Catalog No.
Product Name
Application
Product Information
Citations
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T-cell Activator
Phytohemagglutinin (PHA-M) is a potent T-cell activator derived from the seeds of Phaseolus vulgaris. This lectin stimulates the proliferation of human mononuclear leukocytes, leading to the upregulation of ChAT mRNA and enhancing acetylcholine synthesis. Additionally, Phytohemagglutinin exerts dose- and time-dependent cytotoxic effects on THP-1 monocytes/macrophages, resulting in altered cellular morphology, organelle dysfunction, and increased expression of pro-inflammatory markers such as NF-κB, COX2, and IL-1β. It is valuable for research applications related to immunology and cell signaling pathways. -
Natural Product
Sesame Oil is a natural product derived from the seeds of Sesamum indicum L. It exhibits a variety of biological activities, including the ability to reduce NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4, and nitric oxide levels. Sesame Oil demonstrates antitumor activity against malignant melanoma and provides protective effects against liver damage induced by agents such as Cisplatin and Acetaminophen. Additionally, it possesses notable antinociceptive and anti-inflammatory properties, making it a valuable reagent for various research applications. -
NF-KB Activator
Fibrinogen (Bovine) is a glycoprotein that serves as a potent NF-κB activator, exhibiting selective proteolytic properties when activated by thrombin to form fibrin clots. It plays a critical role in regulating NF-κB activation in endothelial cells and enhances the expression of pro-inflammatory chemokines, including MCP-1. Fibrinogen is essential for understanding blood coagulation processes, thrombosis, atherosclerosis, and the pathological aspects of venous graft development, making it valuable for research in vascular diseases. -
CHI3L1 Inhibitor
K284-6111 is a potent inhibitor of CHI3L1, demonstrating high affinity and oral bioavailability. It effectively suppresses CHI3L1 expression and disrupts key signaling pathways, including ERK and NF-κB, leading to reduced nuclear translocation of p50 and p65 as well as decreased phosphorylation of IκB. K284-6111 shows promise in alleviating memory dysfunction associated with Alzheimer's disease by mitigating amyloidogenesis and neuroinflammation. Additionally, it exhibits therapeutic potential in reducing atopic-like skin inflammation and protecting against LPS-induced liver injury. This compound is suitable for research into neurodegenerative diseases and inflammatory conditions. -
Anti-inflammatory Agent
Militarine is an anti-inflammatory agent that primarily targets the NF-κB signaling pathway. It demonstrates significant biological activity by alleviating PM2.5-induced inflammatory injury and inhibiting cell migration in human alveolar epithelial A549 cells. Additionally, Militarine functions as a plant growth inhibitor, affecting the elongation of radicles and hypocotyls in various plant species. This compound is suitable for research applications related to PM2.5-induced pulmonary diseases and plant physiology studies. -
NF-κB Inhibitor
Valencene is a sesquiterpene that functions as an NF-κB inhibitor. It exhibits significant anti-inflammatory, antiallergic, and antioxidant activities by inhibiting the expression of Th2 chemokines and proinflammatory cytokines. In LPS-stimulated RAW 264.7 cells, Valencene effectively reduces the production of IL-1β and IL-6. Additionally, Valencene has demonstrated potential in alleviating symptoms of atopic dermatitis and restoring filaggrin expression in a DNCB-sensitized mouse model. -
Antioxidant
[10]-Shogaol is a potent orally active antioxidant, primarily targeting pro-inflammatory pathways. Derived from ginger (Zingiber officinale), it inhibits cyclooxygenase-2 (COX-2) with an IC50 of 7.5 μM, reducing the production of pro-inflammatory cytokines such as IL-1β and IL-6, and suppressing NF-κB phosphorylation. This compound exhibits notable anti-inflammatory and anticancer activities, particularly against Docetaxel-resistant prostate cancer. Additionally, [10]-Shogaol demonstrates larvicidal efficacy against L5 larvae of Angiostrongylus cantonensis, making it useful for diverse biological research applications. -
Metabolite Of Oroxylin A
Oroxylin A-7-O-glucuronide is a flavonoid glucuronide derivative and metabolite of Oroxylin A, primarily known for its prolyl oligopeptidase inhibitory activity. This compound demonstrates the ability to inhibit the JNK signaling pathway, upregulate PPARγ, and prevent nuclear translocation of NF-κB p65, leading to reduced production of pro-inflammatory cytokines such as IL-1β and IL-6. Additionally, Oroxylin A-7-O-glucuronide exhibits promising anti-angiogenic, anti-tumor, anti-inflammatory, and hepatoprotective properties, making it a valuable tool in cancer research and inflammatory disease studies. -
