Diplacone is a geranylated flavanone derived from the unripe fruits of Paulownia tomentosa. It exhibits significant anti-inflammatory, antiradical, cytoprotective, antibacterial, and anticancer properties. Diplacone induces ferroptosis-mediated cell death through mechanisms involving increased mitochondrial Ca2+ influx, reactive oxygen species (ROS) production, and mitochondrial permeability transition. Additionally, it effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, making it valuable for research into chronic inflammatory diseases, cancers, and neurological disorders such as Alzheimer's disease.
Diplacone is a geranylated flavanone derived from the unripe fruits of Paulownia tomentosa. It exhibits significant anti-inflammatory, antiradical, cytoprotective, antibacterial, and anticancer properties. Diplacone induces ferroptosis-mediated cell death through mechanisms involving increased mitochondrial Ca2+ influx, reactive oxygen species (ROS) production, and mitochondrial permeability transition. Additionally, it effectively inhibits acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) activity, making it valuable for research into chronic inflammatory diseases, cancers, and neurological disorders such as Alzheimer's disease.
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