively blocking its activity. This compound demonstrates significant antiviral properties by inhibiting the replication of influenza A virus. Cap-dependent endonuclease-IN-23 is intended for research applications focused on understanding and combating influenza virus infections. -
RSV Inhibitor
RSV-IN-4 is a dual inhibitor targeting respiratory syncytial virus (RSV) and influenza virus A (IAV). This compound demonstrates significant anti-RSV activity, achieving an EC50 of 11.76 μM. RSV-IN-4 is primarily utilized in research applications focused on antiviral drug development and understanding viral pathogenesis. -
Influenza Virus Inhibitor
Viral polymerase-IN-1 hydrochloride is a potent inhibitor of influenza A and B viruses, demonstrating inhibitory concentration (IC90) values ranging between 11.4 and 15.9 μM. This compound also exhibits activity against SARS-CoV-2, effectively suppressing viral infection. The primary mechanism of action involves the disruption of viral RNA replication and transcription within host cells, making it a valuable reagent for research into antiviral therapies and viral pathogenesis. -
PAN Inhibitor
Influenza virus-IN-6 is a potent inhibitor of the N-terminal domain of the polymerase acidic protein subunit (PAN) endonuclease, exhibiting an IC50 value of 0.20 μM. This compound demonstrates significant antiviral activity against influenza viruses, making it a valuable tool for research applications focused on influenza virus replication and therapeutics. Its inhibitory effects on PAN endonuclease provide insights into the molecular mechanisms of influenza pathogenesis and potential treatment strategies. -
Neuraminidase Inhibitor
Drechslerine A is a neuraminidase inhibitor with an IC50 value of 0.79 μM. This terpene, isolated from the endophytic fungus Cochliobolus, exhibits significant antiviral activity. Drechsilerine A is utilized in research related to the influenza virus, making it a valuable tool for studying viral pathogenesis and therapeutic interventions. -
Anti-Influenza Agent/PDF Inhibitor
FR198248 is an anti-influenza agent that acts as a peptide deformylase (PDF) inhibitor. Isolated from Aspergillus flavipes, FR198248 demonstrates potent inhibition of the PDF enzyme in Staphylococcus aureus, with an IC50 value of 3.6 µM. This compound is suitable for use in antiviral and antibacterial research applications, allowing for further exploration of its therapeutic potential against viral and bacterial pathogens. -
Neuraminidase Inhibitor
Neuraminidase-IN-3 is a potent inhibitor of influenza neuraminidase, exhibiting IC50 values of 0.73 nM, 0.26 nM, and 0.63 nM against H1N1, H5N1, and H5N8 neuraminidases, respectively. This compound is critical for research focused on antiviral drug development and studying the mechanisms of influenza virus infection and resistance. Its high potency makes it a valuable tool for elucidating neuraminidase functions in viral pathogenesis and therapeutics. -
Influenza Virus Inhibitor
D715-2441 is an influenza virus RNA polymerase inhibitor with an IC50 range of 1.7-4.4 μM. This compound demonstrates broad-spectrum antiviral activity against various influenza A strains. D715-2441 serves as a valuable tool for research pertaining to seasonal influenza and the study of influenza virus dynamics. -
Influenza A Virus Inhibitor
M2WJ332 is a potent inhibitor of the M2 proton channel in the Influenza A virus, specifically targeting the M2S31N mutant variant. With an IC50 of 16 μM, M2WJ332 effectively prevents plaque formation in Influenza A virus carrying the M2S31N mutation. This compound is suitable for research applications focused on understanding and combating Influenza A virus infections. -
Influenza Viru Inhibitor
Laninamivir TFA is a long-acting neuraminidase inhibitor that effectively targets influenza A and B viruses. This antiviral compound exhibits both inhibitory and prophylactic activity, making it a valuable tool for influenza research. Administered via nasal inhalation, Laninamivir TFA demonstrates promising safety and efficacy profiles in the inhibition of viral replication, supporting its application in studies of influenza virus dynamics and treatment strategies. -
Influenza A Inhibitor
Influenza A virus-IN-17 is a selective inhibitor targeting Influenza A viruses, demonstrating effective inhibition with EC90 values of 3.5 μM for H3N2 and 2.6 μM for H1N1. This compound effectively disrupts the cap-snatching polymerase activity, as indicated by an EC90 of 2.1 μM against U2-PB2 chimeric mRNA. Influenza A virus-IN-17 is suitable for research in antiviral drug development and understanding Influenza A virus mechanisms. -