Flavonoid
Saponarin is a flavonoid compound that functions primarily as an inhibitor of ERK/p38, NF-κB, and MAPK phosphorylation while activating AMPK. It exhibits significant biological activities, including antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic, and hypotensive effects. Additionally, Saponarin has been shown to reduce IL-1β and COX-2 levels, making it relevant for research applications related to inflammation and metabolic disorders. Furthermore, this compound has demonstrated potential in addressing sleep disorders. -
Anti-neuroinflammatory Agent
Murrayafoline A is a carbazole alkaloid that functions as an anti-neuroinflammatory agent by directly targeting Specificity protein 1 (Sp1) and inhibiting the NF-κB and MAPK signaling pathways. This compound induces G0/G1-phase cell cycle arrest in PDGF-stimulated vascular smooth muscle cells and promotes the degradation of β-catenin, thereby attenuating the Wnt/β-catenin pathway. Additionally, Murrayafoline A enhances contractility in rat ventricular myocytes and activates L-type calcium currents through protein kinase C activation. Researchers can utilize Murrayafoline A to investigate inflammation, vascular complications, and colon cancer. -
IL8 Regulator
Linoleate sodium is an orally active regulator of interleukin-8 (IL-8) that targets the JNK and NF-κB signaling pathways. This compound modulates fatty acid composition and alters metabolite production in cells, exhibiting significant anti-inflammatory and immune-regulating properties. Linoleate sodium has also demonstrated effects on tumor cell proliferation, making it a valuable tool for research in inflammation and cancer biology. -
PXR Agonist
FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 value of 1.2 µM. This compound demonstrates strong binding affinity to plasma proteins and favorable metabolic stability in human microsomes. FKK6 effectively inhibits the PXR-related NF-κB signaling pathway, reduces the expression of inflammatory cytokines, and displays anti-inflammatory properties in a mouse model of DSS-induced colitis, making it a valuable tool for studies in inflammation and drug metabolism. -
Anti-Inflammatory Compound
12-Oxo phytodienoic acid (12-OPDA) is an anti-inflammatory compound derived from plant lipids. It effectively suppresses neuroinflammation by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-κB) and p38 mitogen-activated protein kinase (MAPK) pathways in lipopolysaccharide (LPS)-activated cells. This compound is valuable for research related to neurodegenerative diseases, enabling the exploration of therapeutic strategies targeting inflammatory responses. -
Anti-IL-17C Antibody
MOR-106 is a humanized anti-IL-17C IgG1 monoclonal antibody that targets interleukin-17C, a cytokine involved in inflammatory responses. By binding specifically to IL-17C, MOR-106 inhibits the NF-κB signaling pathway, demonstrating an IC50 of 59 pM for human IL-17C and 55 pM for mouse IL-17C. This reagent effectively reduces skin inflammation and associated inflammatory factors in preclinical models of psoriasis and atopic dermatitis, making it a valuable tool for research into inflammatory skin disorders. -
Anti-inflammatory Agent
Arvelexin is an anti-inflammatory agent that primarily acts by inhibiting NF-κB activation. Isolated from Brassica rapa L. (Brassicaceae), Arvelexin also downregulates the expression of IL-8, making it a valuable compound for research into colonic inflammation. This compound is of interest for studies focused on inflammatory pathways and potential therapeutic applications in inflammatory bowel disease and related disorders. -
NF-κB Inhibitor
Dimethyl diacetyl cystinate (DACDM) is a potent NF-κB inhibitor that modulates inflammation by shifting the intracellular redox balance towards an oxidized state. This compound increases the levels of oxidized glutathione (GSSG) and competes with activated NF-κB for binding sites on DNA, thus inhibiting the production of pro-inflammatory cytokines such as IL-1κ. DACDM is a valuable reagent for studies related to UVB-induced skin inflammation and various oxidative stress-related diseases. -
Oxidative Stress Modulator/Anti-inflammatory Agent
