Fig. 1 · Structure
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Propoxur-d3
Stable Isotope
Propoxur-d3 is the deuterated form of Propoxur, a reversible and competitive acetylcholinesterase (AChE) inhibitor. It crosses the blood-brain barrier and exerts neurotoxic effects by inhibiting AChE activity, leading to increased acetylcholine levels and resultant neurological dysfunction. Additionally, Propoxur-d3 promotes the expression of matrix metalloproteinase-2 (MMP-2) and enhances tumor cell migration and invasion through the generation of intracellular reactive oxygen species (ROS) and the activation of the ERK/Nrf2 signaling pathway. This compound has applications in neurotoxicity studies and cancer research, as well as in assessing pesticide effects in ecological studies.
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Specifications
| Manufacturer | Adooq Bioscience |
|---|---|
| CAS Number | 1219798-56-7 |
| Applications | Stable Isotope |
| Formula | C11H12D3NO3 |
| Molecular Weight | 212.26 |
| SMILES | O=C(NC([2H])([2H])[2H])OC1=C(OC(C)C)C=CC=C1 |
Storage & Solubility
In Vitro Solubility
Reported Solubility
No reported solubility data are available for this product.
Preparing Stock Solutions
| Concentration | |
|---|---|
Values use four significant digits. Prepare to the final solution volume; this is not the volume of solvent to add.
Stock preparation is unavailable for this product molecular weight.
Calculated stock concentrations do not establish solvent solubility. Refer to the reported solubility data for experimental guidance.
Storage
Store powder at -20°C, keep desiccated.
In powder form, the chemical is stable for 36 months.
In solution, store at -20°C and use within 1 month to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.