Catalog No.
Product Name
Application
Product Information
Citations
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GPR119 Agonist
2-Oleoylglycerol is a GPR119 agonist that activates hGPR119 in transiently transfected COS-7 cells with an EC50 value of 2.5 μM. This lipid enhances the inflammatory response in macrophages and promotes fibrosis through the GPR119/TAK1/NF-κB/TGF-β1 signaling pathway. Additionally, 2-Oleoylglycerol stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. Its effects make it a valuable tool for research into non-alcoholic steatohepatitis (NASH) and related metabolic disorders. -
Syk Inhibitor, NF-κB p65 Inhibitor, TGF-β1/Smad Signaling Inhibitor
Flavanomarein is a potent inhibitor of Syk and NF-κB p65, as well as a modulator of TGF-β1/Smad signaling pathways. This compound exhibits cytoprotective, anti-inflammatory, and antioxidant activities, enhancing AKT phosphorylation while regulating key proteins such as PKC-δ, P85α, PKC-β1, Sirt1, Bcl-2, and ICAD. Flavanomarein also inhibits the nuclear translocation of NF-κB p65 and modulates epithelial-mesenchymal transition (EMT) markers, promoting proliferation in HK-2 cells and protecting neuronal cells from 6-OHDA-induced neurotoxicity. This compound is valuable for research on Parkinson's disease and diabetic nephropathy. -
Stable Isotope
2-Oleoylglycerol-d5 is a deuterium-labeled derivative of 2-Oleoylglycerol, a known agonist of GPR119. It exhibits significant biological activity by activating human GPR119 with an EC50 of 2.5 μM in COS-7 cells, enhancing macrophage inflammatory responses and promoting fibrosis through the GPR119/TAK1/NF-κB/TGF-β1 signaling cascade. Additionally, this compound stimulates glucagon-like peptide 1 (GLP-1) secretion in vivo. 2-Oleoylglycerol-d5 is particularly useful for studying mechanisms underlying non-alcoholic steatohepatitis (NASH). -
Essential Amino Acid
L-Cysteine hydrochloride hydrate is an essential amino acid that serves as a precursor for biologically active molecules, including hydrogen sulfide (H2S), glutathione, and taurine. It modulates the CBS/H2S pathway and has been shown to inhibit NF-κB activation, as well as regulate insulin and ghrelin secretion. This compound is involved in reducing blood glucose levels, vascular inflammation markers, and appetite, while also being noted for its potential to induce kidney damage. Its applications extend to research on neurological diseases and diabetes. -
NF-κB Activator
Isochamaejasmin is a biflavonoid that acts as a potent activator of NF-κB. It exhibits significant anti-cancer properties by inducing apoptosis through the mitochondrial pathway and causing DNA damage in AW1 cells. In addition, Isochamaejasmin demonstrates moderate antiplasmodial activity against P. falciparum with an IC50 of 7.3 μM, while maintaining relatively low cytotoxicity (CC50 of 29.0 μM), making it valuable for various biological research applications. -
Antitumor Agent
SpiD3, a spirocyclic dimer, functions as an antitumor agent with significant inhibitory effects on malignant B-cell proliferation. It suppresses NF-κB activation independently of tumor microenvironment-related stimuli, promoting apoptosis and inhibiting protein synthesis in chronic lymphocytic leukemia (CLL) cells. SpiD3 is suitable for research focused on the mechanisms of CLL and the development of targeted therapies. -
S100P Inhibitor
5-Methyl cromolyn disodium is a selective inhibitor of the S100P protein, targeting its interaction with the receptor for advanced glycation end-products (RAGE). It effectively suppresses NF-κB activity and cell proliferation while enhancing Gemcitabine-induced apoptosis. In preclinical mouse models, 5-Methyl cromolyn disodium demonstrates significant anti-tumor effects by reducing growth and metastasis of pancreatic ductal adenocarcinoma (PDAC), ultimately extending survival. This compound serves as a valuable tool for investigating pancreatic cancer mechanisms and potential therapeutic approaches. -
Xanthonoid Compound
Tovophyllin A is a xanthonoid compound that primarily targets neuroprotection through the activation of the Akt/GSK3β signaling pathway. This compound demonstrates significant neuroprotective effects against Parkinson's disease and induces Nrf2 activation to safeguard against liver injury in mouse models. Additionally, Tovophyllin A exhibits anti-inflammatory properties by inhibiting NF-κB activation and the subsequent release of pro-inflammatory cytokines, while also reducing apoptotic cell death. Its antiplasmodial and cytotoxic activities against lung epithelial and breast cancer cells further establish Tovophyllin A as a valuable reagent for research in diverse applications, including neurodegenerative diseases, liver injury, acute respiratory conditions, and cancer. -