H1N1 Hemagglutinin Inhibitor
RO5464466 is a potent inhibitor of hemagglutinin (HA) in H1N1 influenza viruses. It effectively inhibits HA-mediated hemolysis of chicken erythrocytes, demonstrating an IC50 value of 0.29 μM. This compound is valuable for research applications focused on influenza virus entry mechanisms and the development of antiviral strategies. -
PIV-3 Inhibitor
Caesalmin E is a natural cassane furanoditerpene that acts as a potent inhibitor of the Parainfluenza virus type 3 (PIV-3). Its antiviral properties make it a valuable compound for research focused on combating viral infections, specifically in studies targeting PIV-3-related pathologies. This compound may be utilized in investigations of viral replication mechanisms and as a potential therapeutic agent against respiratory infections. -
Influenza Virus Fusion Inhibitor
BMS-199945 is an influenza virus fusion inhibitor that targets the viral fusion process. It demonstrates significant inhibitory activity with IC50 values of 0.57 μM against influenza A/WSN/33 virus-induced hemolysis in chicken red blood cells and approximately 1 μM in the trypsin protection assay. This reagent is applicable for research into antiviral therapies and the mechanisms of influenza virus pathogenesis. -
NA Inhibitor
ent-Oseltamivir, the enantiomer of Oseltamivir, serves as a neuraminidase (NA) inhibitor targeting influenza virus. Its primary biological activity involves inhibiting viral replication, making it a valuable tool for studying influenza virus infections. Research applications include evaluating antiviral efficacy and resistance mechanisms, contributing to the development of effective therapeutic strategies against influenza. -
Matriptase Inhibitor Intermediate
Sodium 3-iodobenzenesulfonate serves as an intermediate in the synthesis of Matriptase inhibitors, specifically those derived from 3-amidinophenylalanine. This reagent is valuable for research applications involving the inhibition of Matriptase and has been implicated in studies related to the H9N2 influenza virus. Its utility in chemical research makes it an important compound for exploring therapeutic avenues targeting Matriptase and associated viral infections. -
Furin Inhibitor
Furin-IN-3 is a potent and selective inhibitor of the proprotein convertase furin, exhibiting a Ki of 12.4 nM. Additionally, it demonstrates a Ki of 278 nM for PC7. This compound has been shown to exert significant antiviral activity against the furin-dependent H7N7 influenza A virus strain SC35M by inhibiting the cleavage and activation of the viral hemagglutinin (HA), thereby preventing viral membrane fusion with host cells and inhibiting viral replication. Furin-IN-3 is a valuable tool for research into viral infections, particularly those related to influenza. -
Influenza Inhibitor
6-Epi-albassitriol is a potent influenza inhibitor derived from Aspergillus sp. FH-A 6357. It effectively disrupts cholesterol synthesis, achieving an inhibition rate of 40% at a concentration of 10 nM in HepG2 cells. Additionally, 6-Epi-albassitriol demonstrates significant antiviral activity against both influenza A virus and parainfluenza virus, with a minimum inhibitory concentration (MIC) ranging from 44.4 to 133.3 µg/mL, making it a valuable compound for research in antiviral therapeutics. -
IAV Inhibitor
IAV replication-IN-1 is a potent inhibitor of influenza A virus (IAV) replication. This compound effectively reduces the upregulation of inflammatory factors and apoptosis associated with IAV infection, providing potential protective effects against lung injury induced by the virus. It is suitable for research applications focused on viral pathogenesis, inflammation, and therapeutic interventions in respiratory diseases. -
Influenza A Inhibitor
Pimodivir hydrochloride hemihydrate (VX-787) is an orally bioavailable inhibitor targeting the influenza A virus polymerase by specifically interfering with the PB2 subunit. This compound demonstrates significant antiviral activity against various strains of the influenza A virus, making it a valuable tool for research in virology and antiviral drug development. Its mechanism of action paves the way for studying the dynamics of viral replication and the efficacy of potential therapeutic interventions. -
