AChE

Cat. No.

A35996

CAS No.

2766380-73-6

Y13g

Y13g is a potent dual inhibitor of acetylcholinesterase (AChE) and interleukin-6 (IL-6). By targeting these pathways, Y13g demonstrates significant potential in addressing memory deficits associated with Alzheimer’s Disease. In preclinical studies, Y13g effectively reverses memory impairment induced by STZ and exhibits histopathological profiles akin to those of healthy specimens, making it a valuable tool for research in neurodegeneration and inflammatory responses.

Cat. No.

A35998

CAS No.

3077831-11-6

BChE/p38-α MAPK-IN-1

BChE/p38-α MAPK-IN-1 is a selective dual inhibitor targeting human butyrylcholinesterase (BChE) with an IC50 of 772 nM and p38 α MAPK with an IC50 of 191 nM. This compound significantly reduces the production of pro-inflammatory cytokines such as IL-1β, IL-6, IL-8, and TNF-α in cellular models. BChE/p38-α MAPK-IN-1 demonstrates the potential to ameliorate cognitive impairments induced by scopolamine and alleviate spatial learning deficits in LPS-treated mice, making it a valuable tool for studying Alzheimer's disease by addressing cholinergic deficits and neuroinflammation.

Cat. No.

A36234

CAS No.

555-45-3

Trimyristin

Trimyristin is a potent inhibitor of acetylcholinesterase (AChE) as well as acid and alkaline phosphatase (ACP/ALP). It has demonstrated significant inhibitory effects on AChE, ACP, and ALP activities in the nervous tissue of Lymnaea acuminata, with IC50 values of 0.11 mM, 0.16 mM, and 0.18 mM, respectively. This compound is valuable for research applications focused on neurological pathways and enzyme activity modulation.

Cat. No.

A36367

CAS No.

1219804-94-0

Trimyristin--d15

Trimyristin-d15 is a deuterium-labeled derivative of Trimyristin, a naturally occurring compound extracted from Myristica fragrans. This reagent effectively inhibits acetylcholinesterase (AChE), as well as acid and alkaline phosphatase (ACP/ALP) activities in the nervous tissue of Lymnaea acuminata, with IC50 values of 0.11 mM, 0.16 mM, and 0.18 mM, respectively. Trimyristin-d15 serves as a valuable tool for biochemical research and enzyme activity studies, particularly in exploring the mechanisms of neurotoxicity and molluscicidal action.

Cat. No.

A36671

CAS No.

114-26-1

Propoxur

Propoxur is a reversible competitive inhibitor of acetylcholinesterase (AChE) that effectively penetrates the blood-brain barrier. This compound induces neurotoxicity by inhibiting AChE activity, resulting in the accumulation of acetylcholine, thereby causing neurological dysfunction. In addition, Propoxur promotes MMP-2 expression and enhances tumor cell migration and invasion through the generation of reactive oxygen species (ROS) and the activation of the ERK/Nrf2 signaling pathway. It is also utilized as a carbamate insecticide for managing pests in turf, forestry, and household environments.

Cat. No.

A36703

CAS No.

1219798-56-7

Propoxur-d3

Propoxur-d3 is the deuterated form of Propoxur, a reversible and competitive acetylcholinesterase (AChE) inhibitor. It crosses the blood-brain barrier and exerts neurotoxic effects by inhibiting AChE activity, leading to increased acetylcholine levels and resultant neurological dysfunction. Additionally, Propoxur-d3 promotes the expression of matrix metalloproteinase-2 (MMP-2) and enhances tumor cell migration and invasion through the generation of intracellular reactive oxygen species (ROS) and the activation of the ERK/Nrf2 signaling pathway. This compound has applications in neurotoxicity studies and cancer research, as well as in assessing pesticide effects in ecological studies.

Cat. No.

A36772

CAS No.

2140327-65-5

Propoxur-d7

Propoxur-d7 is the deuterium-labeled analog of Propoxur, a reversible and competitive inhibitor of acetylcholinesterase (AChE). This compound exhibits significant neurotoxic effects by inhibiting AChE activity, leading to increased levels of acetylcholine and subsequent neurological dysfunction. Propoxur-d7 also enhances tumor cell migration and invasion through the promotion of matrix metalloproteinase-2 (MMP-2) expression, driven by reactive oxygen species (ROS) generation and activation of the ERK/Nrf2 signaling pathway. Additionally, Propoxur serves as a carbamate insecticide effective against a variety of pests in turf, forestry, and household settings.

Cat. No.

A37266

CAS No.

1262287-23-9

SSZ

SSZ is a multitarget inhibitor that engages multiple pathological mechanisms associated with Alzheimer's disease (AD). It inhibits key enzymes including acetylcholinesterase, butyrylcholinesterase, β-site amyloid precursor protein cleavage enzyme 1 (BACE1), and γ-secretase. Research demonstrates that SSZ enhances cognitive function and provides neuroprotective effects in murine models of Alzheimer's disease, making it a valuable tool for studying therapeutic strategies in neurodegenerative disorders.

