Catalog No.
Product Name
Application
Product Information
Citations
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hBChE Inhibitor
hBChE-IN-1 is a potent inhibitor of human butyrylcholinesterase (hBChE) with an IC50 value of 7 nM, demonstrating high selectivity over human acetylcholinesterase (hAChE). This compound also exhibits inhibitory activity against tau and Aβ40 protein aggregation, with IC50 values of 20 μM and 4.3 μM, respectively. hBChE-IN-1 is valuable in Alzheimer's disease research, aiding in the exploration of therapeutic strategies targeting protein aggregation associated with neurodegeneration. -
Phenserine Racemic Form
(±)Phenserine is a racemic form of the acetylcholinesterase (AChE) inhibitor Phenserine, derived from Physostigmine. This compound exhibits non-competitive and long-lasting inhibition of AChE, leading to a decrease in the formation of β-amyloid precursor protein (APP) and β-amyloid peptide (Aβ). (±)Phenserine has been shown to enhance cognitive abilities and may help to slow the progression of Alzheimer's disease, making it a valuable agent in neurodegenerative research. -
BuChE Inhibitor
BuChE-IN-5 is a potent butyrylcholinesterase (BuChE) inhibitor, exhibiting an IC50 value of 1.94 μM. This compound effectively inhibits the aggregation of amyloid-beta (Aβ) and tau proteins in Escherichia coli, demonstrating significant potential in Alzheimer's disease research. Additionally, BuChE-IN-5 possesses free radical scavenging capabilities and antioxidant activity, making it a valuable tool for studying neurodegenerative processes and related therapeutic approaches. -
hAChE/hBuChE Inhibitor
hAChE-IN-7 is a mixed inhibitor targeting both the catalytic active site and peripheral anionic site of human acetylcholinesterase (hAChE) and human butyrylcholinesterase (hBuChE). It exhibits potent inhibitory activity with IC50 values of 69.8 nM for hAChE and 68.0 nM for hBuChE, along with a notable inhibitory effect on β-secretase-1 (BACE-1) at an IC50 of 3.6 μM. This compound is valuable for research related to Alzheimer's disease, facilitating studies on cholinergic system modulation and potential therapeutic strategies. -
AChE/BACE1 Inhibitor
2-Acetoxyacorenone is a sesquiterpenoid that functions as a potent inhibitor of acetylcholinesterase (AChE) and β-secretase 1 (BACE1). Isolated from the rhizome of Acorus tatarinowii, this compound exhibits significant biological activity relevant to the modulation of cholinergic signaling and amyloid precursor protein processing. It serves as a valuable tool in Alzheimer's disease research, allowing for investigations into therapeutic strategies targeting these key enzymes. -
BACE1 Inhibitor
BACE1-IN-12 is a potent inhibitor of Beta-site amyloid precursor protein cleaving enzyme 1 (BACE1), exhibiting an IC50 of 8.9 µM. This compound demonstrates selective inhibition of butyrylcholinesterase (BuChE) with an IC50 of 3.2 µM and possesses antioxidant activity with an IC50 of 10.2 μM, as assessed by the DPPH assay. BACE1-IN-12 may serve as a potentially valuable agent in Alzheimer's disease research. -
Chromogenic Substrate
Ac-IEAR-pNA is a chromogenic substrate specifically designed for the quantification of endotoxin levels. It serves as a selective substrate for human butyrylcholinesterase (HuBChE), resulting in the cleavage that releases p-nitroaniline, a measurable product. This compound is widely used in research applications focused on endotoxin detection and related studies in immunology and toxicology. -
Acetylcholinesterase Inhibitor
TAK-802 is a potent orally active inhibitor of acetylcholinesterase, a key enzyme in neurotransmitter regulation. This compound demonstrates significant nonlinear pharmacokinetics, with its distribution in red blood cells showing concentration-dependent behavior. TAK-802 is primarily utilized in research applications focused on neurodegenerative disorders and cognitive function enhancement. -
Muscarinic Antagonist
Chlorpyrifos is a muscarinic antagonist and neurotoxic insecticide classified as a thionite ester. This compound acts primarily as an acetylcholinesterase (AChE) inhibitor, disrupting neurological function in various organisms, including insects and mammals. Research applications of Chlorpyrifos include investigations into neurodevelopmental effects, synaptic transmission alterations, and associated toxicological studies. -
Transporter Inhibitor
Hemicholinium 3 is a competitive inhibitor of the high affinity choline transporter (HACU), exhibiting a Ki value of 25 nM. It acts as a neuromuscular blocking agent by inhibiting both the synthesis and release of acetylcholine (ACh). Hemicholinium 3 demonstrates key biological activities, including the inhibition of Epibatidine-induced contraction and [3H]acetylcholine release, with IC50 values of 897 nM and 693 nM, respectively. This compound is useful in research applications focused on neurotransmitter modulation and neuromuscular transmission studies. -
