TU-100 is a novel anticancer agent derived from Japanese herbal medicine. It exhibits significant anti-cancer effects by modulating cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME). TU-100 effectively antagonizes the M2 polarization of macrophages by inhibiting the TLR4/NF-κB/STAT3 signaling pathway, leading to the downregulation of key proteins such as MMP-2, COX-2, and VEGF in tumor-associated macrophages (TAMs). This compound is valuable for research into cancer therapies targeting the tumor microenvironment and immune modulation.
TU-100 is a novel anticancer agent derived from Japanese herbal medicine. It exhibits significant anti-cancer effects by modulating cancer-associated fibroblasts (CAFs) within the tumor microenvironment (TME). TU-100 effectively antagonizes the M2 polarization of macrophages by inhibiting the TLR4/NF-κB/STAT3 signaling pathway, leading to the downregulation of key proteins such as MMP-2, COX-2, and VEGF in tumor-associated macrophages (TAMs). This compound is valuable for research into cancer therapies targeting the tumor microenvironment and immune modulation.
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