Catalog No.
Product Name
Application
Product Information
Citations
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PROTAC Linkers
Bis-PEG1-acid is a polyethylene glycol (PEG)-based linker designed for harnessing the proteolysis-targeting chimera (PROTAC) technology. This compound facilitates the synthesis of PROTACs by providing necessary flexibility and solubility, optimizing the delivery of targeted protein degradation. It is particularly useful in the development of innovative therapeutic agents aimed at selectively eliminating specific proteins within pathological contexts. -
PROTAC Linkers
Mal-PEG24-NHS ester is a PEG-based linker specifically designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound features a maleimide group for selective conjugation to cysteine residues, enhancing the stability and efficacy of PROTAC constructs. Its biocompatibility and hydrophilicity support efficient cellular uptake and biological activity, making it an essential tool in the field of targeted protein degradation. Research applications include the development of novel therapeutics for various diseases through the modulation of protein levels. -
PROTAC Linker
Propargyl-PEG6-NH2 is a PEG-based PROTAC linker that facilitates the synthesis of PROTACs (Proteolysis Targeting Chimeras). Featuring an alkyne functional group, it serves as a click chemistry reagent capable of undergoing copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. This linker is instrumental in the development of targeted protein degradation strategies, enhancing research in protein regulation and therapeutic applications. -
PROTAC Linkers
Amino-PEG8-amine is an 8-unit polyethylene glycol (PEG) based linker designed for PROTAC (proteolysis targeting chimera) synthesis. This compound facilitates the conjugation of small molecules to E3 ligases, enhancing the development of bifunctional compounds that promote targeted protein degradation. It is a valuable tool in biochemical research, enabling studies on protein modulation and therapeutic interventions in various diseases. -
PROTAC Linkers
THP-PEG3-OH is a polyethylene glycol (PEG)-based linker specifically designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the effective recruitment of E3 ligases to target proteins, enhancing the degradation of specific intracellular proteins. Its application is pivotal in the development of novel therapeutic strategies in targeted protein degradation research. -
PROTAC Linker
NH2-PEG1-CH2CH2-Boc is a polyethylene glycol (PEG) and alkyl/ether-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the formation of PROTACs by providing solubility and enabling targeting of specific proteins for degradation. Its use is essential in chemical biology and drug discovery for the development of targeted protein degradation strategies. -
PROTAC Linker
Bromo-PEG4-acid is a polyethylene glycol (PEG)-based linker that facilitates the synthesis of proteolysis-targeting chimeras (PROTACs). Its bromo functional group enables the conjugation of target proteins, enhancing degradation efficiency through the ubiquitin-proteasome system. This compound is widely utilized in chemical biology for the development of targeted protein degradation strategies in various research applications. -
PROTAC Linker
Boc-NH-PEG8-CH2CH2COOH is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTAC (proteolysis-targeting chimera) molecules. This compound facilitates the ubiquitination and subsequent degradation of target proteins through targeted approaches in protein regulation studies. Its application is vital for research in cellular signaling, disease pathways, and development of novel therapeutic strategies by enhancing the specificity and efficacy of PROTACs. -
PROTAC Linker
Acid-C2-PEG4-C2-NHS ester is a PEG-based linker designed for the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound facilitates the conjugation of a protein of interest to an E3 ligase, enhancing targeted protein degradation. Its flexible structure allows for optimal spatial orientation, making it suitable for various research applications in the field of targeted therapy and drug discovery. -
PROTAC Linker
Triethylene glycol bis(p-toluenesulfonate) is a polyethylene glycol (PEG)-based linker specifically designed for PROTAC (proteolysis-targeting chimera) synthesis. This compound facilitates the creation of bifunctional molecules that selectively induce the ubiquitin-proteasome system to degrade targeted proteins. Its properties make it suitable for various research applications in targeted protein degradation and therapeutic development. -