BuChE inhibitor
Iso-OMPA (Tetraisopropyl pyrophosphoramide) is a selective inhibitor of butyrylcholinesterase (BuChE), functioning through irreversible inhibition. This compound is primarily utilized in research to investigate the mechanisms of BuChE and the resulting effects on acetylcholine metabolism. Iso-OMPA has been shown to enhance soman toxicity in rat models, linked to the inhibition of plasma carboxylesterase (CarbE), making it a valuable tool in studies of nerve agent effects and cholinergic signaling. -
Acetylcholinesterase
Acetylcholinesterase, Fly head (ACHE; EC 3.1.1.7) is a crucial cholinergic enzyme that functions at neuromuscular junctions and cholinergic synapses. This enzyme catalyzes the hydrolysis of acetylcholine and other choline esters, leading to the production of acetate and choline. Its primary biological activity involves the termination of neuronal transmission, ensuring precise signaling by preventing excessive acetylcholine activation at synaptic sites. Acetylcholinesterase, Fly head is essential for studies exploring synaptic function, cholinergic signaling, and neuromuscular disorders. -
Phosphorylating Agent
Chlorpyrifos-oxon is a potent phosphorylating agent primarily known for its ability to inhibit acetylcholinesterase (AChE). This active metabolite of Chlorpyrifos can induce cross-linking of tubulin subunits, leading to significant disruption of microtubule function. Its biological activity provides valuable insights into neurotoxic mechanisms and potential pathways for studying neurodegenerative diseases. -
Neurotoxin
(-)-Carvone is a neurotoxin that functions as an irreversible inhibitor of acetylcholinesterase (AChE). This compound is utilized primarily for its biological activity as a bird repellent, as well as its ability to inhibit larval growth, reduce pupation rates, and increase larval mortality. Research applications include studies on insect neurobiology and pest control strategies. -
Cholinesterase (ChE) Inhibitor
Physostigmine salicylate is a reversible acetylcholinesterase (AChE) inhibitor that effectively crosses the blood-brain barrier, enhancing central cholinergic neurotransmission. It has demonstrated the ability to reverse memory deficits in transgenic mice models of Alzheimer's disease, making it a valuable tool in neurodegeneration research. Additionally, Physostigmine salicylate serves as an antidote for anticholinergic poisoning, highlighting its significance in pharmacological studies and therapeutic applications. -
AChE Inhibitor
Tacrine is a potent acetylcholinesterase (AChE) inhibitor, with an IC50 value of 109 nM. This compound is recognized for its ability to ameliorate cognitive deficits, particularly in aged rodent models. Additionally, Tacrine is associated with potential hepatotoxicity and is frequently utilized in research focusing on Alzheimer's disease and related neurodegenerative disorders. -
Antioxidant Agent
Cyanidin-3-O-galactoside chloride is an antioxidant agent that demonstrates significant potential in mitigating oxidative stress. Extracted from hawthorn fruit peel, this compound is known for its ability to inhibit acetylcholinesterase (AChE) activity. Its biological activities make it valuable for research in neuroprotective studies and the exploration of therapeutic applications in neurodegenerative diseases. -
Cholinesterase (ChE) Inhibitor
Chavicol, a cholinesterase (ChE) inhibitor, demonstrates potent inhibition of acetylcholinesterase, with an IC50 of 7.42 μM. This compound exhibits anti-cancer properties, effectively suppressing the growth, survival, migration, and invasion of various cancer cell lines. Notably, Chavicol shows significant cytotoxic effects, evidenced by a notable concentration of approximately 31 μg/mL in A-549 cells. Its dual activities underscore its potential utility in cancer research and therapeutic development. -
Cholinesterase (ChE) Inhibitor
Physostigmine hemisulfate is a reversible inhibitor of acetylcholinesterase (AChE), effectively enhancing cholinergic neurotransmission by crossing the blood-brain barrier. This compound has demonstrated the ability to reverse cognitive deficits in transgenic mouse models of Alzheimer's disease, making it a valuable tool for neurological research. Additionally, Physostigmine hemisulfate serves as an antidote for anticholinergic poisoning, underscoring its significance in pharmacological studies and clinical applications. -
