Catalog No.
Product Name
Application
Product Information
Citations
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Geranylated Flavanone
Diplacone is a geranylated flavanone derived from the unripe fruits of Paulownia tomentosa. It exhibits significant anti-inflammatory, antiradical, cytoprotective, antibacterial, and anticancer properties. Diplacone induces ferroptosis-mediated cell death through mechanisms involving increased mitochondrial Ca2+ influx, reactive oxygen species (ROS) production, and mitochondrial permeability transition. Additionally, it effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, making it valuable for research into chronic inflammatory diseases, cancers, and neurological disorders such as Alzheimer's disease. -
Anti-inflammatory agent, AChE Inhibitor, P450 Inhibitor, Neuroprotective agents
Acetylshikonin is a potent anti-inflammatory agent that also functions as an inhibitor of acetylcholinesterase (AChE) and non-selective cytochrome P450 enzymes. With an IC50 of 34.6 μM for AChE, Acetylshikonin exhibits neuroprotective properties and can induce apoptosis and autophagy in cancer cells. Its ability to regulate blood glucose and liver fat metabolism makes it valuable in research related to diabetes, diabetic nephropathy, obesity, and nonalcoholic fatty liver disease. -
Cholinesterase (ChE) Inhibitor
Scopoletin is a cholinesterase inhibitor that primarily targets acetylcholinesterase (AChE). It possesses notable biological activity in preventing the breakdown of acetylcholine, thereby enhancing cholinergic transmission. Scopoletin is commonly used in research focused on neurodegenerative diseases, cognitive disorders, and potential therapeutic interventions involving cholinergic systems. -
Stable Isotope
Penconazole-d7 is a deuterium-labeled derivative of Penconazole, a triazole fungicide primarily utilized for the management of powdery mildew in crops such as apples, grapes, and vegetables. This compound exerts its biological activity by inhibiting sterol biosynthesis in fungi, thereby disrupting cell membrane integrity. Additionally, Penconazole has been shown to decrease acetylcholinesterase (AChE) activity in the cerebrum and cerebellum of rat models, making it relevant for neurobiological research applications. -
Fungicide
Iprobenfos is an organophosphorus fungicide primarily targeting the rice blast fungus. Its mechanism involves the phosphorylation of the -OH group on serine residues located within the active site of cholinesterases, leading to the inhibition of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activities. This compound is significant in agricultural research for its role in managing fungal diseases in crops and understanding the interaction of organophosphorus compounds with cholinergic systems. -
Cholinesterase (ChE) Inhibitor
(-)-Corynoxidine is an acetylcholinesterase (ChE) inhibitor with an IC50 of 89.0 μM, derived from the aerial parts of Corydalis speciosa. This compound demonstrates antibacterial activity against Staphylococcus aureus, including methicillin-resistant strains, making it a valuable tool for research in neurology and antimicrobial studies. -
Antibacterial Agent
Ilicicolin C is an antibacterial agent with demonstrated efficacy against Pseudomonas syringae, exhibiting an IC50 of 28.5 µg/mL. Additionally, it has shown weak inhibitory effects on acetylcholinesterase and β-glucuronidase, with IC50 values ranging from 30 to 43 µg/mL. The compound also displays weak cytotoxicity in human lung fibroblasts, with IC50 values of 64 to 120 µg/mL. Furthermore, Ilicicolin C influences seed germination and root tip growth in lettuce, indicating potential implications in plant research. -
Antibiotic
Bacillosporin C is an oxaphenalenone dimer that acts as a potent antibiotic. Isolated from the bacterium T. bacillosporus and derived from the lactone bacillosporin D found in the mangrove endophytic fungus SBE-14, Bacillosporin C demonstrates significant antibacterial properties. Additionally, it has been shown to inhibit acetylcholinesterase, making it a valuable tool for research in microbial resistance and neuropharmacology. -