PROTAC Linker
Propargyl-PEG4-alcohol is a PEG-based PROTAC linker that facilitates the synthesis of Proteolysis Targeting Chimeras (PROTACs). This compound features an alkyne functional group, allowing it to undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with azide-containing molecules. Its application is critical in chemical biology for the development of targeted protein degradation strategies, enhancing the efficacy of therapeutic agents in various research areas. -
PROTAC Linker
tert-Butyl (6-aminospiro[3.3]heptan-2-yl)carbamate functions as a PROTAC linker, facilitating the development of targeted protein degradation agents. This compound is integral in the synthesis of the PROTAC degrader CPD-39, enabling the selective modulation of protein levels for research applications in cellular biology and therapeutic discovery. Its structural properties support effective interaction with protein targets, making it valuable for studies aimed at understanding protein dynamics and degradation mechanisms. -
PROTAC Linkers
Biotin-PEG6-azide is a biotin-labeled PEG-based linker specifically designed for synthesizing PROTACs (Proteolysis Targeting Chimeras). This compound features an azide group, enabling it to participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it can engage in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with DBCO or BCN functionalized compounds, making it a versatile tool for chemical biology and therapeutic research involving targeted protein degradation. -
PROTAC Linker
Fmoc-NH-PEG1-C2-acid is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of stable complexes that enhance ubiquitination and degradation of target proteins. Its unique structure supports research into targeted protein degradation, leading to potential therapeutic applications in disease modulation and drug development. -
PROTAC Linkers
3-(2-Pyridyldithio)propanoic Acid serves as an alkyl chain-based linker specifically designed for the synthesis of PROTACs (proteolysis targeting chimeras). This compound facilitates the targeted degradation of proteins by bringing together an E3 ligase and a protein of interest, promoting ubiquitination and subsequent proteasomal degradation. Its unique structure and reactivity allow for enhanced stability and efficacy in various research applications involving targeted protein degradation. -
PROTAC Linkers
m-PEG1-NHS ester is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the conjugation of ligands to E3 ligase while enhancing solubility and bioavailability. It is an essential reagent for researchers developing targeted protein degradation strategies and studying cellular pathways through the modulation of specific protein levels. -
PROTAC Linkers
TCO-PEG2-amine is a PEG-based linker designed for use in the synthesis of PROTACs (Proteolysis Targeting Chimeras). This compound facilitates the targeted degradation of specific proteins through the ubiquitin-proteasome system, making it a valuable tool for chemical biology research. Its flexibility and solubility contribute to improved efficacy in the development of innovative therapeutic strategies targeting various diseases. -
PROTAC Linker
BCN-exo-PEG3-NH2 is a PEG-based linker designed for PROTAC (PROteolysis-TArgeting Chimeras) synthesis. This compound features a BCN (bicyclononyne) group that facilitates strain-promoted alkyne-azide cycloaddition (SPAAC) with azide-containing molecules. Its unique properties make it suitable for applications in targeted protein degradation research, enabling precise modulation of protein levels within biological systems. -
PROTAC Linkers
Biotin-PEG2-CH2CH2N3 is a PEG-based linker designed for PROTAC synthesis, targeting protein degradation pathways. This compound features an azide group that facilitates copper-catalyzed azide-alkyne cycloaddition (CuAAc) with alkyne-containing molecules. Additionally, it is compatible with strain-promoted alkyne-azide cycloaddition (SPAAC) reactions involving DBCO or BCN-tagged compounds, making it versatile for diverse chemical biology applications, including targeted protein degradation studies. -
PROTAC Linker
Boc-NH-PEG3 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of PROTACs (proteolysis-targeting chimeras). This compound facilitates the assembly of PROTACs by providing a flexible and hydrophilic spacer that connects the target ligand and E3 ligase components. Its primary application lies in advancing research in targeted protein degradation, enabling the selective modulation of protein levels within cells. -
