AChE

Cat. No.

A17514

CAS No.

185106-16-5

Acotiamide

Synonyms: Z-338 free base; YM443 free base

Acotiamide is a selective and reversible inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 1.79 μM. It has demonstrated the ability to enhance gastric contractility and promote accelerated gastric emptying. This compound is valuable for investigating functional dyspepsia related to gastric motility dysfunction and intestinal inflammation.

Cat. No.

A17520

CAS No.

35575-96-3

Azamethiphos

Azamethiphos is an organothiophosphate insecticide. It is a veterinary drug used in Atlantic salmon fish farming to control parasites.

Cat. No.

A17526

CAS No.

94-63-3

Pralidoxime Iodide

Synonyms: NSC-7760

Pralidoxime iodide is a Cholinesterase Reactivator.

Cat. No.

A17599

CAS No.

7212-44-4

Nerolidol

Synonyms: BRN 1724135; FCI 119b

Nerolidol is a synthetic AChE inhibitor and F0F1-ATP synthase modulator. It acts as a sedative, inhibits growth of bacteria and fungi, and decreases the mitochondrial transmembrane electric potential to induce cell death in hepatocarcinoma cells.

Cat. No.

A17722

CAS No.

25905-77-5

Minaprine

Synonyms: Cantor; Minaprina; Minaprinum; Brantur; Agr 1240

Minaprine is a reversible inhibitor of MAO-A; weakly inhibit acetylcholinesterase; an antidepressant for treatment of depression.

Cat. No.

A17724

CAS No.

548-66-3

Drofenine Hydrochloride

Synonyms: Cycloadiphenine hydrochloride; NSC 42559; Profenene hydrochloride; Trasentin H; Trasentine A

Drofenine hydrochloride is a potent competitive inhibitor of BChE, and the ki values of Drofenine is calculated to be 3 uM.

Cat. No.

A17794

CAS No.

116-38-1

Edrophonium chloride

Synonyms: Tensilon; Tensilon chloride; Antirex; Enlon; Reversol

Edrophonium Chloride, also known as Tensilon, is an acetylcholinesterase inhibitor used in cardiac arrhythmias and in the diagnosis of myasthenia gravis. Edrophonium Chloride has also been used as an antidote to curare principles.

Cat. No.

A17799

CAS No.

288-32-4

Imidazole

Synonyms: Glyoxaline; 1,3-Diaza-2,4-cyclopentadiene

Imidazole acts as an inhibitor of acetylcholinesterase (AChEI), xanthine oxidase (XO), and thromboxane. This heterocyclic aromatic compound exhibits significant biological activities, including antifungal, antituberculosis, anti-inflammatory, antioxidant, and analgesic properties. By inhibiting the conversion of endoperoxides (PGG2 and PGH2) to thromboxane A2, Imidazole plays a role in cardiovascular research. Additionally, its derivatives have shown potential in inhibiting the SARS-CoV-2 3CLPro enzyme, making it a valuable candidate for studies related to Alzheimer's disease, gout, COVID-19, and thrombo-embolic conditions.

Cat. No.

A17888

CAS No.

56-94-0

Demecarium Bromide

Synonyms: BC-48

Demecarium Bromide is a potent cholinesterase (ChE) inhibitor, exhibiting an apparent affinity (Kiapp) of 0.15 μM. It primarily functions by inhibiting the enzyme cholinesterase, thereby increasing acetylcholine levels. This compound is widely utilized in research related to glaucoma treatment and the study of acetylcholine metabolism, providing valuable insights into neurodegenerative diseases and neurotransmission pathways.

Cat. No.

A17901

CAS No.

1225-55-4

Protriptyline hydrochloride

Protriptyline hydrochloride is a potent tricyclic antidepressant with a primary mechanism of action involving the inhibition of acetylcholinesterase (AChE), with an IC50 of 0.06 mM, as well as the reduction of amyloid beta (Aβ) self-assembly. This compound exhibits significant antidepressant activity and is valuable for research related to depression and Alzheimer's disease. It serves as a useful reagent for studying neurochemical pathways implicated in mood disorders and neurodegenerative conditions.

Cat. No.

A18142

CAS No.

121-75-5

Malathion

Synonyms: Carbophos; Mercaptothion; Carbofos; Karbofos; Maldison; Cythion; Prioderm; Sadophos

Malathion is an organophosphorous compound that inhibits cholinesterase enzyme activity. Malathion is an organophosphate insecticide of relatively low human toxicity.

Cat. No.

A18162

CAS No.

