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Catalog No.
Product Name
Application
Product Information
Citations
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SCD1 Inhibitor
SSI-4 is a potent stearoyl-CoA desaturase (SCD1) inhibitor with an EC50 of 1.9 nM for mouse SCD1. By blocking the conversion of saturated fatty acids to monounsaturated fatty acids, SSI-4 effectively reduces oleic and palmitoleic acid production. It promotes lipid peroxidation, induces endoplasmic reticulum stress, and activates apoptotic pathways. Additionally, SSI-4 inhibits mTORC1 activity, suppresses B cell proliferation and antibody production, and induces autophagy. This compound is valuable for studies related to cancers such as acute myeloid leukemia and renal cell carcinoma, as well as influenza infections. -
actin polymerization inhibitor
Cytochalasin D (also known as Zygosporin A) is a cell-permeable fungal metabolite and a potent inhibitor of actin polymerization. It binds to G-actin, thereby disrupting the G-actin–cofilin interaction and preventing cofilin association with F-actin. Through this mechanism, Cytochalasin D reduces both actin polymerization and depolymerization rates in living cells, leading to profound effects on cytoskeletal organization and cell morphology. In addition, Cytochalasin D suppresses exosome release, consequently decreasing survivin levels within the tumor microenvironment. It also promotes phosphorylation and cytoplasmic retention of YAP, implicating it in the regulation of mechanotransduction and tumor cell signaling. -
NS3-NS4B interaction inhibitor
(+)-JNJ-A07 is a highly potent, orally active pan-serotype dengue virus inhibitor that targets the NS3–NS4B protein interaction. It demonstrates nanomolar to picomolar antiviral activity across a panel of 21 clinical dengue virus isolates. With a favorable pharmacokinetic profile, (+)-JNJ-A07 exhibits exceptional efficacy in mouse models of dengue virus infection, making it a strong candidate for antiviral research and therapeutic development. -
Hsp90/HSV inhibitor
AT-533 is a potent inhibitor of heat shock protein 90 (Hsp90) and herpes simplex virus (HSV), exhibiting strong antitumor and antiviral activities. It suppresses tumor growth and angiogenesis by disrupting the HIF-1α/VEGF/VEGFR-2 signaling axis, a critical pathway in tumor vascularization and progression. Additionally, AT-533 inhibits key downstream signaling cascades, including Akt/mTOR/p70S6K, ERK1/2, and FAK pathways. In endothelial cells, specifically human umbilical vein endothelial cells (HUVECs), AT-533 effectively inhibits tube formation, cell migration, and invasion, highlighting its anti-angiogenic properties. These combined effects position AT-533 as a promising candidate for cancer therapy and angiogenesis-related disease research. -
HIV-1 protease/PTP1B inhibitor
Isosinensetin is a bioactive flavonoid compound with diverse pharmacological properties. It acts as a dual inhibitor of HIV-1 protease and protein tyrosine phosphatase 1B (PTP1B), with an IC₅₀ of 2.61 µM and a Kᵢ of 0.92 µM for PTP1B, indicating its potential in antiviral and metabolic disease research. Additionally, isosinensetin inhibits P-glycoprotein (P-gp) activity in MDR1-MDCKII cells, suggesting its utility in overcoming multidrug resistance. Isosinensetin exhibits multiple therapeutic effects, including anti-tumor, anti-viral, anti-inflammatory, and antioxidant activities. These properties support its application in the research of various conditions such as cancer, chronic inflammation, osteoporosis, diabetes, and infectious diseases. -
glutamine amidotransferase inhibitor
Azaserine (CI-337) is a glutamine analog and competitive inhibitor of glutamine amidotransferase, an enzyme involved in nucleotide biosynthesis. It exhibits both antibiotic and antitumor properties by disrupting glutamine-dependent metabolic processes essential for cell proliferation. Azaserine demonstrates antibacterial activity and has shown antitumor effects in various cancer models. However, it has also been reported to possess tumorigenic potential under certain conditions, warranting cautious evaluation. -
Influenza Virus Inhibitor
Dehydroandrographolide succinate acts as a potent inhibitor of the influenza virus. Extracted from the medicinal plant Andrographis paniculata, it exhibits immunostimulatory, anti-infective, and anti-inflammatory properties, making it valuable for research into viral pneumonia and upper respiratory tract infections. Additionally, it demonstrates antithrombotic effects by significantly reducing platelet aggregation, as evidenced by a calculated ED50 of 386.9 mg/kg. The compound also mitigates muscle atrophy through the Akt/GSK3β and MuRF-1 signaling pathways. -
GPI/NS2B-NS3/CK1ε Inhibitor