PROTAC Linkers
Biotin-PEG12-NHS ester is a polyethylene glycol (PEG)-based PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the covalent attachment of proteins through biotinylation, enhancing the pharmacokinetic properties of PROTACs. Its unique structure allows for improved solubility and stability, making it a valuable tool in targeted protein degradation research and drug discovery applications. -
PROTAC Linker
Boc-NH-PEG12-NH2 is a polyethylene glycol (PEG)-based linker designed for use in the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the conjugation of target protein ligands to E3 ligase recruiters, enhancing the effectiveness of PROTACs in promoting targeted protein degradation. It is a valuable tool for researchers investigating novel therapeutic strategies through the modulation of protein homeostasis. -
PROTAC Linker
2-(4-(((9H-Fluoren-9-yl)methoxy)carbonyl)piperazin-1-yl)acetic acid serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras. This compound effectively engages with E3 ligases, promoting targeted protein degradation. Its application is pivotal in the design and synthesis of hybrid molecules for research in drug discovery and therapeutic development. -
PROTAC Linker
2-(Bromomethyl)-1,3-dioxolane is a chemical linker specifically designed for use in synthesizing PROTACs (proteolysis-targeting chimeras). This compound facilitates the construction of bifunctional molecules that can selectively induce the degradation of target proteins through the ubiquitin-proteasome system. Its utility in the development of targeted protein degradation strategies makes it valuable for research in drug discovery and therapeutic applications. -
PROTAC Linker
tert-Butyl 8-aminooctanoate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. Its structure enables optimal interaction with target proteins, enhancing the overall efficacy of targeted protein degradation assays. This reagent is essential for researchers focused on investigating novel therapeutic strategies involving proteolysis-targeting chimeras. -
PROTAC Linkers
mPEG45-Epoxide is a polyethylene glycol (PEG) derivative featuring polyether units, designed for use as a linker in PROTAC (Proteolysis Targeting Chimera) synthesis. This compound facilitates the conjugation of ligands to E3 ubiquitin ligases, enabling targeted protein degradation. mPEG45-Epoxide is instrumental in the development of novel therapeutic agents and in studying protein regulation mechanisms within cellular environments. -
PROTAC Linker
4-Boc-aminomethyl-piperidine is a versatile PROTAC linker that facilitates the development of targeted protein degradation therapies. This compound is essential for synthesizing various PROTACs, enabling the selective degradation of specific proteins within cellular pathways. Its application in research helps to advance therapeutic strategies for diseases driven by protein misregulation. -
PROTAC Linker
trans-4-[[(1,1-Dimethylethoxy)carbonyl]amino]cyclohexaneacetic acid acts as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras. This compound is instrumental in the synthesis of PROTACs, which harness the cell's ubiquitin-proteasome system for targeted protein degradation. Its unique structure enhances the activity and specificity of PROTACs in various research applications, making it a critical reagent for studies in targeted therapy and protein modulation. -
PROTAC Linker
(E)-tert-Butyldimethyl((4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)but-3-en-1-yl)oxy)silane serves as a versatile PROTAC linker, facilitating the assembly of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins via the ubiquitin-proteasome system and is instrumental in drug discovery and development. Its unique structure allows for effective conjugation, enhancing cellular permeability and targeting specificity in therapeutic applications. -
PROTAC Linker
tert-Butyl (7-azaspiro[3.5]nonan-2-yl)carbamate is a versatile PROTAC linker designed to facilitate the synthesis of PROTAC molecules. This compound enhances the targeted degradation of specific proteins through the ubiquitin-proteasome system, promoting effective protein removal. Its unique structural features support the development of novel therapeutic agents for research in targeted protein degradation. -
PROTAC Linker