Cat. No.

A38797

CAS No.

889665-86-5

Epiberberine chloride

Epiberberine chloride is an alkaloid derived from Coptis chinensis, functioning primarily as a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 1.07 μM and 6.03 μM, respectively. This compound also serves as a non-competitive inhibitor of BACE1, with an IC50 of 8.55 μM. In addition to its cholinesterase inhibition, Epiberberine chloride exhibits antioxidant properties, demonstrated by its ability to scavenge peroxynitrite (IC50 of 16.83 μM), suggesting a potential protective role in Alzheimer’s disease research. Furthermore, it inhibits the early differentiation of 3T3-L1 preadipocytes and downregulates key signaling pathways, indicating its relevance in studies on diabetes.

Cat. No.

A39050

CAS No.

3105860-83-8

Aβ/tau aggregation-IN-4

Aβ/tau aggregation-IN-4 is a potent inhibitor of amyloid-beta (Aβ) and tau aggregation. It effectively promotes the degradation of Aβ40 and Aβ42 with IC50 values of 2.151 μM and 3.622 μM, respectively. Additionally, Aβ/tau aggregation-IN-4 exhibits selective inhibition of acetylcholinesterase (AChE) with an IC50 of 5.56 μM, and inhibits monoamine oxidase A (MAO-A) and B (MAO-B) with IC50 values of 0.59 μM and 0.09 μM, respectively. This compound also reduces intracellular reactive oxygen species (ROS) levels, making it a valuable tool in Alzheimer's disease research.

Cat. No.

A39087

CAS No.

2851012-65-0

MAO-B-IN-7

MAO-B-IN-7 is a selective inhibitor of monoamine oxidase B (MAO-B) and acetylcholinesterase (AChE), demonstrating IC50 values of 41 nM for human AChE, 87 nM for electric eel AChE, and 0.3 μM for MAO-B. This compound is notable for its ability to penetrate the blood-brain barrier, making it suitable for central nervous system research. MAO-B-IN-7 has been shown to mitigate oxidative stress and neuroinflammation, supporting its potential applications in neurodegenerative disease studies.

Cat. No.

A39097

CAS No.

2032-65-7

Methiocarb

Synonyms: Mercaptodimethur

Methiocarb is an orally active carbamate insecticide primarily targeting acetylcholinesterase to induce cholinergic excitation. It exhibits dose-dependent toxic effects on various organisms, including notable oxidative stress through lipid peroxidation in liver, kidney, brain, and testicular tissues, while also altering reduced glutathione levels via reactive oxygen species generation. This compound is utilized for agricultural pest control and serves as a valuable research tool for studying oxidative stress-related cellular damage in mammalian models.

Cat. No.

A39173

CAS No.

2444-49-7

Diallyl tetrasulfide

Diallyl tetrasulfide functions as an antioxidant, primarily by mitigating cadmium-induced neurotoxicity and oxidative liver injury. This compound has demonstrated the ability to regulate acetylcholinesterase and adenosine triphosphatase activities, as well as protect against oxidative stress in the brain and liver tissues of animal models. Diallyl tetrasulfide also inhibits lipid peroxidation and reduces reactive oxygen species (ROS) production, thereby enhancing cell viability and decreasing apoptosis. It is a valuable reagent for studies focused on cadmium-induced cellular damage and neuroprotection.

Cat. No.

A39282

CAS No.

57744-69-1

Aspulvinone H

Aspulvinone H is a potent inhibitor targeting pancreatic lipase, acetylcholinesterase, glutamic-oxaloacetic transaminase 1 (GOT1), and α-glucosidase, with IC50 values of 25.95 μM, 47.06 μM, 5.91/6.91 μM, and 4.6 μM, respectively. It demonstrates key biological activities including inhibition of cancer cell proliferation, disruption of glutamine metabolism, and induction of apoptosis in cancer cells. Additionally, Aspulvinone H lowers postprandial blood glucose levels in mice and exhibits antibacterial properties against Staphylococcus aureus. This compound is suitable for research into pancreatic ductal adenocarcinoma, diabetes management, and infectious diseases caused by Staphylococcus aureus.

Cat. No.

A39284

CAS No.

232617-15-1

D-Ribose-L-cysteine

D-Ribose-L-cysteine is an orally active cysteine analog that enhances intracellular glutathione (GSH) biosynthesis, thereby improving cellular antioxidant capacity. This compound exhibits memory-enhancing effects and can reverse Scopolamine-induced memory impairment through the inhibition of oxidative stress and acetylcholinesterase (AChE) activity. D-Ribose-L-cysteine is valuable for research on neurodegenerative and cardiovascular diseases, providing insights into therapeutic strategies for these conditions.

Cat. No.

A39685

CAS No.