Rhodiolin is a flavonoid that acts as a GPI (glucose 6-phosphate isomerase) and NS2B-NS3 protease inhibitor, with significant implications for cancer and viral research. It demonstrates the ability to inhibit glycolysis in papillary thyroid cancer, leading to suppressed PI3K/AKT/mTOR signaling and induced apoptosis. Additionally, Rhodiolin disrupts dengue viral replication through its action on the NS2B-NS3 protease. With its potential to inhibit CK1ε kinase, it serves as a valuable candidate for developing anticancer strategies and investigating anti-tumor and antiviral mechanisms. -
Bacterial Inhibitor
Vasicine, a quinazoline alkaloid derived from Justicia adhatoda, primarily targets bacterial strains as an inhibitor. This compound is known to activate the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory activities. Its unique biological profile makes Vasicine valuable for research in microbial resistance and inflammation-related studies. -
Bacterial Inhibitor
Vasicine hydrochloride, a quinazoline alkaloid derived from Justicia adhatoda, acts primarily as a bacterial inhibitor. It activates the PI3K/Akt signaling pathway and demonstrates significant antioxidant and anti-inflammatory properties. This compound is valuable for research involving antimicrobial activity and cellular signaling pathways, making it a useful tool for studies in infectious disease and inflammation. -
Androgen/HSV-1 Inhibitor
Brassicasterol is a metabolite of Ergosterol that primarily targets androgen pathways and exhibits antiviral activity against HSV-1. It demonstrates significant anticancer potential in prostate cancer by dual modulation of AKT and androgen receptor signaling pathways. Additionally, Brassicasterol inhibits sterol δ 24-reductase, contributing to the slowdown of atherosclerosis progression. Furthermore, it serves as a cerebrospinal fluid biomarker for Alzheimer's disease, highlighting its relevance in neurodegenerative research. -
Bacterial Inhibitor
Bavachalcone is a bacterial inhibitor known for its multifaceted biological activities. It induces apoptosis and enhances autophagy in HepG2 cancer cells, contributing to its anticancer potential. Additionally, Bavachalcone demonstrates anti-neuroinflammatory and antidepressant effects through modulation of the NF-κB pathway. It also inhibits osteoclast differentiation by interfering with ERK and Akt signaling pathways, as well as the expression of c-Fos and NFATc1, and shows a significant inhibitory effect on BACE-1 activity in vitro. -
NA Inhibitor
Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's. -
HBV Inhibitor
Isoscopoletin, also known as 6-Hydroxy-7-methoxycoumarin, primarily inhibits hepatitis B virus (HBV) replication. It demonstrates significant cytotoxic effects against human CCRF-CEM leukaemia cells and their multidrug-resistant subline, with IC50 values of 4.0 μM and 1.6 μM, respectively. Additionally, Isoscopoletin exhibits anti-inflammatory properties by modulating the MAPK/NF-κB/STAT/AKT signaling pathways, making it a valuable compound for research in virology and cancer biology. -
IL-6 Inhibitor
Koaburaside is an IL-6 inhibitor known for its cytoprotective and anti-inflammatory properties. This natural compound exhibits significant antioxidant activity, with an IC50 value of 9.0 μM in the DPPH free radical scavenging assay. Additionally, Koaburaside effectively reduces histamine release and downregulates the expression of pro-inflammatory cytokines IL-6 and TNF-α in human mast cells. It also demonstrates inhibitory effects on influenza A neuraminidase, highlighting its potential applications in inflammatory and viral research. -
EV71 Inhibitor
Mosloflavone is a flavonoid derived from Scutellaria baicalensis Georgi, exhibiting inhibitory activity against Enterovirus 71 (EV71). It targets the VP2 protein, preventing viral replication and inhibiting the synthesis of viral capsid proteins during the early stages of infection. Additionally, Mosloflavone demonstrates biocidal properties by inhibiting Pseudomonas aeruginosa virulence and biofilm formation, making it a valuable tool for research in virology and microbiology. -
HIV-1 Entry Inhibitor
Trilobatin is a natural sweetener extracted from Lithocarpus polystachyus Rehd, functioning primarily as an HIV-1 entry inhibitor by targeting the HIV-1 Gp41 envelope protein. It demonstrates neuroprotective effects and acts as a selective SGLT1/2 inhibitor, promoting the proliferation of human hepatoblastoma cells. Trilobatin is valuable for research involving HIV-1 entry mechanisms and potential therapeutic applications in hepatoblastoma and neuroprotection studies. -
Bacterial Inhibitor
Lysozyme, also known as Muramidase, is a conserved antimicrobial protein that targets bacterial cell wall peptidoglycan (PG). It exerts a bactericidal effect by hydrolyzing PG, thereby limiting bacterial growth on mucosal surfaces and controlling potential pathogens while preventing dysbiosis through microbiota regulation. Additionally, extracellular lysozyme degrades polymeric PG into soluble fragments, activating NOD receptors in mucosal epithelial cells and stimulating the secretion of chemokines and activating factors by neutrophils and macrophages. This makes lysozyme a valuable reagent for studies involving antimicrobial activity, immune response, and microbiome research. -