tert-Butyl N-{2-azaspiro[3.4]octan-6-yl}carbamate serves as a PROTAC linker, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound enables the selective degradation of target proteins, enhancing cellular studies in target validation and therapeutic development. Its structural properties make it suitable for a variety of research applications in chemical biology and drug discovery. -
PROTAC Linker
tert-Butyl 9-amino-3-azaspiro[5.5]undecane-3-carboxylate serves as a link for PROTAC (proteolysis-targeting chimera) synthesis, facilitating the creation of bifunctional molecules that can selectively target specific proteins for degradation. This compound is instrumental in the field of targeted protein degradation research, enabling the development of novel therapeutics that can modulate protein levels in a controlled manner. -
PROTAC Linker
tert-Butyl (3-(hydroxymethyl)bicyclo[1.1.1]pentan-1-yl)carbamate is a specialized PROTAC linker designed for the synthesis of proteolysis-targeting chimeras (PROTACs). This compound facilitates the formation of covalent bonds between target proteins and E3 ligases, thus enhancing the ubiquitin-proteasome degradation pathway. Its effectiveness in linking various pharmacophores makes it a valuable tool for researchers exploring targeted protein degradation and related therapeutic applications. -
PROTAC Linkers
Di(N-succinimidyl)adipate is an alkyl chain-based PROTAC linker that facilitates the development of proteolysis-targeting chimeras (PROTACs). Its structure allows for effective conjugation with various target proteins and E3 ligases, enabling the selective degradation of specific intracellular proteins. This reagent is essential for researchers aiming to explore targeted protein degradation mechanisms and develop innovative therapeutic strategies. -
Ligands for E3 Ligase
Pomalidomide 4'-PEG5-azide is a Pomalidomide-derived ligand specifically targeting the cereblon (CRBN) protein. This compound facilitates the recruitment of CRBN, making it a valuable tool in the development of PROTACs by linking to proteins through a suitable linker. Its application in chemical biology research enhances understanding of protein degradation pathways and E3 ligase modulation. -
E3 Ligase Ligand-linker Conjugate
E3 Ligase Ligand-linker Conjugate 109 is an E3 ligase ligand-linker conjugate designed for the synthesis of PROTAC SOS1 degrader. This compound facilitates targeted protein degradation, enabling researchers to investigate the therapeutic potential of protein modulation in cellular systems. Its utility in developing targeted degradation strategies makes it an essential tool for drug discovery and development research. -
E3 Ligase Ligand-linker Conjugate
E3 Ligase Ligand-linker Conjugate 108 is an E3 ligase ligand-linker conjugate designed for the synthesis of targeted protein degradation compounds. This reagent facilitates the development of PROTACs, specifically enabling the degradation of the SOS1 protein. It serves as a crucial tool in research applications focused on targeted protein modulation and therapeutic intervention in cellular processes related to disease states. -
CRBN E3 Ligase Modulator
Golcadomide is a potent modulator of the CRBN E3 ligase, functioning as a CELMoD that promotes the ubiquitin-mediated proteasomal degradation of key transcription factors such as Ikaros and Aiolos through its interaction with the CRL4 CRBN substrate receptor. This compound has significant biological activity in cancer research, particularly in the study of chronic lymphocytic leukemia (CLL) and non-Hodgkin lymphoma (NHL). Golcadomide's unique mechanism positions it as a valuable tool for exploring therapeutic pathways in hematological malignancies. -
Ligands for E3 Ligase
Lenalidomide-5-aminomethyl hydrochloride is a derivative of Lenalidomide that acts as a ligand for the E3 ubiquitin ligase cereblon (CRBN). This compound facilitates the recruitment of CRBN to target proteins, enabling targeted protein degradation through the formation of PROTACs (proteolysis-targeting chimeras). It is a valuable tool for researchers exploring protein homeostasis and therapeutic applications in cancer and other diseases where modulation of protein levels is critical. -
Ligands for E3 Ligase
CRBN ligand-109 is a selective ligand for the CRBN E3 ubiquitin ligase, facilitating the development of proteolysis-targeting chimeras (PROTACs). This compound can effectively promote the ubiquitination and subsequent degradation of target proteins, making it a valuable tool in the study of protein regulation and degradation pathways. Its application is critical in drug discovery, particularly in targeting disease-associated proteins for therapeutic intervention. -