Guluronic acid is an oxidative stress modulator and anti-inflammatory agent. It functions by down-regulating pro-inflammatory genes such as TLR4, NF-κB, and iNOS, while inhibiting COX-2, MMPs, and VEGF activity. This compound promotes the up-regulation of immunoregulatory genes including SHIP1 and SOCS1, thereby mitigating cancer-related inflammation, tumor angiogenesis, cell adhesion, and metastasis, while decreasing immunosuppressive cell accumulation. Guluronic acid has demonstrated potential in extending survival times in tumor-bearing hosts within a non-cytotoxic concentration range and has applications in research related to multiple sclerosis, ankylosing spondylitis, breast cancer, and other inflammatory diseases. -
Anticancer Agent
TU-100 is a novel anticancer agent derived from Japanese herbal medicine. It exhibits significant anti-cancer effects by modulating cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME). TU-100 effectively antagonizes the M2 polarization of macrophages by inhibiting the TLR4/NF-κB/STAT3 signaling pathway, leading to the downregulation of key proteins such as MMP-2, COX-2, and VEGF in tumor-associated macrophages (TAMs). This compound is valuable for research into cancer therapies targeting the tumor microenvironment and immune modulation. -
Anticancer Agent
Emodic acid is an anthraquinone compound that primarily targets and inhibits the activity of NF-κB, demonstrating significant anticancer properties. It effectively reduces the proliferation of cancer cells by inhibiting the phosphorylation of key proteins such as p38, ERK, and JNK. Additionally, Emodic acid suppresses the secretion of tumor-promoting cytokines IL-1β and IL-6, as well as the expression of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMPs), thereby limiting the invasion and migration potential of cancer cells. This compound is valuable for research applications in cancer biology and therapeutic development. -
Akr1B1 Inhibitor
β-Glucogallin is a selective inhibitor of aldose reductase (AKR1B1), exhibiting an IC50 value of 58 μM with glyceraldehyde as the substrate. This compound displays significant antioxidant properties, reducing reactive oxygen species (ROS) and influencing key pathways involving PDGF, RAGE, and NF-κB. Additionally, β-Glucogallin enhances superoxide dismutase (SOD) activity and demonstrates hepatoprotective effects. Its biological activity makes it a valuable tool for research in retinal studies and related fields. -
Immune System Activator
Neopterin is an immune system activator derived from GTP and is produced by activated macrophages. It exhibits significant biological activity by inhibiting NF-κB phosphorylation and promoting PPAR-γ expression, which helps mitigate vascular inflammation and atherogenesis. Neopterin is useful for research applications focused on cardiovascular diseases, inflammation-related disorders, and tumor immunomonitoring. -
HIPK2 Inhibitor
XRF-1021 is an orally active inhibitor of Homer-interacting protein kinase 2 (HIPK2), with an IC50 value of 0.18 μM. It effectively decreases the expression of fibrotic markers such as Fibronectin, Collagen I, and α-SMA in TGF-β1 stimulated renal cell lines, including NRK-49F and HK-2. XRF-1021 further inhibits key signaling pathways including TGF-β, NF-κB, p53, Wnt/β-catenin, and Notch. This compound demonstrates potential in reducing renal injury and fibrosis in vivo, making it a valuable tool for research on chronic kidney disease. -
Hormone disruptors
4-Octylphenol is a known hormone disruptor that primarily targets male reproductive cells, significantly lowering the mitotic index and reducing the population of spermatogonia. Its biological activity includes inducing inflammatory damage in fish gills by activating the complement system through the C3a/C3aR and C5a/C5aR1 pathways, resulting in immune suppression and inflammatory damage. This agent also engages the Toll-like receptor 7 (TLR)/IκBα/NF-κB signaling pathway, highlighting its relevance in studies concerning endocrine disruption and aquatic toxicology. -
Serine Protease
Chymotrypsin, a serine protease, primarily inhibits the TLR4/NF-κB signaling pathway, which downregulates the release of pro-inflammatory factors such as TNF-α and IL-6. Key biological activities include anti-inflammatory, hepatoprotective, and anti-tumor metastasis effects, making it valuable in research related to rheumatoid arthritis, non-alcoholic fatty liver disease, and melanoma metastasis. Additionally, Chymotrypsin can reduce tumor cell adhesion molecule expression and has applications in studies involving inflammation and edema. -
LPS Peptide Mimic
RS 09 is an LPS peptide mimic that acts as an agonist for Toll-like receptor 4 (TLR4). By binding to TLR4, RS 09 activates the nuclear factor kappa B (NF-κB) signaling pathway, which is crucial for mediating immune responses. This compound is valuable in research focused on enhancing antigen-specific immune responses and studying TLR4-related signaling pathways in various in vivo models. -