Bacterial Inhibitor
Ciclopirox olamine is a synthetic antifungal agent primarily targeting various fungal pathogens. It exhibits a broad spectrum of activity against dermatophytes, yeasts, molds, and multiple Gram-positive and Gram-negative bacteria. In addition to its antibacterial properties, Ciclopirox olamine has demonstrated anticancer and anti-inflammatory effects, making it a valuable reagent for research in superficial mycoses, cancer biology, and inflammation studies. -
Bacterial Inhibitor
X-Neu5Ac sodium is a neuraminidase substrate that facilitates the chromogenic assay of neuraminidase activity in bacterial expression systems. This compound has a Km value of 0.89 mM for neuraminidase, making it an effective tool for studying neuraminidase function and inhibition. Its use in research applications provides insights into bacterial mechanisms and potential therapeutic targets for bacterial infections. -
Parasite Inhibitor
Isopimpinellin acts as a potent inhibitor of parasitic activity. Isolated from Glomerella cingulata, this orally active compound prevents DNA adduct formation and inhibits skin tumor initiation induced by 7,12-dimethylbenz[a]anthracene. Additionally, Isopimpinellin demonstrates significant anti-leishmania activity, making it a valuable reagent for studies in parasitology and cancer research. -
Bacterial Inhibitor
Sulfamethoxypyridazine is a long-acting sulfonamide antibiotic that primarily targets bacterial growth by inhibiting dihydropteroate synthase and disrupting folate synthesis. This compound exhibits significant antibacterial activity and is primarily utilized in research applications focused on understanding bacterial infections and exploring antibiotic resistance mechanisms. Suitable for studies related to dermatological conditions, it aids in exploring therapeutic strategies for diseases like dermatitis herpetiformis. -
Bacterial Inhibitor
Enoxacin hydrate, a fluoroquinolone antibiotic, targets bacterial DNA gyrase and topoisomerase IV, disrupting DNA replication with IC50 values of 126 µg/ml and 26.5 µg/ml, respectively. This compound exhibits significant antibacterial activity against both gram-positive and gram-negative bacteria. Additionally, Enoxacin hydrate functions as an activator of miRNA processing, facilitating siRNA-mediated mRNA degradation and enhancing the biogenesis of endogenous miRNAs. Its unique mode of action also includes the inhibition of cancer cell growth through the enhancement of TAR RNA-binding protein 2 (TRBP)-mediated microRNA processing. -
Bacterial Inhibitor
Chlorprothixene hydrochloride functions as an antagonist of dopamine and histamine receptors, exhibiting Kis of 18 nM for hD1, 2.96 nM for hD2, 4.56 nM for hD3, 9 nM for hD5, and 3.75 nM for hH1 receptors. This compound demonstrates significant antipsychotic activity, making it a valuable tool for research into neuropharmacology and the mechanisms underlying psychotic disorders. Its receptor modulation also indicates potential applications in the study of bacterial inhibition mechanisms, providing insights into the interplay between neurotransmitter systems and microbial pathogenesis. -
HSV Inhibitor
Acyclovir sodium is a selective inhibitor of herpes simplex virus (HSV), exhibiting strong antiherpetic activity with IC50 values of 0.85 μM for HSV-1 and 0.86 μM for HSV-2. This compound induces cell cycle disturbances and apoptosis in infected cells. Additionally, Acyclovir sodium is utilized to prevent bacterial infections during induction therapy in acute leukemia treatments, demonstrating its versatility in research applications related to viral infections and hematological malignancies. -
Fungal Inhibitor
Dihydrochelerythrine is a natural compound derived from Corydalis yanhusuo, primarily functioning as a fungal inhibitor. This compound exhibits notable antifungal activity, making it a valuable reagent for research applications focused on mycology and the study of fungal infections. Its properties may contribute to the development of novel antifungal therapies. -
Fungal Inhibitor
Cauloside A, a saponin derived from the roots of Dipsacus asper, serves as a potent fungal inhibitor. It exhibits significant antifungal activity, making it a valuable reagent for research focused on fungal pathogenesis and therapeutic interventions. Its effectiveness in combating various fungal strains positions Cauloside A as a crucial tool in the study of antifungal mechanisms and the development of new antifungal agents. -
Bacterial Inhibitor
