Phytohemagglutinin (PHA-M) is a potent T-cell activator derived from the seeds of Phaseolus vulgaris. This lectin stimulates the proliferation of human mononuclear leukocytes, leading to the upregulation of ChAT mRNA and enhancing acetylcholine synthesis. Additionally, Phytohemagglutinin exerts dose- and time-dependent cytotoxic effects on THP-1 monocytes/macrophages, resulting in altered cellular morphology, organelle dysfunction, and increased expression of pro-inflammatory markers such as NF-κB, COX2, and IL-1β. It is valuable for research applications related to immunology and cell signaling pathways.
Phytohemagglutinin (PHA-M) is a potent T-cell activator derived from the seeds of Phaseolus vulgaris. This lectin stimulates the proliferation of human mononuclear leukocytes, leading to the upregulation of ChAT mRNA and enhancing acetylcholine synthesis. Additionally, Phytohemagglutinin exerts dose- and time-dependent cytotoxic effects on THP-1 monocytes/macrophages, resulting in altered cellular morphology, organelle dysfunction, and increased expression of pro-inflammatory markers such as NF-κB, COX2, and IL-1β. It is valuable for research applications related to immunology and cell signaling pathways.
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