Bioactive Alkaloid
Jatrorrhizine chloride is a bioactive alkaloid derived from Coptis chinensis, exhibiting diverse pharmacological properties such as neuroprotection, antimicrobial action, antiplasmodial effects, and antioxidant activity. This compound acts as a potent and selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, demonstrating over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine chloride inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through blockade of uptake-2 transporters, making it a valuable tool in neurological and pharmacological research. -
Bioactive Alkaloid
Jatrorrhizine hydroxide is a bioactive alkaloid derived from Coptis chinensis, primarily known for its neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties. It functions as a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC50 of 872 nM, exhibiting over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine hydroxide inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through the modulation of uptake-2 transporters, making it valuable for research in neuropharmacology and neurodegenerative disorders. -
Bioactive Alkaloid
Jatrorrhizine is a bioactive alkaloid derived from Coptis chinensis, known for its neuroprotective, antimicrobial, antiplasmodial, and antioxidant properties. This compound serves as a potent, orally active inhibitor of acetylcholinesterase (AChE) with an IC50 value of 872 nM, demonstrating over 115-fold selectivity for butyrylcholinesterase (BuChE). Additionally, Jatrorrhizine inhibits the uptake of serotonin (5-HT) and norepinephrine (NE) through the inhibition of uptake-2 transporters, making it a valuable reagent for neurological and pharmacological research. -
Anti-bacterial Agent
Talaromycesone A is an oxaphenalenone dimer with significant antibacterial properties, exhibiting an IC50 of 3.70 μM against Staphylococcus strains pathogenic to humans. Additionally, it demonstrates strong inhibition of acetylcholinesterase with an IC50 of 7.49 μM. This compound is valuable for research applications focusing on antimicrobial susceptibility and neuropharmacology. -
Aprotic Solvent
Dimethyl sulfoxide (DMSO) is an aprotic solvent that effectively dissolves a wide range of polar and nonpolar compounds, including water-insoluble therapeutic agents. DMSO demonstrates the ability to enhance the penetration of substances through biological membranes due to its strong affinity for water. It possesses potential biological activities, including free radical scavenging, anticholinesterase effects, and the ability to influence coagulation activity. Additionally, DMSO is known to induce histamine release from mast cells and exhibits antifreeze and antibacterial properties, making it valuable in various biochemical research applications. -
Bacterial Inhibitor
Medicagenic acid, a potent bacterial inhibitor derived from the roots of Herniaria glabra, demonstrates significant fungistatic activity against various plant pathogens and human dermatophytes. This compound exhibits low enzyme inhibitory activity, specifically targeting xanthine oxidase, collagenase, elastase, tyrosinase, and cholinesterase. Medicagenic acid is valuable for research applications in studying antifungal resistance mechanisms and exploring potential therapeutic avenues for dermatological conditions. -
Antioxidant/Antimicrobial Agent/Cholinesterase Inhibitor
2-Hydroxydocosanoic acid is a versatile compound known for its antioxidant properties, inhibition of cholinesterase, and antimicrobial activity. It has shown potential in mitigating oxidative stress, making it relevant for studies focused on neuroprotection and aging. Additionally, its antimicrobial effects support research applications in combating microbial resistance. This compound serves as a valuable tool for exploring mechanisms related to oxidative damage and microbial inhibition. -
Fluorogenic Substrate
Resorufin butyrate is a fluorogenic substrate primarily utilized for the detection of triglyceride lipases and cholinesterase. With excitation at 570 nm and emission at 580 nm, this compound facilitates sensitive fluorescence-based assays. It is particularly valuable in biochemical studies focusing on lipid metabolism and enzyme activity. -