Bafilomycin B1 is a macrolide antibiotic that targets vacuolar H+-ATPases (V-ATPases). It exhibits neuroprotective properties against Chloroquine-induced cell death and can significantly inhibit the accumulation of lipid droplets induced by oxidized low-density lipoprotein (LDL). Bafilomycin B1 is valuable for research focused on bacterial inhibition and studying lipid metabolism and cellular stress responses. -
PI-3 Virus Inhibitor
Tetrahydroepiberberine is an isoquinoline alkaloid derived from Corydalis impatiens. It exhibits significant antifungal properties and demonstrates selective inhibitory effects against the PI-3 virus. This compound is valuable for research applications focused on viral pathogenesis and the development of antiviral therapeutics. -
Tyrosinase Inhibitor
Geranic acid is a tyrosinase inhibitor with demonstrated antifungal properties, exhibiting an IC50 range of 0.14-2.3 mM against mushroom tyrosinase. This compound significantly reduces the viability of human pancreatic cancer cells and B-lymphoma cells, highlighting its potential in cancer research. Additionally, geranic acid effectively inhibits the mycelial growth of maize pathogens such as Colletotrichum graminicola and Fusarium graminearum. It serves as a valuable reagent for studies on fungal infections, pancreatic cancer, and B-lymphoma. -
Fungal Inhibitor
Xanthyletin is a coumarin compound derived from Stauranthus perforatus that acts primarily as a fungal inhibitor. It exhibits notable anti-tumor and antibacterial activities, making it valuable for various research applications in microbiology and cancer studies. Additionally, Xanthyletin effectively inhibits the symbiotic fungus cultivated by leaf-cutting ants, further highlighting its potential in ecological and agricultural research. -
Cytochrome P-450 Inhibitor
Flusilazole is a potent cytochrome P-450 inhibitor with broad-spectrum fungicidal activity. It is commonly employed in research related to fungal infections, providing insights into metabolic pathways and therapeutic interventions. Its mechanism of action offers valuable applications in evaluating and understanding the role of P-450 enzymes in various biological contexts. -
CHS Inhibitor
2,3,5-Tri-O-benzyl-D-ribose is a potent inhibitor of chitin synthase (CHS) in Botrytis cinerea, exhibiting an IC50 value of 1.8 μM. This compound demonstrates significant antifungal activity, capable of inhibiting the B. cinerea BD90 strain with a minimum inhibitory concentration (MIC) of 190 μM. It is valuable for research applications aimed at understanding fungal growth and developing novel antifungal agents. -
Chitinase Inhibitor
Cyclo(Arg-Pro) is a potent chitinase inhibitor that effectively inhibits cell separation in Saccharomyces cerevisiae without compromising its growth. Additionally, Cyclo(Arg-Pro) prevents the morphological transition of Candida albicans from its yeast form to a filamentous state. This compound is valuable for research applications involving fungal morphology and cell separation processes. -
Fungal Inhibitor
Dihydrosanguinarine is a natural compound known for its antifungal properties, primarily acting as a fungal inhibitor. Isolated from the leaves of Macleaya microcarpa, it exhibits significant biological activity against various fungal species. This compound has potential research applications in investigating antifungal mechanisms and exploring its anticancer properties. -
Antifungal/Exosome Inhibitor
Neticonazole is an imidazole derivative that functions as a potent and long-lasting antifungal agent. Its primary mechanism involves inhibiting fungal cell membrane synthesis, making it effective against a variety of fungal infections. Additionally, Neticonazole exhibits anti-infective and potential anti-cancer properties, making it valuable for research applications in both infectious disease and cancer therapy. -
Fungal Inhibitor
Corypalmine is a naturally occurring alkaloid derived from Stephania cepharantha, known for its antifungal properties. It primarily targets fungal cells, inhibiting their growth and proliferation. This compound is useful in various research applications focused on fungal infections and the development of antifungal therapies. -
Fungal Inhibitor
Multifungin (Bromochlorosalicylanilide) is a potent antifungal agent that inhibits fungal growth, making it particularly effective in treating oral candidiasis. This compound disrupts the formation and accumulation of Zearalenone and is effective in reducing fungal populations in stored-crushed corn. Multifungin is valuable for various research applications aimed at understanding fungal infections and developing antifungal therapies. -
CaFBA Inhibitor
FBA-IN-1 is a first-in-class, covalent allosteric inhibitor of fructose-1,6-bisphosphate aldolase (CaFBA) derived from Candida albicans. This compound effectively inhibits the growth of azole-resistant strains with a minimum inhibitory concentration (MIC80) of 1 µg/mL. Its unique mechanism of action positions FBA-IN-1 as a valuable tool in antifungal research, particularly for studying drug-resistant pathogens and exploring new therapeutic avenues. -