NF-κB Inhibitor
NF-κB-IN-5 is a potent inhibitor of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) that acts by directly interacting with the NF-κB complex. This compound demonstrates significant antitumor activity across multiple human cancer cell lines, including HCT116, U87-MG, HepG2, BGC823, and PC9, with IC50 values ranging from 2.02 to 5.35 μM. NF-κB-IN-5 also promotes apoptosis in U87-MG cells and induces cell cycle arrest in the G0/G1 phase, positioning it as a valuable tool for cancer research and therapeutic development. -
Antitumor
CLEFMA is a curcuminoid known for its antitumor properties. It exhibits significant inhibition of tumor growth, primarily through the modulation of NF-κB pathways, leading to anti-inflammatory and anti-metastatic effects. This compound is utilized in research related to cancer biology and therapeutic development. -
Apoptosi
NF023 is a selective inhibitor of X-BIR1/TAB1 assembly, impacting apoptosis by disrupting XIAP-mediated NF-κB activation. This compound modulates cell survival signaling pathways and demonstrates potential as a P2X1 adenylate receptor antagonist. NF023 may enhance the efficacy of pro-apoptotic therapies, offering a promising avenue for cancer treatment and suppression. -
c-Myc Inhibitor
EP12 is a selective c-Myc inhibitor that stabilizes c-Myc G-quadruplexes. This compound induces apoptosis and causes DNA damage in multiple myeloma cells, effectively inhibiting their growth. Additionally, EP12 disrupts the nuclear translocation of P65/P50 by interfering with the NF-κB signaling pathway, highlighting its potential in cancer research and therapeutic applications. -
Neuroprotective Agent
Tricin 7-O-β-D-glucopyranoside functions as a potent neuroprotective agent, exhibiting significant oral bioavailability. This compound induces apoptosis and effectively reduces the expression levels of TNF-α mediated phospho-IκB-α, phospho-NF-κB, and HMGB1. Its activities make it a valuable reagent for research into neurodegenerative diseases and related biological pathways. -
Antioxidant Agent
Antioxidant agent-5 is a potent antioxidant that targets oxidative stress pathways. It effectively inhibits oxidized low-density lipoprotein (oxLDL)-induced apoptosis and the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in vascular endothelial cells. This compound suppresses oxLDL-mediated reactive oxygen species (ROS) production and nuclear translocation of NF-κB, providing protective effects against oxLDL-induced endothelial injury through the activation of the Nrf2/HO-1 antioxidant pathway. Research applications include studies on cardiovascular health and endothelial function. -
IRAK4 Inhibitor
Emavusertib phosphate is a potent inhibitor of IRAK4, exhibiting an IC50 of 57 nM. This compound effectively disrupts NF-κB and MyD88 signaling pathways, leading to a significant reduction in pro-inflammatory cytokines such as IL-6 and IL-10. Emavusertib phosphate demonstrates both anti-inflammatory and anti-proliferative effects on cancer cells, promoting apoptosis and showcasing antitumor activity in preclinical mouse models. Its applications extend to investigating inflammatory diseases and cancer therapies. -
Stable Isotope
N-Oxide Lidocaine-d10 is a deuterium-labeled derivative of Lidocaine, which primarily targets voltage-gated sodium channels, inhibiting their activity in a complex, use-dependent manner. This compound exhibits significant biological activity, notably reducing the growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145 expression and subsequently inactivating the MEK/ERK and NF-κB signaling pathways. N-Oxide Lidocaine-d10 is valuable for research into ventricular arrhythmias and related cardiac applications. -
IRAK4 Inhibitor
Emavusertib maleate is a potent inhibitor of IRAK4, demonstrating an IC50 of 57 nM, and FLT3. This orally bioavailable compound inhibits NF-κB and MyD88 signaling pathways, effectively reducing the production of pro-inflammatory cytokines such as IL-6 and IL-10. Its anti-inflammatory and anti-proliferative properties make it a valuable tool for cancer research, promoting apoptosis in cancer cells and demonstrating antitumor activity in preclinical mouse models. -
