(+)–Rocaglamide is a selective inhibitor of heat shock factor 1 (HSF1), exhibiting an IC50 value of 50 nM. It is effective in inhibiting NF-κB activation in T-cells and the activity of the translation initiation factor eIF4A. Research applications include its potential use in anti-inflammatory treatments and as an anticancer agent, particularly against leukemia. This compound is derived from the genus Aglaia and demonstrates promising therapeutic properties for various conditions, including inflammatory diseases.
(+)–Rocaglamide is a selective inhibitor of heat shock factor 1 (HSF1), exhibiting an IC50 value of 50 nM. It is effective in inhibiting NF-κB activation in T-cells and the activity of the translation initiation factor eIF4A. Research applications include its potential use in anti-inflammatory treatments and as an anticancer agent, particularly against leukemia. This compound is derived from the genus Aglaia and demonstrates promising therapeutic properties for various conditions, including inflammatory diseases.
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