Chitin Deacetylase Inhibitor
Benzohydroxamic acid (BHA) is a potent inhibitor of chitin deacetylase (CDA), demonstrating significant antifungal activity. With Ki values of 8.31 μM against CDA from Verticillium dahliae and 9.83 μM against CDA from Puccinia striiformis f. sp. tritici, BHA effectively restores defense responses in infected host plants by upregulating defense-related gene expression. Its application is crucial in research focused on mitigating agricultural fungal diseases, including those caused by Verticillium dahliae and Puccinia striiformis, contributing to the control of cotton wilt and wheat stripe rust. -
Antifungal Agent/HIV-1 Inhibitor
Amphotericin B methyl ester is a methyl ester derivative of the polyene antibiotic Amphotericin B, targeting cell membranes through cholesterol binding. Exhibiting potent antifungal activity, it effectively disrupts the structural integrity of fungal cells. Additionally, Amphotericin B methyl ester has demonstrated the ability to inhibit HIV-1 particle production and replication, making it valuable for research in both antifungal therapies and HIV-1 studies. -
Fungal Gwt1 Enzyme Inhibitor
APX2039 is a potent inhibitor of the fungal Gwt1 enzyme, functioning through its ability to disrupt glycosylphosphatidyl inositol (GPI) anchoring of cell wall mannoproteins. This compound demonstrates significant anticryptococcal activity against Cryptococcus neoformans and Cryptococcus gattii. APX2039 is applicable in research focused on Cryptococcal meningitis (CM) and offers valuable insights into fungal pathogenesis and treatment strategies. -
Fungal Inhibitor
Triflumizole is an imidazole fungicide that functions by inhibiting ergosterol biosynthesis, which is essential for fungal cell membrane integrity. This compound is effective against a range of fungal pathogens, particularly in the management of powdery mildew and scabs on various fruits and crops. It serves as a valuable tool in agricultural research and crop protection strategies. -
Fungal Inhibitor
Viridicatol is a quinolinone alkaloid derived from the fermentation of the endophytic fungus Penicillium sp. R22 in Nerium indicum. This compound exhibits significant antifungal activity against Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 15.6 μg/mL. Viridicatol is suitable for research applications focused on fungal inhibition and antimicrobial activity studies. -
eEF2 Inhibitor
Sordarin sodium is an inhibitor of eEF2, targeting the diphthamide modification essential for its function. By obstructing the binding of eEF2 to the ribosome complex, Sordarin sodium effectively inhibits protein synthesis. Additionally, Sordarin sodium exhibits antifungal activity, making it valuable for research in the fields of microbiology and antifungal drug development. -
Fungal Inhibitor
Cyproconazole is a triazole fungicide that primarily targets fungal pathogens, offering effective protection for crops, fruits, and vegetables. Its biological activity includes the induction of hepatocellular adenomas and carcinomas in CD-1 mice, while demonstrating low toxicity to zebrafish embryos and impacting their locomotor activity. This compound is applicable in agricultural research and studies focused on toxicology and environmental effects of fungicides. -
Bacterial Inhibitor
Robinetin, a naturally occurring flavonoid, primarily acts as a bacterial inhibitor. This compound exhibits diverse biological activities, including antifungal, antiviral, antibacterial, antimutagenesis, and antioxidant properties. Additionally, Robinetin has demonstrated the ability to inhibit lipid peroxidation and protein glycosylation, making it valuable for various research applications in microbiology and biochemistry. -
Fungal Inhibitor
Methyl p-coumarate is an esterified derivative of p-Coumaric acid, functioning primarily as a fungal inhibitor. It exhibits significant inhibition of melanin production in B16 mouse melanoma cells, indicating potential roles in cancer research. Additionally, Methyl p-coumarate demonstrates potent in vitro activity against various pathogens, including Alternaria alternata, making it a valuable reagent for studies in antifungal activity and therapeutic applications. -
Aldolase Inhibitor
Phosphoglycolohydroxamic acid is a potent inhibitor of aldolase and triose-phosphate isomerase, demonstrating significant potential in disrupting metabolic pathways. This compound is primarily utilized in research related to antibacterial and antifungal mechanisms, allowing for the exploration of novel therapeutic strategies against microbial infections. Its ability to inhibit key enzymes positions it as a valuable tool in biochemical studies.