Toll-like Receptor (TLR) Inhibitor
Okanin is a potent Toll-like Receptor (TLR) inhibitor derived from the flowering plant Coreopsis tinctoria. It exhibits significant biological activity by attenuating lipopolysaccharide (LPS)-induced microglial activation via the inhibition of the TLR4/NF-κB signaling pathway. This compound is useful for research applications focusing on neuroinflammation and the modulation of immune responses in microglial cells. -
TLR8 Agonist
CL075 is a selective TLR8 agonist that activates the MyD88-dependent signaling pathway, leading to the production of inflammatory cytokines and type I interferons (IFNs). This compound enhances NF-κB and IRF7 activation, contributing to immune modulation. It is primarily used in research applications focused on inflammation and immune response mechanisms. -
Flavonoid
Pongamol is a flavonoid that targets PTPase-1B and intestinal α-Glycosidase with an IC50 of 75 μM and 103.5 μM, respectively. This compound exhibits anti-inflammatory properties by reducing the release of cytokines such as IL-1β and TNF-α while also reversing the nuclear translocation of NF-κB. Additionally, Pongamol promotes glucose uptake through GLUT4 upregulation, inhibits epithelial-mesenchymal transition via the FAK/Akt-mTOR pathway, and demonstrates neuroprotective effects in models of Alzheimer's disease by alleviating oxidative stress and restoring autophagy. Pongamol is valuable for research applications in Alzheimer's disease, type 2 diabetes, and non-small cell lung cancer. -
GPR75 Inhibitor
(Rac)-AAA is a potent inhibitor of GPR75, targeting the receptor to modulate key signaling pathways. This compound effectively blocks the downregulation of GPR75 expression induced by 20-HETE, leading to the inhibition of downstream pathways such as EGFR, AKT, NF-κB, and FAK. (Rac)-AAA also reverses 20-HETE-mediated epithelial-mesenchymal transition, characterized by the downregulation of vimentin and upregulation of E-Cadherin, while reducing MMP-2 activity and cancer cell migration. Additionally, it mitigates the upregulation of HIC-5 and affects the localization of PKC-α and phosphorylated AKT, making (Rac)-AAA a significant tool in the study of castration-resistant prostate cancer. -
RPTPβ/ζ Inhibitor
MY10 is a potent inhibitor of receptor protein tyrosine phosphatase β/ζ (RPTPβ/ζ) that exhibits oral bioactivity. It has been shown to reduce NF-κB p65 expression and activate c-Met tyrosine phosphorylation. Additionally, MY10 prevents the alcohol-induced downregulation of Ptprz1 and Alk expression, while attenuating binge-like ethanol consumption and associated rewards. This compound is valuable for investigating neurological and vascular diseases. -
PROTAC BTK Degrader
PROTAC BTK Degrader-6 is a potent PROTAC degrader targeting Bruton's tyrosine kinase (BTK) with a DC50 of 3.18 nM. This compound exhibits anti-inflammatory activity by inhibiting NF-κB activation and reducing the expression of pro-inflammatory cytokines, including IL-1β and IL-6. It serves as a valuable tool for research into the modulation of immune responses and the development of therapies for inflammatory diseases. -
Drug Derivative
(+)–Rocaglamide is a selective inhibitor of heat shock factor 1 (HSF1), exhibiting an IC50 value of 50 nM. It is effective in inhibiting NF-κB activation in T-cells and the activity of the translation initiation factor eIF4A. Research applications include its potential use in anti-inflammatory treatments and as an anticancer agent, particularly against leukemia. This compound is derived from the genus Aglaia and demonstrates promising therapeutic properties for various conditions, including inflammatory diseases. -
HDAC1/HDAC2 Inhibitor
MRLB-223 is a selective inhibitor of HDAC1 and HDAC2, demonstrating potent activity against tumor cells. It induces histone hyperacetylation and activates the intrinsic apoptotic pathway, leading to tumor cell apoptosis and degradation of Bcr-Abl in a caspase-dependent manner. Notably, MRLB-223 mediates p53-independent cell death in Bcr-Abl-expressing myeloid cells and shows efficacy in animal models of Eμ-myc lymphoma. This compound is valuable for research focusing on the mechanisms of lymphomagenesis and therapeutic strategies for Eμ-myc lymphoma. -
GADD45β/MKK7 Inhibitor