AChE/BChE Inhibitor
Coumarin 106 is a dipolar laser dye that serves as an inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It exhibits mixed-type inhibition of AChE with a pIC50 of 4.97 and a Ki value of 2.36 μM, while also inhibiting BChE with a slightly lower potency (pIC50 of 4.56). This compound is valuable in studying cholinergic signaling pathways and may aid in the exploration of therapeutic strategies for disorders linked to cholinergic dysfunction. -
AChE/BChE Inhibitor
PE154 is a highly potent fluorescent inhibitor of human acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 280 pM and 16 nM, respectively. This compound is effective for visualizing β-amyloid plaques in histochemical analyses, making it a valuable tool in research focused on neurodegenerative diseases and cholinergic system studies. Its high specificity and sensitivity enhance its utility in biochemical assays and pathological examinations. -
AChE/hCA Inhibitor
AChE/hCA I-IN-1 is a selective inhibitor of acetylcholinesterase (AChE) and human carbonic anhydrases (hCA I and hCA II). It demonstrates potent inhibition with IC50 values of 302 nM for AChE, 265 nM for hCA I, and 283 nM for hCA II. This compound is valuable for research applications exploring neurodegenerative disorders and the regulation of physiological pH balance. -
AChE/hCA Inhibitor
AChE/hCA I/II-IN-1 is a potent inhibitor of acetylcholinesterase (AChE) and human carbonic anhydrases I and II (hCA I/II), demonstrating IC50 values of 22.21 nM for AChE, and 60.79 nM and 66.64 nM for hCA I and II, respectively. This compound is valuable for research applications related to glaucoma, Alzheimer’s disease, and diabetes, providing insights into the modulation of these critical enzymatic targets. -
hCA I/II Inhibitor
hCAI/II-IN-5 is a potent inhibitor of human carbonic anhydrase isoenzymes I and II, exhibiting IC50 values of 37.88 nM and 45.23 nM, respectively. Additionally, it demonstrates inhibitory activity against α-Glycosidase and acetylcholinesterase (AChE) with IC50 values of 48.98 nM and 420.14 nM. This compound is valuable for research applications in various diseases, including diabetes, Alzheimer's disease, heart failure, ulcers, and epilepsy. -
CA/ChE Inhibitor
hCA I-IN-4 is an inhibitor of carbonic anhydrase (CA) and cholinesterase (ChE), demonstrating potent inhibitory activity against hCA I, hCA II, acetylcholinesterase (AChE), and butyrylcholinesterase (BChE) with Ki values of 29.94 nM, 17.72 nM, 21.21 nM, and 7.65 nM, respectively. This compound also exhibits cytotoxic effects in BT-549 cancer cells, with an IC50 value of 16.59 μM. hCA I-IN-4 is valuable for research involving enzyme regulation and cancer therapeutics. -
α-GLY Inhibitor
α-Glycosidase-IN-1 is a selective inhibitor of α-glycosidase (α-GLY), exhibiting a potent IC50 of 44.72 nM and a KI of 41.74 nM. Additionally, it demonstrates inhibitory activity against human carbonic anhydrase isoenzymes I and II, as well as acetylcholinesterase, with IC50 values of 104.87 nM, 100.04 nM, and 654.87 nM, respectively. This compound is valuable for research into various conditions, including diabetes, Alzheimer’s disease, heart failure, ulcers, and epilepsy. -
hCAI/II Inhibitor
hCAI/II-IN-8 is a hydrazide derivative that serves as a selective inhibitor of human carbonic anhydrase isomerases I and II, with IC50 values of 21.35 ± 0.39 nM and 7.12 ± 0.12 nM, respectively. In addition to its primary target, hCAI/II-IN-8 also demonstrates inhibitory activity against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 46.27 ± 0.75 nM and 43.38 ± 0.83 nM, respectively. This compound is relevant for studies involving enzyme inhibition and has potential applications in understanding neurodegenerative diseases and carbonic anhydrase-related pathologies. -
Fluorescent probe