Stable Isotope
Sodium propionate-13C-1 is a stable isotope-labeled derivative of sodium propionate, functioning primarily as a short-chain fatty acid. It is synthesized by intestinal bacteria through dietary fiber metabolism and exhibits multiple biological activities, including increased PPAR-γ expression and inhibition of NF-κB activation, COX-2 expression, and NO production. Additionally, sodium propionate induces apoptosis and autophagy while demonstrating neuroprotective, antioxidant, and anti-inflammatory properties. Its applications span various research areas, including spinal cord injury, Alzheimer's disease, and glioblastoma, presenting potential avenues for therapeutic exploration. -
NF-κB Inhibitor
Amorfrutin A is an NF-κB inhibitor that inhibits TNF-α-induced IκBα degradation, p65 nuclear translocation, and DNA-binding activity of the NF-κB complex. This compound promotes apoptosis in HeLa cells by enhancing the proteolytic activities of caspase-3 and PARP. Its mechanism suggests potential research applications in studying inflammation, cancer biology, and cell death pathways. -
IRAK4 Inhibitor
Emavusertib tosylate is a potent inhibitor of IRAK4, displaying an IC50 of 57 nM. By targeting IRAK4 and FLT3, it effectively disrupts NF-κB and MyD88 signaling pathways, resulting in the reduction of pro-inflammatory cytokines such as IL-6 and IL-10. This compound demonstrates significant anti-inflammatory and anti-proliferative properties against cancer cells, promoting apoptotic mechanisms. Additionally, Emavusertib tosylate has shown noteworthy antitumor activity in preclinical mouse models, making it a valuable reagent for cancer research and inflammation studies. -
TAK1 Inhibitor
Triptriolide is a TAK1 inhibitor that plays a pivotal role in regulating apoptosis in mouse podocytes. It enhances cell survival and protects podocyte function by modulating the Bcl-2 family proteins and inhibiting Caspase-3 activity. Additionally, Triptriolide activates the TAK1-NF-κB signaling pathway, leading to the upregulation of podocin. This reagent is relevant for studies focusing on kidney health and podocyte resilience under stress conditions. -
Stable Isotope
Lidocaine-d6 is a deuterated form of Lidocaine, serving as a stable isotope for metabolic studies and analytical applications. Lidocaine primarily targets sodium channels, exhibiting voltage-dependent inhibition. In cancer research, it has been shown to reduce growth, migration, and invasion of gastric carcinoma cells by up-regulating miR-145, which leads to the inactivation of the MEK/ERK and NF-κB signaling pathways. This compound is also relevant for studies on ventricular arrhythmias, providing insights into cardiac electrophysiology. -
Stable Isotope
Carbocisteine-13C3-1 is a stable isotope-labeled derivative of Carbocisteine, primarily targeting mucolytic activity. This compound is known to inhibit the phosphorylation of NF-κB p65 and ERK1/2, modulating the interplay between Nrf2 and HO-1. Additionally, Carbocisteine exhibits apoptotic inhibition properties. It is widely employed in research related to chronic obstructive pulmonary disease (COPD) and other respiratory conditions. -
Antimalarial
Quinacrine methanesulfonate is a potent orally active antimalarial compound that also exhibits antitumor properties. This reagent functions through the inhibition of NF-κB signaling and the activation of p53 pathways, leading to apoptosis in cancer cells. Its dual activity makes it valuable for studying both malaria pathogenesis and cancer biology. -
Stable Isotope
Propanoic acid-13C3 is a stable isotope-labeled derivative of propanoic acid, targeting metabolic pathways involving short-chain fatty acids. This compound demonstrates significant biological activity by enhancing PPAR-γ expression, inhibiting NF-κB activation, and downregulating COX-2 and nitric oxide production. Additionally, propanoic acid-13C3 has been shown to induce apoptosis and autophagy, display neuroprotective effects, and exhibit anti-inflammatory properties. Its applications extend to research in spinal cord injury, Alzheimer's disease, and glioblastoma therapy, making it a valuable tool for metabolic and neurological studies. -
IRAK4 Inhibitor