65725-11-3

Lactupicrin

Synonyms: Lactucopicrin

Lactupicrin, a sesquiterpene lactone, primarily targets acetylcholinesterase (AChE), exhibiting an inhibitory activity with an IC50 of 150.3 μM. This compound demonstrates notable analgesic, sedative, and antimalarial effects, alongside its atheroprotective properties. Lactupicrin is an orally active bitter compound, making it valuable for research applications focused on neuropharmacology and cardiovascular health.

Cat. No.

A40850

CAS No.

3077831-12-7

ARRY-371797

ARRY-371797 is a potent and orally bioavailable inhibitor of p38α MAPK and butyrylcholinesterase (BChE), demonstrating IC50 values of 12.0 µM for p38α MAPK and 0.13 µM for BChE, with minimal activity against human acetylcholinesterase (hAChE). This compound shows promise for research applications in Alzheimer’s disease, particularly in the context of neuroinflammation and cholinergic system modulation.

Cat. No.

A41214

CAS No.

155140-19-5

AChE/hCA I-IN-1

AChE/hCA I-IN-1 is a selective inhibitor of acetylcholinesterase (AChE) and human carbonic anhydrases (hCA I and hCA II). It demonstrates potent inhibition with IC50 values of 302 nM for AChE, 265 nM for hCA I, and 283 nM for hCA II. This compound is valuable for research applications exploring neurodegenerative disorders and the regulation of physiological pH balance.

Cat. No.

A41216

CAS No.

2049681-10-7

AChE/hCA I/II-IN-1

AChE/hCA I/II-IN-1 is a potent inhibitor of acetylcholinesterase (AChE) and human carbonic anhydrases I and II (hCA I/II), demonstrating IC50 values of 22.21 nM for AChE, and 60.79 nM and 66.64 nM for hCA I and II, respectively. This compound is valuable for research applications related to glaucoma, Alzheimer’s disease, and diabetes, providing insights into the modulation of these critical enzymatic targets.

Cat. No.

A41233

CAS No.

3054159-56-4

hCA I-IN-4

hCA I-IN-4 is an inhibitor of carbonic anhydrase (CA) and cholinesterase (ChE), demonstrating potent inhibitory activity against hCA I, hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) with Ki values of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nM, respectively. This compound also exhibits cytotoxic effects in BT-549 cancer cells, with an IC50 value of 16.59 μM. hCA I-IN-4 is valuable for research involving enzyme regulation and cancer therapeutics.

Cat. No.

A41258

CAS No.

2428389-66-4

α-Glycosidase-IN-1

α-Glycosidase-IN-1 is a selective inhibitor of α-glycosidase (α-GLY), exhibiting a potent IC50 of 44.72 nM and a KI of 41.74 nM. Additionally, it demonstrates inhibitory activity against human carbonic anhydrase isoenzymes I and II, as well as acetylcholinesterase, with IC50 values of 104.87 nM, 100.04 nM, and 654.87 nM, respectively. This compound is valuable for research into various conditions, including diabetes, Alzheimer’s disease, heart failure, ulcers, and epilepsy.

Cat. No.

A41269

CAS No.

3036136-18-9

hCAI/II-IN-8

hCAI/II-IN-8 is a hydrazide derivative that serves as a selective inhibitor of human carbonic anhydrase isomerases I and II, with IC50 values of 21.35 ± 0.39 nM and 7.12 ± 0.12 nM, respectively. In addition to its primary target, hCAI/II-IN-8 also demonstrates inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 46.27 ± 0.75 nM and 43.38 ± 0.83 nM, respectively. This compound is relevant for studies involving enzyme inhibition and has potential applications in understanding neurodegenerative diseases and carbonic anhydrase-related pathologies.

Cat. No.

A41306

CAS No.

14204-32-1

hCAI/II-IN-7

hCAI/II-IN-7 is a potent inhibitor of human carbonic anhydrases I and II, characterized by Ki values of 23 nM and 44 nM, respectively. This compound exhibits selective inhibition, with lower activity against bovine carbonic anhydrase. The biological activity of hCAI/II-IN-7 makes it a valuable tool for research applications investigating the roles of carbonic anhydrases in physiological and pathological processes, including cancer and hypertension.

Cat. No.

A41877

CAS No.

216450-65-6

Sophoflavescenol

Sophoflavescenol is a prenylated flavonol that acts as a cholinesterase (ChE) inhibitor, demonstrating potent inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 10.98 μM and 8.21 μM, respectively. Additionally, it shows significant inhibition of other enzymes, including RLAR, HRAR, and BACE1. This compound is primarily utilized in research related to neurodegenerative diseases and cognitive function enhancement, making it a valuable reagent for studying cholinergic pathways.

Cat. No.

A42326

CAS No.

1226776-54-0

Ovotransferrin (328-332)

Ovotransferrin (328-332) is an Angiotensin-Converting Enzyme (ACE) inhibitor that demonstrates protective effects on blood pressure, with an IC50 of 20 μM. Additionally, this fragment exhibits activity against Cholinesterase (ChE), highlighting its potential relevance in Alzheimer's disease research. Its dual inhibitory mechanisms make it a valuable tool for studying cardiovascular health and neurodegenerative disorders.