DTP3 TFA is a highly selective inhibitor of GADD45β/MKK7, targeting a critical pathway involved in cell survival in cancer cells downstream of the NF-κB signaling cascade. This compound exert biological activity by disrupting the function of the GADD45β/MKK7 module, influencing cellular responses to DNA damage and stress. DTP3 TFA serves as a valuable tool in cancer research, particularly in studies investigating the mechanisms of cell survival and the potential for therapeutic interventions in malignancies associated with aberrant NF-κB activity. -
Anti-Inflammatory Agent
Vitisin A is a resveratrol tetramer with potent anti-inflammatory properties. It exerts its biological activity by inhibiting LPS-induced nitric oxide (NO) and inducible nitric oxide synthase (iNOS) production through the down-regulation of ERK1/2, p38, and NF-κB signaling pathways. Additionally, Vitisin A demonstrates antioxidative, anticancer, and neuroprotective effects while also inhibiting adipocyte differentiation. This compound is derived from the roots of Vitis vinifera and serves as a valuable reagent for research in inflammation and related diseases. -
Inflammation Inhibitor
Resolvin D5 is an anti-inflammatory agent primarily targeting the GPR32 receptor, effectively modulating inflammation responses. It alleviates Paclitaxel-induced mechanical allodynia and inflammatory pain in male mice through mechanisms that do not involve TRPV1 or TRPA1 channels. Resolvin D5 reduces LPS-induced ERK phosphorylation and NF-κB nuclear translocation while downregulating pro-inflammatory mediators, inhibiting Th17 differentiation, and promoting regulatory T cell differentiation. This compound is particularly relevant for research on chemotherapy-induced peripheral neuropathy, inflammatory pain, and rheumatoid arthritis. -
NF-κB&ERK1/2 Inhibitor
OP-1118 is a potent dual inhibitor of NF-κB and ERK1/2, targeting critical signaling pathways involved in inflammation and cell survival. This compound demonstrates significant anti-inflammatory, cytoprotective, anti-apoptotic, and antibacterial activities by inhibiting the phosphorylation of NF-κB and ERK1/2, leading to a reduction in pro-inflammatory cytokine expression. In preclinical models of Clostridium difficile infection, OP-1118 effectively mitigates toxin-induced intestinal inflammation, cellular damage, and apoptosis, with its protective effects possibly reversible by PMA. This makes OP-1118 a valuable reagent for research into inflammatory conditions and therapeutic interventions. -
Anti-inflammatory Agent
24-O-Acetyllycoclavanol is a triterpenoid compound that functions as an anti-inflammatory agent by selectively targeting the NF-κB and ERK1/2 signaling pathways. Its biological activity includes the inhibition of lipopolysaccharide (LPS)-induced expression of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2), leading to decreased production of inflammatory mediators like nitric oxide (NO), IL-1β, and IL-8. This compound is particularly relevant for research applications in the context of inflammatory bowel disease (IBD) and can be isolated from the ethyl acetate extract of Lycopodium clavatum. -
Anti-inflammatory Agent
Anti-inflammatory agent 31 is a derivative of andrographolide that functions primarily by inhibiting NF-κB activation through the upstream blockade of the PI3K/Akt and ERK1/2 MAPK signaling pathways. This compound exhibits notable anti-inflammatory activity, promoting the recovery of intracellular glutathione (GSH) levels. Additionally, anti-inflammatory agent 31 demonstrates a protective effect on liver cells, making it a valuable tool for research applications in inflammation and hepatoprotection. -
Antioxidant/Anti-inflammatory/Anticancer Agent
Licoflavanone, a flavanone with antioxidant, anti-inflammatory, and anticancer properties, is isolated from the leaf extract of Glycyrrhiza glabra. It exerts its anticancer effects by downregulating the mTOR/PI3K/AKT signaling pathway, leading to inhibition of cancer cell proliferation, migration, and invasion. Additionally, Licoflavanone activates pro-apoptotic factors such as Bax and Bad, along with multiple caspase enzymes. Its anti-inflammatory activity involves reducing NF-κB nuclear translocation and decreasing the phosphorylation of p38, JNK, and ERK1/2, ultimately inhibiting pro-inflammatory cytokines, COX-2, and iNOS expression. This compound is utilized in research on nasopharyngeal carcinoma and its underlying mechanisms. -
CK1α Degrader
INNO-220 is a CRBN-dependent molecular glue degrader that specifically targets CK1α. This orally active compound induces cell cycle arrest at the G0/G1 phase and promotes apoptosis through the degradation of CK1α. Additionally, INNO-220 disrupts the assembly and function of the CARD11/BCL10/MALT1 complex, effectively inhibiting NF-κB signaling in stimulated T cells and lymphoma cells with activating mutations in CARD11. This reagent serves as a valuable tool for advancing research in lymphoma. -