Emavusertib mesylate is a potent inhibitor of IRAK4, demonstrating an IC50 of 57 nM. This orally active compound effectively disrupts the NF-κB and MyD88 signaling pathways, leading to a reduction in pro-inflammatory cytokines such as IL-6 and IL-10. Emavusertib mesylate displays anti-inflammatory and anti-proliferative properties against cancer cells, promoting apoptosis. Additionally, it has shown significant antitumor activity in mouse models, making it valuable for cancer research and therapeutic studies targeting inflammatory pathways. -
BChE Inhibitor
Pteryxin is a potent butyrylcholinesterase (BChE) inhibitor (IC50 = 12.96 μg/mL) with additional multi-target mechanisms including inhibition of NF-κB, MAPK, NLRP3 inflammasome activation, and modulation of the Nrf2/ARE pathways. This compound demonstrates significant anti-inflammatory, antioxidant, and osteoclastogenesis inhibitory activities. Pteryxin is suitable for research applications related to inflammatory diseases, osteoporosis, diabetes, and neurodegenerative disorders such as Alzheimer's disease. -
PC Inhibitor
Anemoside A3-methyl 6-aminohexanoate is a potent pyruvate carboxylase (PC) inhibitor, exhibiting a Kd value of 10.1 μM against human PC. This compound influences cellular pathways through the PC/NF-κB/NLRP3 inflammasome axis, demonstrating significant efficacy in alleviating symptoms of DSS-induced colitis in murine models. Anemoside A3-methyl 6-aminohexanoate serves as a useful tool in colitis-related research and studies focusing on the modulation of inflammatory pathways. -
NLRP3 Inhibitor
Yadanzigan is a potent NLRP3 inhibitor that exerts its anti-inflammatory effects by inhibiting the NF-κB signaling pathway and reducing Reactive Oxygen Species production. This compound has been shown to mitigate LPS-induced acute lung injury (ALI) in murine models, highlighting its potential for research in inflammation-related conditions. Its mechanism of action positions Yadanzigan as a valuable tool for studying NLRP3-related pathways and their roles in various pathological processes. -
NOD1 Agonist
iE-DAP is a potent NOD1 agonist that activates the NOD1 receptor, leading to the stimulation of the NF-κB and MLCK signaling pathways. This results in enhanced cellular inflammatory responses and disruption of tight junction integrity, as evidenced by the downregulation of ZO-1 and Occludin gene expression. In term human trophoblast cell cultures, iE-DAP promotes the secretion of pro-inflammatory cytokines such as IL-6, GRO-α, MCP-1, IL-8, and MIP-1β. It is particularly relevant for research focused on mastitis and preterm birth, as it has been shown to induce fetal inflammation and impact fetal body weight in pregnant murine models. -
Sodium Channel Inhibitor
Articaine is a selective inhibitor of voltage-gated sodium channels, including rNav1.4, hNav1.7, and rNav1.8, demonstrating an IC50 of 15.8 μM for open-state Na+ channels. It effectively blocks Na+ influx, leading to local anesthetic effects and interruption of nerve impulse conduction. Additionally, Articaine exhibits anti-inflammatory properties by inhibiting NF-κB activation and the NLRP3 inflammasome pathway. This compound is valuable for research in dental anesthesia and inflammatory-related conditions, such as acute kidney injury. -
NLRP3 Inhibitor
NLRP3-IN-69 is a selective inhibitor of the NLRP3 inflammasome, targeting the activation of NF-κB p65. This compound effectively reduces LPS-induced overexpression of pro-inflammatory cytokines including IL-1β, as well as iNOS and COX-2, while inhibiting nitric oxide generation with an IC50 of 5.66 μM. NLRP3-IN-69 serves as a valuable tool in research focused on inflammatory diseases and the modulation of the immune response. -
COX-2/NLRP3 Inhibitor
COX-2/NLRP3-IN-1 is a selective inhibitor targeting both COX-2 and the NLRP3 inflammasome, with an IC50 of 1.53 μM for COX-2. This compound exhibits notable anti-inflammatory properties by disrupting the NF-κB/NLRP3 signaling pathway, making it a valuable tool for research into inflammatory diseases. It is suitable for studying the roles of COX-2 and NLRP3 in various biological processes and therapeutic interventions. -
NOD1/NOD2 Antagonist
NOD1/2 antagonist-2 is a dual antagonist of NOD1 and NOD2, exhibiting IC50 values of 2.36 μM and 4.16 μM, respectively. This compound effectively inhibits NF-κB and MAPK inflammatory signaling pathways, enhancing the efficacy of Paclitaxel in suppressing the growth of Lewis lung carcinoma. It is a valuable tool for investigating the roles of NOD1 and NOD2 in inflammation and cancer research. -
