Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's.
Urolithin M5 is an orally active inhibitor of influenza virus neuraminidase, exhibiting IC50 values of approximately 174.8 μM to 257.1 μM. It effectively suppresses influenza virus replication, including strains resistant to oseltamivir, while demonstrating neuroprotective properties by reducing reactive oxygen species and inhibiting neuronal apoptosis. Urolithin M5 also promotes neurite outgrowth and protects against lung edema in infected mammals. Additionally, it interacts with key signaling proteins such as IGF1R, MAPK14, AKT1, NFKB1, and EGFR, making it a valuable reagent for research into influenza and neurodegenerative diseases like Alzheimer's.
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