Acetylcholinesterase Inhibitor
N-Boc-4-piperidinemethanol is an acetylcholinesterase (AChE) inhibitor that serves as a valuable tool for neurological research. It is particularly relevant in studies focused on Alzheimer's Disease, aiding in the investigation of cholinergic dysfunction. This compound may contribute to the development of therapeutic strategies targeting AChE activity. -
Insecticide
Profenofos is an insecticide that functions as an acetylcholinesterase (AChE) inhibitor, leading to neurotoxicity in target pest species. Its primary mechanism involves the inhibition of AChE, resulting in the accumulation of acetylcholine at synapses, which disrupts normal neural function. Profenofos is effective for the control of a wide range of insect pests on field crops, vegetables, and fruit crops, making it valuable for agricultural research and pest management studies. -
Cholinesterase
Cholinesterase, Horse serum is a catalytic enzyme comprising acetylcholinesterase (AChE) and butyryl cholinesterase (BChE). These enzymes facilitate the hydrolysis of various substrates, including the hydrolysis of 6-monoacetylmorphine (6-MAM) to morphine. This reagent is valuable in biochemical research, particularly in studies involving neurotransmitter metabolism and the pharmacokinetics of opioid compounds. -
CYP2D6/AChE Inhibitor
Rhodiosin is a dual inhibitor of CYP2D6 and acetylcholinesterase (AChE), extracted from the root of Rhodiola rosea. It exhibits an IC50 value of 0.761 μM for CYP2D6 and a Ki of 0.769 μM. This compound demonstrates notable antioxidant and neuroprotective properties, contributing to the regulation of the HIF-1α signaling pathway, which is vital for central nervous system protection. Rhodiosin serves as a valuable tool for research in neuropharmacology and metabolic studies. -
Antidote
Obidoxime dichloride is a potent antidote that acts primarily as a reactivator of acetylcholinesterase (AChE) inhibited by organophosphate compounds, such as sarin. By effectively restoring AChE activity, it mitigates the toxic effects associated with nerve agent exposure. Obidoxime dichloride is widely utilized in research focused on the effects of organophosphate poisoning and the development of therapeutic countermeasures. -
Insecticide
Acephate is a broad-spectrum anticholinesterase insecticide that functions by inhibiting acetylcholinesterase (AChE) activity in insects. This inhibition disrupts neurotransmission, leading to the effective control of various insect species. Acephate is widely utilized in agricultural and horticultural applications to manage pest populations, thereby enhancing crop yield and quality. -
Cholinesterase (ChE) Inhibitor
Violanthin is a cholinesterase (ChE) inhibitor derived from the stems of Dendrobium officinale. It exhibits significant antioxidant and antibacterial properties, making it a valuable compound for biological research. Violanthin effectively inhibits acetylcholinesterase (AChE) with an IC50 value of 79.80 μM, indicating its potential application in studies related to neurodegenerative diseases and cholinergic signaling. -
Stable Isotope
Pyridostigmine-d6 bromide is a deuterated form of Pyridostigmine, functioning as a reversible cholinesterase inhibitor and parasympathomimetic agent. This stable isotope is useful for metabolic studies and tracking the pharmacokinetics of drugs in biological systems. Its labeling with deuterium allows for enhanced precision in mass spectrometry applications and other analytical techniques in chemical research. -
Cationic Charged Quencher
p-Xylene bis(pyridinium bromide) serves as a cationic charged quencher. This compound exhibits inhibitory activity on acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) with IC50 values of 1540 μM and 529 μM, respectively. It is suitable for research applications focusing on cholinergic signaling and enzyme inhibition studies. -
AChE Inhibitor
AChE-IN-84 is a potent inhibitor of acetylcholinesterase (AChE), a key enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. This compound demonstrates significant biological activity in modulating cholinergic signaling pathways, making it an essential tool for studying neurodegenerative diseases such as Alzheimer's. AChE-IN-84 is useful in research applications focusing on cognitive enhancement and synaptic function restoration. -
Cholinesterase (ChE) Inhibitor
Phenthoate is a cholinesterase (ChE) inhibitor that functions primarily as an organophosphorus pesticide. This compound demonstrates low toxicity in animals while effectively inhibiting acetylcholinesterase (AChE), which can provide insights into neurotoxicity and enzyme regulation. Phenthoate is widely used in research applications examining the biochemical pathways of neurotransmission and potential environmental impacts of pesticide exposure. -