NF-κB Inhibitor
1-Caffeoylquinic acid is a potent inhibitor of NF-κB, demonstrating a significant binding affinity to the RH domain of p105 with a Ki value of 0.007 μM. This compound exhibits notable anti-oxidative stress properties and serves as an inhibitor for the PD-1/PD-L1 pathway. Its biological activities make it valuable for research applications in inflammation, immunity, and cancer studies. -
T-cell Activator
Phytohemagglutinin (PHA-M) is a potent T-cell activator derived from the seeds of Phaseolus vulgaris. This lectin stimulates the proliferation of human mononuclear leukocytes, leading to the upregulation of ChAT mRNA and enhancing acetylcholine synthesis. Additionally, Phytohemagglutinin exerts dose- and time-dependent cytotoxic effects on THP-1 monocytes/macrophages, resulting in altered cellular morphology, organelle dysfunction, and increased expression of pro-inflammatory markers such as NF-κB, COX2, and IL-1β. It is valuable for research applications related to immunology and cell signaling pathways. -
Natural Product
Sesame Oil is a natural product derived from the seeds of Sesamum indicum L. It exhibits a variety of biological activities, including the ability to reduce NF-κB, aspartate aminotransferase, alanine aminotransferase, IL-1β, IL-4, and nitric oxide levels. Sesame Oil demonstrates antitumor activity against malignant melanoma and provides protective effects against liver damage induced by agents such as Cisplatin and Acetaminophen. Additionally, it possesses notable antinociceptive and anti-inflammatory properties, making it a valuable reagent for various research applications. -
NF-KB Activator
Fibrinogen (Bovine) is a glycoprotein that serves as a potent NF-κB activator, exhibiting selective proteolytic properties when activated by thrombin to form fibrin clots. It plays a critical role in regulating NF-κB activation in endothelial cells and enhances the expression of pro-inflammatory chemokines, including MCP-1. Fibrinogen is essential for understanding blood coagulation processes, thrombosis, atherosclerosis, and the pathological aspects of venous graft development, making it valuable for research in vascular diseases. -
CHI3L1 Inhibitor
K284-6111 is a potent inhibitor of CHI3L1, demonstrating high affinity and oral bioavailability. It effectively suppresses CHI3L1 expression and disrupts key signaling pathways, including ERK and NF-κB, leading to reduced nuclear translocation of p50 and p65 as well as decreased phosphorylation of IκB. K284-6111 shows promise in alleviating memory dysfunction associated with Alzheimer's disease by mitigating amyloidogenesis and neuroinflammation. Additionally, it exhibits therapeutic potential in reducing atopic-like skin inflammation and protecting against LPS-induced liver injury. This compound is suitable for research into neurodegenerative diseases and inflammatory conditions. -
Anti-inflammatory Agent
Militarine is an anti-inflammatory agent that primarily targets the NF-κB signaling pathway. It demonstrates significant biological activity by alleviating PM2.5-induced inflammatory injury and inhibiting cell migration in human alveolar epithelial A549 cells. Additionally, Militarine functions as a plant growth inhibitor, affecting the elongation of radicles and hypocotyls in various plant species. This compound is suitable for research applications related to PM2.5-induced pulmonary diseases and plant physiology studies. -
NF-κB Inhibitor
Valencene is a sesquiterpene that functions as an NF-κB inhibitor. It exhibits significant anti-inflammatory, antiallergic, and antioxidant activities by inhibiting the expression of Th2 chemokines and proinflammatory cytokines. In LPS-stimulated RAW 264.7 cells, Valencene effectively reduces the production of IL-1β and IL-6. Additionally, Valencene has demonstrated potential in alleviating symptoms of atopic dermatitis and restoring filaggrin expression in a DNCB-sensitized mouse model. -
Antioxidant
[10]-Shogaol is a potent orally active antioxidant, primarily targeting pro-inflammatory pathways. Derived from ginger (Zingiber officinale), it inhibits cyclooxygenase-2 (COX-2) with an IC50 of 7.5 μM, reducing the production of pro-inflammatory cytokines such as IL-1β and IL-6, and suppressing NF-κB phosphorylation. This compound exhibits notable anti-inflammatory and anticancer activities, particularly against Docetaxel-resistant prostate cancer. Additionally, [10]-Shogaol demonstrates larvicidal efficacy against L5 larvae of Angiostrongylus cantonensis, making it useful for diverse biological research applications. -
