17-Epiestriol is an estrogen metabolite that acts as a selective estrogen receptor (ER) β agonist. It is known to inhibit the mRNA and protein expression of vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα), thereby preventing NF-κB migration to the nucleus. Additionally, 17-epiestriol promotes the expression of endothelial nitric oxide synthase at both mRNA and protein levels. This compound is useful in research related to vascular inflammation and endothelial function.
17-Epiestriol is an estrogen metabolite that acts as a selective estrogen receptor (ER) β agonist. It is known to inhibit the mRNA and protein expression of vascular cell adhesion molecule VCAM-1 induced by tumor necrosis factor α (TNFα), thereby preventing NF-κB migration to the nucleus. Additionally, 17-epiestriol promotes the expression of endothelial nitric oxide synthase at both mRNA and protein levels. This compound is useful in research related to vascular inflammation and endothelial function.
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