DTNP is a BchE-activated near infrared (NIR) fluorescent probe known for its ability to permeate the blood-brain barrier. Upon activation by butyrylcholinesterase (BchE), DTNP exhibits inhibitory effects on enzyme activity, making it a valuable tool in the study of Alzheimer's disease (AD). Its unique properties facilitate research into the pathological mechanisms and potential therapeutic strategies related to neurodegeneration. -
AChE Inhibitor
hAChE-IN-6 is a selective acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 0.16 μM. It also inhibits human butyrylcholinesterase (hBuChE) and glycogen synthase kinase 3 beta (GSK3β) with IC50 values of 0.69 μM and 0.26 μM, respectively. Notably, hAChE-IN-6 inhibits the self-aggregation of tau protein and amyloid beta 1-42, making it a valuable reagent for research into Alzheimer's disease pathogenesis and therapeutic strategies. -
AChE/BACE1/GSK3β Inhibitor
AChE/BACE1/GSK3β-IN-1 is a potent triple inhibitor targeting acetylcholinesterase (AChE), beta-secretase 1 (BACE1), and glycogen synthase kinase 3 beta (GSK3β). It demonstrates effective inhibitory activity with IC50 values of 1.0 μM for AChE, 20 μM for BACE1, and 15 μM for GSK3β. With favorable blood-brain barrier penetrability and bioavailability, AChE/BACE1/GSK3β-IN-1 is a valuable tool for research into Alzheimer's disease mechanisms and therapeutics. -
AChE/GSK-3β Inhibitor
ZLWH-23 is a selective inhibitor of acetylcholinesterase (AChE) with an IC50 of 0.27 μM and also inhibits glycogen synthase kinase-3 beta (GSK-3β) with an IC50 of 6.78 μM. It exhibits greater selectivity for AChE compared to butyrylcholinesterase (BChE) and shows preferential inhibition of GSK-3β over a range of multi-kinases. This compound is relevant for research focused on Alzheimer's disease pathophysiology. -
AChE/GSK-3β Inhibitor
PJ17 is a potent dual inhibitor of acetylcholinesterase (AChE) and glycogen synthase kinase 3 beta (GSK-3β), exhibiting IC50 values of 8.84 μM and 4.19 μM, respectively. This compound demonstrates a lack of significant neurotoxicity in primary cerebellar granule neuron cultures, making it a promising candidate for neuropharmacological studies. PJ17 serves as a valuable template for the development of multitarget therapeutics and is relevant in research focused on Alzheimer's disease. -
hAChE/hBuChE Inhibitor
hAChE-IN-5 is a potent inhibitor of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE), exhibiting IC50 values of 0.17 μM for both enzymes. In addition, hAChE-IN-5 demonstrates significant GSK3β inhibition with an IC50 of 0.21 μM. This compound is utilized in research focused on tau protein aggregation and Aβ1-42 self-aggregation, effectively preventing Aβ-dependent neurotoxicity. Furthermore, hAChE-IN-5 can cross the blood-brain barrier, showcasing its potential as a multi-targeted agent in the study of Alzheimer's disease. -
ACE Inhibitor
Ovotransferrin (328-332) is an Angiotensin-Converting Enzyme (ACE) inhibitor that demonstrates protective effects on blood pressure, with an IC50 of 20 μM. Additionally, this fragment exhibits activity against Cholinesterase (ChE), highlighting its potential relevance in Alzheimer's disease research. Its dual inhibitory mechanisms make it a valuable tool for studying cardiovascular health and neurodegenerative disorders. -
Antibacterial Agent
Tellimagrandin II is an antibacterial agent that disrupts the integrity of the cell wall in Staphylococcus aureus, leading to cell lysis and loss of cytoplasmic contents. Additionally, it demonstrates anti-inflammatory properties and inhibits acetylcholinesterase (AChE), which may contribute to improvements in memory impairment. This compound is of interest in research focusing on antibacterial strategies, inflammatory pathways, and neurodegenerative conditions. -
Antibiotic
Manumycin B is an antibiotic that also demonstrates notable antitumor activity. It functions as an inhibitor of acetylcholinesterase (AChE), exhibiting an IC50 value of 15 mM. This compound is valuable for research in cancer biology and neuropharmacology, providing insights into therapeutic strategies for cancer treatment and neurodegenerative disorders. -
Natural Compound