Metabolite Of Oroxylin A
Oroxylin A-7-O-glucuronide is a flavonoid glucuronide derivative and metabolite of Oroxylin A, primarily known for its prolyl oligopeptidase inhibitory activity. This compound demonstrates the ability to inhibit the JNK signaling pathway, upregulate PPARγ, and prevent nuclear translocation of NF-κB p65, leading to reduced production of pro-inflammatory cytokines such as IL-1β and IL-6. Additionally, Oroxylin A-7-O-glucuronide exhibits promising anti-angiogenic, anti-tumor, anti-inflammatory, and hepatoprotective properties, making it a valuable tool in cancer research and inflammatory disease studies. -
Flavonoid
Saponarin is a flavonoid compound that functions primarily as an inhibitor of ERK/p38, NF-κB, and MAPK phosphorylation while activating AMPK. It exhibits significant biological activities, including antioxidant, anti-inflammatory, hepatoprotective, hypoglycemic, and hypotensive effects. Additionally, Saponarin has been shown to reduce IL-1β and COX-2 levels, making it relevant for research applications related to inflammation and metabolic disorders. Furthermore, this compound has demonstrated potential in addressing sleep disorders. -
Anti-neuroinflammatory Agent
Murrayafoline A is a carbazole alkaloid that functions as an anti-neuroinflammatory agent by directly targeting Specificity protein 1 (Sp1) and inhibiting the NF-κB and MAPK signaling pathways. This compound induces G0/G1-phase cell cycle arrest in PDGF-stimulated vascular smooth muscle cells and promotes the degradation of β-catenin, thereby attenuating the Wnt/β-catenin pathway. Additionally, Murrayafoline A enhances contractility in rat ventricular myocytes and activates L-type calcium currents through protein kinase C activation. Researchers can utilize Murrayafoline A to investigate inflammation, vascular complications, and colon cancer. -
IL8 Regulator
Linoleate sodium is an orally active regulator of interleukin-8 (IL-8) that targets the JNK and NF-κB signaling pathways. This compound modulates fatty acid composition and alters metabolite production in cells, exhibiting significant anti-inflammatory and immune-regulating properties. Linoleate sodium has also demonstrated effects on tumor cell proliferation, making it a valuable tool for research in inflammation and cancer biology. -
PXR Agonist
FKK6 is a selective agonist of the pregnane X receptor (PXR) with an EC50 value of 1.2 µM. This compound demonstrates strong binding affinity to plasma proteins and favorable metabolic stability in human microsomes. FKK6 effectively inhibits the PXR-related NF-κB signaling pathway, reduces the expression of inflammatory cytokines, and displays anti-inflammatory properties in a mouse model of DSS-induced colitis, making it a valuable tool for studies in inflammation and drug metabolism. -
Anti-Inflammatory Compound
12-Oxo phytodienoic acid (12-OPDA) is an anti-inflammatory compound derived from plant lipids. It effectively suppresses neuroinflammation by inhibiting the nuclear factor kappa-light-chain-enhancer of activated B cells (Nf-κB) and p38 mitogen-activated protein kinase (MAPK) pathways in lipopolysaccharide (LPS)-activated cells. This compound is valuable for research related to neurodegenerative diseases, enabling the exploration of therapeutic strategies targeting inflammatory responses. -
Anti-IL-17C Antibody
MOR-106 is a humanized anti-IL-17C IgG1 monoclonal antibody that targets interleukin-17C, a cytokine involved in inflammatory responses. By binding specifically to IL-17C, MOR-106 inhibits the NF-κB signaling pathway, demonstrating an IC50 of 59 pM for human IL-17C and 55 pM for mouse IL-17C. This reagent effectively reduces skin inflammation and associated inflammatory factors in preclinical models of psoriasis and atopic dermatitis, making it a valuable tool for research into inflammatory skin disorders. -
Anti-inflammatory Agent
Arvelexin is an anti-inflammatory agent that primarily acts by inhibiting NF-κB activation. Isolated from Brassica rapa L. (Brassicaceae), Arvelexin also downregulates the expression of IL-8, making it a valuable compound for research into colonic inflammation. This compound is of interest for studies focused on inflammatory pathways and potential therapeutic applications in inflammatory bowel disease and related disorders.