AChE/BchE Inhibitor
ACG548B is a potent inhibitor of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE), with IC50 values of 1.78 µM and 0.496 µM, respectively. It exhibits strong affinity and selectivity for AChE over BChE and choline kinase (ChoK). ACG548B is suitable for research applications focused on myasthenia gravis and the mechanisms of neuromuscular blockade. -
AChE Inhibitor
Pseudocoptisine chloride is a quaternary alkaloid derived from the benzylisoquinoline structure, isolated from Corydalis tuber. This compound functions as an acetylcholinesterase (AChE) inhibitor, demonstrating an IC50 of 12.8 μM. Pseudocoptisine chloride exhibits notable anti-inflammatory and anti-amnestic properties, making it a valuable reagent for research related to neurodegenerative diseases and cognitive function studies. -
Anti-inflammatory Agent
Manghaslin is a flavonoid glycoside that serves as an anti-inflammatory agent. It exhibits inhibitory activity against acetylcholinesterase (AChE), with an IC50 value of 94.92 μM. This compound is relevant for research into the modulation of inflammation and potential neuroprotective effects. -
Nematicide
Fosthiazate is a broad-spectrum nematicide that primarily targets plant parasitic nematodes, including Meloidogyne spp., Globodera spp., and Pratylenchus spp. Its mechanism of action involves the inhibition of acetylcholinesterase synthesis, disrupting neurotransmitter regulation in nematodes. This compound is utilized in agricultural research to manage nematode populations effectively and enhance crop health. -
AChE Substrate
1-Naphthyl acetate serves as a chromogenic substrate specifically for the detection of acetylcholinesterase (AChE) activity in erythrocytes. This compound is particularly valuable in research related to organophosphorus pesticide poisoning, enabling the assessment of enzymatic activity and its inhibition. Its colorimetric properties facilitate quantitative analysis in various biochemical studies. -
Cholinesterase (ChE) Inhibitor
Dehydronuciferine acts as an inhibitor of cholinesterase, specifically targeting acetylcholinesterase (AChE) with an IC50 value of 25 μg/mL. This compound is derived from the leaves of Nelumbo nucifera (lotus) and demonstrates potential in research applications related to neurodegenerative diseases and cognitive disorders. Its ability to modulate cholinergic signaling makes it a valuable tool for studying cholinergic system functions and developing therapeutic strategies. -
Cholinesterase (ChE) Inhibitor
Galanthaminone is a competitive and reversible inhibitor of cholinesterase (ChE), primarily targeting acetylcholinesterase (AChE). This compound demonstrates significant biological activity in enhancing cholinergic transmission and is utilized in the study of mild to moderate Alzheimer's disease and related memory impairments. Its application in research aids in understanding the mechanisms underlying cognitive decline and potential therapeutic interventions. -
Cholinesterase (ChE) Inhibitor
Picfeltarraenin IB is a triterpenoid derived from Picria fel-terrae Lour that acts as a cholinesterase (ChE) inhibitor. This compound exhibits significant biological activity by inhibiting acetylcholinesterase (AChE), thereby modulating cholinergic signaling. It is primarily utilized in research settings focusing on therapeutic applications for herpes infections, cancer, and inflammation. -
Cholinesterase (ChE) Inhibitor
Huperzine B is a Lycopodium alkaloid that acts primarily as a selective inhibitor of acetylcholinesterase (AChE). This compound demonstrates significant potential for enhancing cholinergic neurotransmission, which is crucial in the context of neurodegenerative disorders such as Alzheimer's disease. Research applications include studies focused on cognitive enhancement and memory preservation. -
Dual MAO/AChE Inhibitor
Ladostigil hemitartrate is a dual inhibitor of monoamine oxidase (MAO) and acetylcholinesterase (AChE), with established IC50 values of 37.1 μM for MAO-B and 31.8 μM for AChE. This compound is capable of crossing the blood-brain barrier and exhibits neuroprotective, antioxidant, and anti-inflammatory properties. Ladostigil hemitartrate is relevant for research into neurological disorders, including depression and Alzheimer's disease. Additionally, it functions as a click chemistry reagent, featuring an alkyne group that participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc). -
AChE Inhibitor