51-60-5

Neostigmine methyl sulfate

Neostigmine methyl sulfate is a reversible inhibitor of acetylcholinesterase, primarily targeting the peripheral nervous system. This compound enhances cholinergic transmission by preventing the breakdown of acetylcholine, resulting in increased neurotransmitter levels at the neuromuscular junction. It is widely used in research applications related to neuromuscular disorders and pharmacological studies of cholinergic function.

Cat. No.

A18253

CAS No.

25953-17-7

Minaprine dihydrochloride

Minaprine dihydrochloride is a selective monoamine oxidase inhibitor that penetrates the blood-brain barrier. It exhibits biological activity by reducing intraneuronal dopamine metabolism, lowering levels of striatal homovanillic acid and dihydroxyphenylacetic acid, while increasing levels of 3-methoxytyramine and 5-hydroxytryptamine in the striatum. Additionally, Minaprine dihydrochloride weakly inhibits acetylcholinesterase activity and displays both convulsant and antidepressant properties, making it a valuable reagent for research in neuropharmacology and mood disorder studies.

Cat. No.

A18693

CAS No.

2313524-95-5

BuChE-IN-TM-10

BuChE-IN-TM-10 (TM-10) is a potent butyrylcholinesterase (BuChE) inhibitor, with an IC50 of 8.9 nM.

Cat. No.

A19111

CAS No.

81189-92-6

Acetyllovastatin

Acetyllovastatin, a acetate of Lovastatin, presentes a moderate inhibitory effect against the enzyme acetylcholinesterase with an IC50 of 79 μg/mL. Lovastatin has been found to display antifungal activity, and suppresses proliferation of a number of transformed cell lines.

Cat. No.

A20058

CAS No.

147340-43-0

MHP 133

MHP 133 is a drug with multiple CNS targets, and inhibits acetylcholinesterase (AChE) with Ki of 69 μM; also active against muscarinic M1 and M2 receptors, serotonin 5HT4 receptors, and imidazole I2 receptors.

Cat. No.

A20993

CAS No.

116839-68-0

(+)-Phenserine

(+)-Phenserine is a novel selective cholinesterase noncompetitive inhibitor with an IC50 of 45.3 μM.

Cat. No.

A21003

CAS No.

120786-18-7

(±)-Huperzine A

(±)-Huperzine A, an active Lycopodium alkaloid extracted from traditional Chinese herb, is a potent, selective and reversible acetylcholinesterase (AChE) inhibitor and has been widely used in China for the treatment of Alzheimer's disease (AD).

Cat. No.

A21072

CAS No.

1646-88-4

Aldicarb sulfone

Aldicarb sulfone(Temik sulfone) is a carbamate insecticide; is a cholinesterase inhibitor which prevents the breakdown of acetylcholine in the synapse.

Cat. No.

A21454

CAS No.

194930-00-2

(R)-Rivastigmine D6 tartrate

(R)-Rivastigmine D6 (tartrate) is the deuterium labeled (R)-Rivastigmine, which is an cholinesterase inhibitor.

Cat. No.

A22246

CAS No.

1414469-59-2

TAE-1

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. TAE-1 inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.

Cat. No.

A22353

CAS No.

41059-79-4

Timosaponin AIII

Timosaponin AIII is a potent Inhibitor of U46619-induced Rat Platelet Aggregation, Selectively Inhibiting TxA2-induced Platelet Activation, Preferably Suppressing TP-mediated Activation of Gq, not G12/13, Signaling Pathways.

Cat. No.

A22459

CAS No.

525-82-6

Flavone

Synonyms: 2-Phenyl-4-chromone

Flavone (2-Phenylchromone, 2-Phenyl-4-chromone, 2-Phenyl-4-benzopyron), a class of flavonoids, mainly found in spices and red or purple plant foods with antioxidant, anti-proliferative, anti-tumor, anti-microbial, estrogenic, acetyl cholinesterase, anti-inflammatory activities and are also used in cancer, cardiovascular disease, neurodegenerative disorders etc.

Cat. No.

A22624

CAS No.

15876-67-2

Distigmine Bromide

Distigmine Bromide, also known as Ubretid and BC-51, is an acetylcholinesterase inhibitor used for the treatment of underactive neurogenic bladder and myasthenia gravis.

Cat. No.

A24134

CAS No.

2470587-69-8

MAPK-IN-1

MAPK-IN-1 (Compound 2) is an inhibitor of the MAPK signaling pathway with demonstrated neuroprotective and anti-neuroinflammatory properties. It also exhibits acetylcholinesterase (AChE) inhibitory activity, with an IC₅₀ of 23.84 μM, contributing to enhanced cholinergic signaling. These combined actions make MAPK-IN-1 a promising candidate for research in Alzheimer's disease and other neurodegenerative disorders, where modulation of MAPK signaling and cholinergic function are of therapeutic interest.