Lucidadiol is a natural compound derived from Ganoderma lucidum, functioning as an acetylcholinesterase inhibitor with an IC50 value of 31 μM. This compound also demonstrates antiviral activity against influenza virus type A and herpes simplex virus type 1 (HSV-1). Lucidadiol is valuable for research applications exploring neuroprotective mechanisms and viral infection inhibition. -
AChE Inhibitor
Coumaran, also known as 2,3-Dihydrobenzofuran, is an inhibitor of acetylcholinesterase (AChE) and exhibits notable antileishmanial activity. Its mechanisms include the activation of macrophages, contributing to its antiparasitic effects and immunomodulatory properties. Coumaran is also applicable in the field of biopesticides, providing a potential tool for agricultural and biological research. -
ChE Inhibitor
N-p-trans-Coumaroyltyramine is a natural phenolic amide compound that acts as an inhibitor of acetylcholinesterase (AChE) with an IC50 of 122 μM and α-glucosidase with an IC50 of 2.7 μM. It demonstrates significant anti-trypanosomal activity, exhibiting an IC50 of 13.3 µM against Trypanosoma brucei rhodesiense. This compound is valuable for research into neurodegenerative diseases such as Alzheimer's disease, as well as for studies focusing on trypanosomiasis. -
Parasite Inhibitor
Diazinon is an irreversible acetylcholinesterase (AChE) inhibitor with primary applications in pest control as an insecticide. By inhibiting AChE, Diazinon leads to the accumulation of acetylcholine, resulting in overstimulation of acetylcholine receptors and disruption of nervous system function. Additionally, Diazinon generates reactive oxygen species (ROS), contributing to oxidative stress across various biological tissues. This compound is predominantly utilized in agricultural settings but may also hold implications for human and animal health research. -
AChE Inhibitor
Carbosulfan is an orally active acetylcholinesterase (AChE) inhibitor that hydrolyzes to carbofuran, leading to significant insecticidal properties. This compound demonstrates broad-spectrum insecticidal activity while inducing oxidative stress through increases in lipid peroxidation and impairment of antioxidant defenses. Carbosulfan is associated with reproductive toxicity in male rats and developmental disorders in offspring, making it a relevant subject in studies focused on reproductive toxicity and environmental risk assessment. Its persistence in aquatic environments raises concerns regarding potential hazards to non-target organisms. -
Parasite Inhibitor
8-Deoxygartanin, a prenylated xanthone derived from Garcinia mangostana, serves as a selective inhibitor of butyrylcholinesterase (BChE). This compound demonstrates significant antiplasmodial activity, with an IC50 value of 11.8 μM against the W2 strain of Plasmodium falciparum. Additionally, 8-Deoxygartanin inhibits NF-κB (p65) activation, displaying an IC50 of 11.3 μM, making it a valuable reagent for research in parasitic infections and inflammation pathways. -
Organophosphorus Insecticide
Pirimiphos-methyl is an organophosphorus insecticide and acaricide that acts as an acetylcholinesterase (AChE) inhibitor in target organisms. This compound is effective in the prevention and control of a variety of pests, including beetles, snout beetles, moths, and Ephestia cautella, particularly during the storage of agricultural grains. Its efficacy in disrupting neural signaling makes it valuable for research into pest management strategies and environmental impact studies in agricultural settings. -
Cholinesterase (ChE) Inhibitor
Fenchlorphos is an organophosphate compound that acts as a potent inhibitor of acetylcholinesterase (AChE), an important enzyme in cholinergic signaling. By disrupting AChE activity, Fenchlorphos leads to the accumulation of acetylcholine, resulting in increased cholinergic neurotransmission. Additionally, this compound has been shown to induce mitochondrial dysfunction, making it a valuable tool for research on neurobiology and toxicology. Its applications include studies on the mechanisms of insecticide action and investigations into the impacts of cholinergic inhibition on cellular metabolism. -
Carbamate Insecticide