TMA /TMAO Inhinbitor
3,3-Dimethyl-1-butanol is an orally active inhibitor of trimethylamine (TMA) and trimethylamine N-oxide (TMAO), acting via the suppression of the p65 NF-κB signaling pathway and the TGF-β1/Smad3 pathway. This compound exhibits significant potential in the study of cardiovascular diseases (CVD), making it a valuable reagent for researchers investigating the molecular mechanisms underlying these conditions. -
GPR119 Agonist
2-Oleoylglycerol is a GPR119 agonist that activates hGPR119 in transiently transfected COS-7 cells with an EC50 value of 2.5 μM. This lipid enhances the inflammatory response in macrophages and promotes fibrosis through the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. Additionally, 2-Oleoylglycerol stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. Its effects make it a valuable tool for research into non-alcoholic steatohepatitis (NASH) and related metabolic disorders. -
Syk Inhibitor, NF-κB p65 Inhibitor, TGF-β1/Smad Signaling Inhibitor
Flavanomarein is a potent inhibitor of Syk and NF-κB p65, as well as a modulator of TGF-β1/Smad signaling pathways. This compound exhibits cytoprotective, anti-inflammatory, and antioxidant activities, enhancing AKT phosphorylation while regulating key proteins such as PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2, and ICAD. Flavanomarein also inhibits the nuclear translocation of NF-κB p65 and modulates epithelial-mesenchymal transition (EMT) markers, promoting proliferation in HK-2 cells and protecting neuronal cells from 6-OHDA-induced neurotoxicity. This compound is valuable for research on Parkinson's disease and diabetic nephropathy. -
Stable Isotope
2-Oleoylglycerol-d5 is a deuterium-labeled derivative of 2-Oleoylglycerol, a known agonist of GPR119. It exhibits significant biological activity by activating human GPR119 with an EC50 of 2.5 μM in COS-7 cells, enhancing macrophage inflammatory responses and promoting fibrosis through the GPR119/TAK1/NF-κB/TGF-β1 signaling cascade. Additionally, this compound stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol-d5 is particularly useful for studying mechanisms underlying non-alcoholic steatohepatitis (NASH). -
Endogenous Metabolite
9,10-EpOME (9,10-Epoxyoctadecenoic acid) is a cytochrome P450-derived metabolite of linoleic acid. It is known to induce oxidative stress by activating the NF-κB and AP-1 transcription factors and facilitates the chemotaxis of human neutrophils. Additionally, 9,10-EpOME has been shown to induce mechanical and thermal pain in wild-type mice via the PKA pathway. This compound is useful for investigating mechanisms of inflammation and pain in research settings. -
Anti-inflammatory Agent
Anti-inflammatory Agent 58 is a potent inhibitor of IL-1β, demonstrating an IC50 of 1.08 μM. This compound effectively reduces pro-inflammatory gene expression, limits protein secretion, and inhibits NF-κB phosphorylation. It is suitable for research applications focused on inflammatory pathways and the modulation of immune responses. -
Anti-inflammatory Agent
Anti-inflammatory agent 59 is a selective inhibitor of interleukin-1 beta (IL-1β) with an IC50 of 2.28 μM. This compound effectively reduces pro-inflammatory gene expression and protein secretion while inhibiting NF-κB phosphorylation. It serves as a valuable tool in the study of inflammatory pathways and may aid in the development of new therapeutic strategies for inflammatory diseases. -
Anti-inflammatory Agent
Acutissimalignan B is a bioactive compound recognized for its role as an anti-inflammatory agent. It effectively reduces the mRNA expression of key inflammatory cytokines, including inducible nitric oxide synthase (iNOS), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), and interleukin-6 (IL-6). Additionally, Acutissimalignan B inhibits the phosphorylation of IκBα and the nuclear translocation of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) p65, thereby demonstrating potential utility in neuroinflammation research and related disease models. -
NF-κB Inhibitor/TRP Modulator
Cannabitwinol is a selective NF-κB inhibitor and thermosensitive TRP modulator. It effectively inhibits TNFα-induced NF-κB-driven transcription and IL-8 release, exhibiting notable anti-inflammatory and antioxidant properties. Cannabitwinol selectively activates cold-activated TRP channels, such as TRPA1 (EC50 = 3.0 μM), while antagonizing TRPM8 (IC50 = 3.9 μM), with minimal interaction with heat-activated TRP channels like TRPV1 and TRPV2. This compound is applicable in research focused on inflammatory skin diseases, cold allodynia, and hyperalgesia.