Ligands for E3 Ligase
Lenalidomide-Br is an analog of the cereblon (CRBN) ligand Lenalidomide, functioning as a ligand for the E3 ubiquitin ligase. This compound effectively recruits the CRBN protein, facilitating targeted protein degradation. Lenalidomide-Br can be utilized to create PROTACs, such as the PROTAC STAT3 degrader SD-36, expanding its application in studies focused on targeted therapy and protein modulation in various biological contexts. -
Ligands for E3 Ligase
DCAF1 binder 1 is a selective ligand for the CRL4 DCAF1 E3 ligase complex. This compound plays a crucial role in targeted protein degradation (TPD), making it valuable for research applications focused on modulating protein levels and understanding the mechanisms of E3 ligase activity. DCAF1 binder 1 can facilitate investigations into the therapeutic potential of TPD in various disease contexts. -
Ligands for E3 Ligase
Lenalidomide-5-Br is a derivative of Lenalidomide that functions as a ligand for cereblon (CRBN), an E3 ubiquitin ligase. This compound effectively recruits CRBN to target proteins for ubiquitination and degradation, facilitating the development of Proteolysis Targeting Chimeras (PROTACs). Lenalidomide-5-Br is utilized in research focused on targeted protein degradation and therapeutic development for various diseases, including cancers and autoimmune disorders. -
Ligands for E3 Ligase
Lenalidomide-I is a potent ligand for the E3 ubiquitin ligase cereblon (CRBN). It facilitates the recruitment of the CRBN protein, making it a valuable component for the development of PROTACs (Proteolysis Targeting Chimeras). Applications of Lenalidomide-I include the creation of novel PROTACs, such as the PROTAC BET degrader QCA570, which are utilized in targeted protein degradation research. -
Ligands for E3 Ligase
E3 Ligase Ligand 64 functions as a ligand for E3 ligase, enabling its application in targeted protein degradation studies. This compound is instrumental in the synthesis of RP03707, facilitating research in ubiquitin-proteasome pathways and related signaling mechanisms. Its use enhances understanding of E3 ligase activity, making it significant for investigations into disease-related protein dysregulation. -
Ligands for E3 Ligase
(S,R,S)-AHPC-Boc is a ligand that selectively targets the von Hippel-Lindau (VHL) protein, facilitating the recruitment of this E3 ligase. This compound is integral to the development of Proteolysis Targeting Chimeras (PROTACs), enabling the selective degradation of target proteins in cellular systems. Its utility in research applications includes studying protein homeostasis and exploring therapeutic strategies for various diseases. -
Ligands for E3 Ligase
CRBN ligand-13 acts as a ligand for the CRBN-type E3 ubiquitin ligase, facilitating targeted protein degradation via the PROTAC (Proteolysis Targeting Chimeras) approach. It plays a critical role in the development of novel therapeutic strategies for various diseases by enabling the selective elimination of specific proteins within cells. This compound is valuable for researchers focused on protein regulation and targeted drug development. -
Ligands For E3 Ligase
Lenalidomide-OH is a potent analog of the cereblon (CRBN) ligand Lenalidomide, designed to selectively engage E3 ubiquitin ligase. This compound facilitates the recruitment of CRBN protein, essential for targeted protein degradation applications. Lenalidomide-OH can be coupled with various ligands via a linker to construct PROTACs, such as the BTK degrader SJF620, making it a valuable tool in studies of protein homeostasis and therapeutic development. -
Ligands for E3 Ligase
N-Me-Thalidomide 4-fluoride is a ligand for E3 ligase, functioning as a tool in targeted protein degradation studies. It plays a critical role in the synthesis of Anti-inflammatory agent 70, which has potential applications in modulating inflammatory pathways. This compound is of significant interest for researchers investigating therapeutic strategies that harness E3 ligase activity in various biological contexts.
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Ligands for E3 Ligase
5-Aminothalidomide is an E3 ligase ligand that plays a crucial role in PROTAC technology. This compound facilitates the synthesis of targeted protein degraders, enabling the development of specific PROTACs such as BRD9 Degrader-7. Its ability to modulate protein levels provides valuable insights into proteostasis and therapeutic intervention in various biological studies.