Pirimicarb is a selective carbamate insecticide that functions as an acetylcholinesterase (AChE) inhibitor, making it effective against a variety of pests. It exhibits rapid action and is suitable for use on a broad spectrum of crops, including cereals, sugar beet, potatoes, fruits, and vegetables. Pirimicarb's efficacy extends to its acaricidal properties, supporting extensive research in agricultural pest control mechanisms. -
Parasite
Triazophos is a potent non-systemic insecticide and acaricide that functions as an acetylcholinesterase (AChE) inhibitor. By covalently and irreversibly binding to the acetylcholine binding site, Triazophos effectively disrupts the hydrolysis of acetylcholine, resulting in increased neuroexcitability. This compound demonstrates efficacy against a broad spectrum of soil insects and mites, including aphids, thrips, and spider mites, making it valuable for crop protection in various agricultural settings, such as ornamentals, cotton, rice, maize, soybeans, oil palms, olives, and coffee. -
Parasite Inhibitor
Phosalone is an organophosphate insecticide that primarily targets acetylcholinesterase, leading to the inhibition of neurotransmission in parasites. Its potent biological activity makes it effective in controlling a wide range of insect pests. Phosalone is utilized in entomological research and in studies focusing on pest management strategies and the biochemical pathways of insecticide resistance. -
ChE Inhibitor
Isogarcinol is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), exhibiting IC50 values of 1.13 μM and 8.30 μM, respectively. This compound also demonstrates significant leishmanicidal activity, with an IC50 of 0.33 μM against Leishmania donovani. Isogarcinol's dual action makes it a valuable tool for research in neurodegenerative disorders and parasitic diseases. -
Stable Isotope
Temephos-d12 is a deuterated form of Temephos, an organophosphate larvicide. It targets the central nervous system of aquatic larvae, including those of mosquitoes, midges, and black flies, by inhibiting cholinesterase activity. This mechanism leads to larval mortality prior to reaching the adult stage, making Temephos-d12 valuable for research on pesticide efficacy and environmental impact studies. -
BChE Inhibitor/CB2R Agonist
hBChE-IN-2 is a potent butyrylcholinesterase (BChE) inhibitor with an IC50 of 0.62 μM and functions as an agonist for cannabinoid receptor 2 (CB2R). This compound exhibits significant neuroprotective activities, making it a valuable tool in the study of neurodegenerative diseases and cannabinoid signaling pathways. Its dual action positions hBChE-IN-2 as an important reagent for research applications targeting cholinergic regulation and endocannabinoid modulation. -
Topoisomerase I Inhibitor
RPR121056 is a topoisomerase I inhibitor that functions as a metabolite of the chemotherapy agent Irinotecan (CPT-11), produced by the enzyme CYP3A4. This compound induces cell death by disrupting DNA replication, making it relevant for cancer research, particularly in the context of colorectal cancer treatment. Additionally, RPR121056 demonstrates direct inhibition of acetylcholinesterase (AChE), further expanding its potential applications in pharmacological studies. -
Stable Isotope
RPR121056-d3 is a deuterated analog of RPR121056, a metabolite of the anticancer drug Irinotecan. It primarily targets and inhibits topoisomerase type I, leading to apoptosis in cancer cells. RPR121056-d3 is utilized in research applications focused on understanding the metabolic pathways and pharmacokinetics of Irinotecan, particularly in the context of colorectal cancer therapy. Additionally, it may also provide insights into the inhibition of acetylcholinesterase (AChE). -
Alkaloid
Aposcopolamine is an alkaloid isolated from Datura ferox, known for its ability to bind closely with acetylcholinesterase (ACHE), adrenergic receptor alpha-2A (ADRA2A), and muscarinic receptor subtype 2 (CHRM2). This compound is of significant interest in Alzheimer's disease research due to its potential effects on cholinergic signaling pathways. Aposcopolamine serves as a valuable tool in investigating neurodegenerative mechanisms and developing therapeutic strategies.