Phenoxyacetone is a competitive inhibitor of acetylcholinesterase (AChE), targeting the enzyme responsible for the hydrolysis of the neurotransmitter acetylcholine. By inhibiting AChE, phenoxyacetone enhances cholinergic signaling, making it valuable for studying neurological conditions characterized by impaired neurotransmission. This compound is suitable for research applications focused on neuropharmacology and the exploration of treatments for Alzheimer's disease and other memory-related disorders. -
AChE Inhibitor
Vincosamide is a potent acetylcholinesterase (AChE) inhibitor derived from the extract of Psychotria leiocarpa. It exhibits anti-inflammatory properties, making it a valuable compound for studying neurodegenerative diseases related to cholinergic dysfunction. Research applications include exploring potential therapeutic strategies for conditions such as Alzheimer's disease and other disorders characterized by altered AChE activity. -
Stable Isotope
Chlorpyrifos-d10 is a deuterium-labeled variant of Chlorpyrifos, an organophosphate insecticide known for its action as a phosphorothionate. Its active metabolite, Chlorpyrifos oxon, functions as a potent inhibitor of acetylcholinesterase (AChE), thereby disrupting neurological function in a range of organisms, including insects and mammals. This stable isotope is valuable for studying metabolic pathways, neurotoxic effects, and enzyme interactions, particularly in the context of susceptibility to neurotoxicity modulated by plasma enzyme paraoxonase 1 (PON1). -
Cholinesterase (ChE) Inhibitor
Isoprocarb is a cholinesterase (ChE) inhibitor that functions as a carbamate insecticide. It effectively targets pests such as rice paddy lice and leafhoppers, making it valuable in agricultural research. Its role in inhibiting acetylcholinesterase (AChE) provides insights into neuromuscular function and the mechanisms of toxicity, contributing to studies on pest control and environmental impact assessments. -
BChE Inhibitor
BChE-IN-17 is a potent and selective inhibitor of butyrylcholinesterase (BChE) with IC50 values of 10.5 nM for equivalent BChE and 32.5 nM for human BChE. This compound demonstrates a remarkable over 1000-fold selectivity for BChE compared to acetylcholinesterase (AChE). Additionally, BChE-IN-17 exhibits low neurotoxicity and offers moderate neuroprotective effects, making it a valuable reagent for research in neurodegenerative diseases and cholinergic signaling pathways. -
AChE Inhibitor
Neoeriocitrin, a potent acetylcholinesterase (AChE) inhibitor isolated from Drynaria Rhizome, demonstrates significant biological activity in promoting proliferation and osteogenic differentiation in MC3T3-E1 cells. This compound is valuable for research in neurodegenerative diseases, where AChE inhibition is critical, as well as in studies focused on bone biology and regenerative medicine. -
Cholinesterase Inhibitor
Cyclanoline chloride is a potent cholinesterase inhibitor that disrupts the breakdown of acetylcholine, thereby enhancing cholinergic neurotransmission. This compound is primarily utilized in research applications focusing on neurodegenerative diseases and paralysis, as it contributes to understanding the role of neurotransmitter regulation in synaptic function. Its inhibitory effects on cholinesterase make it a valuable tool for studying cholinergic signaling pathways. -
Cholinesterase (ChE) Inhibitor
9-Acridinecarboxylic acid is a potent cholinesterase (ChE) inhibitor, acting on both acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). It serves as a precursor for various derivatives that exhibit nanomolar inhibitory activity. This compound is crucial for research in neurodegenerative diseases and provides insights into the modulation of cholinergic signaling pathways. -
MAO/AChE Inhibitor
Ladostigil hydrochloride is a potent dual inhibitor of acetylcholinesterase (AChE) and monoamine oxidase-B (MAO-B), exhibiting IC50 values of 37.1 µM and 31.8 µM, respectively. This compound demonstrates neuroprotective, antioxidant, and anti-inflammatory properties, making it valuable for research related to depression and Alzheimer's disease. Additionally, Ladostigil hydrochloride functions as a click chemistry reagent, featuring an alkyne group that can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc), facilitating diverse chemical applications. -
Cholinesterase (ChE) Inhibitor
Ebeiedinone is a steroidal alkaloid obtained from Fritillaria species that functions as a cholinesterase (ChE) inhibitor. At a concentration of 0.1 mM, it demonstrates a substantial inhibitory effect of 69.0% on human whole blood cholinesterase activity. This compound is valuable for research involving neuropharmacology and the study of cholinergic signaling pathways.