Influenza Virus Inhibitor
M090 is a potent inhibitor of hemagglutinin, specifically targeting the influenza A virus. It effectively inhibits multiple strains of influenza, demonstrating an EC50 in the micromolar range. This compound is essential for research applications involving antiviral drug development and the study of influenza virus pathogenesis. -
Hemagglutinin Inhibitor
F0045(S) is an effective inhibitor of influenza hemagglutinin, demonstrating a KD value of 6.1 µM. This compound is utilized in biological research to investigate its protective effects against influenza virus infections in human cells, making it a valuable tool for antiviral studies and the development of therapeutic strategies. -
RSV/IAV Inhibitor
RSV/IAV-IN-2 is a potent dual inhibitor targeting respiratory syncytial virus (RSV) and influenza A virus (IAV). This compound demonstrates reduced cytotoxicity compared to the established antiviral Ribavirin, making it a valuable candidate for studies focused on RSV and/or IAV infections. Its efficacy in inhibiting viral replication supports its use in antiviral research and therapeutic development against these respiratory pathogens. -
RSV/IAV Inhibitor
RSV/IAV-IN-1 is a potent dual inhibitor targeting respiratory syncytial virus (RSV) and influenza A virus (IAV). This compound exhibits reduced cytotoxicity compared to the clinical antiviral agent Ribavirin, making it a valuable tool for studying RSV and IAV infections. RSV/IAV-IN-1 facilitates research into antiviral mechanisms and therapeutic strategies against these viral pathogens. -
Influenza Virus Inhibitor
CEF6 is a 9-amino acid peptide derived from residues 418-426 of the nucleocapsid protein of influenza A virus (H1N1). It functions as an inhibitor of influenza virus, demonstrating key antiviral activity through interference with the viral life cycle. This peptide is valuable for research applications focused on studying viral replication mechanisms and the development of antiviral therapeutics targeting influenza infections. -
Parasite Inhibitor
Methylene blue trihydrate is an inhibitor of guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and nitric oxide synthase (NOS). This compound exhibits a range of biological activities including antinociceptive, antimalarial, antidepressant, and anxiolytic effects. Methylene blue trihydrate is utilized in research applications related to methemoglobinemias, neurodegenerative disorders, and treatment of ifosfamide-induced encephalopathy. Additionally, it serves as a dye in various medical procedures, highlighting its versatility in scientific investigations. -
Parasites Inhibitor
Dehydroemetine is an orally active antiparasitic agent that targets and inhibits parasites, particularly Entamoeba histolytica. It exhibits key biological activity in combating parasitic infections and is used in research applications related to various parasitic diseases, including visceral leishmaniasis. -
Parasite Inhibitor
Trans-4-Methylcyclohexanamine is a key intermediate utilized in the development of inhibitors targeting Trypanosoma cruzi enzymes. This compound demonstrates significant biological activity against the parasite, making it a valuable tool for research in parasitology and drug discovery. Its applications extend to the exploration of therapeutic options for parasitic infections, particularly Chagas disease. -
Parasite Inhibitor
Diazinon is an irreversible acetylcholinesterase (AChE) inhibitor with primary applications in pest control as an insecticide. By inhibiting AChE, Diazinon leads to the accumulation of acetylcholine, resulting in overstimulation of acetylcholine receptors and disruption of nervous system function. Additionally, Diazinon generates reactive oxygen species (ROS), contributing to oxidative stress across various biological tissues. This compound is predominantly utilized in agricultural settings but may also hold implications for human and animal health research. -
Chitinase Inhibitor
Argifin is a potent chitinase inhibitor that demonstrates sub-nanomolar activity, targeting multiple chitinase enzymes. It exhibits impressive IC50 values of 0.025 μM for SmChiA from Serratia marcescens, 6.4 μM for SmChiB, 1.1 μM for Aspergillus fumigatus chitinase B1, and 4.5 μM for human chitotriosidase. Argifin is instrumental in studies exploring chitin metabolism and offers potential applications in antifungal research and elucidation of chitinase-related diseases.
